CN106727907A - A kind of Chinese and Western medicine combination for treating viral pneumonia and preparation method thereof - Google Patents
A kind of Chinese and Western medicine combination for treating viral pneumonia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese and Western medicine combination for treating viral pneumonia, the Chinese and Western medicine combination of the treatment viral pneumonia is according to the primary raw material of weight portion：18 30 parts of 8 O glucosides of aloe-emodin, 5 15 parts of blackberry lily aglycon, 8 12 parts of Herba hyperici elodeoidis, 5 12 parts of Herba Andrographitis, 48 parts of karanjin, 26 parts of calceolarioside B, 28 parts of checkerberry glycosides, 7 14 parts of Herba of Artemisiae admsii, 5 18 parts of alpine gentian herb.Medicine of the present invention is strictly selected material composition according to the understanding mechanism of viral pneumonia, so as to reach the purpose of comprehensive rehabilitation, with rapid-action, effect stabilization, carry convenient to take, long-term taking and have no toxic side effect the characteristics of.
Description
Technical field
The present invention relates to a kind of field of medicine preparation, specifically a kind of Chinese and Western medicine combination for treating viral pneumonia.
Background technology
Viral pneumonia be by upper respiratory tract infection, downwards spread caused by lung inflammation.This disease is equal throughout the year
Can occur, but be more common in winter-spring season greatly, can break out or distribute prevalence.Clinic be mainly shown as heating, headache, Muscular stiffness,
Dry cough and lung infiltration etc..The generation of viral pneumonia and virulence, the age of route of infection and host, the immunologic function shape of virus
State etc. is relevant.General children's incidence of disease is higher than adult.
In ARI, virus infection accounts for 90%, and virus infection has common sense then based on the upper respiratory tract
Emit, pharyngitis, larynx-tracheitis and bronchitis, capillary bronchitis, baby's herpangina and epidemic pleurodynia etc..Cause pneumonia
It is viral rare, wherein with influenza virus as common, other are parainfluenza virus, cytomegalovirus, adenovirus, nose
Virus, coronavirus and some enteroviruses, such as COxsackie, echovirus, and herpe simplex, varicella-zoster, wind
The viruses such as rash, measles.Infant also often produces pneumonia by respiratory syncytial virus infection.Viral pneumonia is multiple to be born in winter-spring season
Section, can distribute popular or break out.In non-bacterial pneumonia, virus infection accounts for 25%~50%, and patient is generally children, Cheng Renxiang
To rare.
In recent years due to immunosuppressive drug be widely used in the number of the infected of tumour, organ transplant, and AIDS by
Year increases, and herpes simplex virus, varicella virus, cytomegalovirus etc. can all cause serious pneumonia.Virus
Property pneumonia be apsiration infection, by the droplet infection of person to person, mainly caused by upper respiratory tract infection spreads downwards,
Often with tracheitis and bronchitis, family's pack animal, pig etc. are sometimes with certain influenza virus, accidental contagion.Excrement is oral
Infection sees enterovirus, and Respiratory Syncytial Virus(RSV) passes through dust infection.The case of organ transplant can be by repeatedly transfusing blood, very
Organ to donor causes virus.The viral pneumonia of hematogenous spread is not with tracheitis and bronchitis.
The content of the invention
It is an object of the invention to provide a kind of Chinese and Western medicine combination for treating viral pneumonia, to solve above-mentioned background technology
The problem of middle proposition.
To achieve the above object, the present invention provides following technical scheme：
A kind of Chinese and Western medicine combination for treating viral pneumonia, be according to the primary raw material of weight portion：Aloe-emodin -8-O-
Glucoside 18-30 parts, 5-15 parts of blackberry lily aglycon, Herba hyperici elodeoidis 8-12 parts, Herba Andrographitis 5-12 parts, karanjin 4-8 parts, akebi benzene
2-6 parts of ethanol glycosides B, 2-8 parts, Herba of Artemisiae admsii 7-14 parts, alpine gentian herb 5-18 parts of checkerberry glycosides.
As further scheme of the invention：The Chinese and Western medicine combination of the treatment viral pneumonia, according to the master of weight portion
The raw material is wanted to be：22-27 parts of aloe-emodin -8-O- glucosides, 7-12 parts of blackberry lily aglycon, Herba hyperici elodeoidis 9-11 parts, Herba Andrographitis 7-
10 parts, karanjin 4-8 parts, calceolarioside B 2-6 parts, 2-8 parts of checkerberry glycosides, Herba of Artemisiae admsii 7-14 parts, alpine gentian herb 9-13
Part.
As further scheme of the invention：The Chinese and Western medicine combination of the treatment viral pneumonia, according to the master of weight portion
The raw material is wanted to be：25 parts of aloe-emodin -8-O- glucosides, 10 parts of blackberry lily aglycon, 10 parts of Herba hyperici elodeoidis, 9 parts of Herba Andrographitis, Indian beech
6 parts of element, 4 parts of calceolarioside B, 5 parts of checkerberry glycosides, 11 parts of Herba of Artemisiae admsii, 12 parts of alpine gentian herb.
A kind of preparation method of the Chinese and Western medicine combination for treating viral pneumonia, concretely comprises the following steps：
First, in pharmaceutical grade clean area, aloe-emodin -8-O- glucosides, belamcandin are weighed by above-mentioned metering ratio
Unit, Herba hyperici elodeoidis, Herba Andrographitis, karanjin, calceolarioside B, checkerberry glycosides, Herba of Artemisiae admsii, alpine gentian herb, sieving, machinery are mixed
After add ultra-pure water, place in pharmacy mixer, mix 4-8min, control RSD≤5%, compressing tablet and low temperature drying after mixing, temperature
At 4-8 DEG C, packaging obtains final product the Chinese and Western medicine combination for the treatment of viral pneumonia for degree control.
As further scheme of the invention：Mix 6min in specific steps.
Compared with prior art, the beneficial effects of the invention are as follows：
Medicine of the present invention is strictly selected material composition according to the understanding mechanism of viral pneumonia, so as to reach comprehensively
The purpose of rehabilitation, with rapid-action, effect stabilization, carry convenient to take, long-term taking and have no toxic side effect the characteristics of.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only a part of embodiment of the invention, rather than whole embodiments.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made, all
Belong to the scope of protection of the invention.
Embodiment 1
A kind of Chinese and Western medicine combination for treating viral pneumonia, be according to the primary raw material of weight portion：Aloe-emodin -8-O-
18 parts of glucoside, 5 parts of blackberry lily aglycon, 8 parts of Herba hyperici elodeoidis, 5 parts of Herba Andrographitis, 4 parts of karanjin, 2 parts of calceolarioside B, winter
2 parts of green glycosides, 7 parts of Herba of Artemisiae admsii, 5 parts of alpine gentian herb.
A kind of preparation method of the Chinese and Western medicine combination for treating viral pneumonia, concretely comprises the following steps：
First, in pharmaceutical grade clean area, aloe-emodin -8-O- glucosides, belamcandin are weighed by above-mentioned metering ratio
Unit, Herba hyperici elodeoidis, Herba Andrographitis, karanjin, calceolarioside B, checkerberry glycosides, Herba of Artemisiae admsii, alpine gentian herb, sieving, machinery are mixed
After add ultra-pure water, place in pharmacy mixer, mix 4min, control RSD≤5%, compressing tablet and low temperature drying, temperature after mixing
At 4 DEG C, packaging obtains final product the Chinese and Western medicine combination for the treatment of viral pneumonia for control.
Embodiment 2
A kind of Chinese and Western medicine combination for treating viral pneumonia, be according to the primary raw material of weight portion：Aloe-emodin -8-O-
22 parts of glucoside, 7 parts of blackberry lily aglycon, 9 parts of Herba hyperici elodeoidis, 7 parts of Herba Andrographitis, 4 parts of karanjin, 2 parts of calceolarioside B, winter
2 parts of green glycosides, 7 parts of Herba of Artemisiae admsii, 9 parts of alpine gentian herb.
A kind of preparation method of the Chinese and Western medicine combination for treating viral pneumonia, concretely comprises the following steps：
First, in pharmaceutical grade clean area, aloe-emodin -8-O- glucosides, belamcandin are weighed by above-mentioned metering ratio
Unit, Herba hyperici elodeoidis, Herba Andrographitis, karanjin, calceolarioside B, checkerberry glycosides, Herba of Artemisiae admsii, alpine gentian herb, sieving, machinery are mixed
After add ultra-pure water, place in pharmacy mixer, mix 4min, control RSD≤5%, compressing tablet and low temperature drying, temperature after mixing
At 4 DEG C, packaging obtains final product the Chinese and Western medicine combination for the treatment of viral pneumonia for control.
Embodiment 3
A kind of Chinese and Western medicine combination for treating viral pneumonia, be according to the primary raw material of weight portion：Aloe-emodin -8-O-
25 parts of glucoside, 10 parts of blackberry lily aglycon, 10 parts of Herba hyperici elodeoidis, 9 parts of Herba Andrographitis, 6 parts of karanjin, 4 parts of calceolarioside B,
5 parts of checkerberry glycosides, 11 parts of Herba of Artemisiae admsii, 12 parts of alpine gentian herb.
A kind of preparation method of the Chinese and Western medicine combination for treating viral pneumonia, concretely comprises the following steps：
First, in pharmaceutical grade clean area, aloe-emodin -8-O- glucosides, belamcandin are weighed by above-mentioned metering ratio
Unit, Herba hyperici elodeoidis, Herba Andrographitis, karanjin, calceolarioside B, checkerberry glycosides, Herba of Artemisiae admsii, alpine gentian herb, sieving, machinery are mixed
After add ultra-pure water, place in pharmacy mixer, mix 6min, control RSD≤5%, compressing tablet and low temperature drying, temperature after mixing
At 6 DEG C, packaging obtains final product the Chinese and Western medicine combination for the treatment of viral pneumonia for control.
Embodiment 4
A kind of Chinese and Western medicine combination for treating viral pneumonia, be according to the primary raw material of weight portion：Aloe-emodin -8-O-
27 parts of glucoside, 12 parts of blackberry lily aglycon, 11 parts of Herba hyperici elodeoidis, 10 parts of Herba Andrographitis, 8 parts of karanjin, calceolarioside B 6
Part, 8 parts of checkerberry glycosides, 14 parts of Herba of Artemisiae admsii, 13 parts of alpine gentian herb.
A kind of preparation method of the Chinese and Western medicine combination for treating viral pneumonia, concretely comprises the following steps：
First, in pharmaceutical grade clean area, aloe-emodin -8-O- glucosides, belamcandin are weighed by above-mentioned metering ratio
Unit, Herba hyperici elodeoidis, Herba Andrographitis, karanjin, calceolarioside B, checkerberry glycosides, Herba of Artemisiae admsii, alpine gentian herb, sieving, machinery are mixed
After add ultra-pure water, place in pharmacy mixer, mix 8min, control RSD≤5%, compressing tablet and low temperature drying, temperature after mixing
At 8 DEG C, packaging obtains final product the Chinese and Western medicine combination for the treatment of viral pneumonia for control.
Embodiment 5
A kind of Chinese and Western medicine combination for treating viral pneumonia, be according to the primary raw material of weight portion：Aloe-emodin -8-O-
30 parts of glucoside, 15 parts of blackberry lily aglycon, 12 parts of Herba hyperici elodeoidis, 12 parts of Herba Andrographitis, 8 parts of karanjin, calceolarioside B 6
Part, 8 parts of checkerberry glycosides, 14 parts of Herba of Artemisiae admsii, 18 parts of alpine gentian herb.
A kind of preparation method of the Chinese and Western medicine combination for treating viral pneumonia, concretely comprises the following steps：
First, in pharmaceutical grade clean area, aloe-emodin -8-O- glucosides, belamcandin are weighed by above-mentioned metering ratio
Unit, Herba hyperici elodeoidis, Herba Andrographitis, karanjin, calceolarioside B, checkerberry glycosides, Herba of Artemisiae admsii, alpine gentian herb, sieving, machinery are mixed
After add ultra-pure water, place in pharmacy mixer, mix 8min, control RSD≤5%, compressing tablet and low temperature drying, temperature after mixing
At 8 DEG C, packaging obtains final product the Chinese and Western medicine combination for the treatment of viral pneumonia for control.
Pharmacology test
1st, chronic toxicity test
Experiment is combined as with Chinese and Western medicine obtained in the embodiment of the present invention 3, using gastric infusion mode, is continuously given in 24h
Medicine 3 times, per minor tick 6h, is administered 200mg/kg doses every time, and daily accumulation medicine total amount reaches 600mg medicines/kg, equivalent to people
100 times of quantity.After administration in 7d, mouse activity, feed, excretion are normal, well-grown, hair color light, and its is average
Body weight increases with the extension of experimental period.Every mouse of post mortem at 8d, visually observe the heart, liver, spleen, lung, kidney,
Brain, thymus gland, stomach, intestines etc. do not find color and paramophia, fail to measure median lethal dose (LD50).Result shows：This hair
Bright Chinese and Western medicine combination is without chronic toxicity.
2nd, long term toxicity test
Experiment is combined as with Chinese and Western medicine obtained in the embodiment of the present invention 3, using gastric infusion mode, by Chinese and Western medicine of the present invention
Combination is divided into low dosage, middle dosage, three groups of high dose, the drug dose of each group is respectively 60,120,180mg medicines/kg/d, phase
When in 10,20,30 times of clinical dosage.After gastric infusion 24 weeks, medicine of the present invention refers to the general status of animal, hematology
Mark, blood parameters without obvious influence, Systematic anatomy, organ coefficient and histopathological examination also no abnormal disease
Reason changes.It is discontinued 2 weeks and also has no substantially change.Result shows：Chinese and Western medicine combination of the present invention does not find in long term toxicity test
Overt toxicity reacts and delayed toxicity reaction.It can be seen that, Chinese and Western medicine of the present invention combines non-toxic reaction, and long-term prescription is safe and reliable.
3rd, clinical test
During inventor and 2 months in April, 2015 in 2016, in Shanghai, 135 patients, all patients screen in Disease Control and Prevention Center
Meet viral pneumonia illness.Wherein male 61, women 74, minimal ages 18 years old, max age 62 years old, average age
38.5 years old.All patients take the Chinese and Western medicine combination of the preparation of the embodiment of the present invention 3, and instructions of taking is：Daily 6mg/kg, 3 days one
The individual course for the treatment of, treats three courses for the treatment of altogether.
Curative effect situation criterion：Recovery from illness：The clinical symptoms of viral pneumonia all disappear.Take a turn for the better：Viral pneumonia
Clinical symptom relief, the state of an illness is controlled.It is invalid：No significant improvement or aggravated in clinical symptoms for viral pneumonia.
Therapeutic effect：135 patients, cure 97, take a turn for the better 28, invalid 10, total effective rate 92.6%.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be in other specific forms realized.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit requires to be limited rather than described above, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.
Moreover, it will be appreciated that although the present specification is described in terms of embodiments, not each implementation method is only wrapped
Containing an independent technical scheme, this narrating mode of specification is only that for clarity, those skilled in the art should
Specification an as entirety, the technical scheme in each embodiment can also be formed into those skilled in the art through appropriately combined
May be appreciated other embodiment.
Claims (5)
1. a kind of Chinese and Western medicine combination for treating viral pneumonia, it is characterised in that the primary raw material according to weight portion is：Aloe is big
18-30 parts of flavine -8-O- glucosides, 5-15 parts of blackberry lily aglycon, Herba hyperici elodeoidis 8-12 parts, Herba Andrographitis 5-12 parts, karanjin 4-8
Part, calceolarioside B 2-6 parts, 2-8 parts, Herba of Artemisiae admsii 7-14 parts, alpine gentian herb 5-18 parts of checkerberry glycosides.
2. the Chinese and Western medicine combination for the treatment of viral pneumonia according to claim 1, it is characterised in that the treatment is viral
The Chinese and Western medicine combination of pneumonia, be according to the primary raw material of weight portion：22-27 parts of aloe-emodin -8-O- glucosides, belamcandin
First 7-12 parts, Herba hyperici elodeoidis 9-11 parts, Herba Andrographitis 7-10 parts, karanjin 4-8 parts, calceolarioside B 2-6 parts, checkerberry glycosides 2-
8 parts, Herba of Artemisiae admsii 7-14 parts, alpine gentian herb 9-13 parts.
3. the Chinese and Western medicine combination for the treatment of viral pneumonia according to claim 1 and 2, it is characterised in that the treatment disease
The Chinese and Western medicine combination of toxicity pneumonia, be according to the primary raw material of weight portion：25 parts of aloe-emodin -8-O- glucosides, blackberry lily
10 parts of aglycon, 10 parts of Herba hyperici elodeoidis, 9 parts of Herba Andrographitis, 6 parts of karanjin, 4 parts of calceolarioside B, 5 parts of checkerberry glycosides, Herba of Artemisiae admsii
11 parts, 12 parts of alpine gentian herb.
4. the preparation method that a kind of Chinese and Western medicine for the treatment of viral pneumonia as described in claim 1-3 is any is combined, its feature
It is to concretely comprise the following steps：
First, in pharmaceutical grade clean area, by above-mentioned metering ratio weigh aloe-emodin -8-O- glucosides, blackberry lily aglycon, time
Ground gold, Herba Andrographitis, karanjin, calceolarioside B, checkerberry glycosides, Herba of Artemisiae admsii, alpine gentian herb, sieving, machinery are added after mixing
Ultra-pure water, places in pharmacy mixer, mixes 4-8min, controls RSD≤5%, compressing tablet and low temperature drying, temperature control after mixing
At 4-8 DEG C, packaging obtains final product the Chinese and Western medicine combination for the treatment of viral pneumonia.
5. the preparation method that the Chinese and Western medicine for the treatment of viral pneumonia according to claim 4 is combined, it is characterised in that specific
Mix 6min in step.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114504571A (en) * | 2022-04-11 | 2022-05-17 | 黑龙江中医药大学 | Pharmaceutical composition for treating infantile pneumonia and application thereof |
| JP2023519359A (en) * | 2020-03-23 | 2023-05-10 | ケレシス アクチェンゲゼルシャフト | Antimicrobial solutions and methods of their use in treating or preventing infections |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1470269A (en) * | 2003-06-20 | 2004-01-28 | 陈聪慧 | Lingjingchuandu compound preparation for treating non-typical pneumonia |
-
2016
- 2016-12-17 CN CN201611172245.8A patent/CN106727907A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1470269A (en) * | 2003-06-20 | 2004-01-28 | 陈聪慧 | Lingjingchuandu compound preparation for treating non-typical pneumonia |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023519359A (en) * | 2020-03-23 | 2023-05-10 | ケレシス アクチェンゲゼルシャフト | Antimicrobial solutions and methods of their use in treating or preventing infections |
| JP7518185B2 (en) | 2020-03-23 | 2024-07-17 | ケレシス アクチェンゲゼルシャフト | Antimicrobial solutions and methods of use thereof in treating or preventing infection - Patents.com |
| CN114504571A (en) * | 2022-04-11 | 2022-05-17 | 黑龙江中医药大学 | Pharmaceutical composition for treating infantile pneumonia and application thereof |
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Application publication date: 20170531 |
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| WW01 | Invention patent application withdrawn after publication |