CN106620319A - 一种治疗顽固性失眠的中药制剂及其制备方法 - Google Patents
一种治疗顽固性失眠的中药制剂及其制备方法 Download PDFInfo
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Abstract
本发明涉及中药制剂技术领域。本发明公开了一种治疗顽固性失眠的中药制剂,其由茯苓、白芍、倒提壶、藿香、当归、柏子仁、蒲公英、夜交藤、石菖蒲、酸枣仁、远志、丹参、黄芪、合欢皮、五味子、何首乌、松叶、天竺黄、肉苁蓉、龙齿、山药、甘草、枸杞子、莲子、核桃、燕麦、芝麻、大枣、葵花籽和蜂蜜等原料制得;本发明还公开了一种治疗顽固性失眠的中药制剂的制备方法。本发明具有养血安神、改善睡眠等功效,缓解虚烦、失眠多梦等症状,配方精简,配比合理,方便消费者服用,效果显著。本发明中的制备方法工艺步骤简单且适用于大生产。
Description
技术领域
本发明涉及中药制剂技术领域,尤其是涉及一种治疗顽固性失眠的中药制剂及其制备方法。
背景技术
随着现代社会工作生活节奏越来越快,生活压力的加大,作息时间不规律等情况越来越多,人们普遍变得容易焦虑、心神不宁,甚至会造成脾气暴躁、失眠等严重症状,头晕、面色差、无精打采、入睡困难或睡眠质量不高的情况比比皆是。临床资料显示,调查的385人中存在睡眠障碍的占比27.53%。睡眠障碍已成为困扰并严重影响绝大多数人生活的心理生理疾病。目前,国内外西医主要采用抗焦虑药物安定类治疗,可改善患者的这些症状,但副作用较大,出现神情抑制,萎靡不振的现象,长期使用造成患者对药物的依赖性,用药可入睡,不用药不能入睡,用药量也逐渐加大疗效不佳。中医认为神经衰弱,虚烦不眠是由肝血不足,血不养心,阴虚内热所致,中医中药在治疗该病上有很大潜力。
发明内容
为解决上述问题,本发明提供了一种配方精简,配比合理且适用于大生产,方便消费者服用,治疗失眠效果显著的治疗顽固性失眠的中药制剂;
本发明还提供了一种工艺步骤简单、制备效率高的治疗顽固性失眠的中药制剂的制备方法。
为实现上述目的,本发明采用的技术方案如下:
一种治疗顽固性失眠的中药制剂,由以下重量份的原料制得:
茯苓3~6份,白芍5~9份,倒提壶2~4份,藿香2~6份,当归4~5份,柏子仁2~6份,蒲公英4~7份,夜交藤3~4份,石菖蒲2~5份,酸枣仁5~8份,远志5~7份,丹参2~6份,黄芪2~3份,合欢皮6~7份,五味子2~8份,何首乌2~4份,松叶6~10份,天竺黄3~5份,肉苁蓉3~5份,龙齿1~3份,山药3~7份,甘草5~7份,枸杞子8~12份,莲子6~8份,核桃5~8份,燕麦12~14份,芝麻5~7份,大枣6~7份,葵花籽5~6份,蜂蜜9~11份。
本发明中倒提壶、藿香、当归、柏子仁起清热解毒、养心安神、健脾益气作用,蒲公英、石菖蒲、酸枣仁、远志、丹参、黄芪、合欢皮起舒肝解郁、滋补肝肾作用,全方相互配伍,养心安神效果明显。莲子、核桃、燕麦、芝麻、大枣和葵花籽也是一些可以改善睡眠状况的食物;蜂蜜对安心养神也有一定的作用,另外还可以作为饮品制备过程中口感改良剂,使饮品的口感更佳。
一种治疗顽固性失眠的中药制剂的制备方法,包括以下步骤:
a)将原料切碎至0.5~2cm,加原料3~5倍重量提取剂在40~60℃下蒸煮提取2~3小时,保留蒸煮液;
b)将蒸煮后的原料捣碎,并加入捣碎后原料重量2~3倍的50~60vol%乙醇水溶液在50~60℃下蒸煮提取1~2小时,趁热过滤,得到滤液A和滤渣A;
c)将滤渣A和滤渣A重量1~2倍的60~70vol%乙醇水溶液在65~75℃下蒸煮提取0.5~1小时,趁热过滤,得到滤液B;
d)合并蒸煮液、滤液A和滤液B,并进行浓缩,除去40~50wt%的液体组分,并使其中乙醇的含量小于0.5wt%,制得治疗顽固性失眠的中药制剂。
本发明的方法中,采用多方位提取中药材中的有效成分,使中药材的利用率达到最大。
作为优选,步骤a中的提取剂由氯化钠、碳酸氢钠和水配制而成,其中氯化钠含量为1~2wt%,碳酸氢钠的含量为3~5wt%,余量为水。
作为优选,蒸煮提取在密封条件下进行。
作为优选,步骤a得到蒸煮液后向其中加入适量可食用酸,使蒸煮液的pH值为7.0~7.5。
作为优选,可食用酸为乳酸、柠檬酸或苹果酸中的一种。
因此,本发明具有以下有益效果:本发明具有养血安神、改善睡眠等功效,缓解虚烦、失眠多梦等症状,配方精简,配比合理,方便消费者服用,效果显著。本发明中的制备方法工艺步骤简单且适用于大生产。
具体实施方式
下面结合具体实施方式对本发明的技术方案作进一步的说明。
显然,所描述的实施例仅是本发明的一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其它实施例,都属于本发明保护的范围。
实施例1
一种治疗顽固性失眠的中药制剂,由以下重量份的原料制得:
茯苓3份,白芍5份,倒提壶2份,藿香2份,当归4份,柏子仁2份,蒲公英4份,夜交藤3份,石菖蒲2份,酸枣仁5份,远志5份,丹参2份,黄芪2份,合欢皮6份,五味子2份,何首乌2份,松叶6份,天竺黄3份,肉苁蓉3份,龙齿1份,山药3份,甘草5份,枸杞子8份,莲子6份,核桃5份,燕麦12份,芝麻5份,大枣6份,葵花籽5份,蜂蜜9份。
一种治疗顽固性失眠的中药制剂的制备方法,包括以下步骤:
a)将原料切碎至0.5cm,加原料3倍重量提取剂在40℃下密封条件下蒸煮提取2小时,保留蒸煮液,并向蒸煮液中加入适量乳酸,使蒸煮液的pH值为7.0;提取剂由氯化钠、碳酸氢钠和水配制而成,其中氯化钠含量为1wt%,碳酸氢钠的含量为3wt%,水的含量为96wt%;
b)将蒸煮后的原料捣碎,并加入捣碎后原料重量2倍的50vol%乙醇水溶液在50℃下密封条件下蒸煮提取1小时,趁热过滤,得到滤液A和滤渣A;
c)将滤渣A和滤渣A重量1倍的60vol%乙醇水溶液在65℃下密封条件下蒸煮提取0.5小时,趁热过滤,得到滤液B;
d)合并蒸煮液、滤液A和滤液B,并进行浓缩,除去40wt%的液体组分,并使其中乙醇的含量小于0.5wt%,制得治疗顽固性失眠的中药制剂。
实施例2
一种治疗顽固性失眠的中药制剂,由以下重量份的原料制得:
茯苓5份,白芍7份,倒提壶3份,藿香4份,当归4.5份,柏子仁4份,蒲公英5份,夜交藤3.5份,石菖蒲4份,酸枣仁6份,远志6份,丹参4份,黄芪2.5份,合欢皮6.5份,五味子5份,何首乌3份,松叶8份,天竺黄4份,肉苁蓉4份,龙齿2份,山药5份,甘草6份,枸杞子10份,莲子7份,核桃7份,燕麦13份,芝麻6份,大枣6.5份,葵花籽5.5份,蜂蜜10份。
一种治疗顽固性失眠的中药制剂的制备方法,包括以下步骤:
a)将原料切碎至1cm,加原料4倍重量提取剂在50℃下密封条件下蒸煮提取2.5小时,保留蒸煮液,并向蒸煮液中加入适量柠檬酸,使蒸煮液的pH值为7.2;提取剂由氯化钠、碳酸氢钠和水配制而成,其中氯化钠含量为1.5wt%,碳酸氢钠的含量为4wt%,水的含量为94.5wt%;
b)将蒸煮后的原料捣碎,并加入捣碎后原料重量2.5倍的55vol%乙醇水溶液在55℃下密封条件下蒸煮提取1.5小时,趁热过滤,得到滤液A和滤渣A;
c)将滤渣A和滤渣A重量1.5倍的65vol%乙醇水溶液在70℃下密封条件下蒸煮提取0.75小时,趁热过滤,得到滤液B;
d)合并蒸煮液、滤液A和滤液B,并进行浓缩,除去45wt%的液体组分,并使其中乙醇的含量小于0.5wt%,制得治疗顽固性失眠的中药制剂。
实施例3
一种治疗顽固性失眠的中药制剂,由以下重量份的原料制得:
茯苓6份,白芍9份,倒提壶4份,藿香6份,当归5份,柏子仁6份,蒲公英7份,夜交藤4份,石菖蒲5份,酸枣仁8份,远志7份,丹参6份,黄芪3份,合欢皮7份,五味子8份,何首乌4份,松叶10份,天竺黄5份,肉苁蓉5份,龙齿3份,山药7份,甘草7份,枸杞子12份,莲子8份,核桃8份,燕麦14份,芝麻7份,大枣7份,葵花籽6份,蜂蜜11份。
一种治疗顽固性失眠的中药制剂的制备方法,包括以下步骤:
a)将原料切碎至2cm,加原料5倍重量提取剂在60℃下密封条件下蒸煮提取3小时,保留蒸煮液,并向蒸煮液中加入适量苹果酸,使蒸煮液的pH值为7.5;提取剂由氯化钠、碳酸氢钠和水配制而成,其中氯化钠含量为2wt%,碳酸氢钠的含量为5wt%,水的含量为93wt%;
b)将蒸煮后的原料捣碎,并加入捣碎后原料重量3倍的60vol%乙醇水溶液在60℃下密封条件下蒸煮提取2小时,趁热过滤,得到滤液A和滤渣A;
c)将滤渣A和滤渣A重量2倍的70vol%乙醇水溶液在75℃下密封条件下蒸煮提取1小时,趁热过滤,得到滤液B;
d)合并蒸煮液、滤液A和滤液B,并进行浓缩,除去50wt%的液体组分,并使其中乙醇的含量小于0.5wt%,制得治疗顽固性失眠的中药制剂。
应当理解的是,对于本领域普通技术人员来说,可以根据上述说明加以改进或变换,而所有这些改进和变换都应属于本发明所附权利要求的保护范围。
Claims (6)
1.一种治疗顽固性失眠的中药制剂,其特征在于由以下重量份的原料制得:
茯苓3~6份,白芍5~9份,倒提壶2~4份,藿香2~6份,当归4~5份,柏子仁2~6份,蒲公英4~7份,夜交藤3~4份,石菖蒲2~5份,酸枣仁5~8份,远志5~7份,丹参2~6份,黄芪2~3份,合欢皮6~7份,五味子2~8份,何首乌2~4份,松叶6~10份,天竺黄3~5份,肉苁蓉3~5份,龙齿1~3份,山药3~7份,甘草5~7份,枸杞子8~12份,莲子6~8份,核桃5~8份,燕麦12~14份,芝麻5~7份,大枣6~7份,葵花籽5~6份,蜂蜜9~11份。
2.一种根据权利要求1所述的治疗顽固性失眠的中药制剂的制备方法,其特征在于包括以下步骤:
a)将原料切碎至0.5~2cm,加原料3~5倍重量提取剂在40~60℃下蒸煮提取2~3小时,保留蒸煮液;
b)将蒸煮后的原料捣碎,并加入捣碎后原料重量2~3倍的50~60vol%乙醇水溶液在50~60℃下蒸煮提取1~2小时,趁热过滤,得到滤液A和滤渣A;
c)将滤渣A和滤渣A重量1~2倍的60~70vol%乙醇水溶液在65~75℃下蒸煮提取0.5~1小时,趁热过滤,得到滤液B;
d)合并蒸煮液、滤液A和滤液B,并进行浓缩,除去40~50wt%的液体组分,并使其中乙醇的含量小于0.5wt%,制得治疗顽固性失眠的中药制剂。
3.根据权利要求2所述的一种治疗顽固性失眠的中药制剂的制备方法,其特征在于:所述步骤a中的提取剂由氯化钠、碳酸氢钠和水配制而成,其中氯化钠含量为1~2wt%,碳酸氢钠的含量为3~5wt%,余量为水。
4.根据权利要求2所述的一种治疗顽固性失眠的中药制剂的制备方法,其特征在于:所述蒸煮提取在密封条件下进行。
5.根据权利要求2所述的一种治疗顽固性失眠的中药制剂的制备方法,其特征在于:所述步骤a得到蒸煮液后向其中加入适量可食用酸,使蒸煮液的pH值为7.0~7.5。
6.根据权利要求5所述的一种治疗顽固性失眠的中药制剂的制备方法,其特征在于:所述的可食用酸为乳酸、柠檬酸或苹果酸中的一种。
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CN107952008A (zh) * | 2017-12-12 | 2018-04-24 | 苏州卫生职业技术学院 | 一种改善睡眠保健糖浆的制备方法 |
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CN107952008A (zh) * | 2017-12-12 | 2018-04-24 | 苏州卫生职业技术学院 | 一种改善睡眠保健糖浆的制备方法 |
CN117159658A (zh) * | 2023-11-02 | 2023-12-05 | 中国人民解放军总医院第六医学中心 | 一种预防、减缓或治疗顽固性失眠的中药组合物及制作工艺 |
CN117159658B (zh) * | 2023-11-02 | 2024-02-13 | 中国人民解放军总医院第六医学中心 | 一种预防、减缓或治疗顽固性失眠的中药组合物及制作工艺 |
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