CN106942244A - Thiadiazole derivs compositions for bactericide - Google Patents
Thiadiazole derivs compositions for bactericide Download PDFInfo
- Publication number
- CN106942244A CN106942244A CN201611221244.8A CN201611221244A CN106942244A CN 106942244 A CN106942244 A CN 106942244A CN 201611221244 A CN201611221244 A CN 201611221244A CN 106942244 A CN106942244 A CN 106942244A
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- Prior art keywords
- bactericide
- compound
- compositions
- composition
- zinc thiazole
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/12—Powders or granules
- A01N25/14—Powders or granules wettable
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
For the thiadiazole derivs compositions of bactericide, it is characterized in that described composition is 1 by least one auxiliary material and mass ratio suitable for bactericide:0.07~0.15 zinc thiazole and compound (II) composition.The one kind of the formulation of the bactericide in emulsifiable concentrate, wettable powder, dry suspensoid agent, soluble powder.
Description
Technical field
The present invention relates to a kind of thiadiazole derivs compositions, a kind of plant bactericide is further related to.
Background technology
2- amino -5- sulfydryls -1,3,4- thiadiazoles zinc (Chinese name zinc thiazole) is a kind of plant bactericide, is widely used in
The preventing and treating of the plant diseases such as bacterial blight of rice, but found by research, zinc thiazole or a kind of thyroid interferent, Neng Gouyin
The parathyroid tissue hyperplasia of experimental animal is played, and finds that its toxicity has obvious dosage effect correlation under study for action.As
A kind of agricultural chemicals, can have undesirable effect, and will also result in pollution in the environment to the health of user.Therefore its poison how is reduced
Property, or in the case where not influenceing prevention effect, its consumption is reduced, as urgent problem to be solved in the prior art.
Chinese patent literature CN102718731A is disclosed：：5- (4- aminophenyls) -10,15,20- Triphenylporphyrins join
4- methyl isophthalic acids, 2,3- thiadiazoles -5- formamides and preparation method thereof, and point out in follow-up pharmacological evaluation its compound pair
Plant pathogenic fungi has certain bacteriostatic activity, but unobvious.
The content of the invention
To solve aforementioned technical problem, present invention employs following technical scheme：There is provided the thiophene for bactericide
Oxadiazole derivative composition, it is characterized in that described composition is by least one auxiliary material and mass ratio suitable for bactericide
For 1:0.05~0.1 2- amino -5- sulfydryls -1,3,4- thiadiazoles zinc (common first names zinc thiazole, abbreviation compound (I)) and 5-
(4- aminophenyls) -10,15,20- Triphenylporphyrins join 4- methyl isophthalic acids, 2,3- thiadiazoles -5- formamide (abbreviation compounds
(II)) and composition.The chemical formula of the compound (II) is as follows：
Described thiadiazole derivs compositions, it is characterized in that the formulation of the bactericide is selected from emulsifiable concentrate, wettable
One kind in property pulvis, dry suspensoid agent, soluble powder.Preferably dry suspensoid agent, total matter of compound (I) and compound (II)
Amount accounts for the 15%~30% of the gross mass of the compound zinc thiazole combination.The composition be dry suspensoid agent when, it is described for
The auxiliary material of dry suspensoid agent is made up of the filler of dispersant, wetting agent, disintegrant, binding agent, defoamer, water and surplus,
The one kind or several of the disintegrant in urea, sodium chloride, sulfate, carbonate and sodium carboxymethylcellulose
Kind.
The dispersant is selected from sodium lignin sulfonate, calcium lignosulfonate, polycarboxylate, APES formaldehyde
A kind of froth breaking in condensation product, fatty alcohol polyoxyethylene ether sulfate and APES succinate sulfonate
Agent is selected from organosiloxane, the fatty acid ester compounded thing of higher alcohols, organic silicone, C8~C10 fatty alcohol, C10~C20 saturation
One or more in aliphatic carboxylic acid and C10~C20 representative examples of saturated aliphatic carboxylic esters.
One or more of the binding agent in gelatin, Arabic gum, polyvinyl alcohol, macrogol and starch.
The wetting agent includes lauryl sodium sulfate, neopelex, Negel, alkyl naphthalene sulfonic acid
One or more in sodium formaldehyde condensation product and alkylphenol-polyethenoxy base ether.
It is kaolin, diatomite, bentonite, attapulgite, talcum powder, starch, glucose, sulphur that the filler, which is selected from filler,
At least one in sour sodium, precipitated calcium carbonate.The water content of the composition is 0.2~0.5% (wt).
Under study for action it was found that when compound (I) and compound (II) are carried out into compatibility with special ratios, Ke Yixian
Write the bacteriostatic activity for improving zinc thiazole.Acute toxicity detection to compound (II) shows that it belongs to low toxicity compounds, and without first shape
The side effect of gland interference.Provided by the present invention for the thiadiazole derivs compositions of bactericide, pass through preferred zinc thiazole
(I) with the ratio of compound (II), the antibacterial of composition can be increased substantially in the case where adding minority specioz (II)
Activity.Usage amount of the zinc thiazole when being administered can be substantially reduced.So as to reduce zinc thiazole to the pollution of environment and to applying
The harmful effect that person's health is caused.In an experiment we have found especially that, only when zinc thiazole and compound (II) are provided with the present invention
Ratio when, its antibacterial effect can be significantly improved, and higher or lower compound (II) addition can not all produce the effect.
Embodiment
Provided by the present invention for the thiadiazole derivs compositions of bactericide, preparing turns into dry suspensoid agent, by changing
Compound (I), compound (II) and at least one auxiliary material suitable for dry suspensoid agent are constituted.The formula of the composition is as follows respectively
(percentage shown in table is the mass percent for accounting for composition gross mass) shown in table：
The compound method of the composition is：
1) component respectively than water is added to dosage bunker according to proportioning and adds water to pulpous state, stirred；
2) coarse crushing is carried out using high-speed shearing machine, is crushed to granularity for 100~200 mesh；
3) sand mill is used to be sanded to granularity as 8000~10000 mesh after coarse crushing；
4) feeding pressure spray drying tower is dried, granulated after being sanded, and it is 80~100 to obtain the satisfactory particle diameter of water content
The hollow perforate spherical particle of purpose.
Prevention effect is tested
The compound (I) and compound (II) of bacterium method for measuring test different proportion are connect to the white leaf of paddy rice with field leaf-cutting
The prevention effect of rot, experimental procedure is as follows
1st, the rice leaf spot bacteria strain provided using Institute of Plant Protection of academy of agricultural sciences of Zhejiang Province, culture turns into 109Individual/ml suspension
Afterwards, 3~4cm of paddy rice blade tip is subtracted with the dissecting scissors for being moistened with bacterium solution, 20 rice leaves of every group of selection are prevented in connecing 7 days sprays after bacterium
Control, prevention effect (prevention effect is calculated with Spot expansion) and use Excel pair of the examination in 10 days compared with control group after administration
Experimental result carries out t inspections
2nd, packet see the table below (means ± s, n=20) with administration and effect situation
Dry suspensoid agent is diluted by experimental group 1~4 and negative control 1 according to zinc thiazole final concentration 200ppm, negative right
Preparing compound (II) according to 2 turns into 20% dry suspensoid agent, and is diluted to final concentration 200ppm, and positive controls are used and are added without
The dry suspensoid agent of active component, is diluted with water 1000 times.
Test result indicate that, the composition that the present invention is provided, when the ratio of preferred specific compound (I) and compound (II)
During example (embodiment 1,2), can significantly improve zinc thiazole is used for effect when bacterial blight of rice is prevented and treated.With using existing thiazole
1 group of the negative control of zinc is compared, and the prevention effect of each experimental group is significantly increased (P ＜ 0.01), and comparative example 1,2 is with placing
Bacterial blight of rice effect nothing compared with zinc thiazole is significantly improved.Found in further experiment, when compound (II) is administered alone,
Prevention effect to bacterial blight of rice is poor, the composition provided far away from zinc thiazole and the present invention.
Claims (2)
1. for the thiadiazole derivs compositions of bactericide, it is characterized in that described composition is applied to by least one
The auxiliary material and mass ratio of bactericide are 1:0.05~0.1 zinc thiazole and compound (II) composition, the compound (II)
Chemical formula is as follows：
2. it is used for the thiadiazole derivs compositions of bactericide as claimed in claim 1, it is characterized in that the plant kills
The formulation of microbial inoculum is dry suspensoid agent, and zinc thiazole accounts for total matter of the thiadiazole derivs compositions with the gross mass of compound (II)
The 15%~30% of amount.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611221244.8A CN106942244A (en) | 2016-12-26 | 2016-12-26 | Thiadiazole derivs compositions for bactericide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611221244.8A CN106942244A (en) | 2016-12-26 | 2016-12-26 | Thiadiazole derivs compositions for bactericide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106942244A true CN106942244A (en) | 2017-07-14 |
Family
ID=59466376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611221244.8A Pending CN106942244A (en) | 2016-12-26 | 2016-12-26 | Thiadiazole derivs compositions for bactericide |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106942244A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102718731A (en) * | 2012-07-03 | 2012-10-10 | 天津商业大学 | 4 /5-methyl-1, 2, 3-thiadiazole formic acid derivative and preparation method thereof |
| CN103704222A (en) * | 2013-12-26 | 2014-04-09 | 浙江新农化工股份有限公司 | Zinc thiazole water dispersible granules and preparation method thereof |
-
2016
- 2016-12-26 CN CN201611221244.8A patent/CN106942244A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102718731A (en) * | 2012-07-03 | 2012-10-10 | 天津商业大学 | 4 /5-methyl-1, 2, 3-thiadiazole formic acid derivative and preparation method thereof |
| CN103704222A (en) * | 2013-12-26 | 2014-04-09 | 浙江新农化工股份有限公司 | Zinc thiazole water dispersible granules and preparation method thereof |
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Application publication date: 20170714 |
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