CN106633538A - 一种药品包装材料的制备方法 - Google Patents

一种药品包装材料的制备方法 Download PDF

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CN106633538A
CN106633538A CN201611078586.9A CN201611078586A CN106633538A CN 106633538 A CN106633538 A CN 106633538A CN 201611078586 A CN201611078586 A CN 201611078586A CN 106633538 A CN106633538 A CN 106633538A
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张顺伟
唐进六
陈伟
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XUHUA PHARMACEUTICAL CO Ltd SICHUAN
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    • B32—LAYERED PRODUCTS
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    • B32B27/00—Layered products comprising a layer of synthetic resin
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    • B32B27/00—Layered products comprising a layer of synthetic resin
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    • B32B37/00—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding
    • B32B37/12—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by using adhesives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
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    • B32B7/00—Layered products characterised by the relation between layers; Layered products characterised by the relative orientation of features between layers, or by the relative values of a measurable parameter between layers, i.e. products comprising layers having different physical, chemical or physicochemical properties; Layered products characterised by the interconnection of layers
    • B32B7/04—Interconnection of layers
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
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    • C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
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Abstract

本发明公开了一种药品包装材料的制备方法，包括：(1)将医药或食品级聚偏二氯乙烯(PVDC)、氧化聚乙烯混合均匀，其后加入石膏，进行高速剪切搅拌混合均匀，其后降低搅拌速率，加入聚乙烯吡咯烷酮和二丁基羟基甲苯，再次搅拌均匀并自然冷却，得到预混物；(2)将步骤(1)得到的预混物与茂金属聚乙烯进行共挤出，成型为膜状；(3)将步骤(2)得到的膜层通过粘结层与铝箔层复合，即得到所述药品包装材料。本发明制得的包装材料性质均一、稳定，可用于片剂、药丸、胶囊等剂型的包装，阻湿、阻气、防氧化性能优异，药品可长期在湿热环境下存放。

Description

一种药品包装材料的制备方法
技术领域
本发明涉及药用包装材料的技术领域，特别涉及铝塑包装材料的技术领域。
背景技术
铝塑泡罩包装大量应用于药品片剂、胶囊的包装中，现有技术中这类包装材料通常存在阻隔性能欠佳，特别是阻湿、阻气性能不太理想，导致药品在存放时出现变质的现象。
发明内容
本发明的目的在于提出一种具有高效的阻湿、阻气、防氧化性能的药品包装材料的制备方法。
本发明的技术方案如下：
一种药品包装材料的制备方法，包括以下步骤：
(1)将医药或食品级聚偏二氯乙烯(PVDC)、氧化聚乙烯混合均匀后加热熔融，其后向熔融物中加入石膏，进行高速剪切搅拌，至三者混合均匀，其后降低搅拌速率，向混合物中加入聚乙烯吡咯烷酮和二丁基羟基甲苯，再次搅拌均匀并自然冷却，得到预混物；
(2)将步骤(1)得到的预混物与茂金属聚乙烯进行共挤出，成型为膜状；
(3)将步骤(2)得到的膜层通过粘结层与铝箔层复合，即得到所述药品包装材料。
优选的是：所述预混物按质量份计，包括聚偏二氯乙烯20～25份，氧化聚乙烯15～25份，聚乙烯吡咯烷酮1～1.5份，二丁基羟基甲苯0.1～0.3份，石膏0.5～1份。
另外优选的是：所述预混物按质量份计，包括聚偏二氯乙烯20份，氧化聚乙烯15份，聚乙烯吡咯烷酮1份，二丁基羟基甲苯0.2份，石膏0.6份。
本发明制得的包装材料性质均一、稳定，可用于片剂、药丸、胶囊等剂型的包装，阻湿、阻气、防氧化性能优异，药品可长期在湿热环境下存放。
具体实施方式
实施例1
(1)将医药或食品级聚偏二氯乙烯(PVDC)20份、氧化聚乙烯15份混合均匀后加热熔融，其后向熔融物中加入石膏0.5份，进行高速剪切搅拌，至三者混合均匀，其后降低搅拌速率，向混合物中加入聚乙烯吡咯烷酮1份和二丁基羟基甲苯0.1份，再次搅拌均匀并自然冷却，得到预混物；
(2)将步骤(1)得到的预混物与茂金属聚乙烯进行共挤出，成型为膜状；
(3)将步骤(2)得到的膜层通过粘结层与铝箔层复合，即得到所述药品包装材料。
实施例2
(1)将医药或食品级聚偏二氯乙烯(PVDC)25份、氧化聚乙烯25份混合均匀后加热熔融，其后向熔融物中加入石膏1份，进行高速剪切搅拌，至三者混合均匀，其后降低搅拌速率，向混合物中加入聚乙烯吡咯烷酮1.5份和二丁基羟基甲苯0.3份，再次搅拌均匀并自然冷却，得到预混物；
(2)将步骤(1)得到的预混物与茂金属聚乙烯进行共挤出，成型为膜状；
(3)将步骤(2)得到的膜层通过粘结层与铝箔层复合，即得到所述药品包装材料。
实施例3
(1)将医药或食品级聚偏二氯乙烯(PVDC)20份、氧化聚乙烯15份混合均匀后加热熔融，其后向熔融物中加入石膏0.6份，进行高速剪切搅拌，至三者混合均匀，其后降低搅拌速率，向混合物中加入聚乙烯吡咯烷酮1份和二丁基羟基甲苯0.2份，再次搅拌均匀并自然冷却，得到预混物；
(2)将步骤(1)得到的预混物与茂金属聚乙烯进行共挤出，成型为膜状；
(3)将步骤(2)得到的膜层通过粘结层与铝箔层复合，即得到所述药品包装材料。

Claims (3)

1.一种药品包装材料的制备方法，其特征在于：包括以下步骤：
(1)将医药或食品级聚偏二氯乙烯(PVDC)、氧化聚乙烯混合均匀后加热熔融，其后向熔融物中加入石膏，进行高速剪切搅拌，至三者混合均匀，其后降低搅拌速率，向混合物中加入聚乙烯吡咯烷酮和二丁基羟基甲苯，再次搅拌均匀并自然冷却，得到预混物；
(2)将步骤(1)得到的预混物与茂金属聚乙烯进行共挤出，成型为膜状；
(3)将步骤(2)得到的膜层通过粘结层与铝箔层复合，即得到所述药品包装材料。
2.根据权利要求1所述的药品包装材料的制备方法，其特征在于：所述预混物按质量份计，包括聚偏二氯乙烯20～25份，氧化聚乙烯15～25份，聚乙烯吡咯烷酮1～1.5份，二丁基羟基甲苯0.1～0.3份，石膏0.5～1份。
3.根据权利要求1所述的药品包装材料的制备方法，其特征在于：所述预混物按质量份计，包括聚偏二氯乙烯20份，氧化聚乙烯15份，聚乙烯吡咯烷酮1份，二丁基羟基甲苯0.2份，石膏0.6份。
CN201611078586.9A 2016-11-30 2016-11-30 一种药品包装材料的制备方法 Pending CN106633538A (zh)

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