CN106714804A - 用于预测dlbcl对用btk抑制剂进行的治疗的响应的生物标志 - Google Patents

用于预测dlbcl对用btk抑制剂进行的治疗的响应的生物标志 Download PDF

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Publication number
CN106714804A
CN106714804A CN201580049596.7A CN201580049596A CN106714804A CN 106714804 A CN106714804 A CN 106714804A CN 201580049596 A CN201580049596 A CN 201580049596A CN 106714804 A CN106714804 A CN 106714804A
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dlbcl
lymphoma
modification
inhibitor
cell
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卡尔·施魏格霍费尔
卡尔·埃克特
旭平·郭
贝蒂·张
达林·博普雷
张宏杰
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Pharmacyclics LLC
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Pharmacyclics LLC
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201580049596.7A 2014-08-01 2015-07-31 用于预测dlbcl对用btk抑制剂进行的治疗的响应的生物标志 Pending CN106714804A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201462032430P 2014-08-01 2014-08-01
US62/032,430 2014-08-01
US201562119668P 2015-02-23 2015-02-23
US62/119,668 2015-02-23
US201562127484P 2015-03-03 2015-03-03
US62/127,484 2015-03-03
PCT/US2015/043300 WO2016019341A1 (en) 2014-08-01 2015-07-31 Biomarkers for predicting response of dlbcl to treatment with a btk inhibitor

Publications (1)

Publication Number Publication Date
CN106714804A true CN106714804A (zh) 2017-05-24

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Country Status (13)

Country Link
US (1) US20160032404A1 (https=)
EP (1) EP3185870A4 (https=)
JP (1) JP2017523188A (https=)
KR (1) KR20170042614A (https=)
CN (1) CN106714804A (https=)
AU (1) AU2015296010A1 (https=)
BR (1) BR112017001677A2 (https=)
CA (1) CA2955744A1 (https=)
IL (1) IL250221A0 (https=)
MX (1) MX2017001302A (https=)
RU (1) RU2017106794A (https=)
SG (1) SG11201700774UA (https=)
WO (1) WO2016019341A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110996972A (zh) * 2017-06-08 2020-04-10 恩立夫克治疗有限责任公司 用于癌症治疗的治疗性凋亡细胞
US11500112B2 (en) * 2018-10-10 2022-11-15 Symetrica Limited Gamma-ray spectrum classification

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2350075E (pt) 2008-09-22 2014-06-09 Array Biopharma Inc Compostos imidazo[1,2b]piridazina substituídos como inibidores da trk cinase
AR074052A1 (es) 2008-10-22 2010-12-22 Array Biopharma Inc Compuestos pirazolo{1,5-a}pirimidina sustituida como inhibidores de trk cinasa
AR077468A1 (es) 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
NZ604708A (en) 2010-05-20 2015-05-29 Array Biopharma Inc Macrocyclic compounds as trk kinase inhibitors
CN107898791A (zh) 2010-06-03 2018-04-13 药品循环有限责任公司 布鲁顿酪氨酸激酶(btk)抑制剂的应用
CN104704129A (zh) 2012-07-24 2015-06-10 药品循环公司 与对布鲁顿酪氨酸激酶(btk)抑制剂的抗性相关的突变
WO2016071770A2 (en) * 2014-11-05 2016-05-12 Janssen Pharmaceutica Nv Biological markers for identifying ibrutinib resistance in patients having mantle cell lymphoma and methods of using the same
HUE061448T2 (hu) 2014-11-16 2023-07-28 Array Biopharma Inc (S)-N-(5-((R)-2-(2,5-difluorofenil)-pirrolidin-1-il)-pirazolo[1,5-A]pirimidin-3-il) -3-hidroxipirrolidin-1-karboxamid-hidrogénszulfát kristályos formája
RS64653B1 (sr) 2015-04-06 2023-10-31 Janssen Pharmaceutica Nv Kompozicije koje sadrže ibrutinib
CN108697708A (zh) 2015-10-26 2018-10-23 洛克索肿瘤学股份有限公司 Trk抑制剂抗性癌症中的点突变以及与此相关的方法
US10045991B2 (en) 2016-04-04 2018-08-14 Loxo Oncology, Inc. Methods of treating pediatric cancers
ES2987474T3 (es) 2016-04-04 2024-11-15 Loxo Oncology Inc Formulaciones líquidas de (S)-N-(5-((R)-2-(2,5-difluorofenil)-pirrolidin-1-IL)-pirazolo[1,5-A]pirimidin-3-IL)-3-hidroxipirrolidina-1-carboxamida
ES2836222T3 (es) 2016-05-18 2021-06-24 Loxo Oncology Inc Preparación de (S)-N-(5-((R)-2-(2,5-difluorofenil)pirrolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida
JOP20190092A1 (ar) 2016-10-26 2019-04-25 Array Biopharma Inc عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
US11085039B2 (en) 2016-12-12 2021-08-10 xCella Biosciences, Inc. Methods and systems for screening using microcapillary arrays
CN110268108B (zh) * 2016-12-12 2022-09-06 埃克切拉生物科学公司 用于使用微毛细管阵列进行筛选的方法和系统
EP3562796B1 (en) 2016-12-30 2023-04-19 Xcella Biosciences, Inc. Multi-stage sample recovery system
JOP20190213A1 (ar) 2017-03-16 2019-09-16 Array Biopharma Inc مركبات حلقية ضخمة كمثبطات لكيناز ros1
CZ2017787A3 (cs) 2017-12-08 2019-06-19 Zentiva, K.S. Farmaceutické kompozice obsahující ibrutinib
EA202190045A1 (ru) 2018-06-15 2021-03-17 Янссен Фармацевтика Нв Составы/композиции, содержащие ибрутиниб
US20200171034A1 (en) * 2018-11-30 2020-06-04 Janssen Biotech, Inc. Methods Of Treating Follicular Lymphoma
ES3039910T3 (en) 2018-12-06 2025-10-27 Xcella Biosciences Inc Lateral loading of microcapillary arrays
WO2021087044A1 (en) * 2019-10-30 2021-05-06 Celgene Corporation Methods for predicting responsiveness of lymphoma to drug and methods for treating lymphoma
CN116848267A (zh) * 2021-02-03 2023-10-03 柯瑞斯公司 非美诺司他治疗的生物标志物
JP2024526241A (ja) * 2021-06-30 2024-07-17 ヤンセン ファーマシューティカ エヌ．ベー． ブルトン型チロシンキナーゼの阻害剤及びその使用方法
WO2023275330A1 (en) * 2021-06-30 2023-01-05 Janssen Pharmaceutica Nv Treatments for diffuse large b-cell lymphoma
JP7423090B2 (ja) * 2022-04-07 2024-01-29 学校法人藤田学園 不明熱患者のｂ細胞リンパ腫診断補助キットおよび情報提供方法
WO2025080543A1 (en) * 2023-10-09 2025-04-17 Bristol-Myers Squibb Company Methods for predicting responsiveness of lymphoma to drug and methods for treating lymphoma
JP7696987B1 (ja) * 2023-12-22 2025-06-23 東洋鋼鈑株式会社 遺伝子変異を検出する方法
JP7698850B1 (ja) 2023-12-22 2025-06-26 東洋鋼鈑株式会社 遺伝子変異評価用キット

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013059738A2 (en) * 2011-10-19 2013-04-25 Pharmacyclics, Inc. Use of inhibitors of bruton's tyrosine kinase (btk)
CN103153311A (zh) * 2010-06-03 2013-06-12 药品循环公司 布鲁顿酪氨酸激酶(btk)抑制剂的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130102477A1 (en) * 2010-06-23 2013-04-25 Ryan D. Morin Biomarkers for non-hodgkin lymphomas and uses thereof
AR088570A1 (es) * 2011-10-28 2014-06-18 Celgene Avilomics Res Inc Metodos para tratar una enfermedad o trastorno relacionado con la tirosina quinasa de bruton
JO3754B1 (ar) * 2012-06-04 2021-01-31 Pharmacyclics Llc أشكال كريستالين لمثبط أنزيم كيناز تيروسين بروتون
CN104704129A (zh) * 2012-07-24 2015-06-10 药品循环公司 与对布鲁顿酪氨酸激酶(btk)抑制剂的抗性相关的突变
JP2016505012A (ja) * 2013-01-10 2016-02-18 ニンバス アイリス， インコーポレイテッド Ｉｒａｋ阻害剤およびその使用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103153311A (zh) * 2010-06-03 2013-06-12 药品循环公司 布鲁顿酪氨酸激酶(btk)抑制剂的应用
WO2013059738A2 (en) * 2011-10-19 2013-04-25 Pharmacyclics, Inc. Use of inhibitors of bruton's tyrosine kinase (btk)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WYNDHAM H. WILSON等: "The Bruton"s Tyrosine Kinase (BTK) Inhibitor, Ibrutinib (PCI-32765), Has Preferential Activity in the ABC Subtype of Relapsed/Refractory De Novo Diffuse Large B-Cell Lymphoma (DLBCL):Interim Results of a Multicenter, Open-Label, Phase 2 Study", 《BLOOD》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110996972A (zh) * 2017-06-08 2020-04-10 恩立夫克治疗有限责任公司 用于癌症治疗的治疗性凋亡细胞
US11500112B2 (en) * 2018-10-10 2022-11-15 Symetrica Limited Gamma-ray spectrum classification

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IL250221A0 (en) 2017-03-30
WO2016019341A1 (en) 2016-02-04
US20160032404A1 (en) 2016-02-04
SG11201700774UA (en) 2017-02-27
KR20170042614A (ko) 2017-04-19
EP3185870A4 (en) 2018-06-20
CA2955744A1 (en) 2016-02-04
RU2017106794A (ru) 2018-09-03
JP2017523188A (ja) 2017-08-17
MX2017001302A (es) 2017-10-11
EP3185870A1 (en) 2017-07-05
AU2015296010A1 (en) 2017-02-02
RU2017106794A3 (https=) 2019-02-27
BR112017001677A2 (pt) 2018-07-17

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Application publication date: 20170524