CN106727988A - It is a kind of to treat Chinese and Western medicine composite preparation of constipation and preparation method thereof - Google Patents
It is a kind of to treat Chinese and Western medicine composite preparation of constipation and preparation method thereof Download PDFInfo
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- CN106727988A CN106727988A CN201611172236.9A CN201611172236A CN106727988A CN 106727988 A CN106727988 A CN 106727988A CN 201611172236 A CN201611172236 A CN 201611172236A CN 106727988 A CN106727988 A CN 106727988A
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- constipation
- western medicine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
Abstract
The invention discloses a kind of Chinese and Western medicine composite preparation for treating constipation, the Chinese and Western medicine composite preparation of the treatment constipation is according to the primary raw material of weight portion:12 16 parts of the bighead atractylodes rhizome, 7 15 parts of the capsule of weeping forsythia, 26 32 parts of kakuol, 18 25 parts of deoxyshikonin, II 8 10 parts of different astragaloside, 5 10 parts of timosaponin C, 48 parts of menthol, 24 30 parts of cerevisterol, 46 parts of Bisdemethoxycurcumin.Medicine of the present invention is strictly selected material composition according to the understanding mechanism of constipation, so as to reach the purpose of comprehensive rehabilitation, with rapid-action, effect stabilization, carry convenient to take, long-term taking and have no toxic side effect the characteristics of.
Description
Technical field
The present invention relates to a kind of field of medicine preparation, specifically a kind of Chinese and Western medicine composite preparation for treating constipation.
Background technology
Constipation is obstructed constipation, and defecation frequency is reduced or stool and moist, discharge involved and abstruse or infrequent defecation time
It is long, though or there are awareness of defecation defecation inability, an a kind of difficult illness.Constipation can be temporary, may also be long-term, generally long-term
Constipation we be also referred to as habitual constipation.Daily ingestion vegetables or cellulosic and moisture content deficiency, the life for lacking exercise of fruit
Mode living or environment change etc., are common constipation reasons.Prolonged constipation can be suffered from abdominal pain with abdominal distension, the symptom such as stool band blood, easily
Induce the breaking-out of Cardial or cerebral vascular diseases, induce the diseases such as serious hemorrhoid, anal fissure, prolapse of the anus, hypertrophy of the prostate.Treatment constipation at present
Medicament categories it is various, but effect is not satisfactory, western medical treatment constipation, can only give cathartic defaecation, takes the logical internal organs of tool and rushes down lower work(
The medicine of energy, cathartic long term usage can consume human righteousness, aggravate the exhaustion of intestinal motive force, cause most of patients pharmacological dependence to cause pernicious
Circulation.Additionally, relying on catharsis agent defaecation for a long time, when no longer taking suddenly, constipation is also resulted in.So many people are controlled using Chinese medicine
Constipation is treated, but the pained misery taste of Chinese medicine is troubling, and the prolonged medicine that decocts also causes greatest to current busy crowd
Trouble.
The content of the invention
It is an object of the invention to provide a kind of Chinese and Western medicine composite preparation for treating constipation, with solving above-mentioned background technology
The problem of proposition.
To achieve the above object, the present invention provides following technical scheme:
A kind of Chinese and Western medicine composite preparation for treating constipation, be according to the primary raw material of weight portion:Bighead atractylodes rhizome 12-16 parts, the capsule of weeping forsythia
7-15 parts, kakuol 26-32 parts, deoxyshikonin 18-25 parts, it is 8-10 parts of different astragaloside II, 5-10 parts of timosaponin C, thin
4-8 parts, cerevisterol 24-30 parts, Bisdemethoxycurcumin 4-6 parts of lotus alcohol.
As further scheme of the invention:The Chinese and Western medicine composite preparation of the treatment constipation, according to the main of weight portion
Raw material is:Bighead atractylodes rhizome 13-15 parts, capsule of weeping forsythia 9-12 parts, kakuol 28-30 parts, deoxyshikonin 19-23 parts, the 8- of different astragaloside II
10 parts, 5-10 parts, menthol 4-8 parts, cerevisterol 25-28 parts, Bisdemethoxycurcumin 4-6 parts of timosaponin C.
As further scheme of the invention:The Chinese and Western medicine composite preparation of the treatment constipation, according to the main of weight portion
Raw material is:14 parts of the bighead atractylodes rhizome, 11 parts of the capsule of weeping forsythia, 29 parts of kakuol, 21 parts of deoxyshikonin, II 9 parts of different astragaloside, timosaponin C
8 parts, 6 parts of menthol, 27 parts of cerevisterol, 5 parts of Bisdemethoxycurcumin.
A kind of preparation method of the Chinese and Western medicine composite preparation for treating constipation, concretely comprises the following steps:
First, in pharmaceutical grade clean area, the bighead atractylodes rhizome, capsule of weeping forsythia, kakuol, deoxyshikonin, different is weighed by above-mentioned metering ratio
Astragaloside II, timosaponin C, menthol, cerevisterol, Bisdemethoxycurcumin, sieving, machinery add ultrapure after mixing
Water, places in pharmacy mixer, mixes 4-8min, controls RSD≤5%, compressing tablet and low temperature drying after mixing, and temperature control is in 4-
8 DEG C, packaging obtains final product the Chinese and Western medicine composite preparation for the treatment of constipation.
As further scheme of the invention:Mix 6min in specific steps.
As further scheme of the invention:Temperature control is at 6 DEG C in specific steps.
Compared with prior art, the beneficial effects of the invention are as follows:
Medicine of the present invention is strictly selected material composition according to the understanding mechanism of constipation, so as to reach comprehensive rehabilitation
Purpose, with rapid-action, effect stabilization, carry convenient to take, long-term taking and have no toxic side effect the characteristics of.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only a part of embodiment of the invention, rather than whole embodiments.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made, all
Belong to the scope of protection of the invention.
Embodiment 1
A kind of Chinese and Western medicine composite preparation for treating constipation, be according to the primary raw material of weight portion:12 parts of the bighead atractylodes rhizome, 7 parts of the capsule of weeping forsythia,
26 parts of kakuol, 18 parts of deoxyshikonin, II 8 parts of different astragaloside, 5 parts of timosaponin C, 4 parts of menthol, cerevisterol 24
Part, 4 parts of Bisdemethoxycurcumin.
A kind of preparation method of the Chinese and Western medicine composite preparation for treating constipation, concretely comprises the following steps:
First, in pharmaceutical grade clean area, the bighead atractylodes rhizome, capsule of weeping forsythia, kakuol, deoxyshikonin, different is weighed by above-mentioned metering ratio
Astragaloside II, timosaponin C, menthol, cerevisterol, Bisdemethoxycurcumin, sieving, machinery add ultrapure after mixing
Water, places in pharmacy mixer, mixes 4min, controls RSD≤5%, compressing tablet and low temperature drying after mixing, temperature control at 4 DEG C,
Packaging obtains final product the Chinese and Western medicine composite preparation for the treatment of constipation.
Embodiment 2
A kind of Chinese and Western medicine composite preparation for treating constipation, be according to the primary raw material of weight portion:13 parts of the bighead atractylodes rhizome, 9 parts of the capsule of weeping forsythia,
28 parts of kakuol, 19 parts of deoxyshikonin, II 8 parts of different astragaloside, 5 parts of timosaponin C, 4 parts of menthol, cerevisterol 25
Part, 4 parts of Bisdemethoxycurcumin.
A kind of preparation method of the Chinese and Western medicine composite preparation for treating constipation, concretely comprises the following steps:
First, in pharmaceutical grade clean area, the bighead atractylodes rhizome, capsule of weeping forsythia, kakuol, deoxyshikonin, different is weighed by above-mentioned metering ratio
Astragaloside II, timosaponin C, menthol, cerevisterol, Bisdemethoxycurcumin, sieving, machinery add ultrapure after mixing
Water, places in pharmacy mixer, mixes 4min, controls RSD≤5%, compressing tablet and low temperature drying after mixing, temperature control at 4 DEG C,
Packaging obtains final product the Chinese and Western medicine composite preparation for the treatment of constipation.
Embodiment 3
A kind of Chinese and Western medicine composite preparation for treating constipation, be according to the primary raw material of weight portion:14 parts of the bighead atractylodes rhizome, the capsule of weeping forsythia 11
Part, 29 parts of kakuol, 21 parts of deoxyshikonin, II 9 parts of different astragaloside, 8 parts of timosaponin C, 6 parts of menthol, cerevisterol
27 parts, 5 parts of Bisdemethoxycurcumin.
A kind of preparation method of the Chinese and Western medicine composite preparation for treating constipation, concretely comprises the following steps:
First, in pharmaceutical grade clean area, the bighead atractylodes rhizome, capsule of weeping forsythia, kakuol, deoxyshikonin, different is weighed by above-mentioned metering ratio
Astragaloside II, timosaponin C, menthol, cerevisterol, Bisdemethoxycurcumin, sieving, machinery add ultrapure after mixing
Water, places in pharmacy mixer, mixes 6min, controls RSD≤5%, compressing tablet and low temperature drying after mixing, temperature control at 6 DEG C,
Packaging obtains final product the Chinese and Western medicine composite preparation for the treatment of constipation.
Embodiment 4
A kind of Chinese and Western medicine composite preparation for treating constipation, be according to the primary raw material of weight portion:15 parts of the bighead atractylodes rhizome, the capsule of weeping forsythia 12
Part, 30 parts of kakuol, 23 parts of deoxyshikonin, II 10 parts of different astragaloside, 10 parts of timosaponin C, 8 parts of menthol, beer steroid
28 parts of alcohol, 6 parts of Bisdemethoxycurcumin.
A kind of preparation method of the Chinese and Western medicine composite preparation for treating constipation, concretely comprises the following steps:
First, in pharmaceutical grade clean area, the bighead atractylodes rhizome, capsule of weeping forsythia, kakuol, deoxyshikonin, different is weighed by above-mentioned metering ratio
Astragaloside II, timosaponin C, menthol, cerevisterol, Bisdemethoxycurcumin, sieving, machinery add ultrapure after mixing
Water, places in pharmacy mixer, mixes 8min, controls RSD≤5%, compressing tablet and low temperature drying after mixing, temperature control at 8 DEG C,
Packaging obtains final product the Chinese and Western medicine composite preparation for the treatment of constipation.
Embodiment 5
A kind of Chinese and Western medicine composite preparation for treating constipation, be according to the primary raw material of weight portion:16 parts of the bighead atractylodes rhizome, the capsule of weeping forsythia 15
Part, 32 parts of kakuol, 25 parts of deoxyshikonin, II 10 parts of different astragaloside, 10 parts of timosaponin C, 8 parts of menthol, beer steroid
30 parts of alcohol, 6 parts of Bisdemethoxycurcumin.
A kind of preparation method of the Chinese and Western medicine composite preparation for treating constipation, concretely comprises the following steps:
First, in pharmaceutical grade clean area, the bighead atractylodes rhizome, capsule of weeping forsythia, kakuol, deoxyshikonin, different is weighed by above-mentioned metering ratio
Astragaloside II, timosaponin C, menthol, cerevisterol, Bisdemethoxycurcumin, sieving, machinery add ultrapure after mixing
Water, places in pharmacy mixer, mixes 8min, controls RSD≤5%, compressing tablet and low temperature drying after mixing, temperature control at 8 DEG C,
Packaging obtains final product the Chinese and Western medicine composite preparation for the treatment of constipation.
Pharmacology test
1st, acute toxicity test
It is experiment with Chinese and Western medicine composite preparation obtained in the embodiment of the present invention 3, using gastric infusion mode, connects in 24h
Continuous administration 2 times, per minor tick 8h, is administered 1800mg/kg doses every time, and daily accumulation medicine total amount reaches 3600mg medicines/kg, phase
When in 120 times of people's quantity.After administration in 7d, mouse activity, feed, excretion are normal, well-grown, hair color light,
Its average weight increases with the extension of experimental period.Every mouse of post mortem at 8d, visually observe the heart, liver, spleen,
Lung, kidney, brain, thymus gland, stomach, intestines etc. do not find color and paramophia, fail to measure median lethal dose (LD50).As a result table
It is bright:Chinese and Western medicine composite preparation of the present invention is without acute toxic reaction.
2nd, long term toxicity test
It is experiment with Chinese and Western medicine composite preparation obtained in the embodiment of the present invention 3, using gastric infusion mode, by the present invention
Western medicine compound formulation is divided into low dosage, middle dosage, three groups of high dose, the drug dose of each group is respectively 300,600,900mg medicines
Thing/kg/d, 10,20,30 times equivalent to clinical dosage.After gastric infusion 24 weeks, medicine of the present invention to the general status of animal,
, without obvious influence, Systematic anatomy, organ coefficient and histopathological examination are not sent out yet for hematological indices, blood parameters
Existing abnormal pathologic changes.It is discontinued 2 weeks and also has no substantially change.Result shows:Chinese and Western medicine composite preparation of the present invention is in long term toxicity
In experiment, overt toxicity reaction and delayed toxicity reaction are not found.It can be seen that, medicine composite preparation non-toxic reaction in Chinese and Western of the present invention,
Long-term prescription is safe and reliable.
3rd, clinical test
From in November, 2015 between in March, 2016,200 constipation patients are randomly selected, wherein man 115, female 85, year
Age 22-65 Sui, average 41.3 years old;Course of disease 1-5, average 2.8 years.Symptom:Defecation time extends, and is done with last time, excrement within 3 days
It is dry hard.(daily dose is 30mg/kg, one to 2 courses for the treatment of of Chinese and Western medicine composite preparation through taking the preparation of the embodiment of the present invention 3
The individual course for the treatment of 3 days) after, 175 people cure (once, just matter turn profit, unobstructed during solution for defecation within 2 days, in short term without recurrence);25 people take a turn for the better
(defecation within 3 days, just matter turn profit, defecation owes smooth);0 people is not healed (symptom is without improvement), and total effective rate is 100.0%.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be in other specific forms realized.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit requires to be limited rather than described above, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.
Moreover, it will be appreciated that although the present specification is described in terms of embodiments, not each implementation method is only wrapped
Containing an independent technical scheme, this narrating mode of specification is only that for clarity, those skilled in the art should
Specification an as entirety, the technical scheme in each embodiment can also be formed into those skilled in the art through appropriately combined
May be appreciated other embodiment.
Claims (6)
1. a kind of Chinese and Western medicine composite preparation for treating constipation, it is characterised in that the primary raw material according to weight portion is:Bighead atractylodes rhizome 12-
16 parts, capsule of weeping forsythia 7-15 parts, kakuol 26-32 parts, deoxyshikonin 18-25 parts, 8-10 parts of different astragaloside II, timosaponin C
5-10 parts, menthol 4-8 parts, cerevisterol 24-30 parts, Bisdemethoxycurcumin 4-6 parts.
2. it is according to claim 1 treatment constipation Chinese and Western medicine composite preparation, it is characterised in that in the treatment constipation
Western medicine compound formulation, be according to the primary raw material of weight portion:Bighead atractylodes rhizome 13-15 parts, capsule of weeping forsythia 9-12 parts, kakuol 28-30 parts, deoxidation
Alkannin 19-23 parts, 8-10 parts of different astragaloside II, 5-10 parts of timosaponin C, menthol 4-8 parts, cerevisterol 25-28
Part, Bisdemethoxycurcumin 4-6 parts.
3. it is according to claim 1 and 2 treatment constipation Chinese and Western medicine composite preparation, it is characterised in that the treatment constipation
Chinese and Western medicine composite preparation, be according to the primary raw material of weight portion:14 parts of the bighead atractylodes rhizome, 11 parts of the capsule of weeping forsythia, 29 parts of kakuol, deoxidation Asian puccoon
21 parts of element, II 9 parts of different astragaloside, 8 parts of timosaponin C, 6 parts of menthol, 27 parts of cerevisterol, Bisdemethoxycurcumin 5
Part.
4. the preparation method of the Chinese and Western medicine composite preparation of a kind for the treatment of constipation as described in claim 1-3 is any, its feature exists
In concretely comprising the following steps:
First, in pharmaceutical grade clean area, the bighead atractylodes rhizome, the capsule of weeping forsythia, kakuol, deoxyshikonin, the different Radix Astragali are weighed by above-mentioned metering ratio
Saponin(e II, timosaponin C, menthol, cerevisterol, Bisdemethoxycurcumin, sieving, machinery add ultra-pure water after mixing,
Place in pharmacy mixer, mix 4-8min, control RSD≤5%, compressing tablet and low temperature drying after mixing, temperature control is in 4-8
DEG C, packaging obtains final product the Chinese and Western medicine composite preparation for the treatment of constipation.
5. the preparation method of the Chinese and Western medicine composite preparation for the treatment of constipation according to claim 4, it is characterised in that specific step
Mixing 6min in rapid.
6. the preparation method of the Chinese and Western medicine composite preparation for the treatment of constipation according to claim 4, it is characterised in that specific step
Temperature control is at 6 DEG C in rapid.
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Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102319423A (en) * | 2011-10-11 | 2012-01-18 | 刘鹏 | Health care product for treating habitual constipation caused by internal heat due to yin deficiency |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN102319423A (en) * | 2011-10-11 | 2012-01-18 | 刘鹏 | Health care product for treating habitual constipation caused by internal heat due to yin deficiency |
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Application publication date: 20170531 |