CN106692059A - 一种低氧响应脂质体药物载体及其制备方法与应用 - Google Patents
一种低氧响应脂质体药物载体及其制备方法与应用 Download PDFInfo
- Publication number
- CN106692059A CN106692059A CN201710115777.6A CN201710115777A CN106692059A CN 106692059 A CN106692059 A CN 106692059A CN 201710115777 A CN201710115777 A CN 201710115777A CN 106692059 A CN106692059 A CN 106692059A
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- Prior art keywords
- hypoxemia
- drug carrier
- antineoplastic
- lipidosome
- phosphatide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CN*=C[*@](C*)CC=CCCCCCCCCC[n]1c([N+]([O-])=O)ncc1 Chemical compound CN*=C[*@](C*)CC=CCCCCCCCCC[n]1c([N+]([O-])=O)ncc1 0.000 description 1
- GSVAHSSNGLDEIT-UHFFFAOYSA-N NC1C=CC(COC(CNCCCCCCCCCCCCNC([IH][IH]Cc(cc2)ccc2N=O)=O)=O)=CC1 Chemical compound NC1C=CC(COC(CNCCCCCCCCCCCCNC([IH][IH]Cc(cc2)ccc2N=O)=O)=O)=CC1 GSVAHSSNGLDEIT-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (13)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201710115777.6A CN106692059B (zh) | 2017-03-01 | 2017-03-01 | 一种低氧响应脂质体药物载体及其制备方法与应用 |
Applications Claiming Priority (1)
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CN201710115777.6A CN106692059B (zh) | 2017-03-01 | 2017-03-01 | 一种低氧响应脂质体药物载体及其制备方法与应用 |
Publications (2)
Publication Number | Publication Date |
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CN106692059A true CN106692059A (zh) | 2017-05-24 |
CN106692059B CN106692059B (zh) | 2019-08-23 |
Family
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CN201710115777.6A Active CN106692059B (zh) | 2017-03-01 | 2017-03-01 | 一种低氧响应脂质体药物载体及其制备方法与应用 |
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CN (1) | CN106692059B (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109010311A (zh) * | 2018-09-28 | 2018-12-18 | 中国人民解放军陆军军医大学 | 一种活性氧响应性莫西沙星纳米制剂及其制备方法 |
CN110172403A (zh) * | 2019-04-28 | 2019-08-27 | 青岛大学附属医院 | 280nm LED UV低氧条件下在恶性肿瘤自体移植体外净化中的应用 |
CN111296426A (zh) * | 2020-03-31 | 2020-06-19 | 大连理工大学 | 以非磷脂类脂质体作为载体的纳米农药剂型的制备方法及其应用 |
CN111743861A (zh) * | 2020-07-15 | 2020-10-09 | 南通大学 | 靶向三阴性乳腺癌的低氧响应手性药物胶束及其制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105534908A (zh) * | 2016-01-15 | 2016-05-04 | 徐州医学院 | 一种包载核酸药物的具缺氧响应能力和放疗增敏功能脂质体 |
-
2017
- 2017-03-01 CN CN201710115777.6A patent/CN106692059B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105534908A (zh) * | 2016-01-15 | 2016-05-04 | 徐州医学院 | 一种包载核酸药物的具缺氧响应能力和放疗增敏功能脂质体 |
Non-Patent Citations (1)
Title |
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HONGMEI LIU, ET.AL: "Development of a hypoxia-triggered and hypoxic radiosensitized liposome as a doxorubicin carrier to promote synergetic chemo-/radio-therapy for glioma", 《BIOMATERIALS》 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109010311A (zh) * | 2018-09-28 | 2018-12-18 | 中国人民解放军陆军军医大学 | 一种活性氧响应性莫西沙星纳米制剂及其制备方法 |
CN110172403A (zh) * | 2019-04-28 | 2019-08-27 | 青岛大学附属医院 | 280nm LED UV低氧条件下在恶性肿瘤自体移植体外净化中的应用 |
CN111296426A (zh) * | 2020-03-31 | 2020-06-19 | 大连理工大学 | 以非磷脂类脂质体作为载体的纳米农药剂型的制备方法及其应用 |
CN111296426B (zh) * | 2020-03-31 | 2021-09-24 | 大连理工大学 | 以非磷脂类脂质体作为载体的纳米农药剂型的制备方法及其应用 |
CN111743861A (zh) * | 2020-07-15 | 2020-10-09 | 南通大学 | 靶向三阴性乳腺癌的低氧响应手性药物胶束及其制备方法 |
CN111743861B (zh) * | 2020-07-15 | 2022-01-28 | 南通大学 | 靶向三阴性乳腺癌的低氧响应手性药物胶束及其制备方法 |
Also Published As
Publication number | Publication date |
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CN106692059B (zh) | 2019-08-23 |
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Inventor after: Chen Zhongping Inventor after: Li Yi Inventor after: Zhu Li Inventor after: Liu Yifei Inventor after: Chen Qiuping Inventor after: Zhao Yue Inventor after: Cao Mingxiang Inventor before: Chen Zhongping Inventor before: Li Yi Inventor before: Liu Yifei Inventor before: Chen Qiuping Inventor before: Zhao Yue Inventor before: Cao Mingxiang Inventor before: Zhu Li |
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Effective date of registration: 20201203 Address after: Room 2401, 4 / F, building 7, No. 99, Kechuang 14th Street, Beijing Economic and Technological Development Zone, Daxing District, Beijing Patentee after: Beijing huanuotai Biomedical Technology Co., Ltd Address before: 226019 Jiangsu city of Nantong province sik Road No. 9 Patentee before: NANTONG University |
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