CN106511440A - Compound Chinese and Western medicine composition for treating chronic dysentery and preparation method thereof - Google Patents
Compound Chinese and Western medicine composition for treating chronic dysentery and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a compound Chinese and Western medicine composition for treating chronic dysentery. The compound Chinese and Western medicine composition for treating chronic dysentery is prepared from the following principal raw materials in parts by weight: 18-30 parts of dwarf waxberry, 5-15 parts of amaranthus blitum, 8-12 parts of croton, 5-12 parts of ilicin A, 4-8 parts of methylophiopogonanone B, 2-6 parts of triptophenolide, 2-8 parts of acevaltrate, 7-14 parts of gypsophila sapogenin 3-O-B-D-methyl glucuronate and 5-18 parts of eupatilin. The raw materials of the medicine disclosed by the invention are strictly selected according to the knowledge mechanism of chronic dysentery, so that the purpose of full rehabilitation can be achieved. The compound Chinese and Western medicine composition has the characteristics of fast effect, stable effect, convenience in administration and carrying and no toxic side effect after long-term administration.
Description
Technical field
The present invention relates to a kind of field of medicine preparation, specifically a kind of compound Chinese medicine and western medicine combination for treating chronic dysentery.
Background technology
Dysentery clinical manifestation is stomachache, diarrhoea, tenesmus, evacuation of pus hemafecia, with symptoms such as systemic toxicity profiles.Baby is to infection
Reaction is not strong, and onset is relatively delayed, and it be in initially dyspepsia sample loose stool to defecate more, and the course of disease is easily delayed.More than 3 years old infant onset urgency, with
Heating, diarrhoea, stomachache are cardinal symptom, can faint from fear, vomit.Will Hayes or good fortune Salmonella the infected's state of an illness are heavier, easily occur
Toxic dysentery, is more common in 3～7 years old child.Artificial feeding infant's body constitution is weaker, complication easily occurs.Chronic bacillary dysentery is big
It is because that acute stages treated is improper more, or nutritious bad, ricketss, intestinal parasitic diseases and the health etc. that is not careful in one's diet usually
Many reasons are caused.Often appear as atypical dysentery symptom, stomachache, diarrhoea, abdominal distention etc..When suffer from cold or take food raw food food
Thing, can cause acute attack, can now suffer from diarrhoea, suffer from abdominal pain and draw bloody purulent stool.When it is good when it is bad, although treatment, effect is also good, delay
Do not heal.
The content of the invention
It is an object of the invention to provide a kind of compound Chinese medicine and western medicine combination for treating chronic dysentery, to solve above-mentioned background skill
The problem proposed in art.
For achieving the above object, the present invention provides following technical scheme：
A kind of compound Chinese medicine and western medicine combination for treating chronic dysentery, according to the primary raw material of weight portion be：Cortex myricae nanae radiciss 18-30
Part, concave head amaranth 5-15 part, Fructus Crotonis 8-12 parts, ilicin A 5-12 parts, methylophiopogonanone B 4-8 parts, in thunder phenol
Ester 2-6 parts, acevaltrate 2-8 parts, Gypsogenin 3-O-B-D- glucuronic acid methyl ester 7-14 parts, eupatilin 5-18
Part.
As further scheme of the invention：The compound Chinese medicine and western medicine combination of the treatment chronic dysentery, according to weight portion
Primary raw material is：Cortex myricae nanae radiciss 22-26 parts, concave head amaranth 7-12 part, Fructus Crotonis 9-11 parts, ilicin A 7-11 parts, methyl dihydro Radix Ophiopogonis
Homoisoflavone B 4-8 parts, triptophenolide 2-6 parts, acevaltrate 2-8 parts, Gypsogenin 3-O-B-D- glucuronic acid first
Ester 7-14 parts, eupatilin 6-12 parts.
As further scheme of the invention：The compound Chinese medicine and western medicine combination of the treatment chronic dysentery, according to weight portion
Primary raw material is：24 parts of Cortex myricae nanae radiciss, 10 parts of concave head amaranth, 10 parts of Fructus Crotonis, 9 parts of ilicin A, methylophiopogonanone B 6
Part, 4 parts of triptophenolide, 5 parts of acevaltrate, 10 parts of Gypsogenin 3-O-B-D- glucuronic acid methyl esters, eupatilin 9
Part.
A kind of preparation method of the compound Chinese medicine and western medicine combination for treating chronic dysentery, concretely comprises the following steps：
First, in pharmaceutical grade clean area, Cortex myricae nanae radiciss, concave head amaranth, Fructus Crotonis, ilicin A, methyl are weighed by above-mentioned metering ratio
Radix Ophiopogonis Homoisoflavonoids B, triptophenolide, acevaltrate, Gypsogenin 3-O-B-D- glucuronic acid methyl esters, different Herba Lycopi
Flavin, sieves, and machinery adds ultra-pure water after mixing, and places in pharmacy mixer, mixes 4-8min, controls RSD≤5%, mixing
Tabletting cold drying afterwards, at 4-8 DEG C, packaging obtains final product the compound Chinese medicine and western medicine combination for the treatment of chronic dysentery to temperature control.
As further scheme of the invention：Mix 6min in concrete steps.
Compared with prior art, the invention has the beneficial effects as follows：
Medicine of the present invention is strictly selected to material composition according to the understanding mechanism of chronic dysentery, so as to reach comprehensive health
Multiple purpose, with rapid-action, effect it is stable, carry taking convenience, long-term taking and have no toxic side effect the characteristics of.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only a part of embodiment of the invention, rather than the embodiment of whole.Based in the present invention
Embodiment, the every other embodiment obtained under the premise of creative work is not made by those of ordinary skill in the art, all
Belong to the scope of protection of the invention.
Embodiment 1
A kind of compound Chinese medicine and western medicine combination for treating chronic dysentery, according to the primary raw material of weight portion be：It is 18 parts of Cortex myricae nanae radiciss, recessed
5 parts of Herba Amaranthi tricoloriss of head, 8 parts of Fructus Crotonis, 5 parts of ilicin A, 4 parts of methylophiopogonanone B, 2 parts of triptophenolide, acevaltrate 2
Part, 7 parts of Gypsogenin 3-O-B-D- glucuronic acid methyl esters, 5 parts of eupatilin.
A kind of preparation method of the compound Chinese medicine and western medicine combination for treating chronic dysentery, concretely comprises the following steps：
First, in pharmaceutical grade clean area, Cortex myricae nanae radiciss, concave head amaranth, Fructus Crotonis, ilicin A, methyl are weighed by above-mentioned metering ratio
Radix Ophiopogonis Homoisoflavonoids B, triptophenolide, acevaltrate, Gypsogenin 3-O-B-D- glucuronic acid methyl esters, different Herba Lycopi
Flavin, sieves, and machinery adds ultra-pure water after mixing, and places in pharmacy mixer, mixes 4min, controls RSD≤5%, after mixing
Tabletting cold drying, at 4 DEG C, packaging obtains final product the compound Chinese medicine and western medicine combination for the treatment of chronic dysentery to temperature control.
Embodiment 2
A kind of compound Chinese medicine and western medicine combination for treating chronic dysentery, according to the primary raw material of weight portion be：It is 22 parts of Cortex myricae nanae radiciss, recessed
7 parts of Herba Amaranthi tricoloriss of head, 9 parts of Fructus Crotonis, 7 parts of ilicin A, 4 parts of methylophiopogonanone B, 2 parts of triptophenolide, acevaltrate 2
Part, 7 parts of Gypsogenin 3-O-B-D- glucuronic acid methyl esters, 6 parts of eupatilin.
A kind of preparation method of the compound Chinese medicine and western medicine combination for treating chronic dysentery, concretely comprises the following steps：
First, in pharmaceutical grade clean area, Cortex myricae nanae radiciss, concave head amaranth, Fructus Crotonis, ilicin A, methyl are weighed by above-mentioned metering ratio
Radix Ophiopogonis Homoisoflavonoids B, triptophenolide, acevaltrate, Gypsogenin 3-O-B-D- glucuronic acid methyl esters, different Herba Lycopi
Flavin, sieves, and machinery adds ultra-pure water after mixing, and places in pharmacy mixer, mixes 4min, controls RSD≤5%, after mixing
Tabletting cold drying, at 4 DEG C, packaging obtains final product the compound Chinese medicine and western medicine combination for the treatment of chronic dysentery to temperature control.
Embodiment 3
A kind of compound Chinese medicine and western medicine combination for treating chronic dysentery, according to the primary raw material of weight portion be：It is 24 parts of Cortex myricae nanae radiciss, recessed
10 parts of Herba Amaranthi tricoloriss of head, 10 parts of Fructus Crotonis, 9 parts of ilicin A, 6 parts of methylophiopogonanone B, 4 parts of triptophenolide, acevaltrate 5
Part, 10 parts of Gypsogenin 3-O-B-D- glucuronic acid methyl esters, 9 parts of eupatilin.
A kind of preparation method of the compound Chinese medicine and western medicine combination for treating chronic dysentery, concretely comprises the following steps：
First, in pharmaceutical grade clean area, Cortex myricae nanae radiciss, concave head amaranth, Fructus Crotonis, ilicin A, methyl are weighed by above-mentioned metering ratio
Radix Ophiopogonis Homoisoflavonoids B, triptophenolide, acevaltrate, Gypsogenin 3-O-B-D- glucuronic acid methyl esters, different Herba Lycopi
Flavin, sieves, and machinery adds ultra-pure water after mixing, and places in pharmacy mixer, mixes 6min, controls RSD≤5%, after mixing
Tabletting cold drying, at 6 DEG C, packaging obtains final product the compound Chinese medicine and western medicine combination for the treatment of chronic dysentery to temperature control.
Embodiment 4
A kind of compound Chinese medicine and western medicine combination for treating chronic dysentery, according to the primary raw material of weight portion be：It is 26 parts of Cortex myricae nanae radiciss, recessed
12 parts of Herba Amaranthi tricoloriss of head, 11 parts of Fructus Crotonis, 11 parts of ilicin A, 8 parts of methylophiopogonanone B, 6 parts of triptophenolide, acevaltrate
8 parts, 14 parts of Gypsogenin 3-O-B-D- glucuronic acid methyl esters, 12 parts of eupatilin.
A kind of preparation method of the compound Chinese medicine and western medicine combination for treating chronic dysentery, concretely comprises the following steps：
First, in pharmaceutical grade clean area, Cortex myricae nanae radiciss, concave head amaranth, Fructus Crotonis, ilicin A, methyl are weighed by above-mentioned metering ratio
Radix Ophiopogonis Homoisoflavonoids B, triptophenolide, acevaltrate, Gypsogenin 3-O-B-D- glucuronic acid methyl esters, different Herba Lycopi
Flavin, sieves, and machinery adds ultra-pure water after mixing, and places in pharmacy mixer, mixes 8min, controls RSD≤5%, after mixing
Tabletting cold drying, at 8 DEG C, packaging obtains final product the compound Chinese medicine and western medicine combination for the treatment of chronic dysentery to temperature control.
Embodiment 5
A kind of compound Chinese medicine and western medicine combination for treating chronic dysentery, according to the primary raw material of weight portion be：It is 30 parts of Cortex myricae nanae radiciss, recessed
15 parts of Herba Amaranthi tricoloriss of head, 12 parts of Fructus Crotonis, 12 parts of ilicin A, 8 parts of methylophiopogonanone B, 6 parts of triptophenolide, acevaltrate
8 parts, 14 parts of Gypsogenin 3-O-B-D- glucuronic acid methyl esters, 18 parts of eupatilin.
A kind of preparation method of the compound Chinese medicine and western medicine combination for treating chronic dysentery, concretely comprises the following steps：
First, in pharmaceutical grade clean area, Cortex myricae nanae radiciss, concave head amaranth, Fructus Crotonis, ilicin A, methyl are weighed by above-mentioned metering ratio
Radix Ophiopogonis Homoisoflavonoids B, triptophenolide, acevaltrate, Gypsogenin 3-O-B-D- glucuronic acid methyl esters, different Herba Lycopi
Flavin, sieves, and machinery adds ultra-pure water after mixing, and places in pharmacy mixer, mixes 8min, controls RSD≤5%, after mixing
Tabletting cold drying, at 8 DEG C, packaging obtains final product the compound Chinese medicine and western medicine combination for the treatment of chronic dysentery to temperature control.
Pharmacology test
1st, chronic toxicity test
Test is combined as to be combined Chinese medicine and western medicine obtained in the embodiment of the present invention 3, using gastric infusion mode, is connected in 24h
Continuous administration 3 times, per minor tick 6h, is administered 500mg/kg doses every time, and daily accumulation medicine total amount reaches 1500mg medicines/kg, phase
When in 100 times of people's quantity.After administration in 7d, mice activity, feed, excretion are normal, well-grown, hair color light,
Its average weight increases with the prolongation of experimental period.Every mice of post mortem at 8d, the perusal heart, liver, spleen,
Lung, kidney, brain, thymus, stomach, intestinal etc. do not find color and paramophia, fail to measure median lethal dose(LD 50) (LD50).As a result table
It is bright：The compound Chinese medicine and western medicine of the present invention is combined without chronic toxicity.
2nd, long term toxicity test
Test is combined as to be combined Chinese medicine and western medicine obtained in the embodiment of the present invention 3, it is using gastric infusion mode, the present invention is multiple
Close Chinese medicine and western medicine combination and be divided into low dosage, middle dosage, three groups of high dose, the drug dose respectively 150,300,450mg medicines of each group
Thing/kg/d, equivalent to clinical dosage 10,20,30 times.After gastric infusion 24 weeks, medicine of the present invention to the general status of animal,
, without significantly impact, Systematic anatomy, organ coefficient and histopathological examination are not sent out yet for hematological indices, blood parameters
Existing abnormal pathologic changes.It is discontinued 2 weeks and also has no substantially change.As a result show：The compound Chinese medicine and western medicine of the present invention is combined in long term toxicity
In test, do not it is found that overt toxicity reaction and delayed toxicity react.It can be seen that, the compound Chinese medicine and western medicine combination non-toxic reaction of the present invention,
Long-term prescription is safe and reliable.
3rd, clinical trial
In April, 2015, in Nanjing, 312 patients screened in hospital in May, 2015, and all patients meet chronic dysentery
Disease.Wherein male 169, women 143, minimal ages 2 years old, max age 72 years old, 37.6 years old mean age.All patients
The compound Chinese medicine and western medicine combination of the preparation of the embodiment of the present invention 3 is taken, instructions of taking is：Daily 15mg/kg (the patients between 2-12 year
Halve), 2 days courses for the treatment of treat two courses for the treatment of altogether.
Curative effect situation criterion：Cure：Sign improves completely, and dysentery stops, and diet is normal, in high spirits.It is effective：Body
Levy and significantly improve, dysentery stops substantially, diet is normal, and spirit can.Effectively：Sign improves, and dysentery is reduced, and diet and spirit change
It is kind.It is invalid：Before symptom is as treated.
Therapeutic effect：312 patients, cure 225, effective 49, effective 20, invalid 18, total effective rate
94.2%.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of spirit or essential attributes without departing substantially from the present invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit is required rather than described above is limited, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.
Moreover, it will be appreciated that although this specification is been described by according to embodiment, not each embodiment is only wrapped
Containing an independent technical scheme, this narrating mode of description is only that those skilled in the art should for clarity
Using description as an entirety, the technical scheme in each embodiment can also Jing it is appropriately combined, form those skilled in the art
Understandable other embodiment.
Claims (5)
1. a kind of compound Chinese medicine and western medicine combination for treating chronic dysentery, it is characterised in that the primary raw material according to weight portion is：Short poplar
Prunus mume (sieb.) sieb.et zucc. 18-30 parts, concave head amaranth 5-15 part, Fructus Crotonis 8-12 parts, ilicin A 5-12 parts, methylophiopogonanone B 4-8 parts,
Triptophenolide 2-6 parts, acevaltrate 2-8 parts, Gypsogenin 3-O-B-D- glucuronic acid methyl ester 7-14 parts, different Herba Lycopi are yellow
Plain 5-18 parts.
2. the compound Chinese medicine and western medicine combination for the treatment of chronic dysentery according to claim 1, it is characterised in that the treatment is chronic
The compound Chinese medicine and western medicine combination of dysentery, according to the primary raw material of weight portion be：Cortex myricae nanae radiciss 22-26 parts, concave head amaranth 7-12 part, Fructus Crotonis 9-
11 parts, ilicin A 7-11 parts, methylophiopogonanone B 4-8 parts, triptophenolide 2-6 parts, acevaltrate 2-8 parts,
Gypsogenin 3-O-B-D- glucuronic acid methyl ester 7-14 parts, eupatilin 6-12 parts.
3. the compound Chinese medicine and western medicine combination for the treatment of chronic dysentery according to claim 1 and 2, it is characterised in that the treatment
The compound Chinese medicine and western medicine combination of chronic dysentery, according to the primary raw material of weight portion be：24 parts of Cortex myricae nanae radiciss, 10 parts of concave head amaranth, Fructus Crotonis 10
Part, 9 parts of ilicin A, 6 parts of methylophiopogonanone B, 4 parts of triptophenolide, 5 parts of acevaltrate, Gypsogenin
10 parts of 3-O-B-D- glucuronic acid methyl esters, 9 parts of eupatilin.
4. the preparation method that a kind of compound Chinese medicine and western medicine for the treatment of chronic dysentery as described in claim 1-3 is arbitrary is combined, which is special
Levy and be, concretely comprise the following steps：
First, in pharmaceutical grade clean area, Cortex myricae nanae radiciss, concave head amaranth, Fructus Crotonis, ilicin A, methyl Radix Ophiopogonis are weighed by above-mentioned metering ratio
Homoisoflavonoids B, triptophenolide, acevaltrate, Gypsogenin 3-O-B-D- glucuronic acid methyl esters, different Herba Lycopi are yellow
Element, sieves, and machinery adds ultra-pure water after mixing, and places in pharmacy mixer, mixes 4-8min, controls RSD≤5%, after mixing
Tabletting cold drying, at 4-8 DEG C, packaging obtains final product the compound Chinese medicine and western medicine combination for the treatment of chronic dysentery to temperature control.
5. the preparation method that the compound Chinese medicine and western medicine for the treatment of chronic dysentery according to claim 4 is combined, it is characterised in that tool
Mix 6min in body step.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112245422A (en) * | 2020-09-15 | 2021-01-22 | 广州医科大学 | Novel application of acetyl valerian |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112245422A (en) * | 2020-09-15 | 2021-01-22 | 广州医科大学 | Novel application of acetyl valerian |
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