CN106665606A - Compound thiadiazole plant fungicide - Google Patents
Compound thiadiazole plant fungicide Download PDFInfo
- Publication number
- CN106665606A CN106665606A CN201611218616.1A CN201611218616A CN106665606A CN 106665606 A CN106665606 A CN 106665606A CN 201611218616 A CN201611218616 A CN 201611218616A CN 106665606 A CN106665606 A CN 106665606A
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- China
- Prior art keywords
- compound
- thiadiazoles
- bactericide
- thiadiazole
- zinc thiazole
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
A compound thiadiazole plant fungicide is characterized by being prepared from at least one auxiliary applicable to the plant fungicide as well as zinc thiazole and 4-methyl-1,2,3-thiadiazole-5-o-cresol formate, wherein the mass ratio of zinc thiazole to 4-methyl-1,2,3-thiadiazole-5-o-cresol formate is 1:(0.05-0.07), the compound thiadiazole plant fungicide is a dry suspension, and the total mass of zinc thiazole and the compound (II) is 15%-30% of the total mass of the compound thiadiazole plant fungicide.
Description
Technical field
The present invention relates to a kind of plant antibacterial.
Background technology
2- amino -5- sulfydryl -1,3,4- thiadiazoles zinc (Chinese name zinc thiazole) are a kind of plant antibacterial, are widely used in
The preventing and treating of the plant diseases such as bacterial blight of rice, but through research discovery, zinc thiazole or a kind of thyroid interferent, Neng Gouyin
The parathyroid tissue hypertrophy of laboratory animal is played, and finds that its toxicity has obvious dosage effect dependency under study for action.As
A kind of pesticide, can have undesirable effect to the health of user, and will also result in pollution in the environment.Therefore its poison how is reduced
Property, or in the case where prevention effect is not affected, its consumption is reduced, become problem demanding prompt solution in prior art.
Chinese patent CN2010101798244 is disclosed:4- methyl isophthalic acids, 2,3- thiadiazoles -5- formic acid orthoresol esters and its
Preparation method, and point out that its compound has to tobacco mosaic virus (TMV) and other various pathogen in follow-up pharmacological evaluation
Certain bacteriostatic activity.
The content of the invention
To solve aforementioned technical problem, technical scheme below is present invention employs:There is provided compound recipe thiadiazoles plant sterilization
Agent, is characterized in that described compositionss are 1 by least one adjuvant suitable for bactericide and mass ratio:0.05~0.07
2- amino -5- sulfydryl -1,3,4- thiadiazoles zinc (common first names zinc thiazole, abbreviation compound (I)) and 4- methyl isophthalic acids, 2,3- thiophenes two
Azoles -5- formic acid orthoresol esters (abbreviation compound (II)) and composition.The chemical formula of the compound (II) is as follows:
Described compound recipe thiadiazoles bactericide, is characterized in that dosage form is dry suspending agent, compound (I) and compound
(II) gross mass accounts for the 15%~30% of the compound recipe thiadiazoles bactericide gross mass.
Described compound recipe thiadiazoles bactericide, preferably dry suspending agent, the adjuvant for dry suspending agent by point
The filler composition of powder, wetting agent, disintegrating agent, binding agent, defoamer, water and surplus,
One or more of the disintegrating agent in carbamide, Sodium Chloride, sulfate.
The dispersant is selected from sodium lignin sulfonate, APES formaldehyde condensation product, aliphatic alcohol polyethenoxy
One kind in ether sulfate and alkylphenol polyoxyethylene succinate sulfonate
The defoamer is selected from organosiloxane, the fatty acid ester compounded thing of higher alcohols, the representative examples of saturated aliphatic carboxylic of C10~C20
One or more in acid and C10~C20 representative examples of saturated aliphatic carboxylic esters.
The binding agent is selected from one or more in gelatin, arabic gum, polyvinyl alcohol, macrogol and starch.
The wetting agent includes sodium lauryl sulphate, Negel formaldehyde condensation products and alkylphenol-polyethenoxy base
One or more in ether.
Described filler is Kaolin, kieselguhr, bentonite, attapulgite, Pulvis Talci, starch, glucose, sulfur selected from filler
At least one in sour sodium, precipitated calcium carbonate.The water content of the dry suspension is 0.2~0.5%.
Under study for action it was found that working as zinc thiazole (I) and 4- methyl isophthalic acids, 2,3- thiadiazoles -5- formic acid orthoresol esters
(II) when carrying out compatibility with special ratios, the bacteriostatic activity of zinc thiazole can be significantly improved.Acute toxicity to compound (II)
Detection shows its category low toxicity compounds, and the side effect of athyreosis interference.In compound (II) itself to bacterial blight of rice
In the case of having no obvious prevention effect, the present invention provide compound recipe thiadiazoles bactericide, by preferred zinc thiazole (I) with
The ratio of compound (II), can increase substantially the bacteriostatic activity of compositionss in the case where minority specioz (II) is added.
Usage amount of the zinc thiazole when being administered can be substantially reduced.So as to reduce zinc thiazole to the pollution of environment and to user health
The harmful effect for causing.We have found especially that in an experiment, only when the ratio that zinc thiazole and compound (II) are provided with the present invention
When, its antibacterial effect can be significantly improved, and higher or lower compound (II) addition cannot all produce the effect.
Specific embodiment
The compound recipe thiadiazoles bactericide that the present invention is provided, preparation becomes dry suspension, by compound (I), compound
(II) constitute with least one adjuvant suitable for dry suspension.The formula of the compositionss is respectively such as embodiment 1~4 in following table
Shown (percentage ratio shown in table is the mass percent for accounting for compositionss gross mass):
The compound method of the compositionss is:
1) component respectively than water according to proportioning is added to into dosage bunker and adds water to pulpous state, stirred;
2) coarse pulverization is carried out using high-speed shearing machine, is crushed to granularity for 100~200 mesh;
3) adopt sand mill sand milling to granularity for 8000~10000 mesh after coarse pulverization;
4) pressure spray drying tower drying, pelletize are sent into after sand milling, the satisfactory particle diameter of water content is obtained for 80~100
The hollow perforate spherical particle of purpose.
Filler is Kaolin, and disintegrating agent is carbamide, dispersant is alkylphenol polyoxyethylene succinate sulfonate, moistening
Agent is sodium lauryl sulphate, and binding agent is polyvinyl alcohol, and defoamer is organosiloxane.
Prevention effect is tested
The compound (I) and compound (II) of bacterium method for measuring test different proportion are connect to the white leaf of Oryza sativa L. with field leaf-cutting
The prevention effect of rot, experimental procedure is as follows
1st, the rice leaf spot bacteria strain provided using Institute of Plant Protection of academy of agricultural sciences of Zhejiang Province, culture becomes 109The suspension of individual/ml
Afterwards, Oryza sativa L. 3~4cm of blade tip is deducted with the dissecting scissorss for being moistened with bacterium solution, 20 rice leaves of per group of selection are prevented in 7 days sprays after bacterium are connect
Control, 10 days prevention effects of the examination compared with matched group (prevention effect is calculated with Spot expansion) and using Excel pair after administration
Experimental result carries out t inspections
2nd, packet see the table below (means ± s, n=20) with administration and effect situation
By above-mentioned each group medicine, experimental group 1~4 and negative control 1 are by dry suspension obtained in each embodiment according to thiazole
Zinc final concentration 200ppm is diluted, and negative control 2 prepares 4- methyl isophthalic acids, 2,3- thiadiazoles -5- formic acid orthoresol ester (II)
Become 20% dry suspension, and be diluted to final concentration 200ppm, positive controls adopt the dry suspension for being added without active component,
1000 times of dilute.
Test result indicate that, the compound recipe thiadiazoles bactericide that the present invention is provided, by preferred specific zinc thiazole (I)
With the ratio of compound (II), effect when zinc thiazole is prevented and treated for bacterial blight of rice can be significantly improved.With using existing
1 group of the negative control of zinc thiazole is compared, and the prevention effect of each experimental group is significantly increased (P < 0.01).In further experiment
It was found that, when compound (II) is administered alone, to bacterial blight of rice almost without prevention effect.
Claims (3)
1. compound recipe thiadiazoles bactericide, is characterized in that described compositionss by least one suitable for the auxiliary of bactericide
Material and mass ratio are 1:0.05~0.07 zinc thiazole and 4- methyl isophthalic acids, 2,3- thiadiazoles -5- formic acid orthoresols esters composition is described
Compound (II) chemical formula is as follows:
2. compound recipe thiadiazoles bactericide as claimed in claim 1, is characterized in that the bactericide is dry suspending agent,
Zinc thiazole accounts for the 15%~30% of the compound recipe thiadiazoles bactericide gross mass with the gross mass of compound (II).
3. compound recipe thiadiazoles bactericide as claimed in claim 2, it is characterized in that the adjuvant for dry suspending agent by
The filler composition of dispersant, wetting agent, disintegrating agent, binding agent, defoamer, water and surplus, described filler is kaolinite selected from filler
Soil.
Priority Applications (1)
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CN201611218616.1A CN106665606A (en) | 2016-12-26 | 2016-12-26 | Compound thiadiazole plant fungicide |
Applications Claiming Priority (1)
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CN201611218616.1A CN106665606A (en) | 2016-12-26 | 2016-12-26 | Compound thiadiazole plant fungicide |
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CN106665606A true CN106665606A (en) | 2017-05-17 |
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CN201611218616.1A Pending CN106665606A (en) | 2016-12-26 | 2016-12-26 | Compound thiadiazole plant fungicide |
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1180297A (en) * | 1995-03-31 | 1998-04-29 | 日本农药株式会社 | Agricultural and horticultural disease controller and method for controlling diseases |
CN101194611A (en) * | 2007-06-08 | 2008-06-11 | 浙江新农化工股份有限公司 | Thiazole zincium suspension agent and method for producing the same |
CN101845029A (en) * | 2010-05-24 | 2010-09-29 | 南开大学 | 4-methyl-1,2,3-tiadiazoline-5-formic ether compounds and preparation method and application thereof |
-
2016
- 2016-12-26 CN CN201611218616.1A patent/CN106665606A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1180297A (en) * | 1995-03-31 | 1998-04-29 | 日本农药株式会社 | Agricultural and horticultural disease controller and method for controlling diseases |
CN101194611A (en) * | 2007-06-08 | 2008-06-11 | 浙江新农化工股份有限公司 | Thiazole zincium suspension agent and method for producing the same |
CN101845029A (en) * | 2010-05-24 | 2010-09-29 | 南开大学 | 4-methyl-1,2,3-tiadiazoline-5-formic ether compounds and preparation method and application thereof |
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Application publication date: 20170517 |
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