CN102648956A - Traditional Chinese herbal medicament for treating breast cancer and preparation method thereof - Google Patents
Traditional Chinese herbal medicament for treating breast cancer and preparation method thereof Download PDFInfo
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- CN102648956A CN102648956A CN2012101545586A CN201210154558A CN102648956A CN 102648956 A CN102648956 A CN 102648956A CN 2012101545586 A CN2012101545586 A CN 2012101545586A CN 201210154558 A CN201210154558 A CN 201210154558A CN 102648956 A CN102648956 A CN 102648956A
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Abstract
The invention discloses a traditional Chinese herbal medicament for treating breast cancer and a preparation method thereof, which belong to the technical field of traditional Chinese herbal medicaments. The traditional Chinese herbal medicament comprises the bulk pharmaceutical chemicals in percentage by mass: 15-25 percent of sculellaria barbata, 15-25 percent of Chinese lobelia, 15-25 percent of paris polyphylla, 25-35 percent of oldenlandia diffusa, and 5-15 percent of lucid ganoderma, wherein the sum of the mass percentage of the bulk pharmaceutical chemicals is 100 percent. The preparation method comprises the following steps of: grinding the traditional Chinese medicine into powder, decocting herbals into medicine soup, and mixing the traditional Chinese herbals into medicament. The composition of the traditional Chinese medicine and the herbals is used; characteristics of the herbals are fully utilized; the effects of relaxing the muscles and stimulating the blood circulation, strengthening body resistance, slowing and inhibiting diseased period of breast cancer, and the like are realized; the formula is reasonable; the preparation method is simple; and obvious economic and social benefits are realized.
Description
Technical field
The invention belongs to the Chinese herbal and crude drugs preparations technical field, be specifically related to a kind of Chinese herbal and crude drugs preparations of treating breast carcinoma and preparation method thereof.
Background technology
Breast carcinoma is human a kind of difficult treatment, is seriously threatening people's life.According to domestic relevant medical science, the whole world has the patient with breast cancer to reach more than 5,000 ten thousand people, according to statistics forecast China 7,000,000 people nearly.Following 50 years breast carcinoma will be serious problems of harm Chinese citizen life.Treatment for breast carcinoma has various methods, as: operative treatment, physical therapy, chemotherapy or the like, and external has ointment, medicated wine etc.The physician of the China and foreign countries medicine of having created a large amount of treatment breast carcinoma is treated from ancient times to the present, but does not still have a kind of can generally being suitable for so far, and the medicine that can fundamentally cure breast carcinoma comes out.Its reason is: many medicines all are in the state of " curing the symptoms, not the disease " at present, the breast cancer disease feelings are alleviated to some extent, and the bounce-back rate are very high after the drug withdrawal.The patient who has just must change types of drugs after certain medicine of use reaches certain hour, just can keep curative effect.Show from the interrelated data retrieval that comprises Chinese patent; Existing hundreds of at present are utilized the related patent U.S. Patent No. (containing application) of Chinese herbal treatment breast carcinoma, do not utilize Herba Scutellariae Barbatae, Herba Lobeliae Chinensis, Herba Hedyotidis Diffusae etc. to be made as the relevant report of preparation for the Chinese herbal medicine of main prescription but see as yet.
Summary of the invention
The object of the present invention is to provide a kind of Chinese herbal and crude drugs preparations of treating breast carcinoma and preparation method thereof, the present invention uses the compositions of Chinese medicine and medical herbs, makes full use of Chinese herbal medicine characteristics separately; Play relaxing muscles and tendons to promote blood circulation; Strengthen passive protective physical fitness, slow down and suppresses effect such as breast carcinoma period of disease, prescription is reasonable; Method for preparing is simple, possesses remarkable economical and social benefit.
For realizing above-mentioned purpose, the present invention adopts following technical scheme:
A kind of Chinese herbal and crude drugs preparations of treating breast carcinoma, the mass percent of crude drug is: Herba Scutellariae Barbatae 15-25%, Herba Lobeliae Chinensis 15-25%, Rhizoma Paridis 15-25%, Herba Hedyotidis Diffusae 25-35%, Ganoderma 5-15%; The mass percent sum of each crude drug is 100%.
A kind of method for preparing of Chinese herbal and crude drugs preparations of aforesaid treatment breast carcinoma may further comprise the steps:
(1) Chinese medicine powder is broken into powder: Rhizoma Paridis and Ganoderma by the proportioning raw materials weighing, are mixed, and it is subsequent use to be crushed to 150-300 purpose medicated powder;
(2) medical herbs is fried in shallow oil patent medicine soup: Herba Scutellariae Barbatae, Herba Lobeliae Chinensis and Herba Hedyotidis Diffusae by the proportioning raw materials weighing, are mixed, and the decocting that adds 3 times of quality is subsequent use to remaining 2/3rds;
(3) Chinese herbal medicine is mixed and made into medicament: the medicated powder of step (1) is put in the medicine soup of step (2) after with the gauze parcel, and then fried in shallow oil to the medicine soup of residue 60%.
The instructions of taking of decoction is: once a day, sleeps every night and took in previous hour, and each medication 250-300 gram, 15 days is a course of treatment, drug withdrawal is 3 days between per course of treatment.
According to traditional Chinese medical science combination principle and modern pharmacology result of study, selecting above-mentioned 5 flavor Chinese herbal medicine for use is crude drug of the present invention, and the pharmacological action of wherein every flavor medicine is following:
Herba Scutellariae Barbatae: acrid in the mouth; Bitter; Cold in nature.Return lung meridian; Liver Channel; Kidney channel.Be used for heat-clearing and toxic substances removing; The dissipating blood stasis hemostasis; Inducing diuresis to remove edema.
Herba Lobeliae Chinensis: sweet in the mouth; Property is put down.The GUIXIN warp; Lung meridian; Small intestine meridian.Be used for heat-clearing and toxic substances removing; Inducing diuresis to remove edema.
Rhizoma Paridis: bitter in the mouth; Cool in nature.Mild toxicity.GUIXIN warp, Liver Channel, lung meridian, stomach warp, large intestine channel.Anticancer, reducing swelling and alleviating pain, heat clearing away arresting convulsion, antitussive and antiasthmatic are used to relieve internal heat.
Herba Hedyotidis Diffusae: bitter in the mouth, sweet; Cold in nature; Nontoxic.GUIXIN, liver, spleen, large intestine channel.Be used for heat-clearing and toxic substances removing; Dampness removing.
Ganoderma: sweet in the mouth, property is flat.GUIXIN, lung, liver, kidney channel.Be used for invigorating QI and tranquilization, relieving cough and asthma.
Beneficial effect of the present invention: the present invention uses the compositions of Chinese medicine and medical herbs, makes full use of Chinese herbal medicine characteristics separately, plays relaxing muscles and tendons to promote blood circulation; Strengthen passive protective physical fitness, slow down and suppresses effect such as breast carcinoma period of disease, prescription is reasonable; Method for preparing is simple, possesses remarkable economical and social benefit.
The specific embodiment
Embodiment 1
A kind of Chinese herbal and crude drugs preparations of treating breast carcinoma, the mass percent of crude drug is: Herba Scutellariae Barbatae 20%, Herba Lobeliae Chinensis 20%, Rhizoma Paridis 20%, Herba Hedyotidis Diffusae 30%, Ganoderma 10 %.
A kind of method for preparing of Chinese herbal and crude drugs preparations of aforesaid treatment breast carcinoma may further comprise the steps:
(1) Chinese medicine powder is broken into powder: Rhizoma Paridis and Ganoderma by the proportioning raw materials weighing, are mixed, and it is subsequent use to be crushed to 150-300 purpose medicated powder;
(2) medical herbs is fried in shallow oil patent medicine soup: Herba Scutellariae Barbatae, Herba Lobeliae Chinensis and Herba Hedyotidis Diffusae by the proportioning raw materials weighing, are mixed, and the decocting that adds 3 times of quality is subsequent use to remaining 2/3rds;
(3) Chinese herbal medicine is mixed and made into medicament: the medicated powder of step (1) is put in the medicine soup of step (2) after with the gauze parcel, and then fried in shallow oil to the medicine soup of residue 60%.
The instructions of taking of decoction is: once a day, sleeps every night and took in previous hour, and each medication 250-300 gram, 15 days is a course of treatment, drug withdrawal is 3 days between per course of treatment.
Embodiment 2
A kind of Chinese herbal and crude drugs preparations of treating breast carcinoma, the mass percent of crude drug is: Herba Scutellariae Barbatae 15%, Herba Lobeliae Chinensis 25%, Rhizoma Paridis 25%, Herba Hedyotidis Diffusae 30%, Ganoderma 5 %.
A kind of method for preparing of Chinese herbal and crude drugs preparations of aforesaid treatment breast carcinoma may further comprise the steps:
(1) Chinese medicine powder is broken into powder: Rhizoma Paridis and Ganoderma by the proportioning raw materials weighing, are mixed, and it is subsequent use to be crushed to 150-300 purpose medicated powder;
(2) medical herbs is fried in shallow oil patent medicine soup: Herba Scutellariae Barbatae, Herba Lobeliae Chinensis and Herba Hedyotidis Diffusae by the proportioning raw materials weighing, are mixed, and the decocting that adds 3 times of quality is subsequent use to remaining 2/3rds;
(3) Chinese herbal medicine is mixed and made into medicament: the medicated powder of step (1) is put in the medicine soup of step (2) after with the gauze parcel, and then fried in shallow oil to the medicine soup of residue 60%.
The instructions of taking of decoction is: once a day, sleeps every night and took in previous hour, and each medication 250-300 gram, 15 days is a course of treatment, drug withdrawal is 3 days between per course of treatment.
Embodiment 3
A kind of Chinese herbal and crude drugs preparations of treating breast carcinoma, the mass percent of crude drug is: Herba Scutellariae Barbatae 25%, Herba Lobeliae Chinensis 15%, Rhizoma Paridis 15%, Herba Hedyotidis Diffusae 35%, Ganoderma 10%.
A kind of method for preparing of Chinese herbal and crude drugs preparations of aforesaid treatment breast carcinoma may further comprise the steps:
(1) Chinese medicine powder is broken into powder: Rhizoma Paridis and Ganoderma by the proportioning raw materials weighing, are mixed, and it is subsequent use to be crushed to 150-300 purpose medicated powder;
(2) medical herbs is fried in shallow oil patent medicine soup: Herba Scutellariae Barbatae, Herba Lobeliae Chinensis and Herba Hedyotidis Diffusae by the proportioning raw materials weighing, are mixed, and the decocting that adds 3 times of quality is subsequent use to remaining 2/3rds;
(3) Chinese herbal medicine is mixed and made into medicament: the medicated powder of step (1) is put in the medicine soup of step (2) after with the gauze parcel, and then fried in shallow oil to the medicine soup of residue 60%.
The instructions of taking of decoction is: once a day, sleeps every night and took in previous hour, and each medication 250-300 gram, 15 days is a course of treatment, drug withdrawal is 3 days between per course of treatment.
Long-term toxicity test for animals
Test objective: observe rat and take toxic reaction and the degree that Thallus Laminariae (Thallus Eckloniae) Carapax Trionycis capsule is taken place for a long time, for its clinical drug safety property of objective evaluation provides scientific basis.
Experimental animal:
Age in SD rat: 8-9 week, body weight 90-130g, male and female half and half.
Result of the test:
Give Chinese herbal and crude drugs preparations of the present invention for a long time the rat behavior outward appearance is not had tangible toxic effect.
Give Chinese herbal and crude drugs preparations of the present invention for a long time female, male rat body weight are not had obvious influence.
Give Chinese herbal and crude drugs preparations of the present invention for a long time, in test blood parameters such as the liver of rat, renal function, blood glucose, blood fat are not had obvious influence.
In test the growth course of the heart of rat, liver, spleen, lung, kidney there is not influence.
The histopathology test
Histopathologic examination shows that each organs and tissues does not have the pathology influence in the test.
Purpose: the antiinflammatory action of studying Chinese herbal and crude drugs preparations of the present invention.
Method: adopt the swollen method of mice caused by dimethylbenzene xylene auricle edema method and rat granuloma to study the antiinflammatory action of Chinese herbal and crude drugs preparations of the present invention.The result: it is swollen wide bloated swollen with rat granuloma that Chinese herbal and crude drugs preparations of the present invention can significantly suppress mouse ear.
Conclusion: Chinese herbal and crude drugs preparations of the present invention has tangible antiinflammatory action.
Observe the influence of Chinese herbal and crude drugs preparations of the present invention, for the clinical application of Chinese herbal and crude drugs preparations of the present invention provides foundation to estrogen, progestogen and the corresponding receptor thereof of experimental cyclomastopathy rat.30 of method SD rats are divided into 6 groups at random: normal group, model group, tamoxifen group and the large, medium and small dose groups of Chinese herbal and crude drugs preparations of the present invention, 5 every group.Method with exogenous estradiol benzoate of intramuscular injection and Progesterone is duplicated the rat mammary gland model of hyperplasia; Measure the content of respectively organizing estradiol (E2) in the experimental rat model blood plasma, progesterone (P), the variation of estrogen receptor in the Using immunohistochemical mammary gland tissue (ER) and progesterone receptor (PR) with radioimmunoassay.Result's Chinese herbal and crude drugs preparations of the present invention can reduce the serum E2 level of experimental cyclomastopathy rat; Also can reduce mammary gland tissue ER, PR content, mammary gland tissue is descended to estrogenic sensitivity. conclusion Chinese herbal and crude drugs preparations of the present invention plays the effect that suppresses cyclomastopathy through reducing experimental rat serum E2 level and mammary gland tissue ER, PR content.
Experimental result shows: Chinese herbal and crude drugs preparations treatment mastopathy of the present invention is evident in efficacy, and to menorrhagia, menostaxis, lower abdomen do to expand, the improvement effect of distending pain of the breast, fatigue and weakness and symptoms such as picture of the tongue is unusual, abnormal pulse condition is very obvious.Chinese herbal and crude drugs preparations of the present invention also has better curative effect to the recovery of erythrocyte and haemachrome, and can reduce blood viscosity, improves condition of illness such as blood circulation and anemia.Follow-up results shows that this medicine is to the mastopathy effect stability.Do not find in the clinical experiment that this medicine has tangible untoward reaction.This shows that Chinese herbal and crude drugs preparations clinical efficacy of the present invention is definite, take safety, convenient.
Application examples 1
Poplar * *, 47 years old, the woman, Zhangpu County Sui An town, Fujian Province Hou Gang people from village, breast carcinoma feels that sometimes a side breast mild pain is uncomfortable, or that side shoulder back is sent out heavy, acid is expanded is uncomfortable, even leads and the upper arm of this side, and paroxysmal dull pain, dull pain or twinge are arranged.After 73 days, the state of an illness is not felt any better in the Zhangpu County hospitalize, simultaneously outside hospital, eaten multiple Chinese and western drugs after, also have no effect, after upon somebody's introduction, this prescription is fully recovered after about four months more than adhering to having eaten.
Application examples 2
Open * *, 41 years old, the woman, people from village city, Zhangpu County Jiu Zhen town, Fujian Province in, breast carcinoma, 1, feel that a side breast mild pain is uncomfortable sometimes, or side shoulder back is sent out heavy, the bloated discomfort of acid, even lead and the upper arm of this side.2, can touch the lump of Semen Viciae fabae size in the early stage breast, harder, movable.General no obvious pain, minority has paroxysmal dull pain, dull pain or twinge.3, the mammary gland profile changes: visible lump place skin, the local skin that has is the Pericarpium Citri tangerinae shape, even edema, variable color, eczema appearance change etc.4, the nearly central authorities of nipple bounce back with nipple.Skin of breast has slight depression (medically being called " dimple disease "), and nipple is rotten to the corn, nipple is asymmetric, or the skin of breast thickens chap, pore increases phenomenon; Before and after the hospitalize 91 days in the Zhangzhou City; Sb.'s illness took a turn for the worse, and the household thinks and pasts medical help, and have to lift and go home to wait for death.Listen the people to introduce after going home, just have the phychology of horse alive as dead horse doctor in arms, this prescription was fully recovered after 70 days more than having eaten.
Application examples 3
The king * *, 33 years old, the woman, Zhangpu County Sui An town, Fujian Province Yingshan Mountains people from village, breast carcinoma, the treatment of 175 military hospitals is 32 days in ZhangZhou.The mammary gland profile changes: visible lump place skin, and the local skin that has is the Pericarpium Citri tangerinae shape, even edema, variable color, eczema appearance change etc.; The nearly central authorities of nipple bounce back with nipple.Skin of breast has slight depression (medically being called " dimple disease "), and nipple is rotten to the corn, nipple is asymmetric, or the skin of breast thickens chap, pore increases phenomenon (medically being called " Pericarpium Citri tangerinae disease "); Nipple discharge: the state of an illness does not take a turn for the better.After upon somebody's introduction, find woods to refuel (woods I's father) this old docter of TCM, this prescription was fully recovered after 54 days more than having eaten.
The above is merely preferred embodiment of the present invention, and all equalizations of doing according to claim of the present invention change and modify, and all should belong to covering scope of the present invention.
Claims (4)
1. Chinese herbal and crude drugs preparations of treating breast carcinoma, it is characterized in that: the mass percent of crude drug is: Herba Scutellariae Barbatae 15-25%, Herba Lobeliae Chinensis 15-25%, Rhizoma Paridis 15-25%, Herba Hedyotidis Diffusae 25-35%, Ganoderma 5-15%; The mass percent sum of each crude drug is 100%.
2. the Chinese herbal and crude drugs preparations of treatment breast carcinoma according to claim 1 is characterized in that: the mass percent of crude drug is: Herba Scutellariae Barbatae 20%, Herba Lobeliae Chinensis 20%, Rhizoma Paridis 20%, Herba Hedyotidis Diffusae 30%, Ganoderma 10 %.
3. the method for preparing of the Chinese herbal and crude drugs preparations of a treatment breast carcinoma as claimed in claim 1, it is characterized in that: described method for preparing may further comprise the steps:
(1) Chinese medicine powder is broken into powder: Rhizoma Paridis and Ganoderma by the proportioning raw materials weighing, are mixed, and it is subsequent use to be crushed to 150-300 purpose medicated powder;
(2) medical herbs is fried in shallow oil patent medicine soup: Herba Scutellariae Barbatae, Herba Lobeliae Chinensis and Herba Hedyotidis Diffusae by the proportioning raw materials weighing, are mixed, and the decocting that adds 3 times of quality is subsequent use to remaining 2/3rds;
(3) Chinese herbal medicine is mixed and made into medicament: the medicated powder of step (1) is put in the medicine soup of step (2) after with the gauze parcel, and then fried in shallow oil to the medicine soup of residue 60%.
4. the Chinese herbal and crude drugs preparations that the described method for preparing of the Chinese herbal and crude drugs preparations of treatment breast carcinoma according to claim 1 or claim 3 makes; It is characterized in that: the instructions of taking of decoction is: once a day; Sleep every night and took in previous hour; Each medication 250-300 gram, 15 days is a course of treatment, drug withdrawal is 3 days between per course of treatment.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105327061A (en) * | 2015-12-08 | 2016-02-17 | 刘东滨 | Traditional Chinese medicine for treating breast cancer and preparing method of traditional Chinese medicine |
| CN109125397A (en) * | 2018-11-14 | 2019-01-04 | 杨中泽 | A kind of Chinese materia medica preparation for treating breast cancer |
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| WO2002080951A1 (en) * | 2001-04-06 | 2002-10-17 | Synergistix Biotech, Inc. | Herbal extracts for the treatment of cancer |
| CN101491663A (en) * | 2009-02-26 | 2009-07-29 | 杨杰生 | Traditional Chinese medicine composition for treating various cancer |
| CN101601800A (en) * | 2009-07-13 | 2009-12-16 | 漳州市中草药研究所 | A kind of Chinese herbal and crude drugs preparations for the treatment of cancer and preparation method thereof |
| US20100016420A1 (en) * | 2006-05-11 | 2010-01-21 | Sophie Chen | Composition for the Treatment of Resistant Cancers Comprising Oridonin |
| US20110206721A1 (en) * | 2010-02-19 | 2011-08-25 | Vijaya Nair | Fermented soy nutritional supplements including mushroom components |
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2012
- 2012-05-18 CN CN2012101545586A patent/CN102648956A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002080951A1 (en) * | 2001-04-06 | 2002-10-17 | Synergistix Biotech, Inc. | Herbal extracts for the treatment of cancer |
| US20100016420A1 (en) * | 2006-05-11 | 2010-01-21 | Sophie Chen | Composition for the Treatment of Resistant Cancers Comprising Oridonin |
| CN101491663A (en) * | 2009-02-26 | 2009-07-29 | 杨杰生 | Traditional Chinese medicine composition for treating various cancer |
| CN101601800A (en) * | 2009-07-13 | 2009-12-16 | 漳州市中草药研究所 | A kind of Chinese herbal and crude drugs preparations for the treatment of cancer and preparation method thereof |
| US20110206721A1 (en) * | 2010-02-19 | 2011-08-25 | Vijaya Nair | Fermented soy nutritional supplements including mushroom components |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105327061A (en) * | 2015-12-08 | 2016-02-17 | 刘东滨 | Traditional Chinese medicine for treating breast cancer and preparing method of traditional Chinese medicine |
| CN109125397A (en) * | 2018-11-14 | 2019-01-04 | 杨中泽 | A kind of Chinese materia medica preparation for treating breast cancer |
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Application publication date: 20120829 |