CN101366378A - Bactericial composition - Google Patents
Bactericial composition Download PDFInfo
- Publication number
- CN101366378A CN101366378A CNA2008102112237A CN200810211223A CN101366378A CN 101366378 A CN101366378 A CN 101366378A CN A2008102112237 A CNA2008102112237 A CN A2008102112237A CN 200810211223 A CN200810211223 A CN 200810211223A CN 101366378 A CN101366378 A CN 101366378A
- Authority
- CN
- China
- Prior art keywords
- methyl
- kresoxim
- weight ratio
- bactericidal composition
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 title claims abstract description 34
- 239000005800 Kresoxim-methyl Substances 0.000 claims abstract description 38
- ZOTBXTZVPHCKPN-HTXNQAPBSA-N kresoxim-methyl Chemical compound CO\N=C(\C(=O)OC)C1=CC=CC=C1COC1=CC=CC=C1C ZOTBXTZVPHCKPN-HTXNQAPBSA-N 0.000 claims abstract description 38
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 22
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000005864 Sulphur Substances 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 10
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- 239000004480 active ingredient Substances 0.000 claims description 5
- 239000006185 dispersion Substances 0.000 claims description 5
- 230000000855 fungicidal effect Effects 0.000 claims description 5
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- 239000008187 granular material Substances 0.000 claims description 5
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- 239000000575 pesticide Substances 0.000 claims description 3
- 239000005747 Chlorothalonil Substances 0.000 abstract 3
- 239000005843 Thiram Substances 0.000 abstract 3
- CRQQGFGUEAVUIL-UHFFFAOYSA-N chlorothalonil Chemical compound ClC1=C(Cl)C(C#N)=C(Cl)C(C#N)=C1Cl CRQQGFGUEAVUIL-UHFFFAOYSA-N 0.000 abstract 3
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a bactericidal composition, in particular to a bactericidal composition which comprises kresoxim-methyl with synergistically effective quantity and any bactericidal active composition selected from chlorothalonil, sulfur and thiram, wherein the preferred weight ratio of the kresoxim-methyl to the chlorothalonil is from 10 to 1 to 1 to 50 and the more preferred weight ratio of the kresoxim-methyl to the chlorothalonil is from 1 to 1 to 1 to 15; the preferred weight ratio of the kresoxim-methyl to the sulfur is from 10 to 1 to 1 to 50 and the more preferred weight ratio of the kresoxim-methyl to the sulfur is from 1 to 1 to 1 to 20; and the preferred weight ratio of the kresoxim-methyl to the thiram is from 10 to 1 to 1 to 50 and the more preferred weight ratio of the kresoxim-methyl to the thiram is from 1 to 1 to 1 to 15.
Description
Technical field
The present invention relates to a kind of Synergistic bactericidal composition, particularly relate to a kind of Synergistic bactericidal composition that comprises kresoxim-methyl and be selected from arbitrary fungicide active ingredient of tpn, sulphur and tmtd.
Background technology
Kresoxim-methyl (Kresoxim-methyl) is the methoxy acrylic bactericide of BASF Aktiengesellschaft's exploitation, belongs to the mitochondrial respiratory inhibitor, can act on to be positioned at cytochrome b c1 complex on the mitochondrial membrane.The electron transfer process of kresoxim-methyl blocking-up germ mitochondrial respiratory chain, thus the supply of germ cellular energy suppressed, energy and the death for want of of germ cell.
Kresoxim-methyl belongs to novel half systemic fungicide on the mode of action, mainly with the gaseous form diffusion, both can stop germ spore germination, germ tube elongation and the intrusion of blade, fruit surface, plays the prevention protective effect; Can penetrate cured matter layer and epidermis again or enter in the body, suppress to have invaded the germ growth, make the mycelia atrophy, suppress to produce spore, the spore that has produced can not be sprouted, reach treatment and root out effect, have the therapeutic action of guarantor and protective effect simultaneously by pore.The kresoxim-methyl sterilizing spectrum is wide, has very high activity, and is extremely sensitive to most of fungies, powdery mildew, anthracnose, scab had special efficacy, and can prevent and treat wheat rust, potato late blight, pumpkin eqpidemic disease, rice blast etc.After the use, there is the crop leaf of promotion to enlarge afforested area, increases effects such as photosynthesis.Being mixed property of kresoxim-methyl is good, can use with other insecticidal bactericide; And it is do not have cross resistance, and longer than the conventional sterilization agent lasting period with other bactericide commonly used.Kresoxim-methyl has the selectivity of height, and to crop safety, florescence and fruit phase use and can not produce poisoning, is applicable to various vegetables, fruit and flowers use, and is to people and animals and beneficial organism safety, pollution-free substantially to environment.
The inventor studies have shown that by a series of kresoxim-methyl is mixed with the arbitrary fungicide active ingredient that is selected from tpn, sulphur and tmtd the target bacterium is had extremely strong synergistic effect, has improved bactericidal activity greatly, thereby has finished the present invention.
Summary of the invention
The object of the present invention is to provide a kind of mixed ratio reasonable, control efficiency is good, the Synergistic bactericidal composition that drug cost is low.
Another object of the present invention is to provide by formulations such as the formulated missible oil of this bactericidal composition, wetting powder, aqueous emulsion, suspending agent, water dispersion granule, finishes.
Technical scheme of the present invention is as described below:
A kind of bactericidal composition, the arbitrary fungicide active ingredient that it is characterized in that containing the kresoxim-methyl of synergy effective dose and be selected from tpn, sulphur and tmtd.
Wherein, the weight ratio of kresoxim-methyl and tpn is preferably 10:1～1:50, more preferably 1:1～1:15; The weight ratio of kresoxim-methyl and sulphur is preferably 10:1～1:50, more preferably 1:1～1:20; The weight ratio of kresoxim-methyl and tmtd is preferably 10:1～1:50, more preferably 1:1～1:15.
The present composition can be made formulations such as missible oil, wetting powder, aqueous emulsion, suspending agent, water dispersion granule, finish.
The organic solvent that combination dosage form of the present invention was fit to comprises that the polar solvent of aromatic hydrocarbons, chlorinated aromatic hydrocarbons, chlorinated aliphatic hydrocarbon, aliphatic hydrocarbon, particularly suitable is, for example isopropyl alcohol, butanols, ethylene glycol, diethylene glycol (DEG), triethylene glycol, propane diols, glycerine, sorbierite, phenmethylol, cyclohexanol and acetone, MEK, methyl iso-butyl ketone (MIBK), cyclohexanone, butyrolactone, dimethyl formamide, pyrrolidones, No. two, aromatic hydrocarbons and vegetable oil and methyl cellosolve.
The related surfactant of composition of the present invention can be emulsifier, dispersant or wetting agent.Can be nonionic or ionic.For example, lauryl sodium sulfate, Teepol, neopelex, calcium dodecyl benzene sulfonate, polyoxyethylene fatty acid ester, polyoxyethylene aliphatic alcohol ether, the polyoxyethylene fatty amine, or directly use commercially available emulsifier, as the newborn 0201B of farming, the newborn 0203B of farming etc., the material that is used as dispersant and wetting agent has: sodium lignin sulfonate, draw back powder, calcium lignosulfonate and lauric acid sodium sulphate, alkylol polyoxyethylene groups ether sodium sulfate, octylphenol polyethylene oxyethylene group ether sulfate, alkylphenol-polyethenoxy base ether formaldehyde condensation products sulphate, sodium alkyl sulfonate, neopelex etc.
The related adhesive of composition of the present invention can be for example carbonyl methyl cellulose, polyvinyl alcohol or the polyvinyl acetate that synthesize or natural water-soluble polymer for example xanthans, gelatin, gum Arabic, polyvinylpyrrolidone, aluminium-magnesium silicate, polyvinyl alcohol, polyethylene glycol phenolic resins, shellac, sodium alginate etc., adds in the preparation with powder, particle or latex form.
The related defoamer of composition of the present invention is bubble enemy, silicone, phosphoric acid ester or amide-type etc.
The solid carrier that composition of the present invention is fit to comprises natural or synthetic clay and silicate, is applicable to that the solid carrier of pulvis comprises rock dust, quartz, clay, imvite, silica, diatomite, float stone, gypsum, bentonite, kaolin, potter's clay, the white carbon of natural formation and for example microdispersed silicic acid of the mineral matter that grinds or the aluminium oxide that synthesizes.The particulate vector that is fit to comprises pulverizing and natural rock classification for example calcite, marble, float stone, sepiolite and dolomite and the synthetic particle made by the powder of organic matter and inorganic matter.
Composition of the present invention can be used for control by fungus-caused multiple diseases such as disease fungus such as imperfect fungus, sac fungi, basidiomycetes, Gammaproteobacterias, as grape powdery mildew, wheat rust, potato late blight, pumpkin eqpidemic disease, rice blast, powdery mildew of strawberry, melon powdery mildew, powdery mildew of cucumber, pear scab etc.
The present invention also comprises a kind of method of field control disease.Here it is before or after crop is susceptible, uses bactericidal composition of the present invention to the place of crop or fruit and growth thereof.The amount of application of bactericidal composition of the present invention changes with weather condition and crop onset state.The duration of cover crop is relevant with the content of individualized compound in the composition, also relevant with the amount of application of composition usually.
The characteristics and the advantage of the present composition are: 1, composition shows fabulous synergistic effect in certain ratio range, and protection effect is significantly improved than its single agent.2, because single thinner architectural difference of this composition is very big, the mechanism of action is different fully, does not have mutual pesticide resistance, can delay single agent and use the pesticide resistance problem that is produced separately.
Embodiment
The invention will be further described with following embodiment, and the percentage among the embodiment all is weight percentage, proportioning is weight ratio, and the treatment dosage of biologically-active moiety is active constituent content.But its active ingredient and proportioning thereof, auxiliary element and addition thereof etc. all are not limited to following examples
1. the preparation of missible oil
By the prescription requirement, add solvent, former medicine, emulsifier respectively, mix, heat of solution a little in case of necessity promptly obtains transparence missible oil.As embodiment 1 prescription.
Embodiment 1 (18% missible oil)
Tpn 5.0%
Kresoxim-methyl 13.0%
The newborn 500# 5.0% of farming
Emulsifier 602# 5%
Dimethyl formamide 5.0%
Dimethylbenzene complements to 100%
2. wetting powder preparation
By the prescription requirement, former medicine, various auxiliary agent and filler etc. are fully mixed, after ultra tiny pulverizing machine is pulverized, promptly obtain product.Fill a prescription as embodiment 2-3.
Embodiment 2 (15% wetting powder)
Tpn 60%
Kresoxim-methyl 10%
Lauryl sodium sulfate 2%
White carbon 5%
Sodium lignin sulfonate 5%
Precipitated calcium carbonate is supplemented to 100%
Embodiment 3 (65% wetting powder)
Tmtd 50%
Kresoxim-methyl 15%
Lauryl sodium sulfate 2%
White carbon 8%
Sodium lignin sulfonate 5%
Precipitated calcium carbonate is supplemented to 100%
The preparation of 3 water dispersion granules
Former medicine and powder carrier, wetting agent, spreader-sticker and binding agent etc. are mixed pulverizing, after adding water again and mediating, add in the comminutor that the certain specification screen cloth is housed and carry out granulation.Drying, screening (pressing the screen cloth scope) promptly get granular product again.As embodiment 4 prescriptions.
Embodiment 4 (40% water dispersion granule)
Sulphur 30%
Kresoxim-methyl 10%
Methyl naphthalene sulfonate formaldehyde condensate 10%
Neopelex 15%
Soluble starch 15%
Attapulgite complements to 100%
4. the preparation of suspending agent
By the prescription requirement, be medium with water, former medicine, dispersant, suspending agent and antifreezing agent etc. are added in the sand milling still, carry out porphyrize, make suspending agent.As embodiment 5 prescriptions.
Embodiment 5 (75% suspending agent)
Kresoxim-methyl 20%
Sulphur 50%
Methyl naphthalene sulfonate formaldehyde condensate 7%
0203B 5％
Aluminium-magnesium silicate 0.5%
Ethylene glycol 10%
Water complements to 100%
5. Toxicity Determination
Get healthy the 2nd～8 anosis cucumber leaf, play the directly leaf dish of 15mm of cut-off with card punch, the leaf dish is soaked in the soup of serial variable concentrations, face up after drying to place and use in the culture dish on the filter paper that soaks with concentration liquid, 10 leaf dishes of every ware, every concentration is handled 3 wares.Get 20 μ l spore suspensions in the leaf panel surface with micropipettor, put in the illumination box (24 ℃, illumination 12h/d) and cultivate, according to the grade scale investigation state of an illness, calculate disease index and control efficiency respectively behind 7～10d by following formula.Logarithm and preventive effect probit value with drug concentration calculate concentration EC in virulence regression equation and the inhibition
50Further obtain the coefficient of synergism (SR) of different matched proportion densities.Make the associating in-service evaluation according to coefficient of synergism (SR) value.The result is shown in table 1-2:
Table 1: kresoxim-methyl and tmtd are mixed to the Toxicity Determination result of powdery mildew of cucumber
Ether: good fortune=kresoxim-methyl: tmtd
Table 2: kresoxim-methyl and sulphur are mixed to the Toxicity Determination result of powdery mildew of cucumber
Ether: sulphur=kresoxim-methyl: sulphur
Toxicity Determination to asparagus bean rust: adopt the spore germination method.The fresh uredospore of gathering the asparagus bean rust bacterium is made into spore suspension, and microscopy concentration is about 1 * 105/ml, mixes with the soup of above-mentioned variable concentrations respectively, splashes in the concave slide with dropper, establishes blank, and every concentration repeats 3 times.The upset slide makes drop down, places 25 ℃ of illumination boxs, the 24h that preserves moisture (12h illumination, 12h dark) back microscopy.3 visuals field of every rechecking are write down the spore germination number and are not sprouted number.Surpassing spore with germ tube length is sprouting.Calculate spore germination rate and proofread and correct the inhibition germination rate.Try to achieve the EC of virulence regression equation, correlation coefficient and every kind of medicament with the DPS analysis software
50Value.Further obtain the coefficient of synergism (SR) of different matched proportion densities.Make the associating in-service evaluation according to coefficient of synergism (SR) value.The result is as shown in table 3.
Table 3: kresoxim-methyl and tpn are mixed to the Toxicity Determination result of asparagus bean rust
Ether: hundred=kresoxim-methyl: tpn
Claims (8)
1. bactericidal composition is characterized in that containing the kresoxim-methyl and the arbitrary fungicide active ingredient that is selected from tpn, sulphur and tmtd of synergy effective dose.
2. according to the bactericidal composition of claim 1, it is characterized in that the weight ratio of kresoxim-methyl and tpn is preferably 10:1～1:50.
3. according to the bactericidal composition of claim 1-2, the weight ratio that it is characterized in that kresoxim-methyl and tpn is 1:1～1:15 more preferably.
4. according to the bactericidal composition of claim 1, it is characterized in that the weight ratio of kresoxim-methyl and sulphur is preferably 10:1～1:50.
5. according to the bactericidal composition of claim 1 or 4, it is characterized in that the weight ratio of kresoxim-methyl and sulphur is preferably 1:1～1:20.
6. according to the bactericidal composition of claim 1, it is characterized in that the weight ratio of kresoxim-methyl and tmtd is preferably 10:1～1:50.
7. according to the composition pesticide of claim 1 or 6, it is characterized in that the weight ratio of kresoxim-methyl and tmtd is preferably 1:1～1:15.
8. missible oil, wetting powder, aqueous emulsion, suspending agent, water dispersion granule or the finish formulated according to the described bactericidal composition of arbitrary claim of claim 1-7.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011108754A3 (en) * | 2010-03-03 | 2012-03-01 | Sumitomo Chemical Company, Limited | Plant disease controlling composition and method for controlling plant disease |
| WO2012101660A1 (en) | 2011-01-28 | 2012-08-02 | Deepak Pranjivandas Shah | Pesticidal composition comprising sulphur, a fungicide and an agrochemical excipient |
| CN104814035A (en) * | 2014-02-05 | 2015-08-05 | Upl有限公司 | Combinations |
| EP3932206A1 (en) * | 2013-11-26 | 2022-01-05 | UPL Ltd | A method for controlling rust |
-
2008
- 2008-09-18 CN CNA2008102112237A patent/CN101366378A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011108754A3 (en) * | 2010-03-03 | 2012-03-01 | Sumitomo Chemical Company, Limited | Plant disease controlling composition and method for controlling plant disease |
| AU2011221768B2 (en) * | 2010-03-03 | 2015-07-23 | Sumitomo Chemical Company, Limited | Plant disease controlling composition and method for controlling plant disease |
| WO2012101660A1 (en) | 2011-01-28 | 2012-08-02 | Deepak Pranjivandas Shah | Pesticidal composition comprising sulphur, a fungicide and an agrochemical excipient |
| US20130309327A1 (en) * | 2011-01-28 | 2013-11-21 | Deepak Pranjivandas Shah | Pesticidal composition comprising sulphur, a fungicide and an agrochemical excipient |
| CN105994361A (en) * | 2011-01-28 | 2016-10-12 | 迪帕克·普兰吉万达斯·沙阿 | Pesticidal composition comprising sulphur, a fungicide and an agrochemical excipient |
| US9538761B2 (en) * | 2011-01-28 | 2017-01-10 | Deepak Pranjivandas Shah | Pesticidal composition comprising sulphur, a fungicide and an agrochemical excipient |
| EP3932206A1 (en) * | 2013-11-26 | 2022-01-05 | UPL Ltd | A method for controlling rust |
| CN104814035A (en) * | 2014-02-05 | 2015-08-05 | Upl有限公司 | Combinations |
| CN104814035B (en) * | 2014-02-05 | 2019-11-01 | Upl有限公司 | Combination |
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