CN104998054B - A kind of Chinese materia medica preparation for treating constipation of slow-remove type - Google Patents
A kind of Chinese materia medica preparation for treating constipation of slow-remove type Download PDFInfo
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Abstract
A kind of Chinese materia medica preparation for treating constipation of slow-remove type, belong to the technical field of Chinese materia medica preparation, the weight ratio number of each raw material in Chinese medicine preparation are as follows: 7-13 parts of Radix Astragali, 7-13 parts of Herba Cistanches, 7-13 parts of Snakegourd Seed, 12-18 parts of radish seed, Radix Ophiopogonis 1-9 part, 16-24 parts of Chinese yam, 7-13 parts of root of kirilow rhodiola, 7-13 parts of fructus cannabis.The Chinese materia medica preparation for the treatment of constipation of the invention, takes effect within 3 days taking, has clear improvement within 1 week, no longer occur constipation situation within 2 weeks, and constipation can thoroughly be eradicated by adhering to taking 2-3 months.
Description
Technical field
The invention belongs to the technical fields of Chinese medicine, and in particular to a kind of Chinese materia medica preparation for treating constipation of slow-remove type.
Background technique
Constipation is clinical common complicated symptom, is primarily referred to as defecation frequency reduction, excrement amount is reduced, excrement is dry and hard, row
Just laborious etc..Its reason is complicated, mostly with gastrointestinal function, type of ingesting and habit, living habit, environmental factor, the state of mind
Etc. related.Chinese medicine thinks, constipation is mainly by dryness-heat stagnating in the interior, depression and stagnation of QI, caused by body fluid deficiency and spleen kidney deficiency is cold.Constipation can
To influence the people of each age group, women is more than male, and old age is more than person between twenty and fifty.Because constipation disease incidence is high, the cause of disease is complicated, patient is given
Many worries are brought, will affect quality of life when constipation is serious.
The disease incidence of chronic constipation 60 years old or more crowd be 7.3%-20.39%, 18-70 years old adult onset lead for
6.07%, women is 4 times of male or more.The main clinical manifestation of chronic constipation is that excrement is dry and hard, and difficult defecation, row feels not to the utmost
Or defecation frequency is reduced.Functional consitipation accounts for 57.1% in chronic constipation, and functional consitipation clinic divides slow-remove type, outlet obstructed
Type and three kinds of mixed type, the overwhelming majority are slow-remove type.Functional consitipation refers to generation constipation 6 months or more, and excludes organic
The constipation of lesion.Patient is generally mostly the elderly or is young woman.It is single to be difficult to determine parting from the point of view of the symptom of constipation patient,
Initiation reason is mostly indefinite, and different card types need different targeted treatment schemes.Pass through technique of anorectal manometry stomach function regulating
Intestines transmission experiment is easy to identify the constipation which card type patient is.If in transmission experiment inspection, discharge in patient 72 hours
For marker less than 80%, technique of anorectal manometry defecation acts noncontradictory campaign, can be diagnosed as constipation of slow-remove type.Slow-remove type
Constipation is that colonic peristalsis function is poor, and forward direction pushes inability, and excrement is advanced slowly in enteron aisle, and moisture is drawn by long-time taken in excess
It rises.Patients with slow-transit constipation clinical manifestation is mostly without awareness of defecation or defecation inability, dry and hard excrement or excrement be not dry, skin is coarse, face
Color is simple and unadorned etc..It is that the deficiency of vital energy pushes inability, body fluid deficiency for enteron aisle, and excrement driving power is insufficient, caused by resistance increase.
Existing treatment constipation mostly uses folium sennae, rheum officinale, phenolphthalein tablet, aloe capsule, MAREN RUNCHANG WAN etc. greatly, these
Effect is poor in treatment constipation, only treats the symptoms, does not effect a permanent cure, and melanosis coli, pharmacological dependence etc. can even be generated by taking for a long time.
Summary of the invention
The present invention be solve in the prior art treat constipation drug late result it is poor, existing Instestinal motility medicine only provides
Instestinal motility, though can increase Instestinal motility, relief of constipation, long-term use can generate electrocardiogram Q-T interval prolongation and drug resistance is made
The problem of using.The present invention provides a kind of new medicine preparation for treating constipation, Instestinal motility can be not only provided, but also can be with
It provides " moisture ".
The present invention be realize its purpose the technical solution adopted is that:
A kind of Chinese materia medica preparation for treating constipation of slow-remove type, the weight ratio number of each raw material in Chinese medicine preparation are as follows:
7-13 parts of Radix Astragali, 7-13 parts of Herba Cistanches, 7-13 parts of Snakegourd Seed, 12-18 parts of radish seed, Radix Ophiopogonis 1-9 part, 16-24 parts of Chinese yam, red scape
Its 7-13 parts, 7-13 parts of fructus cannabis.
A kind of Chinese materia medica preparation for treating constipation of slow-remove type, the weight ratio number of each raw material in Chinese medicine preparation are as follows:
8-12 parts of Radix Astragali, 8-12 parts of Herba Cistanches, 8-12 parts of Snakegourd Seed, 13-17 parts of radish seed, Radix Ophiopogonis 2-8 part, 18-22 parts of Chinese yam, red scape
Its 8-11 parts, 8-12 parts of fructus cannabis.
A kind of Chinese materia medica preparation for treating constipation of slow-remove type, the weight ratio number of each raw material in Chinese medicine preparation are as follows:
10 parts of Radix Astragali, 10 parts of Herba Cistanches, 10 parts of Snakegourd Seed, 15 parts of radish seed, 5 parts of Radix Ophiopogonis, 20 parts of Chinese yam, 10 parts of root of kirilow rhodiola, fructus cannabis
10 parts.
A kind of Chinese materia medica preparation for treating constipation of slow-remove type, the weight ratio number of each raw material in Chinese medicine preparation are as follows:
7 parts of Radix Astragali, 7 parts of Herba Cistanches, 7 parts of Snakegourd Seed, 12 parts of radish seed, 1 part of Radix Ophiopogonis, 16 parts of Chinese yam, 7 parts of root of kirilow rhodiola, 7 parts of fructus cannabis.
A kind of Chinese materia medica preparation for treating constipation of slow-remove type, the weight ratio number of each raw material in Chinese medicine preparation are as follows:
13 parts of Radix Astragali, 13 parts of Herba Cistanches, 13 parts of Snakegourd Seed, 18 parts of radish seed, 9 parts of Radix Ophiopogonis, 24 parts of Chinese yam, 13 parts of root of kirilow rhodiola, fructus cannabis
13 parts.
A kind of Chinese materia medica preparation for treating constipation of slow-remove type, the weight ratio number of each raw material in Chinese medicine preparation are as follows:
8 parts of Radix Astragali, 8 parts of Herba Cistanches, 8 parts of Snakegourd Seed, 13 parts of radish seed, 2 parts of Radix Ophiopogonis, 18 parts of Chinese yam, 8 parts of root of kirilow rhodiola, 8 parts of fructus cannabis.
A kind of Chinese materia medica preparation for treating constipation of slow-remove type, the weight ratio number of each raw material in Chinese medicine preparation are as follows:
12 parts of Radix Astragali, 12 parts of Herba Cistanches, 12 parts of Snakegourd Seed, 17 parts of radish seed, 8 parts of Radix Ophiopogonis, 22 parts of Chinese yam, 11 parts of root of kirilow rhodiola, fructus cannabis
11 parts.
The beneficial effects of the present invention are: the Chinese materia medica preparation for the treatment of constipation of the invention, takes effect within 3 days taking, 1 week it
It inside has clear improvement, no longer occurs constipation situation within 2 weeks, constipation can thoroughly be eradicated by adhering to taking 2-3 months.
In the present invention this four traditional Chinese medicine of Radix Astragali, Chinese yam, root of kirilow rhodiola and radish seed combine can make it is bright in body rabbit intestinal tube tensity
Aobvious to increase, wriggling amplitude increases, and has apparent impetus to intestinal motility, in conjunction with the electrodeless ion of effective component in Herba Cistanches
With hydrophily colloid class polysaccharide, the wet and discharge of excrement can be promoted, improve myenteron movement, enhance Intestinal motility, it is significant to contract
Moisture absorption in short defaecation time and inhibition large intestine.Chinese yam: " bowl spares, benefiting energy, long muscle ", also to spleen deficiency have prevention and control
Treatment effect, has dual regulation to isolated intestinal motility.Fructus cannabis matter moistens the relax bowel and defecation of greasiness energy, and has nourishing qi-restoratives concurrently again
Effect generates fatty acid after meeting alkaline intestinal juice in enteron aisle, stimulates intestinal wall, and making to wriggle enhances, to reach defecating feces excretion.
The present invention in the side's of sending medication, both on the basis of recognizing for Chinese medicine the constipation interpretation of the cause, onset and process of an illness, promote the production of body fluid medicine by selected tonifying Qi
While object, has also combined gastrointestinal transit and test the characteristics of found enteron aisle conduction function slows down and helped to being enriched in the rules for the treatment of
Fortune leads to stagnant rule.Helping fortune to lead to stagnant is the innovation for treating slow Constipation principle, this innovation is Traditional Chinese medical theory and modern section
The innovation that combines is learned, is that inventor's summary that studies for a long period of time obtains.Wherein, the invigorating the spleen of Radix Astragali tonifying lung is main ingredient, root of kirilow rhodiola, Chinese yam
Radix Astragali tonifying lung gas is helped, Instestinal motility is enhanced, power-assisted is sailed a boat as adjuvant.Radix Ophiopogonis, which promotes the production of body fluid, the meaning of increasing body fluid for curing constipation, controls body fluid and does few, void
It is secret just difficult, it is also adjuvant.Snakegourd Seed relax bowel and defecation is adjutant.Radish seed acrid flavour benefaction, between walking intestines under priming, and it is stagnant that fortune can be helped to lead to
When to make medicine.Gas dissolving phlegm under radish seed, product of assaulting fortified position, weight after treatment, radish seed energy " lower gas " enter lung channel, and lower gas is the respectful drop for helping lung,
The lung and the large intestine being interior-exteriorly related, then stool is happy for the respectful drop of lung qi.
Chinese materia medica preparation of the invention is the complete combination object that can not be split, and is all played in the composition per medicine simply
Vital effect is complemented each other per medicine simply, not only plays respective effect and the performance of other drug effects and pair is also promoted to make
Inhibition, this is to summarize for a long time as a result, its respective dosage decides the drug effect of entire medicament, Radix Astragali in this composition
Dosage is the determination according to constipation of slow-remove type basic pathogenesis, and prolonged constipation aggravates gas consumption, keeps gas more empty, using Huang in we
Stilbene tonifying Qi, the few effect of amount is poor, measures more " void is not mended ", causes abdominal distension, in prescription screening process, grind by long-term creativeness
Study carefully, is screened, the optimal dose and proportion that must just appear in.Yin-nourishing drug Radix Ophiopogonis is cold and cool, and easily injure one's stomach gas, hinders digestion, dosage
When few, slow effect lead to do not feel like eating when dosage is big, Na Gu is not fragrant, thick greasy tongue coating.It is suitable in conjunction with constipation of slow-remove type basic pathogenesis
Slowly it mends and unsuitable high benefit.Herba Cistanches can enhance Intestinal motility, improve intestinal motive force, measure hour, and not as good as measuring, big effect is good, but this
When dosage is big, it is slightly uncomfortable to can lead to few patients' abdomen since propulsive force is excessive, we by verifying repeatedly, 10 parts of Herba Cistanches
For optimal dose.
Specific embodiment
Embodiment 1
A kind of Chinese materia medica preparation for treating constipation of slow-remove type, the weight ratio number of each raw material in Chinese medicine preparation are as follows:
10 parts of Radix Astragali, 10 parts of Herba Cistanches, 10 parts of Snakegourd Seed, 15 parts of radish seed, 5 parts of Radix Ophiopogonis, 20 parts of Chinese yam, 10 parts of root of kirilow rhodiola, fructus cannabis
10 parts.
Embodiment 2
A kind of Chinese materia medica preparation for treating constipation of slow-remove type, the weight ratio number of each raw material in Chinese medicine preparation are as follows:
7 parts of Radix Astragali, 7 parts of Herba Cistanches, 7 parts of Snakegourd Seed, 12 parts of radish seed, 1 part of Radix Ophiopogonis, 16 parts of Chinese yam, 7 parts of root of kirilow rhodiola, 7 parts of fructus cannabis.
Embodiment 3
A kind of Chinese materia medica preparation for treating constipation of slow-remove type, the weight ratio number of each raw material in Chinese medicine preparation are as follows:
13 parts of Radix Astragali, 13 parts of Herba Cistanches, 13 parts of Snakegourd Seed, 18 parts of radish seed, 9 parts of Radix Ophiopogonis, 24 parts of Chinese yam, 13 parts of root of kirilow rhodiola, fructus cannabis
13 parts.
Embodiment 4
A kind of Chinese materia medica preparation for treating constipation of slow-remove type, the weight ratio number of each raw material in Chinese medicine preparation are as follows:
8 parts of Radix Astragali, 8 parts of Herba Cistanches, 8 parts of Snakegourd Seed, 13 parts of radish seed, 2 parts of Radix Ophiopogonis, 18 parts of Chinese yam, 8 parts of root of kirilow rhodiola, 8 parts of fructus cannabis.
Embodiment 5
A kind of Chinese materia medica preparation for treating constipation of slow-remove type, the weight ratio number of each raw material in Chinese medicine preparation are as follows:
12 parts of Radix Astragali, 12 parts of Herba Cistanches, 12 parts of Snakegourd Seed, 17 parts of radish seed, 8 parts of Radix Ophiopogonis, 22 parts of Chinese yam, 11 parts of root of kirilow rhodiola, fructus cannabis
12 parts.
Embodiment 6
A kind of Chinese materia medica preparation for treating constipation of slow-remove type, the weight ratio number of each raw material in Chinese medicine preparation are as follows:
9 parts of Radix Astragali, 9 parts of Herba Cistanches, 9 parts of Snakegourd Seed, 14 parts of radish seed, 3 parts of Radix Ophiopogonis, 17 parts of Chinese yam, 9 parts of root of kirilow rhodiola, 9 parts of fructus cannabis.
Embodiment 7
A kind of Chinese materia medica preparation for treating constipation of slow-remove type, the weight ratio number of each raw material in Chinese medicine preparation are as follows:
11 parts of Radix Astragali, 11 parts of Herba Cistanches, 11 parts of Snakegourd Seed, 16 parts of radish seed, 4 parts of Radix Ophiopogonis, 19 parts of Chinese yam, 12 parts of root of kirilow rhodiola, fructus cannabis
11 parts.
Embodiment 8
A kind of Chinese materia medica preparation for treating constipation of slow-remove type, the weight ratio number of each raw material in Chinese medicine preparation are as follows:
9.5 parts of Radix Astragali, 9.5 parts of Herba Cistanches, 9.5 parts of Snakegourd Seed, 14.5 parts of radish seed, 6 parts of Radix Ophiopogonis, 21 parts of Chinese yam, 9.5 parts of root of kirilow rhodiola,
9.5 parts of fructus cannabis.
Embodiment 9
A kind of Chinese materia medica preparation for treating constipation of slow-remove type, the weight ratio number of each raw material in Chinese medicine preparation are as follows:
10.5 parts of Radix Astragali, 10.5 parts of Herba Cistanches, 10.5 parts of Snakegourd Seed, 15.5 parts of radish seed, 7 parts of Radix Ophiopogonis, 23 parts of Chinese yam, root of kirilow rhodiola 10.5
Part, 10.5 parts of fructus cannabis.
Embodiment 10
A kind of Chinese materia medica preparation for treating constipation of slow-remove type, the weight ratio number of each raw material in Chinese medicine preparation are as follows:
9.2 parts of Radix Astragali, 12.1 parts of Herba Cistanches, 10.7 parts of Snakegourd Seed, 17.3 parts of radish seed, 6.5 parts of Radix Ophiopogonis, 21.1 parts of Chinese yam, root of kirilow rhodiola
12.7 parts, 12.7 parts of fructus cannabis.
The specific preparation method of Chinese materia medica preparation of the invention is: each raw material is weighed by the proportion of raw material, it then will be each
Raw material, which is placed in high pressure traditional Chinese medicine extracting machine, decocts 0.8-1.5 hours, preferably 1 hour, presses extracting juice, is vacuum-packed.
By above-described embodiment and Mosapride (carry out clinical test, test result is as follows:
Note: the present invention (Mosapride 5mg 3/ day, before meals) △ P < 0.01 compared with Mosapride
Case one
Model, women 51 years old, tell dry and hard excrement, are difficult to walk that defecation laborious 4 years, non-drug cannot go, and take orally " aloe usually
The drugs such as capsule, phenolphthalein tablet ", help defecation, and private prosecution without obvious awareness of defecation, is looked into electronics colonoscopy and shown: melanosis coli usually.Colonic transit
Experiment: 72h film making, marker remain 12 pieces.Diagnosis: constipation of slow-remove type.It is oral to give the present invention, 2 times/day of 150ml, temperature
Clothes, take stool interval two days later and defecation time make moderate progress earlier above, colonic transit test, which showed in 72 hours, is discharged marker
Number makes moderate progress earlier above, and patient tells defecation arduously the symptoms were significantly improved after about 1 week, continues medication 4 days, defecation once a day, matter
Soft forming, defecation time are no more than 5min, and colonic transit test shows 90% or more mark number of discharge in 72 hours, continues to take medicine
Post dose halved within 1 week, then with 4 weeks, was discontinued, and patient symptom does not recur, and follow-up stool is normal always after half a year.
Case two
Mr. Wang, women 47 years old, tell that defecation is unsmooth, firmly just, defecation laborious 2 years, take orally " MAREN RUNCHANG WAN " combination usually and open
The drugs such as Sai Lu help defecation, and private prosecution is usually without obvious awareness of defecation, and look into electronics colonoscopy and show: colon becomes black.Colonic transit experiment: 72h is clapped
Piece, marker remain 11 pieces.Diagnosis: constipation of slow-remove type.It is oral to give the present invention, 2 times/day of 100ml, warmly takes, takes two days
Stool interval and defecation time make moderate progress earlier above afterwards, and colonic transit test shows that mark number is discharged in 72 hours to be changed earlier above
Kind, patient tells defecation arduously the symptoms were significantly improved after about 3 days, continues medication 2 days, defecation once a day, the soft forming of matter, when defecation
Between be no more than 3min, colonic transit test shows in 72 hours 89% or more mark number of discharge, and the post dose on the 3rd that continues to take medicine subtracts
Half, then with 1 week, be discontinued, patient symptom does not recur, and follow-up stool is normal always after half a year.
Case three
Slowly certain, male 39 years old, tells that awareness of defecation is few, and bowel frequency is also few, and defecation laborious 3.5 years, non-drug cannot go, and take orally usually
Drugs such as " intestinal motive force medicines, tegaserod ", help defecation, and private prosecution without obvious awareness of defecation, is looked into electronics colonoscopy and shown: melanosis coli usually.
Colonic transit experiment: 72h film making, marker remain 10 pieces.Diagnosis: constipation of slow-remove type.It is oral to give the present invention, 150ml 2
Times/day, it warmly takes, takes stool interval two days later and defecation time makes moderate progress earlier above, colonic transit test, which showed in 72 hours, to be arranged
Mark number makes moderate progress earlier above out, and patient tells defecation arduously the symptoms were significantly improved after about 1 week, continues medication 3 days, defecation is daily
Once, the soft forming of matter, defecation time are no more than 4min, and colonic transit test shows 90% or more mark number of discharge in 72 hours,
Continue medication post dose on the three to halve, then with 3 weeks, be discontinued, patient symptom does not recur, and follow-up stool is normal always after half a year.
Claims (7)
1. a kind of Chinese materia medica preparation for treating constipation of slow-remove type, it is characterised in that: the weight ratio of each raw material in Chinese medicine preparation
Example number are as follows: 7-13 parts of Radix Astragali, 7-13 parts of Herba Cistanches, 7-13 parts of Snakegourd Seed, 12-18 parts of radish seed, Radix Ophiopogonis 1-9 part, Chinese yam 16-
24 parts, 7-13 parts of root of kirilow rhodiola, 7-13 parts of fructus cannabis.
2. a kind of Chinese materia medica preparation for treating constipation of slow-remove type according to claim 1, it is characterised in that: Chinese medicine preparation
In each raw material weight ratio number are as follows: 8-12 parts of Radix Astragali, 8-12 parts of Herba Cistanches, 8-12 parts of Snakegourd Seed, radish seed 13-17
Part, Radix Ophiopogonis 2-8 part, 18-22 parts of Chinese yam, 8-11 parts of root of kirilow rhodiola, 8-12 parts of fructus cannabis.
3. a kind of Chinese materia medica preparation for treating constipation of slow-remove type according to claim 1, it is characterised in that: Chinese medicine preparation
In each raw material weight ratio number are as follows: 10 parts of Radix Astragali, 10 parts of Herba Cistanches, 10 parts of Snakegourd Seed, 15 parts of radish seed, 5 parts of Radix Ophiopogonis,
20 parts of Chinese yam, 10 parts of root of kirilow rhodiola, 10 parts of fructus cannabis.
4. a kind of Chinese materia medica preparation for treating constipation of slow-remove type according to claim 1, it is characterised in that: Chinese medicine preparation
In each raw material weight ratio number are as follows: 7 parts of Radix Astragali, 7 parts of Herba Cistanches, 7 parts of Snakegourd Seed, 12 parts of radish seed, 1 part of Radix Ophiopogonis, mountain
16 parts of medicine, 7 parts of root of kirilow rhodiola, 7 parts of fructus cannabis.
5. a kind of Chinese materia medica preparation for treating constipation of slow-remove type according to claim 1, it is characterised in that: Chinese medicine preparation
In each raw material weight ratio number are as follows: 13 parts of Radix Astragali, 13 parts of Herba Cistanches, 13 parts of Snakegourd Seed, 18 parts of radish seed, 9 parts of Radix Ophiopogonis,
24 parts of Chinese yam, 13 parts of root of kirilow rhodiola, 13 parts of fructus cannabis.
6. a kind of Chinese materia medica preparation for treating constipation of slow-remove type according to claim 1, it is characterised in that: Chinese medicine preparation
In each raw material weight ratio number are as follows: 8 parts of Radix Astragali, 8 parts of Herba Cistanches, 8 parts of Snakegourd Seed, 13 parts of radish seed, 2 parts of Radix Ophiopogonis, mountain
18 parts of medicine, 8 parts of root of kirilow rhodiola, 8 parts of fructus cannabis.
7. a kind of Chinese materia medica preparation for treating constipation of slow-remove type according to claim 1, it is characterised in that: Chinese medicine preparation
In each raw material weight ratio number are as follows: 12 parts of Radix Astragali, 12 parts of Herba Cistanches, 12 parts of Snakegourd Seed, 17 parts of radish seed, 8 parts of Radix Ophiopogonis,
22 parts of Chinese yam, 11 parts of root of kirilow rhodiola, 11 parts of fructus cannabis.
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| CN115944669B (en) * | 2022-07-20 | 2024-01-30 | 中国人民解放军海军军医大学 | Traditional Chinese medicine composition for relieving constipation and preparation method and application thereof |
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| "便秘的证治体会";张云;《河北中医》;20080430;第30卷(第4期);第379页 * |
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