CN106728145A - It is a kind of to treat Chinese and western medicinal composition of acute diarrhea and preparation method thereof - Google Patents
It is a kind of to treat Chinese and western medicinal composition of acute diarrhea and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/245—Bismuth; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
Abstract
The invention discloses a kind of Chinese and western medicinal composition for treating acute diarrhea, the Chinese and western medicinal composition of the treatment acute diarrhea is according to the primary raw material of weight portion：8 12 parts of methyl caffeate, 15 19 parts of Asiatic plantain extract A, 38 parts of Chinese trumpet creeper extract solution, 7 12 parts of leaf golden flower extract solutions, 0.5 0.7 parts of bismuth subsalicylate, 69 parts of aboktal, 16 22 parts of demethylnobiletin, 7 15 parts of demethyl amphibious crab lactone, 24 parts of lycorine hydrochloride, 24 parts of isocurcumenol, 324 parts of hydrogenation dehydrogenation pine Siberian cocklebur acid, 624 parts of ganoderic acid C, 5 10 parts of different ginkgetin.Medicine of the present invention is strictly selected material composition according to the understanding mechanism of acute diarrhea, so as to reach the purpose of comprehensive rehabilitation, with rapid-action, effect stabilization, carry convenient to take, long-term taking and have no toxic side effect the characteristics of.
Description
Technical field
The present invention relates to a kind of field of medicine preparation, specifically a kind of Chinese and western medicinal composition for treating acute diarrhea.
Background technology
The secretion of intestinal mucosa is vigorous too fast with malabsorption, enterocinesia, causes stool interval to increase, and excrement matter is thin, containing different
Chang Chengfen person, referred to as suffers from diarrhoea.Acute diarrhea onset is hurried, and, up to more than 10 times, excrement amount is more thin, during defecation for daily defecation
Often with borborygmus, intestinal colic or tenesmus.Infection is the most common reason of diarrhoea.In developing country, merge dehydration and nutrition
Bad infectious diarrhea is main cause that possible lethal, even if can also develop into stomach and intestine urgency in developed country's acute diarrhea
Disease.Such as comma bacillus or Clestridium difficile infect, and especially with low blood pressure, shock, kidney failure, enterobrosis or go out
During blood, can threat to life.
Clinically in addition to diarrhoea, typically there are the performances such as heating, stomachache and leukocytosis.These clinical manifestations are common
, the position and pathogen to enteric infection without diagnostic value, therefore, need to first differentiate it is small intestine or colon infections.Small intestine
The characteristics of infectious diarrhea be navel week or Right Lower Abdomen be paroxysmal bitterly, and with abdominal distension or borborygmus, daily 5~10 times, excrement of suffering from diarrhoea
Just measure more in dilute water just, be mixed with foam and do not digest swill, severe infections person is dilute water bloody stool, suffered from abdominal pain before defecation, after an action of the bowels
Stomachache can mitigate or disappear and have comfort.The stomachache of colon infections diarrhoea, often in lower abdomen or left lower abdomen, typically not with intestines
Ring, diarrhoea is frequent, significantly increases compared with small intestine infectious diarrhea number of times, and excrement amount is few, in pus and blood stool outward appearance, have it is tenesmus and under
Pendant sense.Small intestine infectious diarrhea is more common in staphylococcal food poisoning or Salmonella enteritis, and colon infections diarrhoea often by
Caused by shigella dysenteriae or other shigella dysenteriaes.
The content of the invention
It is an object of the invention to provide a kind of Chinese and western medicinal composition for treating acute diarrhea, to solve above-mentioned background technology
The problem of middle proposition.
To achieve the above object, the present invention provides following technical scheme：
A kind of Chinese and western medicinal composition for treating acute diarrhea, be according to the primary raw material of weight portion：Methyl caffeate 8-12
Part, 15-19 parts of Asiatic plantain extract A, 3-8 parts of Chinese trumpet creeper extract solution, 7-12 parts of leaf golden flower extract solutions, bismuth subsalicylate 0.5-
0.7 part, aboktal 6-9 parts, demethylnobiletin 16-22 parts, 7-15 parts of demethyl amphibious crab lactone, lycorine hydrochloride 2-
4 parts, isocurcumenol 2-4 parts, 2-4 parts of 3- hydrogenation dehydrogenation pines Siberian cocklebur acid, 2-4 parts of ganoderic acid C 6, different ginkgetin 5-10 parts.
As further scheme of the invention：The Chinese and western medicinal composition of the treatment acute diarrhea, according to the master of weight portion
The raw material is wanted to be：Methyl caffeate 9-11 parts, 16-18 parts of Asiatic plantain extract A, 5-7 parts of Chinese trumpet creeper extract solution, leaf golden flower extract
Liquid 8-11 parts, bismuth subsalicylate 0.5-0.7 parts, aboktal 6-9 parts, demethylnobiletin 18-21 parts, in demethyl amphibious crab
Ester 8-12 parts, 2-4 parts of lycorine hydrochloride, isocurcumenol 2-4 parts, 2-4 parts of 3- hydrogenation dehydrogenation pines Siberian cocklebur acid, the 2-4 of ganoderic acid C 6
Part, different ginkgetin 6-8 parts.
As further scheme of the invention：The Chinese and western medicinal composition of the treatment acute diarrhea, according to the master of weight portion
The raw material is wanted to be：10 parts of methyl caffeate, 17 parts of Asiatic plantain extract A, 6 parts of Chinese trumpet creeper extract solution, 10 parts of leaf golden flower extract solutions,
0.6 part of bismuth subsalicylate, 8 parts of aboktal, 20 parts of demethylnobiletin, 10 parts of demethyl amphibious crab lactone, lycorine hydrochloric acid
3 parts of salt, 3 parts of isocurcumenol, 3 parts of 3- hydrogenation dehydrogenation pine Siberian cockleburs acid, 63 parts of ganoderic acid C, 7 parts of different ginkgetin.
A kind of preparation method of the Chinese and western medicinal composition for treating acute diarrhea, concretely comprises the following steps：
First, in pharmaceutical grade clean area, methyl caffeate, Asiatic plantain extract A, Chinese trumpet creeper are weighed by above-mentioned metering ratio
Extract solution, leaf golden flower extract solutions, bismuth subsalicylate, aboktal, demethylnobiletin, demethyl amphibious crab lactone, lycorine
Hydrochloride, isocurcumenol, the acid of 3- hydrogenation dehydrogenation pine Siberian cockleburs, ganoderic acid C 6, different ginkgetin, sieving, machinery add ultrapure after mixing
Water, places in pharmacy mixer, mixes 4-8min, controls RSD≤5%, compressing tablet and low temperature drying after mixing, and temperature control is in 4-
8 DEG C, packaging obtains final product the Chinese and western medicinal composition for the treatment of acute diarrhea.
As further scheme of the invention：Mix 6min in specific steps.
As further scheme of the invention：Temperature control is at 6 DEG C in specific steps.
Compared with prior art, the beneficial effects of the invention are as follows：
Medicine of the present invention is strictly selected material composition according to the understanding mechanism of acute diarrhea, so as to reach comprehensive health
Multiple purpose, with rapid-action, effect stabilization, carry convenient to take, long-term taking and have no toxic side effect the characteristics of.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only a part of embodiment of the invention, rather than whole embodiments.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made, all
Belong to the scope of protection of the invention.
Embodiment 1
A kind of Chinese and western medicinal composition for treating acute diarrhea, be according to the primary raw material of weight portion：8 parts of methyl caffeate,
15 parts of Asiatic plantain extract A, 3 parts of Chinese trumpet creeper extract solution, 7 parts of leaf golden flower extract solutions, 0.5 part of bismuth subsalicylate, aboktal 6
Part, 16 parts of demethylnobiletin, 7 parts of demethyl amphibious crab lactone, 2 parts of lycorine hydrochloride, 2 parts of isocurcumenol, 3- hydrogenation
2 parts of dehydrogenation pine Siberian cocklebur acid, 62 parts of ganoderic acid C, 5 parts of different ginkgetin.
A kind of preparation method of the Chinese and western medicinal composition for treating acute diarrhea, concretely comprises the following steps：
First, in pharmaceutical grade clean area, methyl caffeate, Asiatic plantain extract A, Chinese trumpet creeper are weighed by above-mentioned metering ratio
Extract solution, leaf golden flower extract solutions, bismuth subsalicylate, aboktal, demethylnobiletin, demethyl amphibious crab lactone, lycorine
Hydrochloride, isocurcumenol, the acid of 3- hydrogenation dehydrogenation pine Siberian cockleburs, ganoderic acid C 6, different ginkgetin, sieving, machinery add ultrapure after mixing
Water, places in pharmacy mixer, mixes 6min, controls RSD≤5%, compressing tablet and low temperature drying after mixing, temperature control at 6 DEG C,
Packaging obtains final product the Chinese and western medicinal composition for the treatment of acute diarrhea.
Embodiment 2
A kind of Chinese and western medicinal composition for treating acute diarrhea, be according to the primary raw material of weight portion：9 parts of methyl caffeate,
16 parts of Asiatic plantain extract A, 5 parts of Chinese trumpet creeper extract solution, 8 parts of leaf golden flower extract solutions, 0.5 part of bismuth subsalicylate, aboktal 6
Part, 18 parts of demethylnobiletin, 8 parts of demethyl amphibious crab lactone, 2 parts of lycorine hydrochloride, 2 parts of isocurcumenol, 3- hydrogenation
2 parts of dehydrogenation pine Siberian cocklebur acid, 62 parts of ganoderic acid C, 6 parts of different ginkgetin.
A kind of preparation method of the Chinese and western medicinal composition for treating acute diarrhea, concretely comprises the following steps：
First, in pharmaceutical grade clean area, methyl caffeate, Asiatic plantain extract A, Chinese trumpet creeper are weighed by above-mentioned metering ratio
Extract solution, leaf golden flower extract solutions, bismuth subsalicylate, aboktal, demethylnobiletin, demethyl amphibious crab lactone, lycorine
Hydrochloride, isocurcumenol, the acid of 3- hydrogenation dehydrogenation pine Siberian cockleburs, ganoderic acid C 6, different ginkgetin, sieving, machinery add ultrapure after mixing
Water, places in pharmacy mixer, mixes 4min, controls RSD≤5%, compressing tablet and low temperature drying after mixing, temperature control at 4 DEG C,
Packaging obtains final product the Chinese and western medicinal composition for the treatment of acute diarrhea.
Embodiment 3
A kind of Chinese and western medicinal composition for treating acute diarrhea, be according to the primary raw material of weight portion：10 parts of methyl caffeate,
17 parts of Asiatic plantain extract A, 6 parts of Chinese trumpet creeper extract solution, 10 parts of leaf golden flower extract solutions, 0.6 part of bismuth subsalicylate, aboktal 8
Part, 20 parts of demethylnobiletin, 10 parts of demethyl amphibious crab lactone, 3 parts of lycorine hydrochloride, 3 parts of isocurcumenol, 3- hydrogenation
3 parts of dehydrogenation pine Siberian cocklebur acid, 63 parts of ganoderic acid C, 7 parts of different ginkgetin.
A kind of preparation method of the Chinese and western medicinal composition for treating acute diarrhea, concretely comprises the following steps：
First, in pharmaceutical grade clean area, methyl caffeate, Asiatic plantain extract A, Chinese trumpet creeper are weighed by above-mentioned metering ratio
Extract solution, leaf golden flower extract solutions, bismuth subsalicylate, aboktal, demethylnobiletin, demethyl amphibious crab lactone, lycorine
Hydrochloride, isocurcumenol, the acid of 3- hydrogenation dehydrogenation pine Siberian cockleburs, ganoderic acid C 6, different ginkgetin, sieving, machinery add ultrapure after mixing
Water, places in pharmacy mixer, mixes 6min, controls RSD≤5%, compressing tablet and low temperature drying after mixing, temperature control at 6 DEG C,
Packaging obtains final product the Chinese and western medicinal composition for the treatment of acute diarrhea.
Embodiment 4
A kind of Chinese and western medicinal composition for treating acute diarrhea, be according to the primary raw material of weight portion：11 parts of methyl caffeate,
18 parts of Asiatic plantain extract A, 7 parts of Chinese trumpet creeper extract solution, 11 parts of leaf golden flower extract solutions, 0.7 part of bismuth subsalicylate, aboktal 9
Part, 21 parts of demethylnobiletin, 12 parts of demethyl amphibious crab lactone, 4 parts of lycorine hydrochloride, 4 parts of isocurcumenol, 3- hydrogenation
4 parts of dehydrogenation pine Siberian cocklebur acid, 64 parts of ganoderic acid C, 8 parts of different ginkgetin.
A kind of preparation method of the Chinese and western medicinal composition for treating acute diarrhea, concretely comprises the following steps：
First, in pharmaceutical grade clean area, methyl caffeate, Asiatic plantain extract A, Chinese trumpet creeper are weighed by above-mentioned metering ratio
Extract solution, leaf golden flower extract solutions, bismuth subsalicylate, aboktal, demethylnobiletin, demethyl amphibious crab lactone, lycorine
Hydrochloride, isocurcumenol, the acid of 3- hydrogenation dehydrogenation pine Siberian cockleburs, ganoderic acid C 6, different ginkgetin, sieving, machinery add ultrapure after mixing
Water, places in pharmacy mixer, mixes 8min, controls RSD≤5%, compressing tablet and low temperature drying after mixing, temperature control at 8 DEG C,
Packaging obtains final product the Chinese and western medicinal composition for the treatment of acute diarrhea.
Embodiment 5
A kind of Chinese and western medicinal composition for treating acute diarrhea, be according to the primary raw material of weight portion：12 parts of methyl caffeate,
19 parts of Asiatic plantain extract A, 8 parts of Chinese trumpet creeper extract solution, 12 parts of leaf golden flower extract solutions, 0.7 part of bismuth subsalicylate, aboktal 9
Part, 22 parts of demethylnobiletin, 15 parts of demethyl amphibious crab lactone, 4 parts of lycorine hydrochloride, 4 parts of isocurcumenol, 3- hydrogenation
4 parts of dehydrogenation pine Siberian cocklebur acid, 64 parts of ganoderic acid C, 10 parts of different ginkgetin.
A kind of preparation method of the Chinese and western medicinal composition for treating acute diarrhea, concretely comprises the following steps：
First, in pharmaceutical grade clean area, methyl caffeate, Asiatic plantain extract A, Chinese trumpet creeper are weighed by above-mentioned metering ratio
Extract solution, leaf golden flower extract solutions, bismuth subsalicylate, aboktal, demethylnobiletin, demethyl amphibious crab lactone, lycorine
Hydrochloride, isocurcumenol, the acid of 3- hydrogenation dehydrogenation pine Siberian cockleburs, ganoderic acid C 6, different ginkgetin, sieving, machinery add ultrapure after mixing
Water, places in pharmacy mixer, mixes 8min, controls RSD≤5%, compressing tablet and low temperature drying after mixing, temperature control at 8 DEG C,
Packaging obtains final product the Chinese and western medicinal composition for the treatment of acute diarrhea.
Pharmacology test
1st, acute toxicity test
It is experiment with Chinese and western medicinal composition obtained in the embodiment of the present invention 3, it is continuous in 24h using gastric infusion mode
Administration 2 times, per minor tick 6h, is administered 500mg/kg doses every time, and daily accumulation medicine total amount reaches 1000mg medicines/kg, quite
In 100 times of people's quantity.After administration in 7d, mouse activity, feed, excretion are normal, well-grown, hair color light, its
Average weight increases with the extension of experimental period.Every mouse of post mortem at 8d, visually observe the heart, liver, spleen, lung,
Kidney, brain, thymus gland, stomach, intestines etc. do not find color and paramophia, fail to measure median lethal dose (LD50).Result shows：This
Invention Chinese and western medicinal composition is without acute toxic reaction.
2nd, long term toxicity test
It is experiment with Chinese and western medicinal composition obtained in the embodiment of the present invention 3, using gastric infusion mode, by Chinese and Western of the present invention
Drug composition is divided into low dosage, middle dosage, three groups of high dose, the drug dose of each group is respectively 100,200,300mg medicines/
Kg/d, 10,20,30 times equivalent to clinical dosage.After gastric infusion 24 weeks, general status, blood of the medicine of the present invention to animal
, without obvious influence, Systematic anatomy, organ coefficient and histopathological examination do not find yet for liquid index, blood parameters
Abnormal pathologic changes.It is discontinued 2 weeks and also has no substantially change.Result shows：Chinese and western medicinal composition of the present invention is in long term toxicity test
In, do not find overt toxicity reaction and delayed toxicity reaction.It can be seen that, Chinese and western medicinal composition non-toxic reaction of the present invention is long-term to use
Medicine is safe and reliable.
3rd, clinical test
Diagnostic criteria：Acute diarrhea clinically in addition to diarrhoea, typically there is the tables such as heating, stomachache and leukocytosis
It is existing, Nausea and vomiting, stomachache, diarrhoea, heating etc. are mainly shown as, severe patient can cause de- water and rock-soil coupling, shock etc., patient
Show as Nausea and vomiting formerly, after to suffer from diarrhoea, daily three to five times even tens of times, it is in water sample, buff that stool more
Or band green, stench can be with symptoms such as cramp, heating, Muscular stiffness.Accept 67 patients for medical treatment, wherein, male 42,
Women 25.
The Chinese and western medicinal composition of the preparation of the embodiment of the present invention 3 is given, according to 2mg/kg/ time, 2 hours a course for the treatment of and to carry out
Symptom follow-up is recorded；Efficacy assessment standard：It is effective：Acute diarrhea symptom is fully recovered, and recovers normal；Take a turn for the better：Acute diarrhea lesion disease
Shape mitigates, and the state of an illness progressively takes a turn for the better；It is invalid：Improvement standard person is not reached.
Treatment results：By a course for the treatment of, 61 are fully recovered 67 patients, and 3 effective, 3 improvements, and 0 invalid, total effective
Rate 100.0%；3 effective and 3 improvement patients are again by all recoveries from illness of a course for the treatment of.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be in other specific forms realized.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit requires to be limited rather than described above, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.
Moreover, it will be appreciated that although the present specification is described in terms of embodiments, not each implementation method is only wrapped
Containing an independent technical scheme, this narrating mode of specification is only that for clarity, those skilled in the art should
Specification an as entirety, the technical scheme in each embodiment can also be formed into those skilled in the art through appropriately combined
May be appreciated other embodiment.
Claims (6)
1. a kind of Chinese and western medicinal composition for treating acute diarrhea, it is characterised in that the primary raw material according to weight portion is：Caffeic acid
Methyl esters 8-12 parts, 15-19 parts of Asiatic plantain extract A, 3-8 parts of Chinese trumpet creeper extract solution, 7-12 parts of leaf golden flower extract solutions, secondary bigcatkin willow
Sour bismuth 0.5-0.7 parts, aboktal 6-9 parts, demethylnobiletin 16-22 parts, 7-15 parts of demethyl amphibious crab lactone, lycorine
Hydrochloride 2-4 parts, isocurcumenol 2-4 parts, 2-4 parts of 3- hydrogenation dehydrogenation pines Siberian cocklebur acid, 2-4 parts of ganoderic acid C 6, different ginkgetin 5-10
Part.
2. it is according to claim 1 treatment acute diarrhea Chinese and western medicinal composition, it is characterised in that the acute abdomen for the treatment of
The Chinese and western medicinal composition for rushing down, be according to the primary raw material of weight portion：Methyl caffeate 9-11 parts, Asiatic plantain extract A16-18
Part, 5-7 parts of Chinese trumpet creeper extract solution, 8-11 parts of leaf golden flower extract solutions, bismuth subsalicylate 0.5-0.7 parts, aboktal 6-9 parts, go
18-21 parts of methyl Nobiletin, 8-12 parts of demethyl amphibious crab lactone, 2-4 parts of lycorine hydrochloride, isocurcumenol 2-4 parts, 3-
2-4 parts of hydrogenation dehydrogenation pine Siberian cocklebur acid, 2-4 parts of ganoderic acid C 6, different ginkgetin 6-8 parts.
3. it is according to claim 1 and 2 treatment acute diarrhea Chinese and western medicinal composition, it is characterised in that the treatment urgency
Property diarrhoea Chinese and western medicinal composition, be according to the primary raw material of weight portion：10 parts of methyl caffeate, Asiatic plantain extract A 17
Part, 6 parts of Chinese trumpet creeper extract solution, 10 parts of leaf golden flower extract solutions, 0.6 part of bismuth subsalicylate, 8 parts of aboktal, demethyl river dried orange peel
Loose 3 parts of the Siberian cocklebur acid of 20 parts of element, 10 parts of demethyl amphibious crab lactone, 3 parts of lycorine hydrochloride, 3 parts of isocurcumenol, 3- hydrogenation dehydrogenations,
63 parts of ganoderic acid C, 7 parts of different ginkgetin.
4. a kind of preparation method of the Chinese and western medicinal composition for the treatment of acute diarrhea as described in claim 1-3 is any, its feature
It is to concretely comprise the following steps：
First, in pharmaceutical grade clean area, methyl caffeate, Asiatic plantain extract A, Chinese trumpet creeper extraction are weighed by above-mentioned metering ratio
Liquid, leaf golden flower extract solutions, bismuth subsalicylate, aboktal, demethylnobiletin, demethyl amphibious crab lactone, lycorine hydrochloric acid
Salt, isocurcumenol, the acid of 3- hydrogenation dehydrogenation pine Siberian cockleburs, ganoderic acid C 6, different ginkgetin, sieving, machinery add ultra-pure water, put after mixing
In putting pharmacy mixer, mix 4-8min, control RSD≤5%, compressing tablet and low temperature drying after mixing, temperature control at 4-8 DEG C,
Packaging obtains final product the Chinese and western medicinal composition for the treatment of acute diarrhea.
5. the preparation method of the Chinese and western medicinal composition for the treatment of acute diarrhea according to claim 4, it is characterised in that specific
Mix 6min in step.
6. the preparation method of the Chinese and western medicinal composition for the treatment of acute diarrhea according to claim 4, it is characterised in that specific
Temperature control is at 6 DEG C in step.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201611172251.3A CN106728145A (en) | 2016-12-17 | 2016-12-17 | It is a kind of to treat Chinese and western medicinal composition of acute diarrhea and preparation method thereof |
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| CN201611172251.3A CN106728145A (en) | 2016-12-17 | 2016-12-17 | It is a kind of to treat Chinese and western medicinal composition of acute diarrhea and preparation method thereof |
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| CN201611172251.3A Withdrawn CN106728145A (en) | 2016-12-17 | 2016-12-17 | It is a kind of to treat Chinese and western medicinal composition of acute diarrhea and preparation method thereof |
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| Country | Link |
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| CN (1) | CN106728145A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106822133A (en) * | 2016-12-17 | 2017-06-13 | 郑州郑先医药科技有限公司 | A kind of Western medicine compound for treating acute diarrhea |
| CN111658633A (en) * | 2020-06-10 | 2020-09-15 | 大连天星本草生物科技有限公司 | Application of biflavone compound in preparation of drugs and/or pharmaceutical compositions for inhibiting human carboxylesterase 2 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1367016A (en) * | 2002-02-04 | 2002-09-04 | 苏双喜 | Compound preparation for curing diarrhea |
-
2016
- 2016-12-17 CN CN201611172251.3A patent/CN106728145A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1367016A (en) * | 2002-02-04 | 2002-09-04 | 苏双喜 | Compound preparation for curing diarrhea |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106822133A (en) * | 2016-12-17 | 2017-06-13 | 郑州郑先医药科技有限公司 | A kind of Western medicine compound for treating acute diarrhea |
| CN111658633A (en) * | 2020-06-10 | 2020-09-15 | 大连天星本草生物科技有限公司 | Application of biflavone compound in preparation of drugs and/or pharmaceutical compositions for inhibiting human carboxylesterase 2 |
| CN111658633B (en) * | 2020-06-10 | 2023-12-22 | 大连天星本草生物科技有限公司 | Application of biflavone compound in preparation of medicine and/or medicine composition for inhibiting human carboxylesterase 2 |
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Application publication date: 20170531 |