CN106619983A - Ointment for treating glaucoma disease - Google Patents

Ointment for treating glaucoma disease Download PDF

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Publication number
CN106619983A
CN106619983A CN201610753558.6A CN201610753558A CN106619983A CN 106619983 A CN106619983 A CN 106619983A CN 201610753558 A CN201610753558 A CN 201610753558A CN 106619983 A CN106619983 A CN 106619983A
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parts
weight
vaseline
ointment
borneol
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张红伟
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Beijing Zhang Hongwei Biological Science And Technology Co Ltd
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Beijing Zhang Hongwei Biological Science And Technology Co Ltd
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Priority to CN201610753558.6A priority Critical patent/CN106619983A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/51Gentianaceae (Gentian family)
    • A61K36/515Gentiana
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287Chrysanthemum, e.g. daisy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482Cassia, e.g. golden shower tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/533Leonurus (motherwort)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/536Prunella or Brunella (selfheal)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/538Schizonepeta
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718Coptis (goldthread)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
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  • Ophthalmology & Optometry (AREA)
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Abstract

The invention discloses a preparation method of ointment for treating glaucoma disease. The ointment is prepared from the following Chinese herbal medicines in parts by weight: 10 to 40 parts of radix gentianae, 10 to 40 parts of flos chrysanthemi indici, 10 to 40 parts of Chinese angelica, 20 to 50 parts of spica prunellae, 20 to 50 parts of motherwort fruit, 20 to 50 parts of rehmannia root, 15 to 30 parts of coptis chinensis, 15 to 30 parts of semen cassiae, 10 to 20 parts of herba schizonepetae, 10 to 20 parts of tribulus terrestris, and 10 to 20 parts of liquorice root. The preparation method comprises the following steps of A, respectively removing impurities out of the Chinese herbal medicines, drying and crushing, and tightly packaging by four layers of gauze to form a medicine bag for standby use; B, soaking the medicine bag into water for 20min, and decocting for 30min, wherein the amount of water is three times of the weight sum of the Chinese herbal medicines; obtaining supernatant, and filtering for standby use; C, putting 200 to 400 parts by weight of Vaseline and 150 to 350 parts of borneol by weight into a stainless steel container, and heating to completely melt; D, pouring a melted Vaseline and borneol solution into a container containing the supernatant, and uniformly stirring, so as to obtain a finished product.

Description

The ointment for the treatment of glaucoma
First, technical field
The present invention relates to a kind of method for production for treating the ointment of glaucoma
2nd, background technology
Glaucoma is one of causes of blindness illness in eye main at present.The mainly clinical syndrome relevant with intraocular pressure rising or eye Disease, i.e. intraocular pressure have exceeded eyeball inner tissue, the limit that especially retina optic nerve can bear, and will bring visual function damage. Most typically and most prominent performance are the pitting atrophys and defect of visual field, diminution of optic papilla, are such as taken not in time effectively Treatment, the visual field can be with total loss eventually to blind.According to World Health Organization's data display, there is the green light of half in developed country Eye patient does not know oneself, with glaucoma, then has the patient for surpassing 90% to know nothing very the disease of oneself in developing country To having never heard of glaucoma.The year two thousand twenty is expected, the whole world there will be 79,600,000 people with glaucoma, wherein 11,200,000 people are final Eyes may be developed into blind." pay attention to early screening and reduce visual function damage " is the emphasis of glaucoma-controlling, allows prevention to walk and is controlling Before treatment, can largely contain the development of this difficult illness in eye.Glaucoma point primary, Secondary cases, turbidness and congenital Property four kinds, the traditional Chinese medical science is referred to as " drop in tendencies " basic pathogenesis is depressed emotion, mechanism of qi pent-up, liver and gall heated, the institute such as refreshing water is stagnant Cause.At present western medicine routine treatment glaucoma is divided into three kinds of drug injections, operation and laser etc., Timolol, Alphagan, suitable profit Reach, these Western medicine are especially big to the heart, lung, liver, kidney side effect, are all unable to long-term taking.
3rd, the content of the invention
It is an object of the invention to provide one kind has no toxic side effect, therapeutic effect is good, consumes few medicinal material, process is simple, cost It is low, for treating the method for production of the Chinese medicine eye ointment of glaucoma,
Technical scheme is as follows:(1), it is made with the Chinese medicine including following component and its parts by weight: Felwort 10~40, mother chrysanthemum 10~40, Radix Angelicae Sinensis 10~40, selfheal 20~50, motherwort Wei Zi 20~50, the dried rhizome of rehmannia 20~50 is yellow Lotus 15~30, cassia seed 15~30, ching-chieh 10~20, puncture vine 10~20, Radix Glycyrrhizae 10~20;(2), its preparation method include with Lower step:A, above-mentioned Chinese medicine is gone into respectively the removal of impurity, then drying, crush, pack tightly that to form cartridge bag standby with four layers of gauze;B、 Cartridge bag is placed in the water of whole 3 times of Chinese medicine parts by weight summations and is soaked 20 several minutes, decocted 30 minutes, take its supernatant mistake It is standby after filter;C, the borneol of the vaseline of 200~400 weight portions and 150~350 parts by weight is placed in rustless steel container, It is heated to dissolving completely;D, the vaseline for having dissolved, borneol solution are poured into fill in supernatant liquid container, it is agitated uniform This product.
:The parts by weight of described each component are optimized for:Felwort 20~30, mother chrysanthemum 20~30, Radix Angelicae Sinensis 20~30, summer Withered grass 30~40, motherwort Wei Zi 30~40, the dried rhizome of rehmannia 30~40, coptis root 20~25, cassia seed 20~25, ching-chieh 13~17, puncture vine 13~17, Radix Glycyrrhizae 13~17, vaseline 250~350, borneol 200~300.
The property of medicine and drug effect of each component are as follows in above-mentioned formula:
Felwort:Cold in nature, bitter, energy heat-clearing and damp-drying drug, purging the liver of pathogenic fire courage fire controls hot eyes, deaf, bitter taste.
Mother chrysanthemum:Cold in nature, sweet, hardship, energy flat liver improving eyesight can control red eye, swell pain, eyes dim-sighted.
Radix Angelicae Sinensis:Warm in nature, sweet, pungent, energy replenishing and activating blood can control blood deficiency chlorosis, dizziness palpitaition.
Selfheal:Cold in nature, taste is pungent, hardship can relieve inflammation or internal heat, improving eyesight, control red eye, swell pain, mesh pearl nyctalgia, dizziness of having a headache.
Motherwort Wei Zi:Cold nature, taste is pungent, hardship can clear liver and improve vision, and can control cataract, dizzy distending pain.
The dried rhizome of rehmannia:Cold in nature, sweet, energy clearing heat and cooling blood, nourishing Yin and promoting production of body fluid controls yin asthenia generating intrinsic heat, Heat Diabetes.
Coptis root:Cold in nature, heart-fire hyperactivity is controlled in bitter, energy heat-clearing and damp-drying drug, purging intense heat and detonicating, and hot eyes, toothache is quenched one's thirst.
Cassia seed:Cold in nature, sweet, hardship, energy heat-clearing improving eyesight controls the puckery pain of hot eyes, and many tears of photophobia, mesh is secretly failed to understand.
Ching-chieh:Slightly warm in nature, taste is pungent, can induce sweat scattered wind, promoting eruption, cure cold, headache, measles, rubella.Puncture vine:Slightly warm in nature, Taste is pungent, hardship, the flat liver of energy, improving eyesight, can control dizziness, hot eyes.
Radix Glycyrrhizae:It is mild-natured, it is sweet, can invigorate the spleen and benefit qi, clearing heat and detoxicating, coordinating the drug actions of a prescription controls weakness of the spleen and the stomach, carbuncle sore tumefacting virus.
Borneol:Hot eyes, aphtha, abscess of throat are controlled in cold nature, taste is pungent, hardship, energy inducing resuscitation of having one's ideas straightened out, clearing away heat to and alleviating pain.
Above-mentioned each component carries out scientific formula by the monarch of theory of traditional Chinese medical science, minister, the combination principle helped, make, with very strong clear Hot improving eyesight, clearing liver-fire, effect of liver soothing and depression relief, clinical practice obtains significant curative effect.Clinical practice case is as follows:
Case 1:Mao Yaping, female, Sichuan people from Chengdu 42 years old, it is impossible to see TV for a long time, otherwise occurs eyes distending pain, Hand touches eyeball sensation really up to the mark, and by inspection glaucoma is diagnosed as, and Jing multi-treatment DeGrains are tieed up afterwards to Urumchi Visual rehabilitation center, the symptom for treating eyes distending pain after a course for the treatment of with product of the present invention disappears, can be normal after three courses for the treatment of TV is seen, recurrence that so far there are no.
Case 2:Shi little Ying, female, Jinan, Shandong Province people 38 years old, has found that ocular hypertension is diagnosed as when removing examination in hospital because of headache Glaucoma, with western medicine find afterwards for a period of time two eye visions decline more serious, right vision 0.4, left vision 0.3, Dimension eyesight eyes recovery centre eye ointment of the present invention, through the rehabilitation of 4 courses for the treatment of, not bitterly, intraocular pressure is also normal for present head, existing Right vision is 1.0, and left vision is 0.8, follow-up so far there are no recurrence.
Case 3:Zhang Qikang, man, people from Guangzhou Guangdong, 45 years old, daily eye-blurred and with eyes distending pain, oneself is thought Mobile phone use time length causes eye-blurred and eyes distending pain, adheres to that being rarely employed mobile phone eyesight a week still obscures, after Examination in hospital is gone to be diagnosed as glaucoma, hospital advises that he performs an operation, but he is afraid of that operation is risky, and friend Jing introduces and comes Wu Lumu Neat dimension eyesight eyes recovery centre, on inspection right vision is 0.15, left vision 0.2, after 5 courses for the treatment of of eye ointment of the present invention Binocular vision has reached 1.0, and eyes distending pain symptom disappears, and the state of an illness does not recur so far
In addition the present invention also consumes few medicinal material, process is simple, low cost, nontoxic secondary advantage.
4th, specific embodiment
With reference to embodiment, the present invention is further illustrated
Embodiment 1:
Take 4 kilograms of felwort, 1 kilogram of mother chrysanthemum, 4 kilograms of Radix Angelicae Sinensis, 2 kilograms of selfheal, 5 kilograms of motherwort Wei Zi, the dried rhizome of rehmannia 2 is public Jin, 3 kilograms of coptis root, 1 kilogram of cassia seed, 1 kilogram of ching-chieh, 2 kilograms of puncture vine, 1 kilogram of Radix Glycyrrhizae;Above-mentioned Chinese medicine is gone into respectively removal of impurities Matter, then drying, crush, packed tightly to form that cartridge bag is standby with four layers of gauze, cartridge bag is placed in 83 kilograms of water and soaks 20 several points Clock, decoction 30 minutes, take standby after its supernatant liquid filtering;40 kilograms of vaseline and 35 kilograms of borneol are placed in into stainless steel to hold In device, it is heated to dissolving completely;The vaseline for having dissolved, borneol solution are poured into and is filled in supernatant liquid container, it is agitated uniform That is cost product.
Embodiment 2:
Take 1 kilogram of felwort, mother chrysanthemum 4,1 kilogram of kilogram Radix Angelicae Sinensis, 5 kilograms of selfheal, 2 kilograms of motherwort Wei Zi, the dried rhizome of rehmannia 5 is public Jin, 1 kilogram of coptis root, 3 kilograms of cassia seed, 1 kilogram of ching-chieh, 2 kilograms of puncture vine, 1 kilogram of Radix Glycyrrhizae;Above-mentioned Chinese medicine is gone into respectively removal of impurities Matter, then drying, crush, pack tightly that to form cartridge bag standby with four layers of gauze;Cartridge bag is placed in 79 kilograms of water and soaks 20 several points Clock, decoction 30 minutes, take standby after its supernatant liquid filtering;20 kilograms of vaseline and 15 kilograms of borneol are placed in into stainless steel to hold In device, it is heated to dissolving completely;The vaseline for having dissolved, borneol solution are poured into and is filled in supernatant liquid container, it is agitated uniform That is cost product.
Embodiment 3
Take 2.5 kilograms of felwort, 2.5 kilograms of mother chrysanthemum, 2.5 kilograms of Radix Angelicae Sinensis, 3.5 kilograms of selfheal, 3.5 kilograms of motherwort Wei Zi, 3.5 kilograms of the dried rhizome of rehmannia, 1.8 kilograms of coptis root, 2.2 kilograms of cassia seed, 1.5 kilograms of ching-chieh, 1.5 kilograms of puncture vine, 1.5 kilograms of Radix Glycyrrhizae;Will Above-mentioned Chinese medicine goes respectively the removal of impurity, then drying, crush, pack tightly that to form cartridge bag standby with four layers of gauze;Cartridge bag is placed in into 79 Kilogram water in soak 20 several minutes, decoct 30 minutes, take standby after its supernatant liquid filtering;30 kilograms of vaseline and 25 is public The borneol of jin is placed in rustless steel container, is heated to dissolving completely, pours and fill supernatant the vaseline for having dissolved, borneol solution into In liquid container, agitated is uniformly cost product.

Claims (2)

1. the ointment of glaucoma is treated, be it is characterized in that:(1), it is with the Chinese medicine for including following component and its parts by weight Make:Felwort 10~40, mother chrysanthemum 10~40, Radix Angelicae Sinensis 10~40, selfheal 20~50, motherwort Wei Zi 20~50, the dried rhizome of rehmannia 20~ 50, coptis root 15~30, cassia seed 15~30, ching-chieh 10~20, puncture vine 10~20, Radix Glycyrrhizae 10~20;(2), its preparation method Comprise the following steps:A, above-mentioned Chinese medicine is gone into respectively the removal of impurity, then drying, crush, pack tightly to form cartridge bag with four layers of gauze It is standby, B, by cartridge bag be placed in the water of above-mentioned 3 times of Chinese medicine parts by weight summation soak 20 minutes, decoct 30 minutes, take thereon Clear liquid is standby after filtering, and C, the borneol of the vaseline of 200~400 parts by weight and 150~350 parts by weight is placed in into stainless steel In container, it is heated to dissolving completely, D, the vaseline for having dissolved, borneol solution are poured into fills in supernatant liquid container, it is agitated It is uniformly cost product.
2. the ointment of the treatment glaucoma according to described in claim 1, is characterized in that:The parts by weight of described each component For:Felwort 20~30, mother chrysanthemum 20~30, Radix Angelicae Sinensis 20~30, selfheal 30~40, motherwort Wei Zi 30~40, the dried rhizome of rehmannia 30~40, Coptis root 20~25, cassia seed 20~25, ching-chieh 13~17, puncture vine 13~17, Radix Glycyrrhizae 13~17, vaseline 250~350, ice Piece 200~300.
CN201610753558.6A 2016-08-30 2016-08-30 Ointment for treating glaucoma disease Pending CN106619983A (en)

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Application Number Priority Date Filing Date Title
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113018340A (en) * 2020-12-24 2021-06-25 云南百视堂健康管理有限公司 Traditional Chinese medicine preparation for treating ametropia and eye diseases and preparation method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
冯荣敏等,: "治疗急性充血性青光眼10例疗效观察", 《新中医》 *
张亚强等,: "复明丸质量标准研究", 《陕西中医学院学报》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113018340A (en) * 2020-12-24 2021-06-25 云南百视堂健康管理有限公司 Traditional Chinese medicine preparation for treating ametropia and eye diseases and preparation method thereof

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Application publication date: 20170510