CN106720470A - 一种具有辅助抗氧化作用的组合物及其制备方法 - Google Patents
一种具有辅助抗氧化作用的组合物及其制备方法 Download PDFInfo
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Abstract
本发明提供了一种具有辅助抗氧化作用的组合物及其制备方法，所述组合物由奇亚籽油、番茄籽油和玉米胚芽油组成，其中，奇亚籽油、番茄籽油和玉米胚芽油的体积比为45‑65：20‑30：15‑25，混合方式获得；所述组合物精选天然食品为来源，各组分协同作用，能直接或者间接的清除体内的各种自由基，延缓衰老的发生，具有明显的抗氧的辅助作用，并无任何毒副作用；其制备方法简单，适合规模化工业生产的需求。
Description
技术领域
本发明涉及一种组合物及其制备方法，尤其是一种具有辅助抗氧化作用的组合物及其制备方法。
背景技术
衰老是机体组织、器官功能随年龄增长而发生的退行性变化。衰老的自由基学说是英国的Harman于1956年最早提出的。该学说认为自由基攻击生命大分子造成组织损伤，是引起机体衰老的根本原因。近年来，新的抗氧化机制不断被发现，人们越来越趋向于应用天然抗氧化剂，我国有丰富的中草药资源，它们的药效和安全性比较明确，其中有201种中药因其安全性比较明确已被列为可直接应用到保健品或食品中。许多学者认为某些中草药的疗效与其抗氧化作用密切相关。
目前认为中药成分对机体氧化损伤的保护作用主要包括以下几方面：1)直接清除活性氧自由基；2)增强抗氧化酶活性；3)抗脂质过氧化，维持细胞膜稳定性；4)减少DNA损伤；5)对氧化酶系活力及表达的影响；6)对一氧化氮(NO)及一氧化氮合酶的影响。因此对于中药成分有效复配来提高其抗氧化能力具有重要的应用价值。
发明内容
本发明所要解决的技术问题在于提供一种具有辅助抗氧化作用的组合物。
本发明所要解决的另一技术问题在于提供上述具有辅助抗氧化作用的组合物的制备方法。
为解决上述技术问题，本发明的技术方案是：
一种具有辅助抗氧化作用的组合物，由奇亚籽油、番茄籽油和玉米胚芽油组成，其中，奇亚籽油、番茄籽油和玉米胚芽油的体积比为45-65：20-30：15-25。
优选的，上述具有辅助抗氧化作用的组合物，所述奇亚籽油、番茄籽油和玉米胚芽油的体积比为55：30：20。
上述具有辅助抗氧化作用的组合物的制备方法，具体制备步骤如下：
(1)按组方量称取奇亚籽油、番茄籽油和玉米胚芽油为原料；
(2)各原料混匀，即得。
本发明的有益效果：
上述具有辅助抗氧化作用的组合物，精选天然食品为来源，各组分协同作用，能直接或者间接的清除体内的各种自由基，延缓衰老的发生，具有明显的抗氧的辅助作用，并无任何毒副作用；其制备方法简单，适合规模化工业生产的需求。
具体实施方式
下面结合具体实施例对本发明所述技术方案作进一步的说明。
实施例1
一种具有辅助抗氧化作用的组合物，由奇亚籽油、番茄籽油和玉米胚芽油组成，其中，奇亚籽油、番茄籽油和玉米胚芽油的体积比为55：30：20。
上述具有辅助抗氧化作用的组合物的制备方法，具体制备步骤如下：
(1)按组方量称取奇亚籽油、番茄籽油和玉米胚芽油为原料；
(2)各原料混匀，即得。
实施例2
一种具有辅助抗氧化作用的组合物，由奇亚籽油、番茄籽油和玉米胚芽油组成，其中，奇亚籽油、番茄籽油和玉米胚芽油的体积比为45：30：15。所述组合物的制备方法同实施例1。
实施例3
一种具有辅助抗氧化作用的组合物，由奇亚籽油、番茄籽油和玉米胚芽油组成，其中，奇亚籽油、番茄籽油和玉米胚芽油的体积比为65：20：25。所述组合物的制备方法同实施例1。
实施例4
一种具有辅助抗氧化作用的组合物，由奇亚籽油、番茄籽油和玉米胚芽油组成，其中，奇亚籽油、番茄籽油和玉米胚芽油的体积比为50：25：20。所述组合物的制备方法同实施例1。
上述实施例1-4所述具有辅助抗氧化作用的组合物中各原料组分均为市售产品。
各组分组方分析如下：
奇亚籽油富含蛋白质、碳水化合物、膳食纤维、ω-3多不饱和脂肪酸和抗氧化剂等营养成分，奇亚籽中油脂含量较高，为30.0％～35.0％，其中多不饱和脂肪酸的比例约占总脂肪酸80.4％，奇亚籽特别富含ω-3脂肪酸的必需成分α-亚麻酸(ALA)，ALA约占总脂肪酸量的56.9％～64.8％，其含量在各种植物中是最高的。研究表明，除了普通的抗氧化元素(维生素E，C和卵磷脂)以外，奇亚籽内含有更丰富的天然抗氧化剂，是抗老防病防癌的必需：咖啡酸(Caffeic acid)可以预防动脉硬化；绿原酸(Chlorogenic acid)有效抑制癌变，并有减肥作用；其它抗氧剂如栎皮黄素(Quercetin)，山柰黄酮醇(Kaempferol)等也是防癌，抗老化的有效物质。据国内外研究证实，奇亚籽的健康功效主要包括抗氧化、抑制肥胖和改善血脂代谢、降低心血管疾病患病风险等多个方面。根据科学研究，奇亚籽不会引起任何不良过敏反应以及抗营养和毒性作用。
番茄籽油(tomato seed oil)是从番茄籽中提取精炼的天然优质食用油。番茄籽油含有大量的不饱和脂肪酸、生育酚和植物甾醇，并富含番茄红素和维生素E和维生素A的前体胡萝卜素。研究表明它具有抗氧化、调节心血管疾病和增强免疫等多种保健功能，具有极高的营养和药用价值，同时番茄红素还可减轻次氯酸引起的机体损伤。
玉米胚芽油含有丰富的营养成分，它的主要成分是各种脂肪酸与甘油构成的甘油三脂肪酸酯(甘三脂)，其中多聚不饱和酯含量达60％以上，而且不含有胆固醇。不饱和脂肪酸与胆固醇形成的酯熔点低，容易乳化，且能在人体血管中流动，起到输送和代谢的作用。玉米胚芽油脂肪酸中的亚油酸、亚麻酸、花生四烯酸是人体所必需的脂肪酸，其中尤以亚油酸为佳，具有降低人体胆固醇、降血压、软化血管以及增加人体肌肉和心脏、心血管系统的机能，能够预防和改善动脉硬化，减少心脏病发生，并且还可以缓解人体前列腺病症的发作和皮炎的发生。同时，玉米胚芽油还是人体肌肉进行代谢、维持中枢神经系统和血管系统完整及许多其他功能的必需营养素，而且还是一种强氧化剂，可以控制人体内的对细胞膜有害的过氧化物游离基在最低水平。
本发明中富含不饱和脂肪酸，Omage-3与Omage-6不饱和脂肪酸都是人体不可或缺的“必需氨基酸”。二者含量的比例对人体的健康至关重要，合适的比例可以让二者相互制约已达到微妙的平衡，从而通过前列腺素的途径来调节成千上万的新陈代谢功能。而本发明依据现代药理药效结合中医中药的理论研究，精选天然食品作为主料，各组分协同增效，通过使Omage-3与Omage-6达到平衡，最大程度的发挥组合物的抗氧化功效。
实验例
Ⅰ抗氧化实验
(1)分组及饲养：将小鼠按体重随机分为3个实验组和1个对照组，每组10只。各组小鼠均食普通饲料和自来水，对照组给予菜籽油，实验组给予不同剂量的样品，低剂量：0.5g/kg小鼠BW，中剂量：1.0g/kg小鼠BW，高剂量：1.5g/kg小鼠BW。以灌饲方式给予。
(2)测定方法：小鼠喂养30天后，颈椎脱位法处死，去肝组织，用冷生理盐水冲洗，拭干，放入小玻璃瓶中冷冻制备。
(3)测定指标：以5，5′-双硫代对硝基苯甲酸直接比色法(DTNB法)测定谷胱甘肽过氧化物酶(GSH-Px)活力；以邻苯三酚自氧化法测定超氧化物歧化酶(SOD)活力；以硫代巴比妥酸比色法测定丙二醛(MDA)含量水平。
灌饲不同剂量样品后小鼠肝组织中谷胱甘肽过氧化物酶(GSH-Px)活力的比较，见表1。
表1
| 组别 | n | GSH-Px(U/L) |
| 对照组 | 10 | 603.24±48.53 |
| 低剂量组 | 10 | 638.78±64.57 |
| 中剂量组 | 10 | 678.85±45.12 |
| 高剂量组 | 10 | 687.36±54.63 |
灌饲不同剂量样品后小鼠肝组织中超氧化物歧化酶(SOD)活力的比较，见表2。
表2
| 组别 | n | SOD活力(U/ml) |
| 对照组 | 10 | 184.87±41.12 |
| 低剂量组 | 10 | 192.84±34.13 |
| 中剂量组 | 10 | 201.53±46.75 |
| 高剂量组 | 10 | 215.31±43.78 |
灌饲不同剂量样品后小鼠肝组织中丙二醛(MDA)含量的比较，见表3。
表3
结果显示：与对照组比较，灌饲任意剂量的实验组的肝组织的GSH-Px活力均明显提高；实验组的肝组织的SOD活力显著提高以及MDA含量明显降低。
Ⅱ毒理检验及人体试食实验
(1)奇亚籽油复方抗氧化软胶囊对两种性别的SPF级昆明种小鼠急性经口毒性试验，单次灌胃剂量达17.3g/kg BW(相当于人群推荐日摄入量0.0225g/kg BW的768.9倍)，在14d的观察期内动物未见明显中毒症状和死亡，依据急性毒性分级评价标准规定，该受试样品属无毒级。三项致突变试验(Ames试验、小鼠骨髓细胞微核试验和精子畸形试验)结果均为阴性。
(2)经人体试食试验，受试者服用受试物30天，结果表明试食后试食组血清MAD较试验前降低5.2％，血清SOD、血清GSH-Px均有提高，分别较试验前提高2.34％和2.53％，其中SOD活力与对照组(对照组服用水)试食后及自身试验前比较，差异均有显著性。试食前后体重、血压、心率、血常规、尿常规、心电图等安全性指标均未见明显异常改变，且试食期间未见与样品有关的不良反应。
上述参照实施例对该一种具有辅助抗氧化作用的组合物及其制备方法进行的详细描述，是说明性的而不是限定性的，可按照所限定范围列举出若干个实施例，因此在不脱离本发明总体构思下的变化和修改，应属本发明的保护范围之内。
Claims (3)
1.一种具有辅助抗氧化作用的组合物，其特征在于：由奇亚籽油、番茄籽油和玉米胚芽油组成，其中，奇亚籽油、番茄籽油和玉米胚芽油的体积比为45-65：20-30：15-25。
2.根据权利要求1所述的具有辅助抗氧化作用的组合物，其特征在于：所述奇亚籽油、番茄籽油和玉米胚芽油的体积比为55：30：20。
3.权利要求1所述具有辅助抗氧化作用的组合物的制备方法，其特征在于：具体制备步骤如下：
(1)按组方量称取奇亚籽油、番茄籽油和玉米胚芽油为原料；
(2)各原料混匀，即得。
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