CN106692481A - Tablets for treating peptic ulcer and preparation method thereof - Google Patents
Tablets for treating peptic ulcer and preparation method thereof Download PDFInfo
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- CN106692481A CN106692481A CN201611074663.3A CN201611074663A CN106692481A CN 106692481 A CN106692481 A CN 106692481A CN 201611074663 A CN201611074663 A CN 201611074663A CN 106692481 A CN106692481 A CN 106692481A
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- 208000008469 Peptic Ulcer Diseases 0.000 title claims abstract description 12
- 208000011906 peptic ulcer disease Diseases 0.000 title claims abstract description 11
- 238000002360 preparation method Methods 0.000 title claims description 8
- 239000003814 drug Substances 0.000 claims abstract description 27
- 239000008187 granular material Substances 0.000 claims abstract description 13
- 229940079593 drug Drugs 0.000 claims abstract description 12
- 235000006753 Platycodon grandiflorum Nutrition 0.000 claims abstract description 8
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 claims abstract description 8
- 239000000314 lubricant Substances 0.000 claims abstract description 8
- 240000002505 Pogostemon cablin Species 0.000 claims abstract description 7
- 235000011751 Pogostemon cablin Nutrition 0.000 claims abstract description 7
- 240000001949 Taraxacum officinale Species 0.000 claims abstract description 4
- 239000002994 raw material Substances 0.000 claims abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 26
- 239000000284 extract Substances 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 235000009051 Ambrosia paniculata var. peruviana Nutrition 0.000 claims description 9
- 235000003097 Artemisia absinthium Nutrition 0.000 claims description 9
- 240000001851 Artemisia dracunculus Species 0.000 claims description 9
- 235000017731 Artemisia dracunculus ssp. dracunculus Nutrition 0.000 claims description 9
- 235000003261 Artemisia vulgaris Nutrition 0.000 claims description 9
- 239000001138 artemisia absinthium Substances 0.000 claims description 9
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 9
- 241000934856 Daphne Species 0.000 claims description 8
- 244000270834 Myristica fragrans Species 0.000 claims description 8
- 235000009421 Myristica fragrans Nutrition 0.000 claims description 8
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 8
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 8
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 8
- 239000001702 nutmeg Substances 0.000 claims description 8
- 241000132012 Atractylodes Species 0.000 claims description 7
- 241000756943 Codonopsis Species 0.000 claims description 7
- 240000008397 Ganoderma lucidum Species 0.000 claims description 7
- 235000001637 Ganoderma lucidum Nutrition 0.000 claims description 7
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 7
- 240000003582 Platycodon grandiflorus Species 0.000 claims description 7
- 239000012467 final product Substances 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 3
- 235000019359 magnesium stearate Nutrition 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 238000010992 reflux Methods 0.000 claims description 3
- 238000005550 wet granulation Methods 0.000 claims description 3
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 240000004510 Agastache rugosa Species 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 208000002193 Pain Diseases 0.000 abstract description 12
- 230000036407 pain Effects 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 8
- 208000007882 Gastritis Diseases 0.000 abstract description 6
- 208000007107 Stomach Ulcer Diseases 0.000 abstract description 4
- 208000000718 duodenal ulcer Diseases 0.000 abstract description 4
- 201000005917 gastric ulcer Diseases 0.000 abstract description 4
- 230000002195 synergetic effect Effects 0.000 abstract description 2
- 229940126680 traditional chinese medicines Drugs 0.000 abstract description 2
- 241001163443 Daphne giraldii Species 0.000 abstract 2
- 241000007126 Codonopsis pilosula Species 0.000 abstract 1
- 241000222336 Ganoderma Species 0.000 abstract 1
- 244000274050 Platycodon grandiflorum Species 0.000 abstract 1
- 210000001156 gastric mucosa Anatomy 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 description 13
- 206010053155 Epigastric discomfort Diseases 0.000 description 8
- 235000012054 meals Nutrition 0.000 description 7
- 210000002784 stomach Anatomy 0.000 description 7
- 208000019901 Anxiety disease Diseases 0.000 description 6
- 230000001684 chronic effect Effects 0.000 description 6
- 201000006549 dyspepsia Diseases 0.000 description 6
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 235000013305 food Nutrition 0.000 description 5
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 4
- 241000245665 Taraxacum Species 0.000 description 4
- 206010047700 Vomiting Diseases 0.000 description 4
- 210000001015 abdomen Anatomy 0.000 description 4
- 210000000582 semen Anatomy 0.000 description 4
- 241000208340 Araliaceae Species 0.000 description 3
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 3
- 235000003140 Panax quinquefolius Nutrition 0.000 description 3
- 206010067171 Regurgitation Diseases 0.000 description 3
- 235000008434 ginseng Nutrition 0.000 description 3
- 206010000087 Abdominal pain upper Diseases 0.000 description 2
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 2
- 244000077995 Coix lacryma jobi Species 0.000 description 2
- 206010019375 Helicobacter infections Diseases 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 235000004347 Perilla Nutrition 0.000 description 2
- 244000124853 Perilla frutescens Species 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 230000001458 anti-acid effect Effects 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 208000024798 heartburn Diseases 0.000 description 2
- 210000004400 mucous membrane Anatomy 0.000 description 2
- 229940055726 pantothenic acid Drugs 0.000 description 2
- 235000019161 pantothenic acid Nutrition 0.000 description 2
- 239000011713 pantothenic acid Substances 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- 208000010470 Ageusia Diseases 0.000 description 1
- PTHCMJGKKRQCBF-UHFFFAOYSA-N Cellulose, microcrystalline Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC)C(CO)O1 PTHCMJGKKRQCBF-UHFFFAOYSA-N 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 240000002943 Elettaria cardamomum Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000576429 Forsythia suspensa Species 0.000 description 1
- 240000008669 Hedera helix Species 0.000 description 1
- 239000009636 Huang Qi Substances 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 244000197580 Poria cocos Species 0.000 description 1
- 235000008599 Poria cocos Nutrition 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000001354 calcination Methods 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 235000005300 cardamomo Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000002183 duodenal effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 235000015114 espresso Nutrition 0.000 description 1
- 239000000469 ethanolic extract Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 235000003642 hunger Nutrition 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 230000004682 mucosal barrier function Effects 0.000 description 1
- 230000009854 mucosal lesion Effects 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037351 starvation Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 210000002417 xiphoid bone Anatomy 0.000 description 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/83—Thymelaeaceae (Mezereum family), e.g. leatherwood or false ohelo
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- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A61K9/20—Pills, tablets, discs, rods
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- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention discloses tablets for treating peptic ulcer. The tablets are prepared by pressing 100 parts of granules and 1-5 parts of a lubricant both by weight, wherein the granules comprise the following raw materials: 1-3 parts of daphne giraldii nitsche, 7-13 parts of rhizoma atractylodis macrocephalae, 2-3 parts of lucid ganoderma, 5-10 parts of codonopsis pilosula, 5-10 parts of radix pseudostellariae, 5-10 parts of herba artemisiae capillariae, 5-10 parts of dandelion, 3-7 parts of platycodon grandiflorum, 3-7 parts of pogostemon cablin and 2-4 parts of netmeg. In the invention, by combining the daphne giraldii nitsche with other traditional Chinese medicines, synergistic effects are realized, and the tablets can effectively treat superficial gastritis, duodenal ulcer and gastric ulcer while realizing an ideal pain relieving effect and causing few side effects; and moreover, the tablets also have a good gastric mucosa repairing function, and a new option is provided for clinical medication.
Description
Technical field
Peptic ulcer tablet and preparation method thereof is treated the present invention relates to one kind.
Background technology
Peptic ulcer refers mainly to betide stomach and duodenal chronic ulcer.Wherein, taste-blindness rate refers to
The limitation circle or oval full-thickness defects of Grastiodudenal mucosa, muscularis mucosae are pierced, are inevitably stayed after healing
There is fibrous scar, surface is covered by one layer of epithelium, and muscularis mucosae can not regenerate.It is due to many reasons that its cause of disease is summed up
The self-digestion or gastric mucosal barrier of hydrochloric acid in gastric juice, pepsin to stomach lining is caused to be destroyed.Think in recent years the formation of ulcer with
Helicobacter pylori infection also has important relationship in stomach.
Chronic superficial gastritis is disease of the stomach lining in chronic superficial inflammation, is digestive system common disease, is belonged to chronic
One kind in gastritis.Can be because being addicted to drink, drink espresso, bile regurgitation, or because helicobacter pylori infections etc. cause.Patient can have difference
The indigestion symptom of degree, epigastric discomfort, secret anguish after such as taking food, with belch, nausea, pantothenic acid, occasionally there is vomiting.
The medicine of the above-mentioned disease of Current therapeutic is generally chemical drugs, and its is expensive, and side effect is big, and cures required time
It is long.Therefore, be badly in need of that a kind of economical and practical, toxic and side effect is low, and can the above-mentioned disease of rapid healing medicine.
And traditional Chinese medicine in terms of chronic disease is treated one to all playing an important role.Someone is with cardamom 10g, the bighead atractylodes rhizome
20g, Poria cocos 20g, Pogostemon cablin 15g, dandelion 15g, ginseng 5g, perilla leaf 10g, semen armeniacae amarae 10g, coix seed 20g, oriental wormwood 15g
Treatment peptic ulcer, with certain therapeutic effect.In Chinese patent 201110413686.3, there is provided a kind of drug activity
The medicine of good treatment peptic ulcer, by 20 parts of coix seed, 20 parts of Semen Benincasae, 15 parts of oriental wormwood, 15 parts of the bighead atractylodes rhizome, perilla leaf 10
Part, 10 parts of semen armeniacae amarae, 10 parts of Semen Lablab Album, 10 parts of nutmeg, 10 parts of the Radix Astragali, 5 parts of ginseng, 5 parts of the capsule of weeping forsythia are prepared from.But above-mentioned place
Square flavour of a drug are more, medicinal material large usage quantity, relatively costly.
However, Peptic Ulcers are large number of at present, supply falls short of demand for market medicine, therefore, exploitation one kind can have
The new pharmaceutical composition of effect treatment peptic ulcer seems particularly necessary.Meanwhile, traditional Chinese medicine mostly be based on decocting, but
Some active ingredients are not readily dissolved in water, and or lost during decocting, therefore, in order to better profit from herb resource, while
Need to study the preparation method of pharmaceutical composition.
The content of the invention
Peptic ulcer tablet is treated it is an object of the invention to provide one kind.
Peptic ulcer tablet is treated the invention provides one kind, it is by the weight portion of granule 100, the weight of lubricant 1~5
Amount part compacting is formed, wherein, granule is prepared by the following method：
Girald daphne bark 1-3 parts, bighead atractylodes rhizome 7-13 parts, ganoderma lucidum 2-3 parts, Radix Codonopsis 5-10 parts, radix pseudostellariae 5-10 parts, oriental wormwood 5-10 parts,
Dandelion 5-10 parts, balloonflower root 3-7 parts, Pogostemon cablin 3-7 parts, nutmeg 2-4 parts；55-95%v/v ethanol is first added to extract, filtering, alcohol
Extract is standby, and filter residue adds water decoction, merges alcohol extract and decocting liquid obtains final product extract；Microcrystalline cellulose is added in extract
Element, microcrystalline cellulose consumption is 1.0~5.0 times of medicinal substances extract dry weight, after being well mixed, is pelletized, and obtains final product particle.
Further, the proportioning of the bulk drug is as follows：Girald daphne bark 1-2 parts, bighead atractylodes rhizome 9-11 parts, ganoderma lucidum 2-3 parts, Radix Codonopsis 7-
8 parts, radix pseudostellariae 7-8 parts, oriental wormwood 7-8 parts, dandelion 9-10 parts, balloonflower root 3-5 parts, Pogostemon cablin 3-5 parts, nutmeg 3-4 parts.
Further, the proportioning of the bulk drug is as follows：2 parts of girald daphne bark, 10 parts of the bighead atractylodes rhizome, 3 parts of ganoderma lucidum, 8 parts of Radix Codonopsis, too
8 parts of son ginseng, 8 parts of oriental wormwood, 10 parts of dandelion, 5 parts of balloonflower root, 5 parts of Pogostemon cablin, 4 parts of nutmeg.
Further, the granule is by the following method prepared from：
First add 55-95%v/v ethanol to extract, filtering, alcohol extract is standby, and filter residue adds water decoctions, merge alcohol extract with
After decocting liquid, the thick paste that relative density is 1.22~1.25 (60 DEG C) is concentrated into, adds microcrystalline cellulose, wet granulation, i.e.,
Obtain granule.
Wherein, concentration of alcohol is 75~85%v/v, preferably 80%v/v.
Wherein, extracted 1~2 time using alcohol reflux, extracted 1~2 hour every time, medicinal material：Ethanol=1：8~12g/ml.
Wherein, extraction 2~3 times is added water to cook, add water 8~12 times of amounts every time, is decocted 20~40 minutes.
Wherein, the lubricant is selected from magnesium stearate or talcum powder.
Wherein, the lubricant quantity is 2~4 parts (it is 3 parts that lubricant is used in a specific embodiment of the invention).
After be applied in combination for girald daphne bark and other kinds of traditional Chinese medicines by the present invention, synergistic function is played, can effectively treated
Superficial gastritis, duodenal ulcer, gastric ulcer, analgesic effect are preferable, Small side effects, and with good gastric mucosal
Effect, for clinical application provides a kind of new selection.
Medicine preparation piece agent is easy to storage, transport and the packaging of product, while also allow for patient making by the present invention
With.
Specific embodiment
The preparation of the Tablets of embodiment 1
(1) granule is prepared
Girald daphne bark 2g, bighead atractylodes rhizome 10g, ganoderma lucidum 3g, Radix Codonopsis 8g, radix pseudostellariae 8g, oriental wormwood 8g, dandelion 10g, balloonflower root 5g, the wide leaves of pulse plants
Fragrant 5g, nutmeg 4g；First add 10 times and measure 80% ethanol solution refluxing extraction 1 time, extract 1 hour, filtering, filtrate is standby, filter residue
Boiled 2 times with decocting again, add water every time 8 times and measure, decocted 30 minutes every time, after merging ethanol extract and decocting liquid, be concentrated into phase
It is the thick paste of 1.22~1.25 (60 DEG C) to density, adds microcrystalline cellulose, microcrystalline cellulose consumption is dry for medicinal substances extract
1.0 times of weight, wet granulation, drying obtains final product granule of the present invention.
(2) tablet is prepared
The granule 1000g for preparing is taken, 30g magnesium stearates are added, after mixing, compressing tablet obtains final product tablet.
Model case 1
Lee, man, 26 years old, epigastric discomfort, companion's belch, pantothenic acid, idol had vomiting after feed, and symptoms last is existing 2 months.
After diagnosing, chronic superficial gastritis is confirmed as.
1 prescriptions of traditional Chinese medicine water decoction of embodiment is taken after 5 days, epigastric discomfort, belch remission, after 20 days, swollen sense, belch
Phenomenon is disappeared, and after 30 days, feels that appetite, stomach are felt good, and body weight is gone up.
Model case 2
Zhang, man 30 years old, epigastric discomfort after feed, has secret anguish sense, with belch phenomenon.Symptoms last is existing 1
Month.After diagnosing, chronic superficial gastritis is confirmed as.
1 prescriptions of traditional Chinese medicine water decoction of embodiment is taken after 7 days, epigastric discomfort, belch remission, without obvious secret anguish；15 days
Afterwards, swollen sense, belch phenomenon are disappeared, and after 25 days, stomach is felt good, and symptom disappears substantially.
Model case 3
Wang, man, 28 years old, upper abdomen cusalgia, in starvation, secret anguish is uncomfortable sometimes, can be alleviated by antiacid or feed, early
1~3 hour after the meal starts epigastric pain occur, to continue just to alleviate to lunch if not taking medicine or taking food, 2~4 hours after food
Pain, must also have meal to alleviate again.Above-mentioned symptom continues 2 months or so.After diagnosing, duodenal ulcer is confirmed as.
1 prescriptions of traditional Chinese medicine water decoction of embodiment is taken after 15 days, epigastric discomfort remission, after 30 days, symptom disappears substantially.
Subsequent January further consultation once, if not keeping on a diet, occasionally there is recurrence, takes medicine 3~7 days then without morbidity sign.
Model case 4
Certain is shut out, man, 22 years old, there is rest pain under slight or moderate xiphoid-process sometimes in upper abdomen dull pain or distending pain, can quilt
Antiacid or feed are alleviated, early to start epigastric pain occur within 1~3 hour after the meal, to continue to lunch if not taking medicine or taking food
Just alleviate, 2~4 hours and pain, must also have meal to alleviate after food.Above-mentioned symptom continues or so January.After diagnosing, 12 are confirmed as
Duodenalulcer.
1 prescriptions of traditional Chinese medicine water decoction of embodiment is taken after 10 days, epigastric discomfort, belch remission, without obvious secret anguish；15 days
Afterwards, swollen sense, belch phenomenon are disappeared, and after 25 days, stomach is felt good, and symptom disappears substantially.
Model case 5
Liu, man, 35 years old, upper abdomen secret anguish was alleviated after taking alkaline drug, and such pain has rhythmicity, more after the meal 1
Occur in hour, gradually alleviated after 1~2 hour, typically there is also sour regurgitation, belch, heartburn, Abdeminal pain, Nausea and vomiting
Deng indigestion symptom；Symptoms last is existing 2 months.After diagnosing, gastric ulcer is confirmed as.
1 prescriptions of traditional Chinese medicine water decoction of embodiment is taken after 10 days, the remission such as epigastric discomfort, belch, after 30 days, symptom base
This disappearance, through gastrocopy, mucosal lesion position significantly reduces, close to recovery from illness.
Model case 6
To certain, female, 25 years old, upper abdomen had calcination sample bitterly, takes and alleviate after alkaline drug, and pain is more to be gone out in 1 hour after the meal
It is existing, alleviate after meal, there is also the indigestion symptom such as sour regurgitation, belch, heartburn, Abdeminal pain, Nausea and vomiting；Symptom
Continue existing 2 months.After diagnosing, gastric ulcer is confirmed as.
1 prescriptions of traditional Chinese medicine water decoction of embodiment is taken after 15 days, burn feeling is relieved, without obvious pain；After 30 days, pain
Disappeared substantially with indigestion phenomenon.
Claims (8)
1. one kind treats peptic ulcer tablet, it is characterised in that：It is by the weight portion of granule 100, the weight of lubricant 1~5
Part compacting is formed, wherein, granule is prepared by the following method：
Girald daphne bark 1-3 parts, bighead atractylodes rhizome 7-13 parts, ganoderma lucidum 2-3 parts, Radix Codonopsis 5-10 parts, radix pseudostellariae 5-10 parts, oriental wormwood 5-10 parts, Pu Gong
English 5-10 parts, balloonflower root 3-7 parts, Pogostemon cablin 3-7 parts, nutmeg 2-4 parts；55-95%v/v ethanol is first added to extract, filtering, alcohol extract
Standby, filter residue adds water decoction, merges alcohol extract and decocting liquid obtains final product extract；Microcrystalline cellulose is added in extract, it is micro-
Crystalline cellulose consumption is 1.0~5.0 times of medicinal substances extract dry weight, after being well mixed, is pelletized, and obtains final product particle.
2. raw material according to claim 1, it is characterised in that：The proportioning of the bulk drug is as follows：Girald daphne bark 1-2 parts, it is white
Art 9-11 parts, ganoderma lucidum 2-3 parts, Radix Codonopsis 7-8 parts, radix pseudostellariae 7-8 parts, oriental wormwood 7-8 parts, dandelion 9-10 parts, balloonflower root 3-5 parts, it is wide
Wrinkled giant hyssop 3-5 parts, nutmeg 3-4 parts.
3. bulk drug according to claim 2, it is characterised in that：The proportioning of the bulk drug is as follows：It is 2 parts of girald daphne bark, white
10 parts of art, 3 parts of ganoderma lucidum, 8 parts of Radix Codonopsis, 8 parts of radix pseudostellariae, 8 parts of oriental wormwood, 10 parts of dandelion, 5 parts of balloonflower root, 5 parts of Pogostemon cablin, nutmeg 4
Part.
4. granule according to claims 1 to 3, it is characterised in that：The granule is by the following method prepared from：
55-95%v/v ethanol is first added to extract, filtering, alcohol extract is standby, and filter residue adds water decoction, merges alcohol extract and decocting
After liquid, the thick paste that relative density is 1.22~1.25 (60 DEG C) is concentrated into, adds microcrystalline cellulose, wet granulation is obtained final product
Granula.
5. the preparation method according to claim 1 or 4, it is characterised in that：Concentration of alcohol is 75~85%v/v, preferably
80%v/v；Extracted 1~2 time using alcohol reflux, extracted 1~2 hour every time, medicinal material：Ethanol=1：8~12g/ml.
6. preparation method according to claim 5, it is characterised in that：Extraction 2~3 times is added water to cook, 8~12 are added water every time
Measure again, decoct 20~40 minutes.
7. tablet according to claim 1, it is characterised in that：The lubricant is selected from magnesium stearate or talcum powder.
8. tablet according to claim 1, it is characterised in that：The lubricant quantity is 2~4 parts, preferably 3 parts.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105214035A (en) * | 2015-09-30 | 2016-01-06 | 成都恒凌科技有限公司 | One treats peptic ulcer tablet and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105214035A (en) * | 2015-09-30 | 2016-01-06 | 成都恒凌科技有限公司 | One treats peptic ulcer tablet and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 周秋丽等: "《现代中药基础研究与临床》", 30 June 2012, 天津科技翻译出版公司 * |
| 曾晓虎: "《中西汇通中药手册》", 31 May 2006, 人民军医出版社 * |
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Application publication date: 20170524 |