CN106727786A - A kind of antipyretic of children's Integrated TCM and preparation method thereof - Google Patents
A kind of antipyretic of children's Integrated TCM and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of antipyretic of children's Integrated TCM, the antipyretic of children's Integrated TCM is according to the primary raw material of weight portion：23 25 parts of radix bupleuri, 19 28 parts of antelope's horn, 7 18 parts of bicoumarin, 5 22 27 parts of methyl base kuh-seng alcohol C, 35 47 parts of kuh-seng alcohol W, 5 10 parts of Marmesin, 8 16 parts of L hydroxyprolines, 47 parts of Pimpinellin, bent 23 parts of letter stilbene glycosides, 24 parts of 7 glucuronic acid of apiolin, 89 parts of pinobanksin.Medicine of the present invention is strictly selected material composition according to the understanding mechanism of children fever, so as to reach the purpose of comprehensive rehabilitation, with rapid-action, effect stabilization, carry convenient to take, long-term taking and have no toxic side effect the characteristics of.
Description
Technical field
The present invention relates to a kind of field of medicine preparation, specifically a kind of antipyretic of children's Integrated TCM.
Background technology
The antipyretic of Integrated TCM is that one kind can make human body peripheral vascular expand and then borrow by adjusting function of human body
Helping the processes such as perspiration increases radiating, while suppressing shiver with cold, the medicine for reducing body heat production.It can efficiently control hair
Burn, make hypothermia, but can not at all release the reason for causing heating.Fever is one of total symptom of many diseases, treatment
No matter fever cause of disease state of an illness ground is not all right using the antipyretic of Integrated TCM.The poisonous secondary work of antipyretic of Integrated TCM
With.The antipyretic of Integrated TCM is in daily use, but its toxic and side effect is also common.Such as drug rash, gastrointestinal reaction, blood system
System reaction and the infringement to hepatic and renal function etc., especially when using or being excessively used such medicine long, toxic and side effect is more significantly.
Modern medicine thinks that fever is a kind of reaction that human body resists disease, the pathogenic microorganism master for causing children fever
There are bacterium, virus and mycoplasma, Chlamydia.Definite pathogenesis is not fully understood, and is the knot of many factors comprehensive function
Really, immunologic hypofunction is considered as one of major reason of morbidity.In the prior art to the treatment method research of children fever
Substantially (1) Physical temperature-lowering, such as warm water or alcohol bath, ice bag cooling, normal saline enema；(2) drug cooling, it is such as oral
The medicine such as antipyretic, Metamizole nasal drip or intramuscular injection, drip-feed dexamethasone, while taking antibiont medicine to treat sense
Dye；(3) herbal treatment：Such as oral traditional Chinese medicine preparation, the external application of Chinese medicine.There is more defect, physics drop in above-mentioned therapeutic modality
Temperature or simple Chinese medicine effect are poor, by reduction body temperature that can not be efficiently and effectively, occur body temperature rise, body after bringing down a fever again soon
Temperature fluctuation is larger.Antibiotic therapy is mainly using oral administration or intramuscular injection, the big approach of drip-feed two.The oral antibiosis of infant
Gastrointestinal reaction can usually be caused, the serious toxic and side effect such as can also cause allergic reaction, while infant medication is more difficult, it is difficult to
Operation, intramuscular injection or drip-feed antibiotic, risk is big, and operation difficulty is high, and infant is cry and screamed uneasiness, and pole is mismatched.
The content of the invention
It is an object of the invention to provide a kind of antipyretic of children's Integrated TCM, with solving above-mentioned background technology
The problem of proposition.
To achieve the above object, the present invention provides following technical scheme：
A kind of antipyretic of children's Integrated TCM, be according to the primary raw material of weight portion：Radix bupleuri 23-25 parts, antelope
Angle 19-28 parts, bicoumarin 7-18 parts, 5- methyl base -22-27 parts of kuh-seng alcohol C, 35-47 parts of kuh-seng alcohol W, different RADIX PEUCEDANI
Lactone 5-10 parts, 8-16 parts of L- hydroxyprolines, Pimpinellin 4-7 parts, bent 2-3 parts of letter stilbene glycosides, apiolin -7- glucuronic acids 2-
4 parts, pinobanksin 8-9 parts.
As further scheme of the invention：The antipyretic of children's Integrated TCM, according to the main of weight portion
Raw material is：Radix bupleuri 23-25 parts, antelope's horn 22-26 parts, bicoumarin 12-16 parts, it is 5- methyl base -24-26 parts of kuh-seng alcohol C, bitter
38-44 part of alcohol W of ginseng, Marmesin 5-10 parts, 10-13 parts of L- hydroxyprolines, Pimpinellin 4-7 parts, song letter stilbene glycosides 2-
3 parts, 2-4 parts, pinobanksin 8-9 parts of apiolin -7- glucuronic acids.
As further scheme of the invention：The antipyretic of children's Integrated TCM, according to the main of weight portion
Raw material is：It is 24 parts of radix bupleuri, 24 parts of antelope's horn, 14 parts of bicoumarin, 5- methyl base -25 parts of kuh-seng alcohol C, 42 parts of kuh-seng alcohol W, different
8 parts of nodakenetin, 12 parts of L- hydroxyprolines, 6 parts of Pimpinellin, bent 3 parts of letter stilbene glycosides, apiolin -7- glucuronic acids 3
Part, 9 parts of pinobanksin.
A kind of preparation method of the antipyretic of children's Integrated TCM, concretely comprises the following steps：
First, in pharmaceutical grade clean area, by above-mentioned metering ratio weigh radix bupleuri, antelope's horn, bicoumarin, 5- methyl base-
Kuh-seng alcohol C, kuh-seng alcohol W, Marmesin, L- hydroxyprolines, Pimpinellin, bent letter stilbene glycosides, apiolin -7- grape alditols
Sour, pinobanksin, sieving, machinery adds ultra-pure water after mixing, in placement pharmacy mixer, mixing 4-8min, control RSD≤
5%, compressing tablet and low temperature drying after mixing, at 4-8 DEG C, packaging obtains final product the antipyretic of children's Integrated TCM to temperature control.
As further scheme of the invention：Mix 6min in specific steps.
As further scheme of the invention：Temperature control is at 6 DEG C in specific steps.
Compared with prior art, the beneficial effects of the invention are as follows：
Medicine of the present invention is strictly selected material composition according to the understanding mechanism of children fever, so as to reach comprehensive health
Multiple purpose, with rapid-action, effect stabilization, carry convenient to take, long-term taking and have no toxic side effect the characteristics of.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only a part of embodiment of the invention, rather than whole embodiments.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made, all
Belong to the scope of protection of the invention.
Embodiment 1
A kind of antipyretic of children's Integrated TCM, be according to the primary raw material of weight portion：23 parts of radix bupleuri, antelope's horn 19
Part, 7 parts of bicoumarin, 5- methyl base -22 parts of kuh-seng alcohol C, 35 parts of kuh-seng alcohol W, 5 parts of Marmesin, L- hydroxyl dried meat ammonia
8 parts of acid, 4 parts of Pimpinellin, bent 2 parts of letter stilbene glycosides, 2 parts of apiolin -7- glucuronic acids, 8 parts of pinobanksin.
A kind of preparation method of the antipyretic of children's Integrated TCM, concretely comprises the following steps：
First, in pharmaceutical grade clean area, by above-mentioned metering ratio weigh radix bupleuri, antelope's horn, bicoumarin, 5- methyl base-
Kuh-seng alcohol C, kuh-seng alcohol W, Marmesin, L- hydroxyprolines, Pimpinellin, bent letter stilbene glycosides, apiolin -7- grape alditols
Acid, pinobanksin, sieving, machinery add ultra-pure water after mixing, place in pharmacy mixer, mix 4min, control RSD≤5%,
Compressing tablet and low temperature drying after mixing, at 4 DEG C, packaging obtains final product the antipyretic of children's Integrated TCM to temperature control.
Embodiment 2
A kind of antipyretic of children's Integrated TCM, be according to the primary raw material of weight portion：23 parts of radix bupleuri, antelope's horn 22
Part, 12 parts of bicoumarin, 5- methyl base -24 parts of kuh-seng alcohol C, 38 parts of kuh-seng alcohol W, 5 parts of Marmesin, L- hydroxyl dried meat ammonia
10 parts of acid, 4 parts of Pimpinellin, bent 2 parts of letter stilbene glycosides, 2 parts of apiolin -7- glucuronic acids, 8 parts of pinobanksin.
A kind of preparation method of the antipyretic of children's Integrated TCM, concretely comprises the following steps：
First, in pharmaceutical grade clean area, by above-mentioned metering ratio weigh radix bupleuri, antelope's horn, bicoumarin, 5- methyl base-
Kuh-seng alcohol C, kuh-seng alcohol W, Marmesin, L- hydroxyprolines, Pimpinellin, bent letter stilbene glycosides, apiolin -7- grape alditols
Acid, pinobanksin, sieving, machinery add ultra-pure water after mixing, place in pharmacy mixer, mix 4min, control RSD≤5%,
Compressing tablet and low temperature drying after mixing, at 4 DEG C, packaging obtains final product the antipyretic of children's Integrated TCM to temperature control.
Embodiment 3
A kind of antipyretic of children's Integrated TCM, be according to the primary raw material of weight portion：24 parts of radix bupleuri, antelope's horn 24
Part, 14 parts of bicoumarin, 5- methyl base -25 parts of kuh-seng alcohol C, 42 parts of kuh-seng alcohol W, 8 parts of Marmesin, L- hydroxyl dried meat ammonia
12 parts of acid, 6 parts of Pimpinellin, bent 3 parts of letter stilbene glycosides, 3 parts of apiolin -7- glucuronic acids, 9 parts of pinobanksin.
A kind of preparation method of the antipyretic of children's Integrated TCM, concretely comprises the following steps：
First, in pharmaceutical grade clean area, by above-mentioned metering ratio weigh radix bupleuri, antelope's horn, bicoumarin, 5- methyl base-
Kuh-seng alcohol C, kuh-seng alcohol W, Marmesin, L- hydroxyprolines, Pimpinellin, bent letter stilbene glycosides, apiolin -7- grape alditols
Acid, pinobanksin, sieving, machinery add ultra-pure water after mixing, place in pharmacy mixer, mix 6min, control RSD≤5%,
Compressing tablet and low temperature drying after mixing, at 6 DEG C, packaging obtains final product the antipyretic of children's Integrated TCM to temperature control.
Embodiment 4
A kind of antipyretic of children's Integrated TCM, be according to the primary raw material of weight portion：25 parts of radix bupleuri, antelope's horn 26
Part, 16 parts of bicoumarin, 5- methyl base -26 parts of kuh-seng alcohol C, 44 parts of kuh-seng alcohol W, 10 parts of Marmesin, L- hydroxyl dried meat
13 parts of propylhomoserin, 7 parts of Pimpinellin, bent 3 parts of letter stilbene glycosides, 4 parts of apiolin -7- glucuronic acids, 9 parts of pinobanksin.
A kind of preparation method of the antipyretic of children's Integrated TCM, concretely comprises the following steps：
First, in pharmaceutical grade clean area, by above-mentioned metering ratio weigh radix bupleuri, antelope's horn, bicoumarin, 5- methyl base-
Kuh-seng alcohol C, kuh-seng alcohol W, Marmesin, L- hydroxyprolines, Pimpinellin, bent letter stilbene glycosides, apiolin -7- grape alditols
Acid, pinobanksin, sieving, machinery add ultra-pure water after mixing, place in pharmacy mixer, mix 8min, control RSD≤5%,
Compressing tablet and low temperature drying after mixing, at 8 DEG C, packaging obtains final product the antipyretic of children's Integrated TCM to temperature control.
Embodiment 5
A kind of antipyretic of children's Integrated TCM, be according to the primary raw material of weight portion：25 parts of radix bupleuri, antelope's horn 28
Part, 18 parts of bicoumarin, 5- methyl base -27 parts of kuh-seng alcohol C, 47 parts of kuh-seng alcohol W, 10 parts of Marmesin, L- hydroxyl dried meat
16 parts of propylhomoserin, 7 parts of Pimpinellin, bent 3 parts of letter stilbene glycosides, 4 parts of apiolin -7- glucuronic acids, 9 parts of pinobanksin.
A kind of preparation method of the antipyretic of children's Integrated TCM, concretely comprises the following steps：
First, in pharmaceutical grade clean area, by above-mentioned metering ratio weigh radix bupleuri, antelope's horn, bicoumarin, 5- methyl base-
Kuh-seng alcohol C, kuh-seng alcohol W, Marmesin, L- hydroxyprolines, Pimpinellin, bent letter stilbene glycosides, apiolin -7- grape alditols
Acid, pinobanksin, sieving, machinery add ultra-pure water after mixing, place in pharmacy mixer, mix 8min, control RSD≤5%,
Compressing tablet and low temperature drying after mixing, at 8 DEG C, packaging obtains final product the antipyretic of children's Integrated TCM to temperature control.
Pharmacology test
1st, acute toxicity test
It is experiment with Western medicine compound obtained in the embodiment of the present invention 3, using gastric infusion mode, is continuously given in 24h
Medicine 2 times, per minor tick 8h, is administered 800mg/kg doses every time, and daily accumulation medicine total amount reaches 1600mg medicines/kg, equivalent to
80 times of people's quantity.After administration in 7d, mouse activity, feed, excretion are normal, well-grown, hair color light, and its is average
Body weight increases with the extension of experimental period.Every mouse of post mortem at 8d, visually observe the heart, liver, spleen, lung, kidney,
Brain, thymus gland, stomach, intestines etc. do not find color and paramophia, fail to measure median lethal dose (LD50).Result shows：This hair
Bright Western medicine compound is without acute toxic reaction.
2nd, long term toxicity test
It is experiment with Western medicine compound obtained in the embodiment of the present invention 3, using gastric infusion mode, by Western medicine group of the present invention
Compound is divided into low dosage, middle dosage, three groups of high dose, the drug dose of each group is respectively 200,400,600mg medicines/kg/d,
10,20,30 times equivalent to clinical dosage.After gastric infusion 24 weeks, medicine of the present invention refers to the general status of animal, hematology
Mark, blood parameters without obvious influence, Systematic anatomy, organ coefficient and histopathological examination also no abnormal disease
Reason changes.It is discontinued 2 weeks and also has no substantially change.Result shows：Western medicine compound of the present invention does not find in long term toxicity test
Overt toxicity reacts and delayed toxicity reaction.It can be seen that, Western medicine compound non-toxic reaction of the present invention, long-term prescription is safe and reliable.
3rd, clinical test
Accept totally 200 patients for medical treatment, wherein, male 96, women 104；Age 6-12 Sui, fever is all suffered from, there is flu
Fever symptoms.
The Western medicine compound of the preparation of the embodiment of the present invention 3 is given, is within 4 hours a course for the treatment of (treatment two according to 10mg/kg/ times
The individual course for the treatment of) carry out symptom follow-up record；Clinical efficacy criterion is to cure：Various metabolic disorders recover normal completely, clinical
Symptom disappears, and clinical biochemistry indications are preferable；Effectively：Clinical symptoms are clearly better, and no longer high fever cough, various metabolic disorders are obvious
Improve, clinical biochemistry indications are more satisfactory；It is invalid：Clinical symptoms do not improve, and various metabolic disorders refer to without change, clinical biochemical
Mark is undesirable.
Treatment results：200 patients, 167 recoveries from illness, 24 are effective, and 7 are effectively, and 2 are invalid, total effective rate 99.0%.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be in other specific forms realized.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit requires to be limited rather than described above, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.
Moreover, it will be appreciated that although the present specification is described in terms of embodiments, not each implementation method is only wrapped
Containing an independent technical scheme, this narrating mode of specification is only that for clarity, those skilled in the art should
Specification an as entirety, the technical scheme in each embodiment can also be formed into those skilled in the art through appropriately combined
May be appreciated other embodiment.
Claims (6)
1. a kind of antipyretic of children's Integrated TCM, it is characterised in that the primary raw material according to weight portion is：Radix bupleuri 23-
25 parts, antelope's horn 19-28 parts, bicoumarin 7-18 parts, it is 5- methyl base -22-27 parts of kuh-seng alcohol C, 35-47 parts of kuh-seng alcohol W, different
Nodakenetin 5-10 parts, 8-16 parts of L- hydroxyprolines, Pimpinellin 4-7 parts, bent 2-3 parts of letter stilbene glycosides, apiolin -7- grapes
Uronic acid 2-4 parts, pinobanksin 8-9 parts.
2. the antipyretic of children's Integrated TCM according to claim 1, it is characterised in that children's Chinese and Western medicine
With reference to antipyretic, be according to the primary raw material of weight portion：Radix bupleuri 23-25 parts, antelope's horn 22-26 parts, bicoumarin 12-16
Part, 5- methyl base -24-26 parts of kuh-seng alcohol C, 38-44 parts of kuh-seng alcohol W, Marmesin 5-10 parts, L- hydroxyprolines
10-13 parts, Pimpinellin 4-7 parts, bent 2-3 parts of letter stilbene glycosides, 2-4 parts, pinobanksin 8-9 parts of apiolin -7- glucuronic acids.
3. the antipyretic of children's Integrated TCM according to claim 1 and 2, it is characterised in that during the children use
The antipyretic that Western medicine is combined, be according to the primary raw material of weight portion：24 parts of radix bupleuri, 24 parts of antelope's horn, 14 parts of bicoumarin, 5- first
Ji Ji -25 parts of kuh-seng alcohol C, 42 parts of kuh-seng alcohol W, 8 parts of Marmesin, 12 parts of L- hydroxyprolines, 6 parts of Pimpinellin,
Bent 3 parts of letter stilbene glycosides, 3 parts of apiolin -7- glucuronic acids, 9 parts of pinobanksin.
4. a kind of preparation method of the antipyretic of children's Integrated TCM as described in claim 1-3 is any, its feature exists
In concretely comprising the following steps：
First, in pharmaceutical grade clean area, radix bupleuri, antelope's horn, bicoumarin, 5- methyl base-kuh-seng are weighed by above-mentioned metering ratio
Alcohol C, kuh-seng alcohol W, Marmesin, L- hydroxyprolines, Pimpinellin, bent letter stilbene glycosides, apiolin -7- glucuronic acids,
Pinobanksin, sieving, machinery adds ultra-pure water after mixing, place in pharmacy mixer, mixes 4-8min, controls RSD≤5%,
Compressing tablet and low temperature drying after mixing, at 4-8 DEG C, packaging obtains final product the antipyretic of children's Integrated TCM to temperature control.
5. the preparation method of the antipyretic of children's Integrated TCM according to claim 4, it is characterised in that specific step
Mixing 6min in rapid.
6. the preparation method of the antipyretic of children's Integrated TCM according to claim 4, it is characterised in that specific step
Temperature control is at 6 DEG C in rapid.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1476890A (en) * | 2003-07-24 | 2004-02-25 | 亚宝药业大同制药有限公司 | Chinese medicine composition for curing child common cold fever |
| CN1562115A (en) * | 2004-03-26 | 2005-01-12 | 吉林敖东延边药业股份有限公司 | Antipyretic Chinese medicine preparation for child made of bupleurum root and cinnamon twig |
| CN105362623A (en) * | 2015-11-29 | 2016-03-02 | 黑龙江江恒医药科技有限公司 | Xiao'er Feireping capsule and preparation method thereof |
-
2016
- 2016-12-17 CN CN201611171910.1A patent/CN106727786A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1476890A (en) * | 2003-07-24 | 2004-02-25 | 亚宝药业大同制药有限公司 | Chinese medicine composition for curing child common cold fever |
| CN1562115A (en) * | 2004-03-26 | 2005-01-12 | 吉林敖东延边药业股份有限公司 | Antipyretic Chinese medicine preparation for child made of bupleurum root and cinnamon twig |
| CN105362623A (en) * | 2015-11-29 | 2016-03-02 | 黑龙江江恒医药科技有限公司 | Xiao'er Feireping capsule and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 王本祥: "《现代中药药理与临床》", 30 June 2004, 天津科技翻译出版公司 * |
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