CN104491015A - Traditional Chinese medicine composition for treating allergic conjunctivitis - Google Patents
Traditional Chinese medicine composition for treating allergic conjunctivitis Download PDFInfo
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- CN104491015A CN104491015A CN201410721988.0A CN201410721988A CN104491015A CN 104491015 A CN104491015 A CN 104491015A CN 201410721988 A CN201410721988 A CN 201410721988A CN 104491015 A CN104491015 A CN 104491015A
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Classifications
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- A—HUMAN NECESSITIES
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
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Abstract
The invention discloses a traditional Chinese medicine composition for treating allergic conjunctivitis, relating to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from Chinese herbal medicines such as wild chrysanthemum, fructus kochiae, semen plantaginis, astragalus, mint, equisetum hyemale, climbing groundsel herbs and liquorice. The traditional Chinese medicine composition disclosed by the invention is high in effect taking speed, short in treatment course and high in cure rate and can be popularized and applied on the aspect of treating allergic conjunctivitis. The traditional Chinese medicine composition disclosed by the invention can take a synergistic effect and simultaneously take the effects of dispelling wind and evils, clearing away heat and toxic materials as well as dispelling wind and arresting itching.
Description
Technical field
The invention belongs to tcm field, be specifically related to a kind of Chinese medicine composition for the treatment of anaphylaxis conjunctivitis and preparation method thereof.
Background technology
Anaphylaxis conjunctivitis is also called allergic conjunctivitis, be conjunctiva to external world allergen produce a kind of allergy.Mainly comprise anaphylaxis and type Ⅳ allergy, wherein the most common with the anaphylaxis conjunctivitis caused by anaphylaxis.Anaphylaxis conjunctivitis caused by anaphylaxis is anaphylactic type, mainly refers to that anaphylaxis conjunctivitis comprises seasonal allergic conjunctivitis, perennial allergic conjunctivitis, macropapillary conjunctivitis, vernal keratoconjunctivitis, atopy keratoconjunctivitis etc.; Anaphylaxis conjunctivitis caused by type Ⅳ allergy is delayed, mainly contains phlyctenular conjunctivitis.
Clinical symptoms: ophthalmic pruritus, nearly all anaphylaxis conjunctivitis patient all can occur, wherein vernal keratoconjunctivitis shows the most obvious usually.Other symptoms are shed tears, burning sensation, photophobia and secretions increase etc.Secretions mostly is mucus.Some more serious anaphylaxis conjunctivitises, as vernal keratoconjunctivitis and atopy keratoconjunctivitis can occur visual deterioration sometimes.The modal sign of anaphylaxis conjunctivitis is conjunctival congestion.Conjunctival papilla hypertrophy is another common sign, and nipple comes across upper tarsal conjunctiva more.The morphological characteristic that the nipple of macropapillary conjunctivitis and vernal keratoconjunctivitis hypertrophy has it special.Atopy keratoconjunctivitis often occurs that conjunctiva fibrosis (cicatrix) changes.Also can chemosis be there is during seasonal allergic conjunctivitis outbreak, particularly common child.Corneal injury with vernal keratoconjunctivitis and atopy keratoconjunctivitis the most common.
Current clinical conventional eye Claritin, mainly comprise mast cell stabilizers, antihistaminic, glucocorticoid, but these Drug therapys are long for the course for the treatment of, and side effect is larger.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of anaphylaxis conjunctivitis.
In order to realize object of the present invention, technical solution of the present invention is as follows:
Treat a Chinese medicine composition for anaphylaxis conjunctivitis, it is formed by following Chinese drug preparation: Flos Chrysanthemi Indici, the Fructus Kochiae, Semen Plantaginis, the Radix Astragali, Herba Menthae, Herba Equiseti Hiemalis, Herba Senecionis Scandentis and Radix Glycyrrhizae.
Preferably, the Chinese medicine composition that the present invention treats anaphylaxis conjunctivitis is formed by the Chinese drug preparation of following parts by weight:
Flos Chrysanthemi Indici 10-40, Fructus Kochiae 10-30, Semen Plantaginis 10-30, Radix Astragali 10-30, Herba Senecionis Scandentis 5-20, Herba Menthae 1-10, Herba Equiseti Hiemalis 1-10, Radix Glycyrrhizae 5-20.
Most preferably, the Chinese medicine composition that the present invention treats anaphylaxis conjunctivitis is formed by the Chinese drug preparation of following parts by weight:
Flos Chrysanthemi Indici 20, the Fructus Kochiae 20, Semen Plantaginis 10, the Radix Astragali 10, Herba Senecionis Scandentis 10, Herba Menthae 5, Herba Equiseti Hiemalis 5, Radix Glycyrrhizae 10.
Fang Zhong:
Flos Chrysanthemi Indici: nature and flavor, bitter in the mouth; Pungent; Property is put down.Return lung; Liver Channel.Heat-clearing and toxic substances removing; Dispelling wind suppressing the hyperactive liver.Main furuncle; Carbuncle; Erysipelas; Eczema; Dermatitis; Anemopyretic cold; Laryngopharynx swelling and pain; Hypertension.
The Fructus Kochiae: nature and flavor is pungent, bitter, cold.Return kidney, urinary bladder channel.Clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.For difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.
Semen Plantaginis: sweet in the mouth; Light; Cold nature.Return lung; Liver; Kidney; Urinary bladder channel.Clearing away heat and promoting diuresis; Eliminating dampness by diuresis antidiarrheal; Improving eyesight; Eliminate the phlegm.Main dysuria; Stranguria with turbid discharge leukorrhagia; Edema distension; Heat-damp in summer dysentery; Conjunctival congestion is hidden from view; Expectorant heat syndrome cough is breathed heavily.
The Radix Astragali: nature and flavor, sweet, temperature.Return lung, spleen channel.Invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Herba Senecionis Scandentis: nature and flavor is bitter, pungent, cool.Slightly poisonous.Heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling, liver heat removing and eyesight improving.For wind-fire acute conjunctivitis, furuncle toxic swelling, the diseases such as skin eczema and dysentery stomachache.
Herba Menthae: pungent is cool.Return lung, Liver Channel.Dispelling wind-heat.Refresh oneself, rash.For anemopyretic cold, pathogenic wind-warm from the beginning of, headache, conjunctival congestion, sore throat, aphtha, rubella, measles, breast the side of body feeling of distension and oppression.
Herba Equiseti Hiemalis: sweetness and bitterness; Flat; Nontoxic.Return lung; Liver; Gallbladder meridian.Wind and heat dispersing; Cooling blood for hemostasis; Improving acuity of vision and removing nebula.The hot conjunctival congestion of main air; The raw nebula of order; Epiphora induced by wind; Discharging fresh blood stool; Hemorrhoidal bleeding; Dysentery; Married woman's metrorrhagia; Proctoptosis
Radix Glycyrrhizae: nature and flavor, sweet, flat.Gui Jing, GUIXIN, lung, spleen, stomach warp.Function cures mainly, invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Pharmaceutical formulation of the present invention is oral formulations, can according to existing preparation process add prepare different dosage form time required various customary adjuvant, for the selection of adjuvant, the present invention does not specifically limit.Such as disintegrating agent, lubricant, adhesive etc. are prepared into the conventional oral formulations of any one with the method for Chinese medicinal of routine, such as, can be capsule, tablet, powder, pill, granule or oral liquid etc.
Another object of the present invention is to provide a kind of preparation method for the treatment of the Chinese medicine composition pill of anaphylaxis conjunctivitis, and concrete preparation process is as follows:
Get each medical material of above-mentioned components by weight percent, add the 5-10 water doubly of medical material gross weight, soak 30-60 minute, decoct 1-3 time, each 1-3 hour, filter, merging filtrate, filtrate reduced in volume is to the extractum of relative density 1.05-1.25, and this relative density is testing result at 60 c, and adding ethanol to alcohol content is 60-90%(v/v), leave standstill 24 hours, get supernatant, reclaim ethanol to concentrated, be prepared into above-mentioned dosage form.
Chinese medicine composition of the present invention can be worked in coordination with mutually, plays wind dispelling altogether loose evil, the merit of heat-clearing and toxic substances removing, dispelling wind for relieving itching.Through clinical verification, Chinese medicine of the present invention has the following advantages:
1) good effect, effective percentage is high;
2) therapeutic dose is low, has no side effect;
3) preparation technology is simple;
4) raw material is natural common, cheap and easy to get.
clinical data: Chinese medicine composition of the present invention is to the therapeutical effect of anaphylaxis conjunctivitis
1 physical data
Seasonal allergic conjunctivitis 80 example through making a definite diagnosis and perennial allergic conjunctivitis 20 example totally 100 examples.Clients is divided into two groups by the method making a definite diagnosis rear employing district group random: each 50 examples.Two groups of physical data are through statistical procedures, and no significant difference (P>0.05), has comparability.
2 inclusive criterias
Seasonal allergic conjunctivitis except seasonality outbreak and symptom, somatic feature score all relatively low except, other clinical characters are quite similar with perennial allergic conjunctivitis, so both unified to include in.Diagnosis is main with reference to " Chinese ophthalmology ", symptom: ophthalmic pruritus, shed tears, burning sensation, foreign body sensation, photophobia and secretions increases (mostly being mucus).Sign: conjunctival congestion, edema, palpebral conjunctiva nipple follicle hypertrophy.
3 exclusion standards
With eye patients such as keratitis, xerophthalmia, glaucomas; Within nearly 1 month, execute ophthalmic surgery; Use may other hydryllin of influence research result, mast cell stabilizers and corticosteroid collyrium, nasal mist or systemic drug patient; Intentionally, the patient of the severe primary disease such as brain, liver, kidney and hemopoietic system; Not by regulation medication, the infull person of curative effect or data cannot be judged.
4. Therapeutic Method
Treatment group: capsule prepared by the oral embodiment of the present invention 1, every day 3 times.Each 4, successive administration 5 days.
Matched group: oral hydrochloride cetirizine tablet 10mg/ sheet, a slice on the one.
Within 1 week, carry out checking and following up a case by regular visits to after 3 days, 5 days, 7 days and drug withdrawal after the treatment respectively, record eye subjective symptom and slit lamp examination palpebra inferior, conjunctiva, cornea.
5. curative effect determinate standard: adopt " clinical characters of anaphylaxis conjunctivitis ".Symptom and sign standards of grading evaluation index: ophthalmic pruritus, shed tears, foreign body sensation, eyelid nipple, palpebral follicles, secretions, conjunctival congestion, chemosis.And calculate symptom integral.Computing formula: total mark × 100% before total mark decline index=(before treatment the rear total mark of total mark-treatment)/treatment.Effective: integration reduces >70%; Effective: integration reduces 30%-70%; Invalid: integration reduces <30%.
6. therapeutic effect
Two groups of clinical therapeutic efficacies are in table 1.
Table 1 liang group medicine is to the therapeutic effect of anaphylaxis conjunctivitis
| Group | Case load | Effective (obvious effective rate) | Effectively | Invalid | Total effective rate |
| Treatment group | 50 | 36（72%） | 13 | 1 | 98% |
| Matched group | 50 | 17（34%） | 21 | 12 | 76% |
Visible Chinese medicine composition of the present invention is significantly better than cetirizine hydrochloride for the therapeutic effect of anaphylaxis conjunctivitis, can as the medicinal application for the treatment of anaphylaxis conjunctivitis.
Detailed description of the invention
Below will further illustrate the present invention by specific embodiment, but it should be appreciated by those skilled in the art that the specific embodiment of the invention and do not limit the present invention in any way.Take up an official post on basis of the present invention and how all fall within protection scope of the present invention with replacement.
EXAMPLE l
Get Flos Chrysanthemi Indici 20kg, Fructus Kochiae 20kg, Semen Plantaginis 10kg, Radix Astragali 10kg, Herba Senecionis Scandentis 10kg, Herba Menthae 5kg, Herba Equiseti Hiemalis 5kg, Radix Glycyrrhizae 10kg, add the water of 10 times of medical material gross weight, soak 60 minutes, decoct 3 times, each 3 hours, filter, merging filtrate, filtrate reduced in volume is to the extractum of relative density 1.05-1.25, adding ethanol to alcohol content is 70%(v/v), leave standstill 24 hours, get supernatant, reclaim ethanol, concentrated, drying, adds customary adjuvant and is prepared into capsule, and every capsules is containing crude drug 0.6g.
Embodiment 2
Get Flos Chrysanthemi Indici 18kg, Fructus Kochiae 18kg, Semen Plantaginis 18 kg, the Radix Astragali 16 kg, Herba Senecionis Scandentis 10kg, Herba Menthae 6 kg, Herba Equiseti Hiemalis 6 kg, Radix Glycyrrhizae 20 kg, add the water of 12 times of medical material gross weight, soak 45 to decoct 3 times, each 2 hours, filter, merging filtrate, filtrate reduced in volume is to the extractum of relative density 1.05-1.25, and adding ethanol to alcohol content is 70%(v/v), leave standstill 24 hours, get supernatant, reclaim ethanol, concentrated, dry, add customary adjuvant tabletting, obtain tablet, every sheet is containing crude drug 0.5g.
Embodiment 3
Get Flos Chrysanthemi Indici 3kg, Fructus Kochiae 3kg, Semen Plantaginis 18kg, Radix Astragali 12kg, Herba Senecionis Scandentis 16kg, Herba Menthae 6kg, Herba Equiseti Hiemalis 8kg, Radix Glycyrrhizae 22kg, add the water of 8 of medical material gross weight, soak 30, decoct 3 times, each 2 hours, filter, merging filtrate, filtrate reduced in volume is to the extractum of relative density 1.05-1.25, and adding ethanol to alcohol content is 80%(v/v), leave standstill 24 hours, get supernatant, reclaim ethanol, concentrated, dry, add customary adjuvant and be prepared into granule, pack, every bag containing crude drug 2.5g.
Embodiment 4
Get Flos Chrysanthemi Indici 20kg, Fructus Kochiae 20kg, Semen Plantaginis 10kg, Radix Astragali 10kg, Herba Senecionis Scandentis 10kg, Herba Menthae 5kg, Herba Equiseti Hiemalis 5kg, Radix Glycyrrhizae 10kg, add the water of 7 of medical material gross weight, soak 45, decoct 3 times, each 2 hours, filter, merging filtrate, filtrate reduced in volume is to the extractum of relative density 1.05-1.25, and adding ethanol to alcohol content is 75%(v/v), leave standstill 24 hours, get supernatant, reclaim ethanol, concentrated, add purified water and be prepared into oral liquid, every ml is containing crude drug 0.25g.
Claims (6)
1. treat a Chinese medicine composition for anaphylaxis conjunctivitis, it is characterized in that, it is formed by following Chinese drug preparation: Flos Chrysanthemi Indici, the Fructus Kochiae, Semen Plantaginis, the Radix Astragali, Herba Menthae, Herba Equiseti Hiemalis, Herba Senecionis Scandentis and Radix Glycyrrhizae.
2. Chinese medicine composition as claimed in claim 1, it is characterized in that, formed by the Chinese drug preparation of following parts by weight: Flos Chrysanthemi Indici 10-40, Fructus Kochiae 10-30, Semen Plantaginis 10-30, Radix Astragali 10-30, Herba Senecionis Scandentis 5-20, Herba Menthae 1-10, Herba Equiseti Hiemalis 1-10, Radix Glycyrrhizae 5-20.
3. Chinese medicine composition as claimed in claim 2, is characterized in that, formed by the Chinese drug preparation of following parts by weight: Flos Chrysanthemi Indici 20, the Fructus Kochiae 20, Semen Plantaginis 10, the Radix Astragali 10, Herba Senecionis Scandentis 10, Herba Menthae 5, Herba Equiseti Hiemalis 5, Radix Glycyrrhizae 10.
4. the Chinese medicine composition as described in as arbitrary in claim 1-2, it is characterized in that, its pharmaceutical formulation is oral formulations.
5. Chinese medicine composition as claimed in claim 3, it is characterized in that, described oral formulations is capsule, tablet, powder, pill, granule or oral liquid.
6. Chinese medicine composition as claimed in claim 3, it is characterized in that, the preparation method of described oral formulations comprises the steps: each medical material getting above-mentioned components by weight percent, add the 5-10 water doubly of medical material gross weight, soak 30-60 minute, decoct 1-3 time, each 1-3 hour, filter, merging filtrate, filtrate reduced in volume is to the extractum of relative density 1.05-1.25, this relative density is testing result at 60 c, adding ethanol to alcohol content is 60-90%(v/v), leave standstill 24 hours, get supernatant, reclaim ethanol to concentrated, be prepared into above-mentioned dosage form.
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