CN106719712A - Compound thiazole Zn composition and bactericide - Google Patents
Compound thiazole Zn composition and bactericide Download PDFInfo
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- CN106719712A CN106719712A CN201611099470.3A CN201611099470A CN106719712A CN 106719712 A CN106719712 A CN 106719712A CN 201611099470 A CN201611099470 A CN 201611099470A CN 106719712 A CN106719712 A CN 106719712A
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- compound
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- thiazole
- amino
- thiadiazoles
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
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- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to bactericide field, more particularly to a kind of compound thiazole Zn composition and bactericide.Described compound thiazole Zn composition is by mass ratio 1:The 0.05 0.2 thiadiazoles zinc of 2 amino, 5 sulfydryl 1,3,4 and 1 (2 aminoethyl) amino 9,10 anthraquinone join the formamide composition of 4 methyl, 1,2,3 thiadiazoles 5.When by the sulfydryl 1 of 2 amino of compound 5,3,4 thiadiazoles zinc (hereinafter referred to as compound (I)) and 1 (2 aminoethyl) amino 9,10 anthraquinones join 4 methyl 1,2, when the formamide of 3 thiadiazoles 5 (hereinafter referred to as compound II) carries out compatibility with special ratios, the bacteriostatic activity of zinc thiazole can be significantly improved.Acute toxicity detection to compound (II) simultaneously shows that the compound belongs to low toxicity compounds, and its acute toxicity is basically identical with zinc thiazole.And the side effect of athyreosis interference.
Description
Technical field
The invention belongs to bactericide field, more particularly to a kind of compound thiazole Zn composition and bactericide.
Background technology
2- amino -5- sulfydryl -1,3,4- thiadiazoles zinc (Chinese name zinc thiazole) are a kind of plant bactericide, are widely used in
The preventing and treating of the plant diseases such as bacterial blight of rice, but by research discovery, zinc thiazole or a kind of thyroid interferent, Neng Gouyin
The parathyroid tissue hyperplasia of experimental animal is played, and finds that its toxicity has obvious dosage effect correlation under study for action.As
A kind of agricultural chemicals, can have undesirable effect, and will also result in pollution in the environment to the health of user.Therefore its poison how is reduced
Property, or in the case where prevention effect is not influenceed, its consumption is reduced, as problem demanding prompt solution in the prior art.
Chinese patent literature CN102718731A is disclosed：1- (2- aminoethyls) amino -9,10- anthraquinones join 4- methyl isophthalic acids,
2,3- thiadiazoles -5- formamides and preparation method thereof, and point out its compound to pathogenic in follow-up pharmacological evaluation
Fungi has certain bacteriostatic activity, but unobvious.
The content of the invention
Defect it is an object of the invention to overcome prior art, there is provided a kind of compound thiazole Zn composition and plant
Bactericide.
To realize the purpose of the present invention, the technical scheme for being used for：
A kind of compound thiazole Zn composition, by mass ratio 1:2- amino -5- sulfydryl -1,3,4- thiadiazoles the zinc of 0.05-0.2
Join 4- methyl isophthalic acids, 2,3- thiadiazoles -5- formamides composition with 1- (2- aminoethyls) amino -9,10- anthraquinones.
Preferably, described 2- amino -5- sulfydryl -1,3,4- thiadiazoles zinc and 1- (2- aminoethyls) Amino-9,10-anthraquinone
Connection 4- methyl isophthalic acids, the mass ratio of 2,3- thiadiazoles -5- formamides is 1:0.08-0.15.
Present invention additionally comprises a kind of bactericide, including described compound thiazole Zn composition.
Wherein, the formulation of described bactericide is in emulsifiable concentrate, wettable powder, dry suspending agent, soluble powder
One kind.
Preferably, formulation is dry suspending agent, including compound thiazole Zn composition and auxiliary material, and compound thiazole Zn composition
The ratio for accounting for bactericide gross mass is 10%-40%.
Described auxiliary material includes dispersant, wetting agent, disintegrant, binding agent, defoamer, water and filler.
The disintegrant is selected from the one kind or several in urea, sodium chloride, sulfate, carbonate and sodium carboxymethylcellulose
Kind.
The dispersant is selected from sodium lignin sulfonate, calcium lignosulfonate, polycarboxylate, APES formaldehyde
One kind in condensation product, fatty alcohol polyoxyethylene ether sulfate and APES succinate sulfonate.
The defoamer is selected from organosiloxane, the fatty acid ester compounded thing of higher alcohols, organic silicone, the fat of C8~C10
One or more in alcohol, the representative examples of saturated aliphatic carboxylic of C10~C20 and C10~C20 representative examples of saturated aliphatic carboxylic esters.
The binding agent is selected from one or more in gelatin, Arabic gum, polyvinyl alcohol, macrogol and starch.
The wetting agent includes lauryl sodium sulfate, neopelex, Negel, alkyl naphthalene sulfonic acid
One or more in sodium formaldehyde condensation product and alkylphenol-polyethenoxy base ether.
It is kaolin, diatomite, bentonite, attapulgite, talcum powder, starch, glucose, sulphur that described filler is selected from filler
At least one in sour sodium, precipitated calcium carbonate.
Compared with prior art, the beneficial effects of the invention are as follows：
Under study for action it was found that when by compound 2- amino -5- sulfydryl -1,3,4- thiadiazoles zinc (hereinafter referred to as chemical combination
Thing (I)) and 1- (2- aminoethyls) amino -9,10- anthraquinones connection 4- methyl isophthalic acids, 2,3- thiadiazoles -5- formamides (hereinafter referred to as chemical combination
Thing II) when carrying out compatibility with special ratios, the bacteriostatic activity of zinc thiazole can be significantly improved.Simultaneously to the acute of compound (II)
Toxicity detection shows that the compound belongs to low toxicity compounds, and its acute toxicity is basically identical with zinc thiazole.And athyreosis interference
Side effect.Based on this discovery the invention provides a kind of compound thiazole Zn composition, by preferred zinc thiazole (I) and compound
(II) ratio, can increase substantially the bacteriostatic activity of composition in the case where minority specioz (II) is added.Significantly subtract
Few usage amount of the zinc thiazole when being administered.From reduce zinc thiazole caused to the pollution of environment and to user health it is bad
Influence.
Specific embodiment
In order that those skilled in the art more fully understand technical scheme, below in conjunction with specific implementation
Example is described in further detail to the present invention.
The compound thiazole Zn composition that the present invention is provided, preparing turns into dry suspensoid agent, by compound (I), compound (II)
Constituted with least one auxiliary material suitable for dry suspensoid agent.The formula of the composition is respectively as shown in embodiment 1-5 in following table
(percentage shown in table is the mass percent for accounting for composition gross mass)：In the present invention to commonly use dispersant, wetting agent, collapse
Solution agent, binding agent, defoamer are tested, and experiment proves that the selection of its species is little on experimental result influence, herein no longer
Repeat.
The compound method of the bactericide is：
1) component respectively than water according to proportioning is added to dosage bunker and adds water to pulpous state, stirred；
2) coarse crushing is carried out using high-speed shearing machine, is crushed to granularity for 100-200 mesh；
3) it is 8000-10000 mesh to use sand mill to be sanded to granularity after coarse crushing；
4) pressure spray drying tower is sent into after being sanded to dry, granulate, and obtains water content (0.1-1%) satisfactory particle diameter
It is the hollow perforate spherical particle of 80-100 purposes.
Prevention effect is tested：
The compound (I) and compound (II) of bacterium method for measuring test different proportion are connect to the white leaf of paddy rice with field leaf-cutting
The prevention effect of rot, experimental procedure is as follows
1st, the rice leaf spot bacteria strain provided using Institute of Plant Protection of academy of agricultural sciences of Zhejiang Province, suspension of the culture as 109/ml
Afterwards, paddy rice blade tip 3-4cm is subtracted with the dissecting scissors for being moistened with bacterium solution, 20 rice leaves of every group of selection spray and prevent and treat for 7 days after bacterium is connect,
Prevention effect (with Spot expansion calculate prevention effect) and use Excel of the examination in 10 days compared with control group are to experiment after administration
Result carries out t inspections.
2nd, packet see the table below (means ± s, n=20) with administration and effect situation
By above-mentioned each group medicine, experimental group 1-5 and negative control 1 are by dry suspensoid agent obtained in each embodiment according to zinc thiazole
Final concentration 200ppm is diluted, and negative control 2 prepares compound (II) turns into 20% dry suspensoid agent, and is diluted to final concentration
200ppm, positive controls are diluted with water 1000 times using the dry suspensoid agent for being added without active component.
Test result indicate that, the composition that the present invention is provided, by preferred specific compound (I) and compound (II)
Ratio, can significantly improve effect when zinc thiazole is prevented and treated for bacterial blight of rice.It is negative right with the existing zinc thiazole of use
Compared according to 1 group, the prevention effect of each experimental group is significantly increased (P ＜ 0.05), and using preferred compound (I) and chemical combination
The effect of the experimental group 2-4 of thing (II) proportioning is more notable (P ＜ 0.01).Found in further experiment, compound is administered alone
(II) when, although also with certain prevention effect, but the composition provided far away from zinc thiazole, the more too late present invention.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (6)
1. a kind of compound thiazole Zn composition, it is characterised in that by mass ratio 1:2- amino -5- sulfydryl -1,3 of 0.05-0.2,
4- thiadiazoles zinc and 1- (2- aminoethyls) amino -9,10- anthraquinones connection 4- methyl isophthalic acids, 2,3- thiadiazoles -5- formamides composition.
2. compound thiazole Zn composition according to claim 1, it is characterised in that described 2- amino -5- sulfydryl -1,3,
4- thiadiazoles zinc joins 4- methyl isophthalic acids, the mass ratio of 2,3- thiadiazoles -5- formamides with 1- (2- aminoethyls) amino -9,10- anthraquinones
It is 1:0.08-0.15.
3. a kind of bactericide, it is characterised in that including the compound thiazole Zn composition described in claim any one of 1-2.
4. bactericide according to claim 3, it is characterised in that formulation is emulsifiable concentrate, wettable powder, dry suspends
One kind in agent, soluble powder.
5. bactericide according to claim 3, it is characterised in that formulation is dry suspending agent, including compound zinc thiazole
Composition and auxiliary material, and compound thiazole Zn composition account for bactericide gross mass ratio be 10%-40%.
6. bactericide according to claim 5, it is characterised in that described auxiliary material includes dispersant, wetting agent, collapses
Solution agent, binding agent, defoamer, water and filler.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611099470.3A CN106719712A (en) | 2016-12-05 | 2016-12-05 | Compound thiazole Zn composition and bactericide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611099470.3A CN106719712A (en) | 2016-12-05 | 2016-12-05 | Compound thiazole Zn composition and bactericide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106719712A true CN106719712A (en) | 2017-05-31 |
Family
ID=58884075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611099470.3A Pending CN106719712A (en) | 2016-12-05 | 2016-12-05 | Compound thiazole Zn composition and bactericide |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106719712A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1308070A (en) * | 2000-12-15 | 2001-08-15 | 浙江新农化工有限公司 | Anilidothiobiazole metal complex and its preparation and use |
| CN102718731A (en) * | 2012-07-03 | 2012-10-10 | 天津商业大学 | 4 /5-methyl-1, 2, 3-thiadiazole formic acid derivative and preparation method thereof |
-
2016
- 2016-12-05 CN CN201611099470.3A patent/CN106719712A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1308070A (en) * | 2000-12-15 | 2001-08-15 | 浙江新农化工有限公司 | Anilidothiobiazole metal complex and its preparation and use |
| CN102718731A (en) * | 2012-07-03 | 2012-10-10 | 天津商业大学 | 4 /5-methyl-1, 2, 3-thiadiazole formic acid derivative and preparation method thereof |
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Application publication date: 20170531 |