CN106727642A - A kind of children's antipyretic - Google Patents
A kind of children's antipyretic Download PDFInfo
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- CN106727642A CN106727642A CN201611171675.8A CN201611171675A CN106727642A CN 106727642 A CN106727642 A CN 106727642A CN 201611171675 A CN201611171675 A CN 201611171675A CN 106727642 A CN106727642 A CN 106727642A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of children's antipyretic, children's antipyretic is according to the primary raw material of weight portion：23 25 parts of tectochrysin, 19 28 parts of persantine, 7 18 parts of bicoumarin, 5 22 27 parts of methyl base kuh-seng alcohol C, 35 47 parts of kuh-seng alcohol W, 5 10 parts of Marmesin, 8 16 parts of L hydroxyprolines, 47 parts of Pimpinellin, bent 23 parts of letter stilbene glycosides, 24 parts of 7 glucuronic acid of apiolin, 89 parts of pinobanksin.Medicine of the present invention is strictly selected material composition according to the understanding mechanism of children fever, so as to reach the purpose of comprehensive rehabilitation, with rapid-action, effect stabilization, carry convenient to take, long-term taking and have no toxic side effect the characteristics of.
Description
Technical field
The present invention relates to a kind of field of medicine preparation, specifically a kind of children's antipyretic.
Background technology
Antipyretic is that one kind can make human body peripheral vascular expand and then be waited by means of perspiration by adjusting function of human body
Journey increases radiating, while suppressing shiver with cold, the medicine for reducing body heat production.It can efficiently control fever, make hypothermia,
But can not at all release the reason for causing heating.Fever is one of total symptom of many diseases, no matter treatment fever cause of disease disease
Feelings ground is not all right using antipyretic.Antipyretic toxic side effect.Antipyretic is in daily use, but its toxic and side effect is also common.
Drug rash, gastrointestinal reaction, hematological system reaction and infringement to hepatic and renal function etc., especially when long using or be excessively used this
During class medicine, toxic and side effect is more significantly.
Modern medicine thinks that fever is a kind of reaction that human body resists disease, the pathogenic microorganism master for causing children fever
There are bacterium, virus and mycoplasma, Chlamydia.Definite pathogenesis is not fully understood, and is the knot of many factors comprehensive function
Really, immunologic hypofunction is considered as one of major reason of morbidity.In the prior art to the treatment method research of children fever
Substantially (1) Physical temperature-lowering, such as warm water or alcohol bath, ice bag cooling, normal saline enema；(2) drug cooling, it is such as oral
The medicine such as antipyretic, Metamizole nasal drip or intramuscular injection, drip-feed dexamethasone, while taking antibiont medicine to treat sense
Dye；(3) herbal treatment：Such as oral traditional Chinese medicine preparation, the external application of Chinese medicine.There is more defect, physics drop in above-mentioned therapeutic modality
Temperature or simple Chinese medicine effect are poor, by reduction body temperature that can not be efficiently and effectively, occur body temperature rise, body after bringing down a fever again soon
Temperature fluctuation is larger.Antibiotic therapy is mainly using oral administration or intramuscular injection, the big approach of drip-feed two.The oral antibiosis of infant
Gastrointestinal reaction can usually be caused, the serious toxic and side effect such as can also cause allergic reaction, while infant medication is more difficult, it is difficult to
Operation, intramuscular injection or drip-feed antibiotic, risk is big, and operation difficulty is high, and infant is cry and screamed uneasiness, and pole is mismatched.
The content of the invention
It is an object of the invention to provide a kind of children's antipyretic, to solve the problems, such as to be proposed in above-mentioned background technology.
To achieve the above object, the present invention provides following technical scheme：
A kind of children's antipyretic, be according to the primary raw material of weight portion：Tectochrysin 23-25 parts, persantine 19-28
Part, bicoumarin 7-18 parts, 5- methyl base -22-27 parts of kuh-seng alcohol C, 35-47 parts of kuh-seng alcohol W, Marmesin 5-10
Part, 8-16 parts of L- hydroxyprolines, Pimpinellin 4-7 parts, bent 2-3 parts of letter stilbene glycosides, 2-4 parts of apiolin -7- glucuronic acids, short leaf
Loose 8-9 parts of element.
As further scheme of the invention：Children's antipyretic, be according to the primary raw material of weight portion：Poplar bud is yellow
It is plain 23-25 parts, persantine 22-26 parts, bicoumarin 12-16 parts, 5- methyl base -24-26 parts of kuh-seng alcohol C, kuh-seng alcohol W38-44
Part, Marmesin 5-10 part, 10-13 parts of L- hydroxyprolines, Pimpinellin 4-7 parts, 2-3 parts of song letter stilbene glycosides, apiolin-
2-4 parts, pinobanksin 8-9 parts of 7- glucuronic acids.
As further scheme of the invention：Children's antipyretic, be according to the primary raw material of weight portion：Poplar bud is yellow
24 parts of element, 24 parts of persantine, 14 parts of bicoumarin, 5- methyl base -25 parts of kuh-seng alcohol C, 42 parts of kuh-seng alcohol W, different RADIX PEUCEDANI
8 parts of lactone, 12 parts of L- hydroxyprolines, 6 parts of Pimpinellin, bent 3 parts of letter stilbene glycosides, 3 parts of apiolin -7- glucuronic acids, jack pine
9 parts of element.
A kind of preparation method of children's antipyretic, concretely comprises the following steps：
First, in pharmaceutical grade clean area, tectochrysin, persantine, bicoumarin, 5- methyl are weighed by above-mentioned metering ratio
Base-kuh-seng alcohol C, kuh-seng alcohol W, Marmesin, L- hydroxyprolines, Pimpinellin, bent letter stilbene glycosides, apiolin -7- grapes
Uronic acid, pinobanksin, sieving, machinery add ultra-pure water after mixing, place in pharmacy mixer, mix 4-8min, control RSD
≤ 5%, compressing tablet and low temperature drying after mixing, at 4-8 DEG C, packaging obtains final product children's antipyretic to temperature control.
As further scheme of the invention：Mix 6min in specific steps.
As further scheme of the invention：Temperature control is at 6 DEG C in specific steps.
Compared with prior art, the beneficial effects of the invention are as follows：
Medicine of the present invention is strictly selected material composition according to the understanding mechanism of children fever, so as to reach comprehensive health
Multiple purpose, with rapid-action, effect stabilization, carry convenient to take, long-term taking and have no toxic side effect the characteristics of.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only a part of embodiment of the invention, rather than whole embodiments.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made, all
Belong to the scope of protection of the invention.
Embodiment 1
A kind of children's antipyretic, be according to the primary raw material of weight portion：23 parts of tectochrysin, 19 parts of persantine, double perfume (or spice)
7 parts of legumin, 5- methyl base -22 parts of kuh-seng alcohol C, 35 parts of kuh-seng alcohol W, 5 parts of Marmesin, 8 parts of L- hydroxyprolines, fennel
4 parts of sedanonic acid lactone, bent 2 parts of letter stilbene glycosides, 2 parts of apiolin -7- glucuronic acids, 8 parts of pinobanksin.
A kind of preparation method of children's antipyretic, concretely comprises the following steps：
First, in pharmaceutical grade clean area, tectochrysin, persantine, bicoumarin, 5- methyl are weighed by above-mentioned metering ratio
Base-kuh-seng alcohol C, kuh-seng alcohol W, Marmesin, L- hydroxyprolines, Pimpinellin, bent letter stilbene glycosides, apiolin -7- grapes
Uronic acid, pinobanksin, sieving, machinery add ultra-pure water after mixing, in placement pharmacy mixer, mixing 4min, control RSD≤
5%, compressing tablet and low temperature drying after mixing, at 4 DEG C, packaging obtains final product children's antipyretic to temperature control.
Embodiment 2
A kind of children's antipyretic, be according to the primary raw material of weight portion：23 parts of tectochrysin, 22 parts of persantine, double perfume (or spice)
12 parts of legumin, 5- methyl base -24 parts of kuh-seng alcohol C, 38 parts of kuh-seng alcohol W, 5 parts of Marmesin, 10 parts of L- hydroxyprolines,
4 parts of Pimpinellin, bent 2 parts of letter stilbene glycosides, 2 parts of apiolin -7- glucuronic acids, 8 parts of pinobanksin.
A kind of preparation method of children's antipyretic, concretely comprises the following steps：
First, in pharmaceutical grade clean area, tectochrysin, persantine, bicoumarin, 5- methyl are weighed by above-mentioned metering ratio
Base-kuh-seng alcohol C, kuh-seng alcohol W, Marmesin, L- hydroxyprolines, Pimpinellin, bent letter stilbene glycosides, apiolin -7- grapes
Uronic acid, pinobanksin, sieving, machinery add ultra-pure water after mixing, in placement pharmacy mixer, mixing 4min, control RSD≤
5%, compressing tablet and low temperature drying after mixing, at 4 DEG C, packaging obtains final product children's antipyretic to temperature control.
Embodiment 3
A kind of children's antipyretic, be according to the primary raw material of weight portion：24 parts of tectochrysin, 24 parts of persantine, double perfume (or spice)
14 parts of legumin, 5- methyl base -25 parts of kuh-seng alcohol C, 42 parts of kuh-seng alcohol W, 8 parts of Marmesin, 12 parts of L- hydroxyprolines,
6 parts of Pimpinellin, bent 3 parts of letter stilbene glycosides, 3 parts of apiolin -7- glucuronic acids, 9 parts of pinobanksin.
A kind of preparation method of children's antipyretic, concretely comprises the following steps：
First, in pharmaceutical grade clean area, tectochrysin, persantine, bicoumarin, 5- methyl are weighed by above-mentioned metering ratio
Base-kuh-seng alcohol C, kuh-seng alcohol W, Marmesin, L- hydroxyprolines, Pimpinellin, bent letter stilbene glycosides, apiolin -7- grapes
Uronic acid, pinobanksin, sieving, machinery add ultra-pure water after mixing, in placement pharmacy mixer, mixing 6min, control RSD≤
5%, compressing tablet and low temperature drying after mixing, at 6 DEG C, packaging obtains final product children's antipyretic to temperature control.
Embodiment 4
A kind of children's antipyretic, be according to the primary raw material of weight portion：25 parts of tectochrysin, 26 parts of persantine, double perfume (or spice)
16 parts of legumin, 5- methyl base -26 parts of kuh-seng alcohol C, 44 parts of kuh-seng alcohol W, 10 parts of Marmesin, L- hydroxyprolines 13
Part, 7 parts of Pimpinellin, bent 3 parts of letter stilbene glycosides, 4 parts of apiolin -7- glucuronic acids, 9 parts of pinobanksin.
A kind of preparation method of children's antipyretic, concretely comprises the following steps：
First, in pharmaceutical grade clean area, tectochrysin, persantine, bicoumarin, 5- methyl are weighed by above-mentioned metering ratio
Base-kuh-seng alcohol C, kuh-seng alcohol W, Marmesin, L- hydroxyprolines, Pimpinellin, bent letter stilbene glycosides, apiolin -7- grapes
Uronic acid, pinobanksin, sieving, machinery add ultra-pure water after mixing, in placement pharmacy mixer, mixing 8min, control RSD≤
5%, compressing tablet and low temperature drying after mixing, at 8 DEG C, packaging obtains final product children's antipyretic to temperature control.
Embodiment 5
A kind of children's antipyretic, be according to the primary raw material of weight portion：25 parts of tectochrysin, 28 parts of persantine, double perfume (or spice)
18 parts of legumin, 5- methyl base -27 parts of kuh-seng alcohol C, 47 parts of kuh-seng alcohol W, 10 parts of Marmesin, L- hydroxyprolines 16
Part, 7 parts of Pimpinellin, bent 3 parts of letter stilbene glycosides, 4 parts of apiolin -7- glucuronic acids, 9 parts of pinobanksin.
A kind of preparation method of children's antipyretic, concretely comprises the following steps：
First, in pharmaceutical grade clean area, tectochrysin, persantine, bicoumarin, 5- methyl are weighed by above-mentioned metering ratio
Base-kuh-seng alcohol C, kuh-seng alcohol W, Marmesin, L- hydroxyprolines, Pimpinellin, bent letter stilbene glycosides, apiolin -7- grapes
Uronic acid, pinobanksin, sieving, machinery add ultra-pure water after mixing, in placement pharmacy mixer, mixing 8min, control RSD≤
5%, compressing tablet and low temperature drying after mixing, at 8 DEG C, packaging obtains final product children's antipyretic to temperature control.
Pharmacology test
1st, acute toxicity test
It is experiment with Western medicine compound obtained in the embodiment of the present invention 3, using gastric infusion mode, is continuously given in 24h
Medicine 2 times, per minor tick 8h, is administered 800mg/kg doses every time, and daily accumulation medicine total amount reaches 1600mg medicines/kg, equivalent to
80 times of people's quantity.After administration in 7d, mouse activity, feed, excretion are normal, well-grown, hair color light, and its is average
Body weight increases with the extension of experimental period.Every mouse of post mortem at 8d, visually observe the heart, liver, spleen, lung, kidney,
Brain, thymus gland, stomach, intestines etc. do not find color and paramophia, fail to measure median lethal dose (LD50).Result shows：This hair
Bright Western medicine compound is without acute toxic reaction.
2nd, long term toxicity test
It is experiment with Western medicine compound obtained in the embodiment of the present invention 3, using gastric infusion mode, by Western medicine group of the present invention
Compound is divided into low dosage, middle dosage, three groups of high dose, the drug dose of each group is respectively 200,400,600mg medicines/kg/d,
10,20,30 times equivalent to clinical dosage.After gastric infusion 24 weeks, medicine of the present invention refers to the general status of animal, hematology
Mark, blood parameters without obvious influence, Systematic anatomy, organ coefficient and histopathological examination also no abnormal disease
Reason changes.It is discontinued 2 weeks and also has no substantially change.Result shows：Western medicine compound of the present invention does not find in long term toxicity test
Overt toxicity reacts and delayed toxicity reaction.It can be seen that, Western medicine compound non-toxic reaction of the present invention, long-term prescription is safe and reliable.
3rd, clinical test
Accept totally 200 patients for medical treatment, wherein, male 96, women 104；Age 6-12 Sui, fever is all suffered from, there is flu
Fever symptoms.
The Western medicine compound of the preparation of the embodiment of the present invention 3 is given, is within 4 hours a course for the treatment of (treatment two according to 10mg/kg/ times
The individual course for the treatment of) carry out symptom follow-up record；Clinical efficacy criterion is to cure：Various metabolic disorders recover normal completely, clinical
Symptom disappears, and clinical biochemistry indications are preferable；Effectively：Clinical symptoms are clearly better, and no longer high fever cough, various metabolic disorders are obvious
Improve, clinical biochemistry indications are more satisfactory；It is invalid：Clinical symptoms do not improve, and various metabolic disorders refer to without change, clinical biochemical
Mark is undesirable.
Treatment results：200 patients, 167 recoveries from illness, 24 are effective, and 7 are effectively, and 2 are invalid, total effective rate 99.0%.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be in other specific forms realized.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit requires to be limited rather than described above, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.
Moreover, it will be appreciated that although the present specification is described in terms of embodiments, not each implementation method is only wrapped
Containing an independent technical scheme, this narrating mode of specification is only that for clarity, those skilled in the art should
Specification an as entirety, the technical scheme in each embodiment can also be formed into those skilled in the art through appropriately combined
May be appreciated other embodiment.
Claims (6)
1. a kind of children's antipyretic, it is characterised in that the primary raw material according to weight portion is：Tectochrysin 23-25 parts, Pan Sheng
Fourth 19-28 parts, bicoumarin 7-18 parts, 5- methyl base -22-27 parts of kuh-seng alcohol C, 35-47 parts of kuh-seng alcohol W, different RADIX PEUCEDANI
Lactone 5-10 parts, 8-16 parts of L- hydroxyprolines, Pimpinellin 4-7 parts, bent 2-3 parts of letter stilbene glycosides, apiolin -7- glucuronic acids 2-
4 parts, pinobanksin 8-9 parts.
2. children's antipyretic according to claim 1, it is characterised in that children's antipyretic, according to weight portion
Primary raw material be：Tectochrysin 23-25 parts, persantine 22-26 parts, bicoumarin 12-16 parts, 5- methyl base-kuh-seng alcohol C
24-26 parts, 38-44 parts of kuh-seng alcohol W, Marmesin 5-10 parts, 10-13 parts of L- hydroxyprolines, Pimpinellin 4-7 parts,
2-3 parts of bent letter stilbene glycosides, 2-4 parts, pinobanksin 8-9 parts of apiolin -7- glucuronic acids.
3. children's antipyretic according to claim 1 and 2, it is characterised in that children's antipyretic, according to weight
Part primary raw material be：24 parts of tectochrysin, 24 parts of persantine, 14 parts of bicoumarin, 5- methyl base -25 parts of kuh-seng alcohol C, hardship
42 parts of ginseng alcohol W, 8 parts of Marmesin, 12 parts of L- hydroxyprolines, 6 parts of Pimpinellin, bent 3 parts of letter stilbene glycosides, apiolin -7-
3 parts of glucuronic acid, 9 parts of pinobanksin.
4. a kind of preparation method of children's antipyretic as described in claim 1-3 is any, it is characterised in that specific steps
For：
First, in pharmaceutical grade clean area, by above-mentioned metering ratio weigh tectochrysin, persantine, bicoumarin, 5- methyl base-
Kuh-seng alcohol C, kuh-seng alcohol W, Marmesin, L- hydroxyprolines, Pimpinellin, bent letter stilbene glycosides, apiolin -7- grape alditols
Sour, pinobanksin, sieving, machinery adds ultra-pure water after mixing, in placement pharmacy mixer, mixing 4-8min, control RSD≤
5%, compressing tablet and low temperature drying after mixing, at 4-8 DEG C, packaging obtains final product children's antipyretic to temperature control.
5. the preparation method of children's antipyretic according to claim 4, it is characterised in that mix in specific steps
6min。
6. the preparation method of children's antipyretic according to claim 4, it is characterised in that temperature control in specific steps
At 6 DEG C.
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| CN201611171675.8A CN106727642A (en) | 2016-12-17 | 2016-12-17 | A kind of children's antipyretic |
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| CN201611171675.8A CN106727642A (en) | 2016-12-17 | 2016-12-17 | A kind of children's antipyretic |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114867486A (en) * | 2019-12-26 | 2022-08-05 | 丸善制药株式会社 | Composition containing Heijiang extract and oral composition |
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|---|---|---|---|---|
| EP0065905A1 (en) * | 1981-05-13 | 1982-12-01 | Institut Pasteur | Stabilizing agents for live viruses for the preparation of vaccines, and stabilized vaccines containing these stabilizing agents |
| CN104606204A (en) * | 2015-02-11 | 2015-05-13 | 湖南中医药大学 | Febrifuge for children |
| CN106074940A (en) * | 2016-08-18 | 2016-11-09 | 上海颂露医药科技有限公司 | Tongxuan lifei pills and preparation method thereof |
-
2016
- 2016-12-17 CN CN201611171675.8A patent/CN106727642A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0065905A1 (en) * | 1981-05-13 | 1982-12-01 | Institut Pasteur | Stabilizing agents for live viruses for the preparation of vaccines, and stabilized vaccines containing these stabilizing agents |
| CN104606204A (en) * | 2015-02-11 | 2015-05-13 | 湖南中医药大学 | Febrifuge for children |
| CN106074940A (en) * | 2016-08-18 | 2016-11-09 | 上海颂露医药科技有限公司 | Tongxuan lifei pills and preparation method thereof |
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| Title |
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| 王本祥 主编: "《现代中药药理与临床》", 30 June 2004 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114867486A (en) * | 2019-12-26 | 2022-08-05 | 丸善制药株式会社 | Composition containing Heijiang extract and oral composition |
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