CN106389677A - Bismuth-containing medicine aqueous extract granule for curing peptic ulcer - Google Patents
Bismuth-containing medicine aqueous extract granule for curing peptic ulcer Download PDFInfo
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- CN106389677A CN106389677A CN201611074650.6A CN201611074650A CN106389677A CN 106389677 A CN106389677 A CN 106389677A CN 201611074650 A CN201611074650 A CN 201611074650A CN 106389677 A CN106389677 A CN 106389677A
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- 239000003814 drug Substances 0.000 title claims abstract description 24
- 239000008187 granular material Substances 0.000 title claims abstract description 15
- 208000008469 Peptic Ulcer Diseases 0.000 title claims abstract description 12
- 208000011906 peptic ulcer disease Diseases 0.000 title claims abstract description 12
- 229910052797 bismuth Inorganic materials 0.000 title abstract description 4
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 title abstract description 4
- 239000006286 aqueous extract Substances 0.000 title abstract 4
- 241001163443 Daphne giraldii Species 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 9
- 241000756943 Codonopsis Species 0.000 claims abstract description 8
- 241000222336 Ganoderma Species 0.000 claims abstract description 8
- 229920001353 Dextrin Polymers 0.000 claims abstract description 7
- 239000004375 Dextrin Substances 0.000 claims abstract description 7
- 235000019425 dextrin Nutrition 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- 239000000284 extract Substances 0.000 claims description 21
- 210000000582 semen Anatomy 0.000 claims description 14
- KZFDVWZZYOPBQZ-UHFFFAOYSA-K bismuth;potassium;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [K+].[Bi+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KZFDVWZZYOPBQZ-UHFFFAOYSA-K 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 8
- 238000000605 extraction Methods 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 6
- 239000000853 adhesive Substances 0.000 claims description 4
- 230000001070 adhesive effect Effects 0.000 claims description 4
- 235000014347 soups Nutrition 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 3
- 229920002472 Starch Polymers 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 239000011230 binding agent Substances 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 2
- 239000012467 final product Substances 0.000 claims description 2
- 238000011017 operating method Methods 0.000 claims description 2
- 239000002002 slurry Substances 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 7
- 208000007882 Gastritis Diseases 0.000 abstract description 6
- 229940079593 drug Drugs 0.000 abstract description 5
- 208000007107 Stomach Ulcer Diseases 0.000 abstract description 4
- 208000000718 duodenal ulcer Diseases 0.000 abstract description 4
- 201000005917 gastric ulcer Diseases 0.000 abstract description 4
- 210000001156 gastric mucosa Anatomy 0.000 abstract description 3
- 230000000202 analgesic effect Effects 0.000 abstract description 2
- 230000002195 synergetic effect Effects 0.000 abstract description 2
- 229940126680 traditional chinese medicines Drugs 0.000 abstract description 2
- ZQUAVILLCXTKTF-UHFFFAOYSA-H bismuth;tripotassium;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [K+].[K+].[K+].[Bi+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O ZQUAVILLCXTKTF-UHFFFAOYSA-H 0.000 abstract 2
- 235000009051 Ambrosia paniculata var. peruviana Nutrition 0.000 abstract 1
- 235000003097 Artemisia absinthium Nutrition 0.000 abstract 1
- 240000001851 Artemisia dracunculus Species 0.000 abstract 1
- 235000017731 Artemisia dracunculus ssp. dracunculus Nutrition 0.000 abstract 1
- 235000003261 Artemisia vulgaris Nutrition 0.000 abstract 1
- 244000274050 Platycodon grandiflorum Species 0.000 abstract 1
- 235000006753 Platycodon grandiflorum Nutrition 0.000 abstract 1
- 240000001949 Taraxacum officinale Species 0.000 abstract 1
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 abstract 1
- 239000001138 artemisia absinthium Substances 0.000 abstract 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 description 16
- 230000036407 pain Effects 0.000 description 16
- 208000024891 symptom Diseases 0.000 description 13
- 206010053155 Epigastric discomfort Diseases 0.000 description 8
- 235000012054 meals Nutrition 0.000 description 7
- 239000008194 pharmaceutical composition Substances 0.000 description 6
- 230000001684 chronic effect Effects 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 201000006549 dyspepsia Diseases 0.000 description 5
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 4
- 206010047700 Vomiting Diseases 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 241000208340 Araliaceae Species 0.000 description 3
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 3
- 235000003140 Panax quinquefolius Nutrition 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 235000008434 ginseng Nutrition 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 206010000087 Abdominal pain upper Diseases 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 2
- 206010019375 Helicobacter infections Diseases 0.000 description 2
- 206010067171 Regurgitation Diseases 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 229940069428 antacid Drugs 0.000 description 2
- 239000003159 antacid agent Substances 0.000 description 2
- 230000001458 anti-acid effect Effects 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 208000024798 heartburn Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 229940055726 pantothenic acid Drugs 0.000 description 2
- 235000019161 pantothenic acid Nutrition 0.000 description 2
- 239000011713 pantothenic acid Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- 208000010470 Ageusia Diseases 0.000 description 1
- 208000001387 Causalgia Diseases 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 208000023890 Complex Regional Pain Syndromes Diseases 0.000 description 1
- 240000008669 Hedera helix Species 0.000 description 1
- 239000009636 Huang Qi Substances 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 241001619461 Poria <basidiomycete fungus> Species 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 208000006766 bile reflux Diseases 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000001354 calcination Methods 0.000 description 1
- 208000014439 complex regional pain syndrome type 2 Diseases 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 235000015114 espresso Nutrition 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- 238000002575 gastroscopy Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000004682 mucosal barrier function Effects 0.000 description 1
- 230000009854 mucosal lesion Effects 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/83—Thymelaeaceae (Mezereum family), e.g. leatherwood or false ohelo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/245—Bismuth; Compounds thereof
-
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/30—Extraction of the material
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention discloses a bismuth-containing medicine aqueous extract granule for curing peptic ulcer. The bismuth-containing medicine aqueous extract granule is prepared from the following raw materials and an adjunct by weight: 0.2-0.4 part of colloidal bismuth subcitrate, 1-3 parts of daphne giraldii nitsche, 7-13 parts of rhizoma atractylodis, 2-3 parts of lucid ganoderma, 5-10 parts of radix codonopsis, 5-10 parts of radix pseudostellariae, 5-10 parts of virgate wormwood herb, 5-10 parts of dandelion, 3-7 parts of platycodon grandiflorum, 3-7 parts of herba pogostemonis, and 2-4 parts of netmeg. The adjunct is dextrin, and the use amount of the dextrin is 0.5-5 times the dry weight of an aqueous extract including the raw materials. After the multiple traditional Chinese medicines containing daphne giraldii nitsche are combined with colloidal bismuth subcitrate for use, the synergetic effect is achieved, the superficial gastritis, the duodenal ulcer and the gastric ulcer are effectively cured, the analgesic effect is ideal, the side effect is little, the effect of repairing gastric mucosa is excellent, and a new choice is provided for clinical medication.
Description
Technical field
The present invention relates to a kind of water extract granule treating peptic ulcer.
Background technology
Taste-blindness rate refers to that the limitation of Grastiodudenal mucosa is circular or oval full-thickness defects, mucosa flesh
Layer is pierced, and inevitably leaves fibrous scar, surface is covered by one layer of epithelium, and muscularis mucosae can not regenerate after healing.
It is because many reasons cause gastric acid, pepsin to the self-digestion of gastric mucosa or gastric mucosal barrier quilt that its cause of disease sums up
Destroy.Think that the formation of ulcer and gastric Helicobacter pylori infection also have important relationship in recent years.
Chronic superficial gastritiss are the diseases that gastric mucosa is in chronic superficial inflammation, are digestive system commonly encountered diseases, belong to chronic
One of gastritis.Can be because of be addicted to drink, drink espresso, bile reflux, or because helicobacter pylori infections etc. cause.Patient can have difference
The indigestion symptom of degree, epigastric discomfort, dull pain after such as taking food, with belch, nausea, pantothenic acid, occasionally there is vomiting.
The medicine of the above-mentioned disease of Current therapeutic mostly is chemical drugs, and it is expensive, large side effects, and cures required time
Long.Therefore, be badly in need of that a kind of economical and practical, toxic and side effects are low, and can the above-mentioned disease of rapid healing medicine.
And Chinese medicine in terms for the treatment of chronic disease one to all playing an important role.Someone is with Fructus Amomi Rotunduss 10g, the Rhizoma Atractylodis Macrocephalae
20g, Poria 20g, Herba Pogostemonis 15g, Herba Taraxaci 15g, Radix Ginseng 5g, Folium Perillae 10g, Semen Armeniacae Amarum 10g, Semen Coiciss 20g, Herba Artemisiae Scopariae 15g
Treatment peptic ulcer, has certain therapeutic effect.In Chinese patent 201110413686.3, there is provided a kind of drug activity
The medicine of good treatment peptic ulcer, by 20 parts of Semen Coiciss, 20 parts of Semen Benincasae, 15 parts of Herba Artemisiae Scopariae, 15 parts of the Rhizoma Atractylodis Macrocephalae, Folium Perillae 10
Part, 10 parts of Semen Armeniacae Amarum, 10 parts of Semen Lablab Album, 10 parts of Semen Myristicae, 10 parts of the Radix Astragali, 5 parts of Radix Ginseng, 5 parts of Fructus Forsythiae are prepared from.But above-mentioned place
Square flavour of a drug are more, medical material large usage quantity, relatively costly.
Content of the invention
It is an object of the invention to provide a kind of water extract granule treating peptic ulcer.
A kind of water extract granule treating peptic ulcer of the present invention, it is by the supplementary material preparation of following weight proportion
Form：
Bismuth potassium citrate 0.2-0.4 part, Daphne giraldii Nitsche 1-3 part, Rhizoma Atractylodis Macrocephalae 7-13 part, Ganoderma 2-3 part, Radix Codonopsis 5-10 part, crown prince
Ginseng 5-10 part, Herba Artemisiae Scopariae 5-10 part, Herba Taraxaci 5-10 part, Radix Platycodoniss 3-7 part, Herba Pogostemonis 3-7 part, Semen Myristicae 2-4 part；
Adjuvant：Dextrin, its consumption is 0.5～5 times of water extract of TCM dry weight.
Further, raw material weight proportioning of soup processed is as follows：
0.3 part of bismuth potassium citrate, Daphne giraldii Nitsche 1-2 part, Rhizoma Atractylodis Macrocephalae 9-11 part, Ganoderma 2-3 part, Radix Codonopsis 7-8 part, Radix Pseudostellariae 7-8
Part, Herba Artemisiae Scopariae 7-8 part, Herba Taraxaci 9-10 part, Radix Platycodoniss 3-5 part, Herba Pogostemonis 3-5 part, Semen Myristicae 3-4 part.
Further, raw material weight proportioning of soup processed is as follows：
2 parts of Daphne giraldii Nitsche, 10 parts of the Rhizoma Atractylodis Macrocephalae, 3 parts of Ganoderma, 8 parts of Radix Codonopsis, 8 parts of Radix Pseudostellariae, 8 parts of Herba Artemisiae Scopariae, 10 parts of Herba Taraxaci, Radix Platycodoniss 5
Part, 5 parts of Herba Pogostemonis, 4 parts of Semen Myristicae.
Wherein, water extract preparation method is as follows：
Take Chinese medicine, add water to cook extraction 3 times, add 4～15 times of water every time, extract 5～20min, second and third time for the first time
Extract 10～30min, merge decocting liquid, you can.
Present invention also offers the preparation of above-mentioned capsule, it includes following operating procedure：
(1) weigh supplementary material by weight ratio；
(2) take Chinese medicine, add water to cook extraction 3 times, add 4～15 times of water every time, for the first time extraction 5～20min, second,
Three extraction 10～30min, merge decocting liquid, concentrate, be dried, obtain dry extract standby；
(3) take dry extract, add bismuth potassium citrate, dextrin and suitable amount of adhesive, prepare granule, obtain final product granule.
Wherein, described adhesive is selected from water, ethanol water or starch slurry.
Present invention also offers purposes in the medicine of preparation treatment peptic ulcer for the said extracted composition granule agent.
After kinds of traditional Chinese medicines containing Daphne giraldii Nitsche and bismuth potassium citrate are applied in combination by the present invention, play Synergistic work
With, energy effectively treatment superficial gastritiss, duodenal ulcer, gastric ulcer, analgesic effect is preferable, Small side effects, and has good
Good gastric mucosal effect, is that clinical application provides a kind of new selection.
The present invention adopts decocting technique, can simply, safely prepare the definite medicine for the treatment of peptic ulcer drug effect
Thing or extract, are conducive to the saving of production cost, and are easy to industrialized production.
Medicated powder is prepared into granule by the present invention, that is, be easy to storage, transport and the packaging of product, and also allow for patient makes simultaneously
With.
Specific embodiment
The preparation of embodiment 1 medicine of the present invention
Take Daphne giraldii Nitsche 2g, Rhizoma Atractylodis Macrocephalae 10g, Ganoderma 3g, Radix Codonopsis 8g, Radix Pseudostellariae 8g, Herba Artemisiae Scopariae 8g, Herba Taraxaci 10g, Radix Platycodoniss 5g, wide
Herba Pogostemoniss 5g, Semen Myristicae 4g.Add water to cook 3 times, add 10 times amount decoctings for the first time and boil 5 minutes, add 8 times amount decoctings second and boil 10 points
Clock, third time plus 8 times amount decoctings boil 15 minutes, filter, and merge decocting liquid.
Water intaking decocting liquid, concentrate, be dried after, add 0.5～5 times of dry extract weight dextrin, bismuth potassium citrate 0.3g mixing,
With water as binding agent, prepare granule.
Model case 1
Zhang, female, 36 years old, after feed, epigastric discomfort, companion's belch, pantothenic acid, idol had vomiting, existing 3 months of symptoms last,
Weight loss is obvious.After diagnosing, chronic superficial gastritiss are confirmed as.
Take embodiment 1 pharmaceutical composition after 3 days, epigastric discomfort, belch remission, after 15 days, swollen sense, belch phenomenon
Disappear, after 20 days, stomach is felt good, body weight is gone up.
Model case 2
Pay certain, man, 29 years old, epigastric discomfort after feed, there is dull pain sense, with belch phenomenon.Existing 1 of symptoms last
Month.After diagnosing, chronic superficial gastritiss are confirmed as.
Take embodiment 1 pharmaceutical composition after 3 days, epigastric discomfort, belch remission, no obvious dull pain；After 10 days, stomach
Portion feels good, and symptom disappears substantially.
Model case 3
Slowly certain, female, 31 years old, epigastrium causalgia, can by antacid or feed alleviate, upper abdominal pain is more obvious after the meal, if not
Medication or feed then will continue just to alleviate to lunch, and after food, 2～4 hours and pain, also must have meal to alleviate.Above-mentioned symptom continues
1 month about.After diagnosing, confirm as duodenal ulcer.
Take embodiment 1 pharmaceutical composition after 3 days, epigastric discomfort remission, after 20 days, symptom disappears substantially.
Model case 4
Permitted certain, female, 25 years old, epigastrium dull pain or distending pain, can be alleviated by antacid or feed, occur within 1～3 hour after the meal on
Stomachache, if do not taken medicine or taking food, continue just to alleviate to lunch, and after food, 2～4 hours and pain, also must have meal to alleviate.On
State symptoms last 2 months about.After diagnosing, confirm as duodenal ulcer.
Take embodiment 1 pharmaceutical composition after 5 days, epigastric discomfort, belch remission, no obvious dull pain；After 25 days, stomach
Portion feels good, and symptom disappears substantially.
Model case 5
Lee, man, 25 years old, upper abdomen dull pain, take and alleviate after alkalescent medicine, such pain has a rhythmicity, how after the meal 1
Occur in hour, gradually alleviated after 1～2 hour, typically there is also acid regurgitation, belch, heartburn, Abdeminal pain, Nausea and vomiting
Deng indigestion symptom；Existing 1 month of symptoms last.After diagnosing, confirm as gastric ulcer.
Take embodiment 1 pharmaceutical composition after 3 days, the remission such as epigastric discomfort, belch, after 25 days, symptom disappears substantially
Lose, through gastroscopy, mucosal lesion position significantly reduces, close to recovery from illness.
Model case 6
Slowly certain, southern, 30 years old, and upper abdomen has calcination sample pain, alleviates after taking alkalescent medicine, and pain is many to be gone out in after the meal 1 hour
Existing, alleviate after meal, there is also acid regurgitation, belch, the heartburn, indigestion symptom such as Abdeminal pain, Nausea and vomiting；Symptom
Continue existing 3 months.After diagnosing, confirm as gastric ulcer.
Take embodiment 1 pharmaceutical composition after 7 days, burn feeling is relieved, no obvious pain；After 40 days, pain and disappearing
Change bad phenomenon substantially to disappear.
Claims (7)
1. a kind of water extract granule treating peptic ulcer it is characterised in that：It is by the supplementary material of following weight proportion
It is prepared from：
Bismuth potassium citrate 0.2-0.4 part, Daphne giraldii Nitsche 1-3 part, Rhizoma Atractylodis Macrocephalae 7-13 part, Ganoderma 2-3 part, Radix Codonopsis 5-10 part, Radix Pseudostellariae 5-
10 parts, Herba Artemisiae Scopariae 5-10 part, Herba Taraxaci 5-10 part, Radix Platycodoniss 3-7 part, Herba Pogostemonis 3-7 part, Semen Myristicae 2-4 part；
Adjuvant：Dextrin, its consumption is 0.5～5 times of water extract of TCM dry weight.
2. raw material according to claim 1 it is characterised in that：Raw material weight proportioning of soup processed is as follows：
0.3 part of bismuth potassium citrate, Daphne giraldii Nitsche 1-2 part, Rhizoma Atractylodis Macrocephalae 9-11 part, Ganoderma 2-3 part, Radix Codonopsis 7-8 part, Radix Pseudostellariae 7-8 part, mattress
Old 7-8 part, Herba Taraxaci 9-10 part, Radix Platycodoniss 3-5 part, Herba Pogostemonis 3-5 part, Semen Myristicae 3-4 part.
3. raw material according to claim 2 it is characterised in that：Raw material weight proportioning of soup processed is as follows：
2 parts of Daphne giraldii Nitsche, 10 parts of the Rhizoma Atractylodis Macrocephalae, 3 parts of Ganoderma, 8 parts of Radix Codonopsis, 8 parts of Radix Pseudostellariae, 8 parts of Herba Artemisiae Scopariae, 10 parts of Herba Taraxaci, 5 parts of Radix Platycodoniss,
5 parts of Herba Pogostemonis, 4 parts of Semen Myristicae.
4. raw material according to claims 1 to 3 it is characterised in that：Water extract preparation method is as follows：
Take Chinese medicine, add water to cook extraction 3 times, add 4～15 times of water every time, extract 5～20min, second and third extraction for the first time
10～30min, merges decocting liquid, you can.
5. capsule described in claim 1 preparation it is characterised in that：It includes following operating procedure：
(1) weigh supplementary material by weight ratio；
(2) take Chinese medicine, add water to cook extraction 3 times, add 4～15 times of water every time, extract 5～20min, second and third time for the first time
Extract 10～30min, merge decocting liquid, concentrate, be dried, obtain dry extract standby；
(3) take dry extract, add bismuth potassium citrate, dextrin and suitable amount of adhesive, prepare granule, obtain final product granule.
6. binding agent according to claim 6 it is characterised in that：Described adhesive is selected from water, ethanol water or starch
Slurry.
7. purposes in the medicine of preparation treatment peptic ulcer for the extract particles agent described in claim 1.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201611074650.6A CN106389677A (en) | 2016-11-30 | 2016-11-30 | Bismuth-containing medicine aqueous extract granule for curing peptic ulcer |
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| CN201611074650.6A CN106389677A (en) | 2016-11-30 | 2016-11-30 | Bismuth-containing medicine aqueous extract granule for curing peptic ulcer |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105214031A (en) * | 2015-09-30 | 2016-01-06 | 成都恒凌科技有限公司 | A kind of water extract granule for the treatment of peptic ulcer |
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2016
- 2016-11-30 CN CN201611074650.6A patent/CN106389677A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105214031A (en) * | 2015-09-30 | 2016-01-06 | 成都恒凌科技有限公司 | A kind of water extract granule for the treatment of peptic ulcer |
Non-Patent Citations (3)
| Title |
|---|
| 周秋丽等: "《现代中药基础研究与临床》", 30 June 2012, 天津科技翻译出版公司 * |
| 张先家等: "《老年临床药物治疗学》", 31 July 2014, 科学技术文献出版社 * |
| 曾晓虎: "《中西汇通中药手册》", 31 May 2006, 人民军医出版社 * |
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