CN106665607A

CN106665607A - Compound plant fungicide

Info

Publication number: CN106665607A
Application number: CN201611219267.5A
Authority: CN
Inventors: 蔡志浩
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-12-26
Filing date: 2016-12-26
Publication date: 2017-05-17

Abstract

A compound plant fungicide is characterized by being prepared from at least one auxiliary applicable to the plant fungicide as well as 2-amino-5-mercapto-1,3,4-zinc thiadiazole ( with the common name zinc thiazole and compound (I) for short) and 5-methyl-1,2,3-thiadiazole-4-formic acid 4-[N,N-bis(4-methylphenyl)amino] benzaldoxime ester (compound (II) for short), wherein the mass ratio of compound (I) to the compound (II) is 1:(0.07-0.15).

Description

Compound plant bactericide

Technical field

The present invention relates to a kind of plant antibacterial with thiadiazoles derivative as active component.

Background technology

2- amino -5- sulfydryl -1,3,4- thiadiazoles zinc (Chinese name zinc thiazole) are a kind of plant antibacterial, are widely used in The preventing and treating of the plant diseases such as bacterial blight of rice, but through research discovery, zinc thiazole or a kind of thyroid interferent, Neng Gouyin The parathyroid tissue hypertrophy of laboratory animal is played, and finds that its toxicity has obvious dosage effect dependency under study for action.As A kind of pesticide, can have undesirable effect to the health of user, and will also result in pollution in the environment.Therefore its poison how is reduced Property, or in the case where prevention effect is not affected, its consumption is reduced, become problem demanding prompt solution in prior art.

Chinese patent literature CN102718731A is disclosed：5- methyl isophthalic acids, 2,3- thiadiazoles -4- formic acid the 4- [(4- of N, N- bis- Aminomethyl phenyl) amino] benzaldoxime ester and preparation method thereof, and point out its compound to BC in follow-up pharmacological evaluation (botrytis cinerea pers, Botrytis cinerea), SS (Sclerotinia sclerotiorum, Sclerotinia sclerotiorum), RC (Rhizoctonia cerealis, Rhizoctonia cerealis), PS (Rhizoctonia solani Kuhn Pellicularia sasakii) have compared with Good prevention effect (more than 50%), but it is poor to other bacteria-treating effects listed by the document.

The content of the invention

To solve aforementioned technical problem, technical scheme below is present invention employs：There is provided compound plant bactericide, it is special Levy be described compound plant bactericide by least one adjuvant suitable for bactericide and mass ratio is 1:0.07~ 0.15 2- amino -5- sulfydryl -1,3,4- thiadiazoles zinc (common first names zinc thiazole, abbreviation compound (I)) and 5- methyl isophthalic acids, 2,3- Thiadiazoles -4- formic acid 4- [N, N- bis- (4- aminomethyl phenyls) amino] benzaldoxime ester (abbreviation compound (II)) and composition.It is described The chemical formula of compound (II) is as follows：

Described compound plant bactericide, is characterized in that described compound (I) is preferred with the mass ratio of compound (II) For 1:0.1~0.12.

Described compound plant bactericide, the dosage form that it is characterized in that the bactericide is selected from emulsifiable concentrate, wettable powder One kind in agent, dry suspension, soluble powder.Preferably dry suspension, compound (I) is accounted for the gross mass of compound (II) The 15%~30% of the gross mass of the compound recipe zinc thiazole combination.It is described for dry-mixed when the compositionss are dry suspension The adjuvant of suspension is made up of the filler of dispersant, wetting agent, disintegrating agent, binding agent, defoamer, water and surplus,

The one kind or several of the disintegrating agent in carbamide, Sodium Chloride, sulfate, carbonate and sodium carboxymethyl cellulose Kind.

The dispersant is selected from sodium lignin sulfonate, calcium lignosulfonate, polycarboxylate, alkylphenol polyoxyethylene formaldehyde A kind of described froth breaking in condensation substance, fatty alcohol polyoxyethylene ether sulfate and alkylphenol polyoxyethylene succinate sulfonate Agent is selected from organosiloxane, the fatty acid ester compounded thing of higher alcohols, organic silicone, the fatty alcohol of C8~C10, the saturation of C10~C20 One or more in aliphatic carboxylic acid and C10~C20 representative examples of saturated aliphatic carboxylic esters.

The binding agent is selected from one or more in gelatin, arabic gum, polyvinyl alcohol, macrogol and starch.

The wetting agent includes sodium lauryl sulphate, dodecylbenzene sodium sulfonate, Negel, alkyl naphthalene sulfonic acid One or more in sodium formaldehyde condensation substance and alkylphenol-polyethenoxy base ether.

Described filler is Kaolin, kieselguhr, bentonite, attapulgite, Pulvis Talci, starch, glucose, sulfur selected from filler At least one in sour sodium, precipitated calcium carbonate.The water content of the compositionss is 0.2~0.5% (wt).

Under study for action it was found that when compound (I) and compound (II) are carried out into compatibility with special ratios, Ke Yixian The bacteriostatic activity for improving zinc thiazole is write so as to obtain a kind of new compound plant bactericide.Acute toxicity to compound (II) Detection shows its category low toxicity compounds, and the side effect of athyreosis interference.The compound plant bactericide that the present invention is provided, passes through It is preferred that zinc thiazole (I) and the ratio of compound (II), can increase substantially group in the case where minority specioz (II) is added The bacteriostatic activity of compound.Usage amount of the zinc thiazole when being administered can be substantially reduced.So as to reduce dirt of the zinc thiazole to environment Dye and the harmful effect that user health is caused.We have found especially that in an experiment, only when zinc thiazole and compound (II) with During the ratio compatibility that the present invention is provided, its antibacterial effect can be significantly improved, and higher or lower compound (II) addition is all The effect cannot be produced, and the effect is more projected in the optimum ratio of the present invention.

Specific embodiment

Provided by the present invention for the thiadiazole derivs compositions of bactericide, preparation becomes dry suspension, by changing Compound (I), compound (II) and at least one adjuvant suitable for dry suspension are constituted.The formula of the compositionss is as follows respectively In table (percentage ratio shown in table is the mass percent for accounting for compositionss gross mass) shown in embodiment 1~4：

The compound method of the compositionss is：

1) component respectively than water according to proportioning is added to into dosage bunker and adds water to pulpous state, stirred；

2) coarse pulverization is carried out using high-speed shearing machine, is crushed to granularity for 100~200 mesh；

3) adopt sand mill sand milling to granularity for 8000~10000 mesh after coarse pulverization；

4) pressure spray drying tower drying, pelletize are sent into after sand milling, the satisfactory particle diameter of water content is obtained for 80~100 The hollow perforate spherical particle of purpose.

Prevention effect is tested

The compound (I) and compound (II) of bacterium method for measuring test different proportion are connect to the white leaf of Oryza sativa L. with field leaf-cutting The prevention effect of rot, experimental procedure is as follows

1st, the rice leaf spot bacteria strain provided using Institute of Plant Protection of academy of agricultural sciences of Zhejiang Province, culture becomes 10⁹The suspension of individual/ml Afterwards, Oryza sativa L. 3~4cm of blade tip is deducted with the dissecting scissorss for being moistened with bacterium solution, 20 rice leaves of per group of selection are prevented in 7 days sprays after bacterium are connect Control, 10 days prevention effects of the examination compared with matched group (prevention effect is calculated with Spot expansion) and using Excel pair after administration Experimental result carries out t inspections

2nd, packet see the table below (means ± s, n=20) with administration and effect situation

By above-mentioned each group medicine, experimental group 1~4 and negative control 1 are by dry suspension obtained in each embodiment according to thiazole Zinc final concentration 200ppm is diluted, and negative control 2 prepares compound (II) becomes 20% dry suspension, and is diluted to dense eventually Degree 200ppm, positive controls are using the dry suspension for being added without active component, 1000 times of dilute.

Test result indicate that, the compositionss that the present invention is provided, by preferred specific compound (I) and compound (II) Ratio, can significantly improve effect when zinc thiazole is prevented and treated for bacterial blight of rice.With using the negative right of existing zinc thiazole Compare according to 1 group, the prevention effect of each experimental group is significantly increased (P ＜ 0.05), and using preferred compound (I) and chemical combination The effect more notable (P ＜ 0.01) of the experimental group 2~3 of thing (II) proportioning.Find in further experiment, compound is administered alone (II) poor to the prevention effect of bacterial blight of rice when, compound (II) is administered alone cannot play the effect of effective preventing and treating.

Claims

1. compound plant bactericide, is characterized in that by least one adjuvant and mass ratio suitable for bactericide be 1:0.07 ~0.15 zinc thiazole and compound (II) are constituted, and compound (II) chemical formula is as follows：

2. compound plant bactericide as claimed in claim 1, is characterized in that the quality of described zinc thiazole and compound (II) Than being preferably 1:0.1~0.12.

3. compound plant bactericide as claimed in claim 1, it is characterized in that the dosage form of the bactericide selected from emulsifiable concentrate, One kind in wettable powder, dry suspension, soluble powder.

4. compound plant bactericide as claimed in claim 1, the dosage form that it is characterized in that the bactericide is dry suspension, Zinc thiazole accounts for the 15%~30% of the gross mass of the compound recipe thiazole Zn composition with the gross mass of compound (II).

5. compound plant bactericide as claimed in claim 1, it is characterized in that the adjuvant for dry suspension by dispersant, The filler composition of wetting agent, disintegrating agent, binding agent, defoamer, water and surplus.

6. compound plant bactericide as claimed in claim 5, is characterized in that the disintegrating agent is selected from carbamide, Sodium Chloride, sulphuric acid One or more in salt, carbonate and sodium carboxymethyl cellulose.

7. compound plant bactericide as claimed in claim 5, is characterized in that the defoamer is selected from organosiloxane, higher alcohols Fatty acid ester compounded thing, organic silicone, the fatty alcohol of C8~C10, the representative examples of saturated aliphatic carboxylic of C10~C20 and C10~C20 satisfy With one or more in aliphatic carboxylic acid esters.