CN106620723B - G蛋白信号转导调节蛋白10在治疗脂肪肝和ⅱ型糖尿病中的功能和应用 - Google Patents
G蛋白信号转导调节蛋白10在治疗脂肪肝和ⅱ型糖尿病中的功能和应用 Download PDFInfo
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- CN106620723B CN106620723B CN201610916268.9A CN201610916268A CN106620723B CN 106620723 B CN106620723 B CN 106620723B CN 201610916268 A CN201610916268 A CN 201610916268A CN 106620723 B CN106620723 B CN 106620723B
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- rgs10
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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Abstract
Description
引物名称 | 引物序列 | 酶切位点 |
RGS10LA-F | CTTCTGAATGCTGGCCTCTT | XhoI |
RGS10LA-R | CCGCTCGAGCCAGCTCTCTGATGGACCTC | HindIII |
RGS10M-F | <u>CCCAAGCTTATCGACCTCC</u>CCGACCCAGCATCCACTCTT | AgeI |
RGS10M-R | TCTACCGGTGGAAGGTGGGTTGCAGAGA | BamHI |
RGS10RA-F | CGGGATCCGTGATACGTTCAAAGAGACTCTGAG | MluI |
RGS10RA-R | CGACGCGTCACTGGTGAGAGAGGTTGGAT | NotI |
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CN201610916268.9A CN106620723B (zh) | 2016-10-20 | 2016-10-20 | G蛋白信号转导调节蛋白10在治疗脂肪肝和ⅱ型糖尿病中的功能和应用 |
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CN201610916268.9A CN106620723B (zh) | 2016-10-20 | 2016-10-20 | G蛋白信号转导调节蛋白10在治疗脂肪肝和ⅱ型糖尿病中的功能和应用 |
Publications (2)
Publication Number | Publication Date |
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CN106620723A CN106620723A (zh) | 2017-05-10 |
CN106620723B true CN106620723B (zh) | 2020-06-30 |
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CN201610916268.9A Active CN106620723B (zh) | 2016-10-20 | 2016-10-20 | G蛋白信号转导调节蛋白10在治疗脂肪肝和ⅱ型糖尿病中的功能和应用 |
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Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2008091598A2 (en) * | 2007-01-23 | 2008-07-31 | University Of Miami | CONFORMATION AND ACTIVITY OF Gβ5 COMPLEXES |
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2016
- 2016-10-20 CN CN201610916268.9A patent/CN106620723B/zh active Active
Non-Patent Citations (3)
Title |
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Depletion of regulator-of-G-protein signaling-10 in mice exaggerates high-fat diet-induced insulin resistance and inflammation, and this effect is mitigated by dietary green tea extract;Xi Fang et al.;《Nutrition Research》;20181231;第1-9页 * |
Loss of Regulator of G Protein Signaling 5 Exacerbates Obesity, Hepatic Steatosis, Inflammation and Insulin Resistance;Wei Deng et al.;《PLoS ONE》;20120117;第7卷(第1期);摘要,第1页 * |
Regulator of G Protein Signaling-4 Controls Fatty Acid and Glucose Homeostasis;Irena Iankova et al.;《Endocrinology》;20080717;第149卷(第11期);摘要 * |
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