CN115006445A - Traditional Chinese medicine formula for resisting liver cancer by using quinones extracted from plants - Google Patents
Traditional Chinese medicine formula for resisting liver cancer by using quinones extracted from plants Download PDFInfo
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- CN115006445A CN115006445A CN202210540303.7A CN202210540303A CN115006445A CN 115006445 A CN115006445 A CN 115006445A CN 202210540303 A CN202210540303 A CN 202210540303A CN 115006445 A CN115006445 A CN 115006445A
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- 201000007270 liver cancer Diseases 0.000 title claims abstract description 35
- 239000003814 drug Substances 0.000 title claims abstract description 34
- 208000014018 liver neoplasm Diseases 0.000 title claims abstract description 34
- 150000004053 quinones Chemical class 0.000 title claims abstract description 25
- 239000007788 liquid Substances 0.000 claims abstract description 22
- 241000222336 Ganoderma Species 0.000 claims abstract description 15
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 claims abstract description 15
- 235000006533 astragalus Nutrition 0.000 claims abstract description 15
- 235000012907 honey Nutrition 0.000 claims abstract description 13
- 241000045403 Astragalus propinquus Species 0.000 claims abstract description 12
- AZQWKYJCGOJGHM-UHFFFAOYSA-N para-benzoquinone Natural products O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 12
- 241000196324 Embryophyta Species 0.000 claims abstract description 9
- -1 quinone compound Chemical class 0.000 claims abstract description 4
- 241000304195 Salvia miltiorrhiza Species 0.000 claims abstract 6
- 229940126680 traditional chinese medicines Drugs 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 5
- 241001061264 Astragalus Species 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 238000002791 soaking Methods 0.000 claims description 3
- 210000004233 talus Anatomy 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 230000001644 anti-hepatocarcinoma Effects 0.000 claims 3
- 230000000694 effects Effects 0.000 abstract description 9
- 244000132619 red sage Species 0.000 description 9
- 230000004083 survival effect Effects 0.000 description 8
- 206010028980 Neoplasm Diseases 0.000 description 7
- 230000001737 promoting effect Effects 0.000 description 4
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
- 206010027476 Metastases Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 2
- 230000003908 liver function Effects 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 238000007674 radiofrequency ablation Methods 0.000 description 2
- 238000002271 resection Methods 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 102000001707 3',5'-Cyclic-AMP Phosphodiesterases Human genes 0.000 description 1
- 108010054479 3',5'-Cyclic-AMP Phosphodiesterases Proteins 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 240000008397 Ganoderma lucidum Species 0.000 description 1
- 235000001637 Ganoderma lucidum Nutrition 0.000 description 1
- 241000700721 Hepatitis B virus Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 240000007164 Salvia officinalis Species 0.000 description 1
- 102000003929 Transaminases Human genes 0.000 description 1
- 108090000340 Transaminases Proteins 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 229940107666 astragalus root Drugs 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 235000021152 breakfast Nutrition 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000003560 cancer drug Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 208000002672 hepatitis B Diseases 0.000 description 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 235000005412 red sage Nutrition 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Insects & Arthropods (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Animal Husbandry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a traditional Chinese medicine formula for resisting liver cancer by using plant extracted quinones, which is prepared from the following raw materials in parts by mass: 5 parts of quinone compound, 1-5 parts of salvia miltiorrhiza, 1-5 parts of astragalus membranaceus, 1-5 parts of lucid ganoderma and 1 part of honey; the liquid medicine of the formula contains quinone compounds, has obvious anti-liver cancer activity and can play an effective role in treating liver cancer.
Description
Technical Field
The invention relates to the technical field of medicinal chemistry, in particular to a traditional Chinese medicine formula for resisting liver cancer by using plant extracted quinones.
Background
Primary liver cancer is one of the most common malignancies worldwide, especially in asia, africa and south america. In china, 80% of HCC is caused by hepatitis b virus and 20% by hepatitis c. The prevalence rate of hepatitis B in China is about 8600 ten thousand. Primary hepatocellular carcinoma is a serious disease which endangers the health and life of people in China. Because of the high difficulty of liver cancer surgery, high surgical techniques are required. The 5-year survival rate of liver cancer patients in China is below 50%, most of the current anti-tumor drug patents are mastered in foreign hands, and the curative effect of the domestic anti-liver cancer drugs is poor.
Disclosure of Invention
Aiming at the technical defects, the invention provides a traditional Chinese medicine formula for resisting liver cancer by using plant extracted quinones.
In order to solve the technical problems, the invention adopts the following technical scheme:
a traditional Chinese medicine formula for resisting liver cancer by using quinones extracted from plants is prepared from the following raw materials in parts by mass: 5 parts of quinone compounds, 1-5 parts of salvia miltiorrhiza, 1-5 parts of astragalus membranaceus, 1-5 parts of lucid ganoderma and 1 part of honey.
Preferably, the raw materials used by the traditional Chinese medicine specifically comprise, by weight: 100g of quinone compounds, 20g of salvia miltiorrhiza, 20g of astragalus membranaceus, 20g of lucid ganoderma and 20g of honey.
Preferably, the raw materials used by the traditional Chinese medicine specifically comprise, by weight: 100g of quinone compounds, 50g of salvia miltiorrhiza, 50g of astragalus membranaceus, 50g of lucid ganoderma and 20g of honey.
Preferably, the raw materials used by the traditional Chinese medicine specifically comprise, by weight: 100g of quinone compounds, 100g of salvia miltiorrhiza, 100g of astragalus membranaceus, 100g of lucid ganoderma and 20g of honey.
Preferably, the preparation method comprises the following steps: putting the quinone compound and the salvia miltiorrhiza in a pot according to the formula amount, adding water to 5 times of the total weight of the traditional Chinese medicines, quickly decocting with strong fire until the liquid medicine is boiled, then decocting with slow fire for 20-30 minutes, pouring out the liquid medicine for later use, adding alcohol which is 3 times of the total weight of the traditional Chinese medicines into the pot, soaking for 20 days, pouring out the liquid for later use, adding the astragalus and the lucid ganoderma according to the formula amount into the liquid for later use, and mixing the liquid medicine for later use with the liquid to obtain a finished product.
The invention has the beneficial effects that: the liquid medicine of the formula contains quinone compounds, has obvious anti-liver cancer activity and can play an effective role in treating liver cancer.
The following is combined with the main components in the invention to further explain the beneficial effects:
quinone compounds: has antibacterial, hemostatic, and diuretic effects, and also has effects in inhibiting cancer cells, cAMP phosphodiesterase, and high immunity.
Red sage root: has effects in promoting blood circulation, dispelling blood stasis, dredging channels, relieving pain, clearing away heart-fire, relieving restlessness, cooling blood, and eliminating carbuncle.
Astragalus root: has effects in invigorating qi, consolidating exterior, expelling toxin, expelling pus, promoting urination, and promoting granulation.
Ganoderma lucidum: has effects in tonifying body, strengthening body constitution, strengthening brain, relieving inflammation, promoting urination, and invigorating kidney.
Honey: has effects in clearing away heat, invigorating middle warmer, moistening dryness, relieving pain, removing toxic materials, caring skin, and caring skin.
Detailed Description
The present invention will be described in further detail with reference to examples, but the present invention is not limited thereto.
Example 1
A traditional Chinese medicine formula for resisting liver cancer by using quinones extracted from plants is prepared from the following raw materials in parts by weight: 100g of quinone compounds, 20g of salvia miltiorrhiza, 20g of astragalus membranaceus, 20g of lucid ganoderma and 20g of honey.
Further, the preparation method comprises the following steps: putting the quinone compound and the salvia miltiorrhiza in a pot according to the formula amount, adding water to 5 times of the total weight of the traditional Chinese medicines, quickly decocting with strong fire until the liquid medicine is boiled, then decocting with slow fire for 20-30 minutes, pouring out the liquid medicine for later use, adding alcohol which is 3 times of the total weight of the traditional Chinese medicines into the pot, soaking for 20 days, pouring out the liquid for later use, adding the astragalus and the lucid ganoderma according to the formula amount into the liquid for later use, and mixing the liquid medicine for later use with the liquid to obtain a finished product.
Example 2
A traditional Chinese medicine formula for resisting liver cancer by using quinones extracted from plants is prepared from the following raw materials in parts by weight: 100g of quinone compounds, 50g of salvia miltiorrhiza, 50g of astragalus membranaceus, 50g of lucid ganoderma and 20g of honey.
The preparation method is the same as in example 1.
Example 3
A traditional Chinese medicine formula for resisting liver cancer by using quinones extracted from plants is prepared from the following raw materials in parts by weight: 100g of quinone compounds, 100g of salvia miltiorrhiza, 100g of astragalus membranaceus, 100g of lucid ganoderma and 20g of honey.
The preparation method is the same as that of example 1.
And (3) clinical observation:
clinical data
The inventor carries out clinical observation and treatment on 110 liver cancer patients; wherein 75 cases of men and 35 cases of women have an average age of 40-65 years;
5 cases of small/small liver cancer, 80 cases of large liver cancer and 25 cases of large liver cancer;
severe cases/intrahepatic metastases/multiple cases were combined in 5 cases;
the micro/small liver cancer is liver cancer with a tumor diameter of 0-4.9 cm; the large liver cancer is the liver cancer with the tumor diameter of 5-9.9 cm; giant liver cancer is liver cancer with tumor diameter larger than 10 cm; severe patients with liver function index above CHILDC, such as combined liver function transaminase (AST/ALT), bilirubin, albumin, and fibrinogen;
the treatment method comprises the following steps:
performing radio frequency ablation on patients with minimal/small liver cancer;
performing surgical resection on patients with large liver cancer and giant liver cancer;
intervention treatment is applied to the patient with severe disease/intrahepatic metastasis/multiple diseases;
on the basis, all patients take the liquid medicine twice a day after discharge, and the liquid medicine is taken before breakfast and after supper, and the dosage of each time is 40-50 ml.
And (4) judging the standard:
the patient is cured without affecting the tumor residue after tumor resection/radiofrequency ablation; monitoring the 5-year survival rate of all cured patients and patients who cannot be operated; and monitoring the survival rate of patients who cannot be resected;
as a result:
in 85 cured patients, the survival period of 49 people is more than 5 years, and the 5-year survival rate is 58 percent; in 20 cases of giant liver cancer, 4 people with a survival time of more than 5 years are present, and the 5-year survival rate is 20%. The longest survival time in the group of patients who could not perform the operation was 4 years.
The traditional Chinese medicine contains quinone compounds, has obvious anti-liver cancer activity, and can play an effective treatment role on liver cancer.
It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.
Claims (5)
1. The traditional Chinese medicine formula for resisting liver cancer by using quinones extracted from plants is characterized by being prepared from the following raw materials in parts by mass: 5 parts of quinone compounds, 1-5 parts of salvia miltiorrhiza, 1-5 parts of astragalus membranaceus, 1-5 parts of lucid ganoderma and 1 part of honey.
2. The plant-extracted quinone anti-hepatoma traditional Chinese medicine formula as claimed in claim 1, wherein the raw materials used by the traditional Chinese medicine specifically comprise by weight: 100g of quinone compounds, 20g of salvia miltiorrhiza, 20g of astragalus membranaceus, 20g of lucid ganoderma and 20g of honey.
3. The plant-extracted quinone anti-hepatoma traditional Chinese medicine formula as claimed in claim 1, wherein the raw materials used by the traditional Chinese medicine specifically comprise by weight: 100g of quinone compounds, 50g of salvia miltiorrhiza, 50g of astragalus membranaceus, 50g of lucid ganoderma and 20g of honey.
4. The plant-extracted quinone anti-hepatoma traditional Chinese medicine formula as claimed in claim 1, wherein the raw materials used by the traditional Chinese medicine specifically comprise by weight: 100g of quinone compounds, 100g of salvia miltiorrhiza, 100g of astragalus membranaceus, 100g of lucid ganoderma and 20g of honey.
5. The plant-extracted quinone anti-liver cancer traditional Chinese medicine formula of claim 1, which is characterized by comprising the following preparation method: putting the quinone compound and the salvia miltiorrhiza in a pot according to the formula amount, adding water to 5 times of the total weight of the traditional Chinese medicines, quickly decocting with strong fire until the liquid medicine is boiled, then decocting with slow fire for 20-30 minutes, pouring out the liquid medicine for later use, adding alcohol which is 3 times of the total weight of the traditional Chinese medicines into the pot, soaking for 20 days, pouring out the liquid for later use, adding the astragalus and the lucid ganoderma according to the formula amount into the liquid for later use, and mixing the liquid medicine for later use with the liquid to obtain a finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210540303.7A CN115006445A (en) | 2022-05-18 | 2022-05-18 | Traditional Chinese medicine formula for resisting liver cancer by using quinones extracted from plants |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210540303.7A CN115006445A (en) | 2022-05-18 | 2022-05-18 | Traditional Chinese medicine formula for resisting liver cancer by using quinones extracted from plants |
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| Publication Number | Publication Date |
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| CN115006445A true CN115006445A (en) | 2022-09-06 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210540303.7A Pending CN115006445A (en) | 2022-05-18 | 2022-05-18 | Traditional Chinese medicine formula for resisting liver cancer by using quinones extracted from plants |
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| Country | Link |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109316573A (en) * | 2018-11-24 | 2019-02-12 | 李就镁 | A kind of Chinese medicine composition and preparation method thereof for treating liver cancer |
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2022
- 2022-05-18 CN CN202210540303.7A patent/CN115006445A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109316573A (en) * | 2018-11-24 | 2019-02-12 | 李就镁 | A kind of Chinese medicine composition and preparation method thereof for treating liver cancer |
Non-Patent Citations (5)
| Title |
|---|
| 曹亮: "蒽醌类化合物的研究进展", 西北药学杂志, vol. 24, no. 3, pages 237 - 238 * |
| 沈章阳: "醌类化合物及其衍生物抗肿瘤活性研究进展", 大众科技, vol. 19, no. 10, pages 55 - 56 * |
| 许荣: "扶正抑瘤方改善肝癌微波术后患者中医证侯临床观察", 中国社区医师, vol. 13, no. 272, pages 159 - 160 * |
| 许荣;赵红佳;游涛;欧阳秋芳;王秀丽;: "扶正抑瘤方改善肝癌微波术后患者中医证侯临床观察", 中国社区医师(医学专业), vol. 13, no. 272, pages 165 - 166 * |
| 顾小侠,刘书林,陶玉华: "岩舒注射液治疗中晚期肝癌32例临床观察", 吉林中医药, no. 09, pages 19 - 20 * |
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