CN106722989A - A kind of preparation method of spina date seed original powder piece - Google Patents
A kind of preparation method of spina date seed original powder piece Download PDFInfo
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- CN106722989A CN106722989A CN201611176409.4A CN201611176409A CN106722989A CN 106722989 A CN106722989 A CN 106722989A CN 201611176409 A CN201611176409 A CN 201611176409A CN 106722989 A CN106722989 A CN 106722989A
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of preparation method of spina date seed original powder piece, belong to health product technology field.The selection of preparation method including raw material, frying, deoil into frost, crushing, softwood processed, granulation, drying, mixing, press nine steps.The present invention is using the medicinal extract of Zizyphus Spinosa Hu Flesh pulp concentration as adhesive compressing tablet, without any auxiliary material, the bioavailability of raising product, product is longer using the more convenient, shelf-life, processing cost is low, with fabulous dispersibility, miscibility and absorbability, the active ingredient of spina date seed is quickly entered in vivo, both remain original flavor, more improve healthcare function, and dose can be made to reduce at double, effectively improve the utilization rate of scarce resource.
Description
Technical field
The present invention relates to a kind of preparation method of spina date seed original powder piece, belong to health product technology field.
Background technology
The preparing raw material of spina date seed original powder piece uses Taihang the foot of a mountain genunie medicinal materials rhamnaceae plant wild jujubeZiziphus jujubaMill. var.spinosa （Bunge）The dry mature seed of Hu ex H.F.Chou.Spina date seed containing organic acid,
Fat oil, protein, vitamin C, phytosterol etc..Its property is sweet, acid, puts down.Return liver, courage, the heart channel of Hang-Shaoyin.For restlessness of asrhenia type and insomnia, palpitation with fear
Dreaminess, body void hidrosis, injury thirst.With antitoxic heart-soothing and sedative, sleep quality is improved, it is calming the nerves, insomnia field has its original
Place, and it is evident in efficacy, by doctor patient's laudatory title " sleeping fruit in east ".An earliest medicine book of China《Sheng Nong's herbal classic》Middle note
Carry：Bowl spares benefit liver, hard muscles and bones helps cloudy gas, all work(of spina date seed.Ming Dynasty's Li Shizhen《Compendium of Materia Medica》Described in, the ripe use of jujube kernel
Insomnia due to insufficiency of the gallbladder-qi for treatment, the disease of polydipsia abnormal sweating；Life is treated gallbladder-heat and is slept well, all sufficient cloudy few sun medicine of fainting.
Spina date seed integration of drinking and medicinal herbs, can be made into plurality kinds of health care food, health drink.At present, a large amount of health cares of spina date seed exploitation
Product, such as spina date seed tea bag, compound Semen Ziziphi Spinosae piece, Ziziphus Jujuba Mill Granules, spina date seed syrup.
The content of the invention
The technical problem to be solved in the invention is how to provide a kind of bioavailability for improving product, and product is using more
The preparation method of longer spina date seed original powder piece of convenient, shelf-life.
In order to solve the above technical problems, the technical solution adopted in the present invention is：
1. the selection of raw material：Spina date seed is put into the removal of impurity, foreign matter and non-Leaf-feeding insects；
2. frying：Heaved being fried to surface is micro- by the spina date seed slow fire of selection, micro- tool focal spot, with burnt odor gas, after taking-up
Dry in the air cool to room temperature；
3. frost is deoiled into：By the oil extruder degreasing of the spina date seed after frying, spina date seed frost is made；
4. crush：At a certain temperature, the spina date seed frost that will be made carries out pulverization process, is ground into a range of particle diameter, system
Obtain spiny jujuba seed powder；
5. softwood processed：By step 4. in add appropriate wild jujube flesh fruit slurry medicinal extract to be made spina date seed in the spiny jujuba seed powder that crushes soft
Material；
6. pelletize：Spina date seed softwood is made the particle of certain size；
7. dry：Ziziphus Jujuba Mill Granules are vacuum dried, control the water content of particle after certain limit, stopped drying；
8. mix：Dried Ziziphus Jujuba Mill Granules are mixed；
9. compressing tablet：By mixed granulation, substrate is made.
Technical solution of the present invention further improvement is that：The step 2. in will be chosen for spina date seed be put into preheating rolling
Frying in cartridge type machine for stir-frying Chinese medicine, 80~120 DEG C of frying temperature, 25~35 minutes frying time.
Technical solution of the present invention further improvement is that：15~30 revs/min of the rotating speed of the preheating roller type machine for stir-frying Chinese medicine
Clock.
Technical solution of the present invention further improvement is that：3. middle spina date seed squeezing uses cold pressing oil press to the step,
The temperature of squeezing is 50~75 DEG C.
Technical solution of the present invention further improvement is that：The step 4. middle crushing temperature for≤- 36 DEG C, crushing
Time is 1~30 minute, and the particle diameter after crushing is 0.1~800 μm.
Technical solution of the present invention further improvement is that：5. middle Zizyphus Spinosa Hu Flesh pulp medicinal extract is that wild jujube mashing is gone to the step
Fruit stone, excessively elimination pulp, the concentration of pulp low temperature are the medicinal extract of relative density 1.30-1.38, and the component of Zizyphus Spinosa Hu Flesh pulp medicinal extract is
Mass fraction is 93%~81% spiny jujuba seed powder, and spiny jujuba seed powder is 1 with the mass ratio of wild jujube pulp medicinal extract：0.1~1：0.3.
Technical solution of the present invention further improvement is that：6. middle spina date seed softwood is placed in oscillating granulator to the step
The size for being made particle is 10~50 mesh.
Technical solution of the present invention further improvement is that：The drying machine that 7. step uses is dry for low temperature belt vacuum
Dry machine, when drying, layer thickness is 10~20mm, 20~80 DEG C of drying temperature, vacuum -0.08~-0.1Mpa, dry particle
Moisture ＜ 5.0%.
Technical solution of the present invention further improvement is that：The step 8. in dried particle is placed in three-dimensional hybrid
Incorporation time is 15~30 minutes in machine.
Technical solution of the present invention further improvement is that：The step 9. in the weight of substrate after rotary compressing tablet be
0.1~3g/ pieces, weight differential is ± 4~± 6%, hardness >=3kg/ cm2, friability≤1%, moisture ＜ 5.0%, the shape of substrate
Shape is ellipse, triangle, pentagon or olive shape.
By adopting the above-described technical solution, the technological progress that the present invention is obtained is：
Present invention squeezing uses screw press principle, using progradation of the helical axis of rotation in press chamber, connects spina date seed
It is continuous be constantly pushed into squeeze cage, shaft and squeeze capitiform into press chamber in.Due to the continuous push-in of spina date seed, press chamber space is constantly contracted
It is small and to spina date seed produce squeezing action, squeeze head be cut compression after, spine date seed oil at a proper temperature from squeeze cage it is fuel-displaced
Outflow is extruded in hole, while marc is pressed into definite shape, from the discharge of press chamber end.Controlled automatically using constant temperature in expressing process
Device processed and Water Cooling Technology, realize the process control of temperature, it is ensured that oil outlet temperature is less than 75 DEG C, and being really achieved low-temperature cold pressing will
Ask, because spine date seed oil temperature is maintained at less than 75 DEG C, spina date seed mainly occurs physical change, and protein denaturation is small, maximum limit
Remain the active material in spina date seed frost degree.Spina date seed frost is directly separated from spina date seed, coordinates stir-fry above to process
Process step, overall process is without any chemical addition agent, it is ensured that product safety, health, pollution-free, and natural nutrition is not damaged.It is special
It is not in the production process of spina date seed frost, to remain contained abundant vitamin C in spina date seed.Vitamin C is a kind of
Important powerful antioxidant, is conducive to maintaining the stability of spina date seed frost, extends the spina date seed original powder sheet finished product shelf-life.
The present invention is improved existing preparation technology, and it is broken that spina date seed breaking method is improved into low-temperature submicron powder, just
In by spina date seed breaking-wall cell, active ingredient is set more preferably to discharge, good stability, drug effect is improved, in good taste, suitable mouth containing.
Stable preparation process of the present invention is strong, and product spina date seed original powder piece is disintegrated rapidly in oral cavity, without sand type, has
Fabulous dispersibility, miscibility and absorbability, nonirritant to mucous membrane of mouth, with nourishing heart tonifying liver, antitoxic heart-soothing and sedative is held back
Sweat, function of promoting the production of body fluid；Oral gastrointestinal absorption approach is combined by mucous membrane of mouth, the active ingredient of spiny jujuba seed powder is quickly entered body
It is interior, both remain original flavor, more improve healthcare function, it is possible to dose is reduced at double, effectively improve the rare money of spina date seed
The utilization rate in source.
Ultramicro grinding adopts micronizer, and the temperature that the micronizer can be below -36 DEG C carries out low-temperature grinding, prevents
The heat produced during crushing material raises crushing chamber temperature, retains the nutritional ingredient of material, will not destroy material activity
Material, energy consumption is low；Be ground into the micro mist that average grain diameter is 0.1~800 μm, micron-sized crushing, it is ensured that material it is detailed-oriented, carry
Quality and efficiency that high/low temperature is crushed, and control safe and reliable, it is easy to promotion and implementation.
Refrigerant used by micronizer is liquid nitrogen or A type freezing liquids, and liquid nitrogen or A type freezing liquids are in micronizer
Extremely cold space is formed in the external jacket of crushing chamber, the function of low temperature Quench material in crushing chamber is realized.Liquid nitrogen no color or smell, stabilization
Property good, compressible acquisition, but cryogenic freezing is relatively costly, it is more difficult to which being attached the low product of value uses, and market applicability is poor；A
Content is respectively the component of type freezing liquid by mass percentage：HFCS 20%~28%, propane diols 25%~35%, sodium chloride 3%
~7%, gelatin hydrolysate 2%~3%, balance of water.Using HFCS, propane diols as major part so that A type freezing liquids
Production cost is relatively low, simple production process；Wherein HFCS can select F42 HFCSs, F55 HFCSs, F90 fruits Portugal
At least one of syrup, sorting is convenient；Propane diols is moderate, and good fluidity is not volatile, and fusing point is low, harmless, right
Equipment is corrosion-free, there is anti-corrosion, sterilizing, while propane diols is soluble in water, preparing process is simple, can arbitrarily be made into various
Freezing point, its reachable -68 DEG C of minimum freezing point, refrigerating effect is good.Without ethanol, the potential safety hazard in process of manufacture is reduced, no
Containing ethylene glycol, safety non-toxic；Contained sodium chloride concentration is relatively low, reduces the corrosion to equipment；The a small amount of gelatin hydrolysate for adding, plays
The effect of stabilizer, is conducive to improving the service life of A type freezing liquids.HFCS, propane diols, sodium chloride, gelatin hydrolysate are equal
Using food grade materials, using safety non-toxic, with boiling point is high, foam is inclined to good low, viscosity temperature characteristic, good fluidity, anti-corrosion, easily
The features such as configuration.
The micro mist that average grain diameter is 0.1~800 μm is ground into, particle diameter is small, due to the huge increasing of powder specific-surface area detection, be significantly greatly increased
Medicine and the active area of human enzymes, average grain diameter are smaller, and breaking-wall cell effect is better, make to enrich medical treatment taste contained by spina date seed
Composition is mended easily for human body is sufficiently digested and assimilated comprehensively, absorptivity more than 99.99% improves the medical treatment taste of spina date seed original powder piece
Mend effect and utilization rate.
In Chinese medicine preparation field, particle is thinner, and the molecular number on surface is more, and the interfacial energy of particle is also got over
Greatly, the property of medicine effect of Chinese medicine can be improved from physical angle；On the other hand, particle is thinner, is more easily absorbed by the body, can maximum limit
Degree ground eliminates reaction of the human body caused by the difference for absorbing to drug effect.The important property of medicine composition of Chinese medicine is typically distributed about cell
Interior and cytoplasm, and surrounded with intracellular, after cell is crushed broken wall, effective ingredient is fully exposed, so drug effect
Can increase substantially, and it is rapid-action, easily absorb, by the Chinese medicine after ultramicro grinding, can to greatest extent meet absorption of human body
Function, so as to also just overcome to a certain extent because human body is to the difference caused by drug absorption.Being ground into average grain diameter is
During 0.1~800 μm of micro mist, micro mist mobility is very poor, can substantially smell the unique smell at Chinese medicine high-drug-effect position, now in
Medicine micro mist, can be directly absorbed by the body.
Particle drying link, the dry heat source of low temperature band-type vacuum drier is hot water or heating oil, the water of heating or
Oil is circulated by pipeline into the fixed heating plate interlayer of low temperature band-type vacuum drier, and conveyer belt closely connects with heating plate
Touching makes it be heated and run, particle uniform distribution on the conveyor belt, carries out heat exchange, and is equipped with refrigeration system, dried
The water vapour that particle is produced in journey is by the cryogenic vacuum condenser that the temperature cooled down by freezing liquid is -20 DEG C, water vapour volume
Rapid reducing is changed into liquid.The vacuum of low temperature band-type vacuum drier can reach -0.1Mpa, drying temperature control 20~
In 80 DEG C, drying temperature is relatively low, thus thermo-labile to spina date seed organic acid, fat oil, protein, vitamin C, phytosterol etc.
Material composition do not destroy, and the original fragrance of material can be kept, be sufficiently reserved effective nutritional ingredient and the life of spina date seed
Thing natural activity；Ziziphus Jujuba Mill Granules water content ＜ 5% after drying, is conducive to product to preserve for a long time and is gone mouldy without being damaged by worms, being difficult,
And the unique features of spina date seed original powder piece can be kept.
Traditional drying uses electric heating circulating bellows, in insulation indoor hot air sinuous flow, causes to be close to the material of heating tube both sides
Dry quickly, and centre position heating is relatively slow, it is necessary to artificial stirring, not only increases manpower, and also the efficiency of heating surface is low, drying time
8~12 hours, the particles by heat time was long, has loss in drying process to nutritional ingredient；Use low temperature band-type vacuum drier
It is vacuum dried, production efficiency can be improve with continuous feed, continuous discharge, moist closet difference variation can be caused 1~2
Between DEG C, 1~1.5 hour drying time, stabilization is uniformly heated.
Granulation and mixing link, directly do not carry out compressing tablet by the micro mist after crushing, and reason is that the surface tension of micro mist is big,
Direct tablet compressing difficulty is very big, difficult forming, while spina date seed different parts active constituent content is different, the substrate composition of compacting contains
Amount disunity, is unfavorable for production process uniformity controlling；By pelletizing and mixing link, the particle of 10~50 mesh is first made, subtracted
The surface tension of few micro mist, reduces compressing tablet difficulty, then be sufficiently mixed within 15~30 minutes, makes the different parts of spina date seed effective
Composition is easily upset, and improves the control of product quality of compressing tablet uniformity and production process, meanwhile, it is employed herein three-dimensional mixed
Conjunction machine, in the running of three-dimensional mixer, because mix cylinder has multi-direction motion, makes material in mixed process
In, flowing and diffusion are accelerated, while avoiding the machine of generally mixing with because of the material gravity segregation produced by centrifugal action
And accumulation phenomenon, mixing is without dead angle, not stratified, well mixed and production efficiency is high, simple to operate, will not also pollute raw material,
The best in quality of mixed material can effectively be ensured.
Substrate piece weight after compacting is 0.1~3g/ pieces, and weight differential is ± 4~± 6%, hardness >=3kg/cm2, friability
≤ 1%, moisture ＜ 5%.Label any surface finish, no color differnece, mobility of particle is good in tableting processes, and therapeutic effect is good, substrate product
Appearance character and hardness meet tablet quality standard, and dissolution rate increases.It is maximum without any auxiliary material in manufacturing process
Degree improves the valid density of medicine, improves the bioavailability of product, category green, safety food.Take instant effect, mouthfeel
Good, the quality guarantee period of medicament phase is long, good stability, low cost, preparation process is simple, saves the time for preparing medicine.What is processed contains
Piece can be sufficiently reserved the effective nutritional ingredient of spina date seed and its biological natural activity, and the spina date seed original powder piece outward appearance for suppressing is put down
Whole, processing step is simple, process time is short, shape is smooth, be easy to preservation.Rotary tablet machine is used in the present invention, its
Slice is smooth, is convenient to mount and dismount, and compact structure is simple, and regulation is accurate, improves yield rate and operating efficiency, reduces the dimension of equipment
Shield cost, and with the effect of recovery powder stock.
The spina date seed original powder piece that the inventive method is obtained, organic acid, fat oil, protein, vitamin C, phytosterol etc.
Nutritional ingredient is saved from damage preferably, green health, instant, and water content is low, and good stability, shelf lives are long；And can be great
Increase the active area of medicine and human enzymes, it is people in the presence of enzyme, easily to make to enrich composition contained by spina date seed original powder piece
Body is sufficiently digested and assimilated comprehensively, improves spina date seed original powder piece medical treatment tonic effect and utilization rate, and be easy to measure and take.
With antitoxic heart-soothing and sedative, the effect of sleep quality is improved, be organic, green product, pharmaceutical food resource is all good.
Specific embodiment
The present invention is described in further details with reference to embodiment：
1. the selection of raw material：Spina date seed is put into the removal of impurity, foreign matter and non-Leaf-feeding insects；
2. frying：Heaved being put into preheating roller type machine for stir-frying Chinese medicine to be fried to surface is micro- with slow fire by the spina date seed of selection, micro- tool
Focal spot, dries in the air cool to room temperature, 80~120 DEG C of frying temperature, 25~35 minutes frying time, preheating rolling with burnt odor gas, after taking-up
15~30 revs/min of the rotating speed of cartridge type machine for stir-frying Chinese medicine；
3. frost is deoiled into：Spina date seed after frying is squeezed into degreasing, spina date seed frost is made；
4. crush：Crushed under low temperature, the temperature of smashing is≤- 36 DEG C, the time of crushing is 1~30 minute, the wild jujube that will be made
Benevolence frost carries out pulverization process, and the particle diameter after crushing is 0.1~800 μm, and spiny jujuba seed powder is obtained；
5. softwood processed：By step 4. in add wild jujube pulp low temperature concentrated extract, the leaching of wild jujube pulp in the spiny jujuba seed powder that crushes
Cream is made spina date seed softwood, and spiny jujuba seed powder is 1 with the mass ratio of low temperature concentrated extract：0.1~1：0.3；
6. pelletize：Spina date seed softwood is made the particle that size is 10~50 mesh；
7. dry：Wild jujube benevolence wet granular is inserted and is dried in low temperature band-type vacuum drier, when being dried, stone
Thickness is 10~20mm, 20~80 DEG C of drying temperature, vacuum -0.08~-0.1Mpa, dry particle moisture ＜ 5.0%.
8. mix：Dried Ziziphus Jujuba Mill Granules are mixed, incorporation time is 15~30 minutes；
9. compressing tablet：By mixed granulation, substrate is made, the weight of substrate is 0.1~3g/ pieces, weight differential is ± 4~
± 6%, hardness >=3kg/ cm2, friability≤1%, moisture ＜ 10.0%, substrate be shaped as ellipse, triangle, pentagon or
Olive shape.
The present invention is described in further details with reference to embodiment：
Embodiment 1,
1. the selection of raw material：Spina date seed is put and is cleaned on operating desk, pick net impurity, foreign matter, damage by worms, go mouldy and non-Leaf-feeding insects；
2. frying：Net spina date seed is put in preheating roller type machine for stir-frying Chinese medicine, control 110 DEG C of temperature, 25 minutes time, 25 turns of rotating speed/
Minute fries and is heaved to surface is micro-, and micro- tool focal spot, slightly burnt odor gas take out, and dry in the air cool to room temperature；
3. frost is deoiled into：The spina date seed of frying is placed in oil press, degreasing is squeezed and is made spina date seed frost；
4. crush：The spina date seed frost that will be made, refrigerant is inserted in the external jacket of micronizer crushing chamber, makes Ultramicro-powder
Broken machine external jacket temperature control carries out low-temperature grinding 1~30 minute at -36 DEG C, is finally ground into the acid that average grain diameter is 500 μm
Jujube kernel powder, the refrigerant selected in the present embodiment can be A type freezing liquids, and its mass percentage content is respectively：F42 fruits Portugal
Syrup 20%, propane diols 25%, sodium chloride 3%, gelatin hydrolysate 2%, balance of water；
5. softwood processed：It is 1 according to mass ratio by the spiny jujuba seed powder after crushing and wild jujube pulp medicinal extract：0.1 is placed in combining machine is made
Softwood；
6. pelletize：Spina date seed softwood is inserted in oscillating granulator the particle for being made 12 mesh；
7. dry：Spina date seed wet granular is inserted and is dried in low temperature band-type vacuum drier, when being dried, layer thickness
It is 15mm, 60 DEG C of drying temperature, vacuum -0.08Mpa, dry particle moisture ＜ 5%.
8. mix：The particle that will be made is mixed 15 minutes with three-dimensional mixer；
9. compressing tablet：Mixed particle is carried out into compressing tablet with rotary tablet machine, substrate is made.
Tablet die is ellipse in the present embodiment, and the piece weight of the substrate after compressing tablet is 0.5g/ pieces, and weight differential is ± 4
~± 6%, hardness >=3kg/cm2, friability≤1%, moisture ＜ 5%.
Embodiment 2,
The present embodiment is distinguished as with embodiment 1：In step frying step 2., 100 DEG C of frying temperature, turns 30 minutes time
30 revs/min of speed.
Embodiment 3,
The present embodiment is distinguished as with embodiment 1：In step pulverising step 4., refrigerant is A type freezing liquids, the fruit of selection
Glucose slurry is F42 HFCSs and F55 HFCSs, and the two mass percentage content is 60% and 40%.By micronizer powder
The external jacket temperature control in broken chamber carries out low-temperature grinding 20 minutes at -40 DEG C, is ground into the micro mist that average grain diameter is 5 μm.
Embodiment 4,
The present embodiment is distinguished as with embodiment 1：The mass percentage content of step 4. middle A types freezing liquid is respectively：High fructose corn
Slurry 27%（F42 HFCSs, F55 HFCSs, F90 HFCSs mass percentage content are respectively 9%）, propane diols 29%, chlorination
Low-temperature grinding temperature can be down to -45 DEG C by sodium 4%, gelatin hydrolysate 2.5%, balance of water.
Embodiment 5,
The present embodiment is distinguished as with embodiment 1：Step 4. in be finally ground into micronizer average grain diameter for 0.1~
200 μm of micro mist.
Embodiment 6,
The present embodiment is distinguished as with embodiment 1：In step softwood step processed 5., spina date seed micro mist and wild jujube meat medicinal extract quality
Than 1：0.2.
Embodiment 7,
The present embodiment is distinguished as with embodiment 1：In step granulation step 6., insert in oscillating granulator and be made 13 purposes
Grain.
Embodiment 8,
The present embodiment is distinguished as with embodiment 1：In step drying steps 7., spina date seed wet granular is inserted into low temperature belt true
It is dried in empty drying machine, when being dried, layer thickness is 10mm, and 50 DEG C of drying temperature, vacuum -0.1Mpa is dried
Granule moisture level ＜ 4.0%.
Embodiment 9,
The present embodiment is distinguished as with embodiment 1：In step blend step 8., the time of three-dimensional mixer mixing is 5 minutes.
Embodiment 10,
The present embodiment is distinguished as with embodiment 1：In step tableting step 9., the compression mold that rotary tablet machine is used for
Triangle xenotype mold, the piece weight of the substrate after compressing tablet is 0.7g/ pieces, and weight differential is ± 5%, and hardness >=3.5kg/ ㎝ 2 is crisp
Broken degree≤0.8%, moisture ＜ 4.0%.
Claims (10)
1. the preparation method of a kind of spina date seed original powder piece, it is characterised in that comprise the following steps：
1. the selection of raw material：Spina date seed is put into the removal of impurity, foreign matter and non-Leaf-feeding insects；
2. frying：Heaved being fried to surface is micro- by the spina date seed slow fire of selection, micro- tool focal spot, with burnt odor gas, after taking-up
Dry in the air cool to room temperature；
3. frost is deoiled into：By the oil extruder degreasing of the spina date seed after frying, spina date seed frost is made；
4. crush：At a certain temperature, the spina date seed frost that will be made carries out pulverization process, is ground into a range of particle diameter, system
Obtain spiny jujuba seed powder；
5. softwood processed：By step 4. in add appropriate wild jujube flesh fruit slurry medicinal extract to be made spina date seed in the spiny jujuba seed powder that crushes soft
Material；
6. pelletize：Spina date seed softwood is made the particle of certain size；
7. dry：Ziziphus Jujuba Mill Granules are vacuum dried, control the water content of particle after certain limit, stopped drying；
8. mix：Dried Ziziphus Jujuba Mill Granules are mixed；
9. compressing tablet：By mixed granulation, substrate is made.
2. the preparation method of a kind of spina date seed original powder piece according to claim 1, it is characterised in that：The step is 2. middle will
It is chosen for spina date seed and is put into frying in preheating roller type machine for stir-frying Chinese medicine, 80~120 DEG C of frying temperature, 25~35 points of frying time
Clock.
3. the preparation method of a kind of spina date seed original powder piece according to claim 2, it is characterised in that：The preheating roller type
15~30 revs/min of the rotating speed of machine for stir-frying Chinese medicine.
4. the preparation method of a kind of spina date seed original powder piece according to claim 3, it is characterised in that：The step 3. middle acid
Jujube kernel squeezing uses cold pressing oil press, and the temperature of squeezing is 50~75 DEG C.
5. the preparation method of a kind of spina date seed original powder piece according to claim 4, it is characterised in that：The step 4. middle powder
Broken temperature is≤- 36 DEG C, and the time of crushing is 1~30 minute, and the particle diameter after crushing is 0.1~800 μm.
6. a kind of preparation method of the former powder piece of spina date seed according to any one of Claims 1 to 4, it is characterised in that：It is described
5. middle Zizyphus Spinosa Hu Flesh pulp medicinal extract is relative density 1.30- for wild jujube is beaten removal core, crosses elimination pulp, the concentration of pulp low temperature to step
1.38 medicinal extract, the component of Zizyphus Spinosa Hu Flesh pulp medicinal extract is the spiny jujuba seed powder that mass fraction is 93%~81%, spiny jujuba seed powder and wild jujube
The mass ratio of pulp medicinal extract is 1：0.1~1：0.3.
7. the preparation method of a kind of spina date seed original powder piece according to claim 6, it is characterised in that：The step 6. middle acid
Jujube kernel softwood be placed in oscillating granulator be made particle size be 10~50 mesh.
8. a kind of preparation method of the former powder piece of spina date seed according to any one of Claims 1 to 4, it is characterised in that：It is described
The drying machine that 7. step uses is low temperature band-type vacuum drier, when drying, layer thickness be 10~20mm, drying temperature 20~
80 DEG C, vacuum -0.08~-0.1Mpa, dry particle moisture ＜ 5.0%.
9. the preparation method of a kind of spina date seed original powder piece according to claim 8, it is characterised in that：The step is 8. middle will
It is 15~30 minutes that dried particle is placed in incorporation time in three-dimensional mixer.
10. the preparation method of a kind of spina date seed original powder piece according to claim 9, it is characterised in that：The step 9. in
The weight of the substrate after rotary compressing tablet is 0.1~3g/ pieces, and weight differential is ± 4~± 6%, hardness >=3kg/ cm2, friability
Degree≤1%, moisture ＜ 5.0%, substrate is shaped as ellipse, triangle, pentagon or olive shape.
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| CN109874908A (en) * | 2019-02-02 | 2019-06-14 | 山西中医药大学 | A kind of semen ziziphi spinosae purified protein powder and preparation method thereof |
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| CN105902587A (en) * | 2016-04-29 | 2016-08-31 | 河北林益堂药业有限公司 | Preparation method of panax quinquefolius raw powder tablets |
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- 2016-12-19 CN CN201611176409.4A patent/CN106722989A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105902587A (en) * | 2016-04-29 | 2016-08-31 | 河北林益堂药业有限公司 | Preparation method of panax quinquefolius raw powder tablets |
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| CN109874908A (en) * | 2019-02-02 | 2019-06-14 | 山西中医药大学 | A kind of semen ziziphi spinosae purified protein powder and preparation method thereof |
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Application publication date: 20170531 |