CN105477469A - Traditional Chinese medicine for treating lung-deficiency-related cold type anaphylactic rhinitis and preparation method of traditional Chinese medicine - Google Patents
Traditional Chinese medicine for treating lung-deficiency-related cold type anaphylactic rhinitis and preparation method of traditional Chinese medicine Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine for treating lung-deficiency-related cold type anaphylactic rhinitis and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine is prepared from the following raw medicinal materials: malachite, pigeon peas, common nostoc, cowpea roots, beechey fig leaf, mume kernels, herb of scape-like sage, globose phaenosperma herb, herb of hairystalk loosestrife, Herb of Birdsfoot Trefoil, Indochina dragonplum fruit, silky cinquefoil, Smilax perfoliata Lour, rabdosia amethystoides, Stachys sieboldii Miq. and pothos repens. The traditional Chinese medicine has the beneficial effects that the traditional Chinese medicine is strong in pertinence and good in treatment effects for lung-deficiency-related cold type anaphylactic rhinitis, and has no toxic and side effects.
Description
Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to and a kind ofly treating deficiency of the lung sense and to tremble with fear the Chinese medicine and preparation method thereof of type allergic rhinitis.
Background technology
Allergic rhinitis is a kind of disease occurred frequently, and time symptom is lighter, and common " flu " is similar, can not produce much impacts to normal work, life.Drag for a long time and do not control, the symptoms such as nasal obstruction, sneeze, rhinorrhea increase the weight of gradually, and not only affect personal image, personal lifestyle also can be perplexed.Feel not sleep well, hyposmia, headache and dizzy are common manifestations, time serious, also can with auditory dysesthesia, and the diseases such as sleep apnea.In fact, allergic rhinitis is larger on teenager impact.Growth and development stage is because of long-term nasal obstruction, rhinorrhea, sneeze, cannot have a good rest, sleep quality is not high, memory is not concentrated, people does not have spirit yet, normal intelligent development and growth promoter are all affected, so the child suffering from allergic rhinitis is compared with healthy child, school grade general performance can be weaker.Allergic rhinitis and allergic rhinitis, after referring to atopic individuals contact allergen, primarily of medium (mainly histamine) release of IgE mediation, and have the nasal mucosa non-infectious inflammatory disease that panimmunity competent cell and cytokine etc. participate in.Its essential condition occurred has 3: namely specific antigen causes the material of organism immune response; Atopic individuals and so-called individual variation, allergic constitution; Specific antigen and spy answer both type individualities to meet.Allergic rhinitis are global health problem, can cause numerous disease and disability.Classical symptom mainly paroxysmal sneeze, clear water sample nasal mucus, nasal obstruction and the rhinocnesmus of allergic rhinitis.Part is with hyposmia.
Allergic rhinitis, ancient literature is discussed abundant to primary disease, to its etiology and pathogenesis, ancient Chinese medicine doctor have main cold, main heat point, have the different viewpoints such as the cold renal cold of lungs cold caused by deficiency, brain, lungs sense are cold, the cold lung cold of brain; Main hot person, intentionally pathogenic fire heat does, pathogenic heat objective lung bright in sun etc.The former is advocated by most doctor."Nei Jing" thinks relevant with seasonal weather, also relevant with kidney, as " Plain Questions declares five gas " is said: five kinds of diseases caused by disorders of ZANG-QI, disorder of the kidney giving rise to sneezing and yawning.Sui Chao Shi " General Treatise on the Cause and Symptoms of Diseases " rolls up 29 and thinks that lungs cold caused by deficiency is the main cause of morbidity, points out: " lung-QI connecting with the nose, it is dirty has cold, and cold air enters to take advantage of in nose, therefore makes body fluid can not from receiving." golden Liu Hejian " etiology based on plain questions six gas for sick " point out: " itch as cremating, heart-fire pathogenic heat are done in sun bright, send out and itch in nose, sneeze also." think rhinocnesmus, sneeze be due to intimately invade and sun bright caused by.Ming Daisi respectful " secretly handing down key to diagnosis and treatment and class side " rolls up ten and says: " thin nasal discharge person, caused by the cold lung cold of brain, should Herba Asari, crow, attached, Rhizoma Zingiberis genus." Xu Chunfu ancient and Modern Medicine then thinks: " and allergic rhinitis person, heat visitor lunar through also." these understanding are all representative.The generation of primary disease is main with lung spleen kidney yang gas virtual loss, and body constitution is special, and weakened defensive QI is in close relations, therefore does not appoint the unclean gas cuts such as wind and cold unusual pathogen or pollen to attack, or triggers because of some ingesta, causes paroxysmal rhinocnesmus, sneeze, thin nasal discharge is long flows, and recurrent exerbation.Also or because accumulateing in hot and suffocating, imbalance of YIN and YANG, caused by coldheat complex.
Summary of the invention:
Technical problem to be solved by this invention is, utilizes the theory of Chinese medical science that China is traditional, provides a kind of and treats deficiency of the lung sense and to tremble with fear the Chinese medicine and preparation method thereof of type allergic rhinitis, and the treatment by Chinese herbs deficiency of the lung of the present invention sense is trembled with fear type allergic rhinitis determined curative effect, and toxic and side effects is little.
In order to solve the problems of the technologies described above, the invention provides and a kind ofly treat deficiency of the lung sense and to tremble with fear the Chinese medicine of type allergic rhinitis, its raw medicinal material comprises: Malachitum, Semen Cajani, Nostoc, Radix vignae sinensis, Caulis et Folium Fici beecheyanae, Semen Mume, Herba Salviae Scapiformis, Herba Phaenospermatis globosae, Herba lysimachiae capillipedis, Radix Loti Corniculati, Fructus Dracontomeli Duperreani, Potentilla sericea L.(Potentilla poteroides Franch), nine Niu Li, Herba Rabdosiae glaucocalycis, Rhizoma Humatae Tyermanni and Herba Pofhos repensae.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Malachitum 10 ~ 20 parts, Semen Cajani 20 ~ 30 parts, Nostoc 15 ~ 25 parts, Radix vignae sinensis 10 ~ 20 parts, Caulis et Folium Fici beecheyanae 5 ~ 15 parts, Semen Mume 20 ~ 30 parts, Herba Salviae Scapiformis 10 ~ 20 parts, Herba Phaenospermatis globosae 10 ~ 20 parts, Herba lysimachiae capillipedis 10 ~ 20 parts, Radix Loti Corniculati 20 ~ 30 parts, Fructus Dracontomeli Duperreani 10 ~ 20 parts, Potentilla sericea L.(Potentilla poteroides Franch) 20 ~ 30 parts, nine Ns of power 20 ~ 30 parts, Herba Rabdosiae glaucocalycis 10 ~ 20 parts, Rhizoma Humatae Tyermanni 10 ~ 20 parts and Herba Pofhos repensae 15 ~ 25 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be as follows: Malachitum 10 ~ 15 parts, Semen Cajani 20 ~ 25 parts, Nostoc 17 ~ 22 parts, Radix vignae sinensis 13 ~ 18 parts, Caulis et Folium Fici beecheyanae 8 ~ 13 parts, Semen Mume 25 ~ 30 parts, Herba Salviae Scapiformis 12 ~ 17 parts, Herba Phaenospermatis globosae 15 ~ 20 parts, Herba lysimachiae capillipedis 13 ~ 18 parts, Radix Loti Corniculati 22 ~ 27 parts, Fructus Dracontomeli Duperreani 10 ~ 15 parts, Potentilla sericea L.(Potentilla poteroides Franch) 23 ~ 28 parts, nine Ns of power 20 ~ 25 parts, Herba Rabdosiae glaucocalycis 15 ~ 20 parts, Rhizoma Humatae Tyermanni 10 ~ 15 parts and Herba Pofhos repensae 18 ~ 23 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is most preferably as follows: Malachitum 14 parts, Semen Cajani 20 parts, Nostoc 21 parts, Radix vignae sinensis 14 parts, Caulis et Folium Fici beecheyanae 12 parts, Semen Mume 25 parts, Herba Salviae Scapiformis 16 parts, Herba Phaenospermatis globosae 15 parts, Herba lysimachiae capillipedis 18 parts, Radix Loti Corniculati 24 parts, Fructus Dracontomeli Duperreani 14 parts, Potentilla sericea L.(Potentilla poteroides Franch) 24 parts, nine Ns of power 25 parts, Herba Rabdosiae glaucocalycis 15 parts, Rhizoma Humatae Tyermanni 14 parts and Herba Pofhos repensae 20 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is most preferably as follows: Malachitum 12 parts, Semen Cajani 25 parts, Nostoc 18 parts, Radix vignae sinensis 16 parts, Caulis et Folium Fici beecheyanae 10 parts, Semen Mume 28 parts, Herba Salviae Scapiformis 14 parts, Herba Phaenospermatis globosae 20 parts, Herba lysimachiae capillipedis 15 parts, Radix Loti Corniculati 26 parts, Fructus Dracontomeli Duperreani 10 parts, Potentilla sericea L.(Potentilla poteroides Franch) 26 parts, nine Ns of power 22 parts, Herba Rabdosiae glaucocalycis 20 parts, Rhizoma Humatae Tyermanni 10 parts and Herba Pofhos repensae 22 parts.
Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is powder, its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, the first step is obtained powder and add in cold water and soak 6 hours ~ 12 hours, with slow fire boiling, decocting time is 3 hours ~ 5 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 2 ~ 4 times of the powder quality that the first step obtains;
3rd step, filters second step the filtering residue obtained and again adds in cold water, with slow fire boiling 2 hours ~ 4 hours, filters acquisition second filtrate, and the quality of the water added is 2 ~ 4 times of the filtering residue quality that second step obtains;
4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 80 ~ 120 orders;
5th step, in the powder that described 4th step obtains, add starch, the percentage by weight of described starch in described powder is 15% ~ 30%, and by the material pouch after mixing or packing box subpackage, every 5 ~ 10 grams is one bag or a box subpackage.
Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is granule, its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
Beneficial effect of the present invention: Chinese medicine of the present invention to be trembled with fear type allergic rhinitis to deficiency of the lung sense, and with strong points, therapeutic effect is good, use safety, has no side effect.
Detailed description of the invention
The invention provides and a kind ofly treat deficiency of the lung sense and to tremble with fear the Chinese medicine of type allergic rhinitis, its raw medicinal material comprises: Malachitum, Semen Cajani, Nostoc, Radix vignae sinensis, Caulis et Folium Fici beecheyanae, Semen Mume, Herba Salviae Scapiformis, Herba Phaenospermatis globosae, Herba lysimachiae capillipedis, Radix Loti Corniculati, Fructus Dracontomeli Duperreani, Potentilla sericea L.(Potentilla poteroides Franch), nine Niu Li, Herba Rabdosiae glaucocalycis, Rhizoma Humatae Tyermanni and Herba Pofhos repensae.
In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:
Malachitum: [another name] malachite green, stone are commonplace, green greatly.[source] medical material Ji Yuan: be the Ore of carbonate mineral malachite.[nature and flavor] acid; Cold; Nontoxic.[return through] Liver Channel.[function cures mainly] is emetic eliminates the phlegm; Relieving convulsion; Sore.Main air expectorant is jammed; Faint with dizziness; Expectorant fan infantile convulsion; Chancre.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "
Semen Cajani: [another name] kwan-yin bean, large Semen Cajani, tree bean, Russian red clover, flower spiral shell are set bean, turned round bean, wild Semen Glycines.[source] medical material Ji Yuan: be the seed of leguminous plant Semen Cajani.[nature and flavor] are pungent, puckery; Flat; Nontoxic.[return through] liver; Spleen channel.[function cures mainly] dampness removing, detumescence, dissipating blood stasis, hemostasis.Main air pain of dampness syndrome, traumatic injury, epistaxis, has blood in stool, furuncle toxic swelling, prolonged lochia, edema, icterohepatitis.[extracts] " China's book on Chinese herbal medicine "
Nostoc: [another name] ear, step on mushroom, nasal mucus meat, step on dish, sky rosetangle, beauty's rice, soft, lichens, Nostoc commune, land for building dish, pick up skin.[source] medical material Ji Yuan: be the frond of nostocaceae plant nostoc or its congener.[nature and flavor] are sweet; Light; Cool; Cold.[return through] Liver Channel.[function cures mainly] clearing away heat to improve acuity of vision; Convergence QI invigorating.Argument is crimson swollen; Nyctalopia; Burn and scald; Chronic dysentery; Proctoptosis.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "
Radix vignae sinensis: [source] medical material Ji Yuan: be the root of leguminous plant Semen vignae sinensis.[nature and flavor] are sweet; Flat.[return through] spleen; Stomach warp.[function cures mainly] invigorating the spleen and benefiting QI; Removing food stagnancy; Removing toxic substances.Main weakness of the spleen and stomach; Food stagnation; Leucorrhea; Stranguria with turbid discharge; Hemorrhoidal bleeding; Furuncle.[extracts] " China's book on Chinese herbal medicine "
Caulis et Folium Fici beecheyanae: [source] medical material Ji Yuan: be stem, the leaf of moraceae plants Fructus Fici Beecheyanae.[nature and flavor] are sweet; Light; Warm in nature.[return through] lung; Spleen; Kidney channel.[function cures mainly] invigorating middle warmer spleen invigorating; Wind-damp dispelling; Promoting blood circulation to remove obstruction in the collateral.The main deficiency of vital energy is weak; Extremity are aching and limp; Rheumatic arthralgia; Stiffness of the muscle and joint; Traumatic injury; Amenorrhea; Galactostasis.[extracts] " China's book on Chinese herbal medicine "
Semen Mume: [source] medical material Ji Yuan: be the kernel of rose department plant plum.[nature and flavor] acid; Flat; Nontoxic.[return through] lung; The heart; Liver; Large intestine channel.[function cures mainly] drives away summer heat network clearly; Liver-benefiting eye-brightening; Clearing away heat and eliminating dampness.Main summer heat cholera; Dysphoria with smothery sensation; Blurring of vision.[extracts] " China's book on Chinese herbal medicine "
Herba Salviae Scapiformis: [another name] overturns the heavens Thunder God.[source] medical material Ji Yuan: be the herb of labiate bristle field bund Salvia japonica Thunb..[nature and flavor] acrid in the mouth; Sweet; Property is put down.[function cures mainly] tonify deficiency benefit is damaged; Bone and muscle strengthening.Main pneumonopathy; Weak skinny and wizened; The vertigo; Impairment caused by overstrain dish bone.[extracts] " China's book on Chinese herbal medicine "
Herba Phaenospermatis globosae: [another name] rock Sorghum vulgare Pers..[source] medical material Ji Yuan: be the herb of grass Herba Phaenospermatis globosae.[nature and flavor] are sweet; Micro-puckery; Flat.The spleen invigorating of [function cures mainly] tonify deficiency; Promoting blood flow to regulate menstruation.Main body is after being ill empty; Amenorrhea.[extracts] " China's book on Chinese herbal medicine "
Herba lysimachiae capillipedis: [another name] Herba lysimachiae capillipedis, rake grass.[source] medical material Ji Yuan: be the root and rhizome of labiate Herba lysimachiae capillipedis.[nature and flavor] acrid in the mouth; Warm in nature.[function cures mainly] removing dampness keeps away turbid; Inducing diuresis to remove edema.Main summer-heat is aobvious vomits and diarrhoea; Edema; Dysuria.[extracts] " China's book on Chinese herbal medicine "
Radix Loti Corniculati: [another name] cypress root of pulse, Birdfoot, all grass, golden flower, Herba Erodii, bird are apart from grass.[source] medical material Ji Yuan: be the root of leguminous plant Radix Loti Corniculati.[nature and flavor] are sweet; Bitter; Be slightly cold.[return through] lung meridian.[function cures mainly] tonify deficiency; Heat clearing away; Quench the thirst.Main asthenia; Fever due to yin deficiency; Thirsty.[extracts] " China's book on Chinese herbal medicine "
Fructus Dracontomeli Duperreani: [another name] people face fruit, Dracontomelon dao.[source] medical material Ji Yuan: be the fruit of Anacardiaceae plant man face.[nature and flavor] are sweet; Acid; Cool in nature.[return through] spleen; Stomach; Liver Channel.[function cures mainly] stomach invigorating; Promote the production of body fluid; Relieving alcoholic intoxication; Removing toxic substances.Main inappetence; Calentura is thirsty; Drunk; Laryngopharynx swelling and pain; Pathogenic wind-toxic sore is itched.[extracts] " China's book on Chinese herbal medicine "
Potentilla sericea L.(Potentilla poteroides Franch): [source] medical material Ji Yuan: be the herb of rosaceous plant lower reaches of the Changjiang River Herba Potentillae Chinensis.[nature and flavor] are sweet; Temperature.[return through] kidney channel.[function cures mainly] strengthening spleen, tonifying kidney, arresting sweating, hemostasis.Main weakness due to chronic disease, night sweat due to yin deficiency, metrorrhagia, leukorrhagia.[extracts] " China's book on Chinese herbal medicine "
Nine Niu Li: [another name] CHUANTAI, native Rhizoma Dioscoreae Septemlobae.[source] medical material Ji Yuan: be the rhizome of liliaceous plant Smilax perfoliate.[nature and flavor] are sweet; Light; Flat.[function cures mainly] strengthening the spleen and stomach; Bone and muscle strengthening.Main insufficiency of the spleen few food; Tinnitus; Weak; Soreness of the waist and knees.[extracts] " China's book on Chinese herbal medicine "
Herba Rabdosiae glaucocalycis: [another name] Radix Picriae felterrae, Herba Dracocephali, Serpentis siphunculus, Herba Rabdosiae Amethystoidis, sow fresh idea, Rhizoma Bergeniae scopulosae.[source] medical material Ji Yuan: be the aerial parts of labiate Herba Rabdosiae glaucocalycis.[nature and flavor] acrid in the mouth; Bitter; Cool in nature.[return through] returns liver; Kidney channel.[function cures mainly] clearing away heat-damp and promoting diuresis; Promoting blood circulation to remove blood stasis; Removing toxic substances and promoting subsidence of swelling.Main jaundice due to damp-heat; Stranguria; Edema; Laryngopharynx swelling and pain; Arthralgia; Amenorrhea; Acute mastitis; Hemorrhoid; Carbuncle on the back; Traumatic injury; Venom.[extracts] " China's book on Chinese herbal medicine "
Rhizoma Humatae Tyermanni: [another name] Chinese artichoke, drip dew, Stachys geobombycis C. Y. Wu, Chinese artichoke, native common house centipede, Chinese artichoke, snail dish, eupolyphage sece steleophaga grass, Radix Talini Paniculati, native stamen, hair dish, wind is careless, Myrmeleonmicans Mac Lachlan is careless, knob, screw dish.[source] medical material Ji Yuan: be tuber and the herb of labiate Rhizoma Humatae Tyermanni.[nature and flavor] sweet in the mouth; Property is put down.[return through] returns lung; Liver; Spleen channel.[function cures mainly] induces sweat lung heat clearing; Eliminating damp, detoxifying; Tonify deficiency spleen invigorating.Main anemopyretic cold; Cough due to consumptive disease; Jaundice; Stranguria; Sore swells and ache; Venom.[extracts] " China's book on Chinese herbal medicine "
Herba Pofhos repensae: Scolopendra, Caulis et Folium Pothi Repentis, centipede grass, iron speck turtledove, Ba Yanjiang, Jiang Teng, sky Scolopendra, native stone Scolopendra, cock tail, thin Herba pteridis vittatae, Herba pteridis vittatae, stone Scolopendra, Scolopendra of going down the hill on [another name] Lysimachia christinae Hance, stone.[source] medical material Ji Yuan: be the herb of aroid Herba Pofhos repensae.[nature and flavor] acrid in the mouth; Warm in nature.[return through] Liver Channel.The synthetism of [function cures mainly] dissipating blood stasis, reducing swelling and alleviating pain.Main impairment caused by overstrain; Treating swelling and pain by traumatic injury; Fracture; Sore.[extracts] " China's book on Chinese herbal medicine "
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Malachitum 10 ~ 20 parts, Semen Cajani 20 ~ 30 parts, Nostoc 15 ~ 25 parts, Radix vignae sinensis 10 ~ 20 parts, Caulis et Folium Fici beecheyanae 5 ~ 15 parts, Semen Mume 20 ~ 30 parts, Herba Salviae Scapiformis 10 ~ 20 parts, Herba Phaenospermatis globosae 10 ~ 20 parts, Herba lysimachiae capillipedis 10 ~ 20 parts, Radix Loti Corniculati 20 ~ 30 parts, Fructus Dracontomeli Duperreani 10 ~ 20 parts, Potentilla sericea L.(Potentilla poteroides Franch) 20 ~ 30 parts, nine Ns of power 20 ~ 30 parts, Herba Rabdosiae glaucocalycis 10 ~ 20 parts, Rhizoma Humatae Tyermanni 10 ~ 20 parts and Herba Pofhos repensae 15 ~ 25 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be as follows: Malachitum 10 ~ 15 parts, Semen Cajani 20 ~ 25 parts, Nostoc 17 ~ 22 parts, Radix vignae sinensis 13 ~ 18 parts, Caulis et Folium Fici beecheyanae 8 ~ 13 parts, Semen Mume 25 ~ 30 parts, Herba Salviae Scapiformis 12 ~ 17 parts, Herba Phaenospermatis globosae 15 ~ 20 parts, Herba lysimachiae capillipedis 13 ~ 18 parts, Radix Loti Corniculati 22 ~ 27 parts, Fructus Dracontomeli Duperreani 10 ~ 15 parts, Potentilla sericea L.(Potentilla poteroides Franch) 23 ~ 28 parts, nine Ns of power 20 ~ 25 parts, Herba Rabdosiae glaucocalycis 15 ~ 20 parts, Rhizoma Humatae Tyermanni 10 ~ 15 parts and Herba Pofhos repensae 18 ~ 23 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is most preferably as follows: Malachitum 14 parts, Semen Cajani 20 parts, Nostoc 21 parts, Radix vignae sinensis 14 parts, Caulis et Folium Fici beecheyanae 12 parts, Semen Mume 25 parts, Herba Salviae Scapiformis 16 parts, Herba Phaenospermatis globosae 15 parts, Herba lysimachiae capillipedis 18 parts, Radix Loti Corniculati 24 parts, Fructus Dracontomeli Duperreani 14 parts, Potentilla sericea L.(Potentilla poteroides Franch) 24 parts, nine Ns of power 25 parts, Herba Rabdosiae glaucocalycis 15 parts, Rhizoma Humatae Tyermanni 14 parts and Herba Pofhos repensae 20 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is most preferably as follows: Malachitum 12 parts, Semen Cajani 25 parts, Nostoc 18 parts, Radix vignae sinensis 16 parts, Caulis et Folium Fici beecheyanae 10 parts, Semen Mume 28 parts, Herba Salviae Scapiformis 14 parts, Herba Phaenospermatis globosae 20 parts, Herba lysimachiae capillipedis 15 parts, Radix Loti Corniculati 26 parts, Fructus Dracontomeli Duperreani 10 parts, Potentilla sericea L.(Potentilla poteroides Franch) 26 parts, nine Ns of power 22 parts, Herba Rabdosiae glaucocalycis 20 parts, Rhizoma Humatae Tyermanni 10 parts and Herba Pofhos repensae 22 parts.
Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is powder, its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, the first step is obtained powder and add in cold water and soak 6 hours ~ 12 hours, with slow fire boiling, decocting time is 3 hours ~ 5 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 2 ~ 4 times of the powder quality that the first step obtains;
3rd step, filters second step the filtering residue obtained and again adds in cold water, with slow fire boiling 2 hours ~ 4 hours, filters acquisition second filtrate, and the quality of the water added is 2 ~ 4 times of the filtering residue quality that second step obtains;
4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 80 ~ 120 orders;
5th step, in the powder that described 4th step obtains, add starch, the percentage by weight of described starch in described powder is 15% ~ 30%, and by the material pouch after mixing or packing box subpackage, every 5 ~ 10 grams is one bag or a box subpackage.
Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is granule, its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.
Embodiment 1: powder
Get Malachitum 120g, Semen Cajani 250g, Nostoc 180g, Radix vignae sinensis 160g, Caulis et Folium Fici beecheyanae 100g, Semen Mume 280g, Herba Salviae Scapiformis 140g, Herba Phaenospermatis globosae 200g, Herba lysimachiae capillipedis 150g, Radix Loti Corniculati 260g, Fructus Dracontomeli Duperreani 100g, Potentilla sericea L.(Potentilla poteroides Franch) 260g, nine Ns of power 220g, Herba Rabdosiae glaucocalycis 200g, Rhizoma Humatae Tyermanni 100g and Herba Pofhos repensae 220g;
Prepare according to the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, the first step is obtained powder and add in cold water and soak 10 hours, with slow fire boiling, decocting time is 4 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 2 times of the powder quality that the first step obtains;
3rd step, filters second step the filtering residue obtained and again adds in cold water, with slow fire boiling 2 hours, filters acquisition second filtrate, and the quality of the water added is 3 times of the filtering residue quality that second step obtains;
4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 100 orders;
5th step, in the powder that described 4th step obtains, add starch, the percentage by weight of described starch in described powder is 20%, and by the material pouch subpackage after mixing, every 10 grams is one bag of subpackage.
Embodiment 2: granule
Get Malachitum 140g, Semen Cajani 200g, Nostoc 210g, Radix vignae sinensis 140g, Caulis et Folium Fici beecheyanae 120g, Semen Mume 250g, Herba Salviae Scapiformis 160g, Herba Phaenospermatis globosae 150g, Herba lysimachiae capillipedis 180g, Radix Loti Corniculati 240g, Fructus Dracontomeli Duperreani 140g, Potentilla sericea L.(Potentilla poteroides Franch) 240g, nine Ns of power 250g, Herba Rabdosiae glaucocalycis 150g, Rhizoma Humatae Tyermanni 140g and Herba Pofhos repensae 200g;
Prepare according to the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 times, mixture is the ethanol of 95%, be heated to boiling reflux 3 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 55 DEG C subsequently under vacuum 0.07Mpa, relative density is the mastic of 1.08, spraying dry, the inlet temperature 170 DEG C of spray dryer, leaving air temp 80 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.25 times and 0.13 times in the dried cream powder obtained, makes granule, in 45 DEG C of dryings, obtains granule.
Toxicity test:
Acute toxicity testing: application mice 60, male and female half and half, body weight 18 ~ 30g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese powder medicine prepared by embodiments of the invention 1, (concentration is 7.26g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 36.3 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage powder LD50>36.3 crude drug/kg of the present invention, every day, maximum dosage-feeding was 72.6 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 6.2g crude drug/day/people, adult body weight in 60KG, average dosage is 0.103g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 24g) oral administration gavage Chinese medicine of the present invention is 705 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine embodiment 1 powder of the present invention to three groups of mices (often organize 20) by 13.25,19.36 and 32.65g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
Case selection: whole 120 routine cases are my Out-patient Department patient.120 people are divided into two groups at random, matched group 60 people, male 33 people, women 27 people, 15 ~ 45 years old age, the course of disease 9 months ~ 6 year half, catarrhus perennialis 36 people, seasonal allergic rhinitis 24 people; Treatment group 60 people, male 35 people, women 25 people, 16 ~ 48 years old age, the course of disease 1 ~ 7 year, catarrhus perennialis 38 people, seasonal allergic rhinitis 22 people.The aspect data such as 2 groups of sexes, age, courses of disease are through statistical procedures, and difference there are no significant meaning (p > 0.05), has comparability.
Western medicine diagnose standard: have rhinitis history of repeated attack is seasonal or perennially show effect; There are in rhinocnesmus, sneeze, nasal discharge and nasal obstruction 4 symptoms at least 2, perennially person symptom every day in the Symptomatic date accumulatively reach more than O.5 ~ 1 hour.The visible nasal mucosa of nasal cavity inspection is pale, edema or hyperemia, swelling.Pollinosis patient often has obvious conjunctival congestion, edema, severe patient eyelid swelled.Stage of attack nasal smear and (or) conjunctiva scraping blade eosinophilic granulocyte check positive.Allergen skin test is positive, and at least one is more than (++) or (++), the feasible serum of the person of having ready conditions or the inspection of nasal discharge specific IgE.Row allergen nasal mucosa provocative test if desired.
Syndrome Differentiation of Traditional Chinese Medicine standard: deficiency of the lung sense is trembled with fear type: because falling ill by air-cooled unusual pathogen, sneeze continuous cropping, pallor, cough of breathing hard, expectoration color is white, pale tongue with thin fur in vain, floating pulse.
Therapeutic Method:
Treatment group: give the embodiment of the present invention 1 powder, each 20g, every day 3 times.Within 7 days, be a course for the treatment of, treat 2 courses for the treatment of.
Matched group: oral cetirizine sheet 10mg, every day 1 time; Beclometasone nose aerosol spray nose, each 2 press, every day 2 times, within 2 weeks, are a course for the treatment of, treat 1 course for the treatment of.
Curative effect judging standard: clinical cure: nasal obstruction, rhinocnesmus, sneeze, stream clear water tears transference cure, olfactory sensation recovers, and nasal mucosa is normally ruddy, and more than 3 months without recurrence.Take a turn for the better: nasal obstruction alleviates, sneeze, stream clear water tears obviously reduce, and sign alleviates, and attack times reduces, and the intermission extends.Invalid: symptom and sign are not improved, and still often show effect.
Therapeutic outcome: two groups treat 2 weeks respectively after, statistical result is see table 1.
A table 1 liang group treats two groups of comparitive study (example) after 2 weeks respectively:
| Group | n | Clinical cure | Effectively | Invalid | Effectively total |
| Treatment group | 60 | 41 | 16 | 3 | 57(95％) |
| Matched group | 60 | 30 | 19 | 11 | 49(81.7％) |
As can be seen from Table 1, adopt the treatment by Chinese herbs deficiency of the lung of the present invention sense to tremble with fear type allergic rhinitis, relative to matched group, there is significant improvement.
Concrete case: Zhang, female, 38 years old, suffer from allergic rhinitis to have a surplus for 4 years half, once used a large amount of anti allergic drug thing, effect is undesirable, seasonal allergic rhinitis is diagnosed as, then according to tcm symptom: because falling ill by air-cooled unusual pathogen, sneeze continuous cropping through every inspection, pallor, breathe hard cough, expectoration color is white, and pale tongue with thin fur is white, floating pulse, typing is that deficiency of the lung sense is trembled with fear type seasonal allergic rhinitis.Give powder of the present invention oral, each 20g, every day 3 times, take medicine 10 days, nasal obstruction, rhinocnesmus, sneeze, stream clear water tears transference cure, olfactory sensation recovers, and nasal mucosa is normally ruddy, follows up a case by regular visits to 5 months without recurrence, clinical cure.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (9)
1. treat deficiency of the lung sense to tremble with fear the Chinese medicine of type allergic rhinitis, it is characterized in that, each raw medicinal material of described Chinese medicine comprises: Malachitum, Semen Cajani, Nostoc, Radix vignae sinensis, Caulis et Folium Fici beecheyanae, Semen Mume, Herba Salviae Scapiformis, Herba Phaenospermatis globosae, Herba lysimachiae capillipedis, Radix Loti Corniculati, Fructus Dracontomeli Duperreani, Potentilla sericea L.(Potentilla poteroides Franch), nine Niu Li, Herba Rabdosiae glaucocalycis, Rhizoma Humatae Tyermanni and Herba Pofhos repensae.
2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Malachitum 10 ~ 20 parts, Semen Cajani 20 ~ 30 parts, Nostoc 15 ~ 25 parts, Radix vignae sinensis 10 ~ 20 parts, Caulis et Folium Fici beecheyanae 5 ~ 15 parts, Semen Mume 20 ~ 30 parts, Herba Salviae Scapiformis 10 ~ 20 parts, Herba Phaenospermatis globosae 10 ~ 20 parts, Herba lysimachiae capillipedis 10 ~ 20 parts, Radix Loti Corniculati 20 ~ 30 parts, Fructus Dracontomeli Duperreani 10 ~ 20 parts, Potentilla sericea L.(Potentilla poteroides Franch) 20 ~ 30 parts, nine Ns of power 20 ~ 30 parts, Herba Rabdosiae glaucocalycis 10 ~ 20 parts, Rhizoma Humatae Tyermanni 10 ~ 20 parts and Herba Pofhos repensae 15 ~ 25 parts.
3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Malachitum 10 ~ 15 parts, Semen Cajani 20 ~ 25 parts, Nostoc 17 ~ 22 parts, Radix vignae sinensis 13 ~ 18 parts, Caulis et Folium Fici beecheyanae 8 ~ 13 parts, Semen Mume 25 ~ 30 parts, Herba Salviae Scapiformis 12 ~ 17 parts, Herba Phaenospermatis globosae 15 ~ 20 parts, Herba lysimachiae capillipedis 13 ~ 18 parts, Radix Loti Corniculati 22 ~ 27 parts, Fructus Dracontomeli Duperreani 10 ~ 15 parts, Potentilla sericea L.(Potentilla poteroides Franch) 23 ~ 28 parts, nine Ns of power 20 ~ 25 parts, Herba Rabdosiae glaucocalycis 15 ~ 20 parts, Rhizoma Humatae Tyermanni 10 ~ 15 parts and Herba Pofhos repensae 18 ~ 23 parts.
4. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Malachitum 14 parts, Semen Cajani 20 parts, Nostoc 21 parts, Radix vignae sinensis 14 parts, Caulis et Folium Fici beecheyanae 12 parts, Semen Mume 25 parts, Herba Salviae Scapiformis 16 parts, Herba Phaenospermatis globosae 15 parts, Herba lysimachiae capillipedis 18 parts, Radix Loti Corniculati 24 parts, Fructus Dracontomeli Duperreani 14 parts, Potentilla sericea L.(Potentilla poteroides Franch) 24 parts, nine Ns of power 25 parts, Herba Rabdosiae glaucocalycis 15 parts, Rhizoma Humatae Tyermanni 14 parts and Herba Pofhos repensae 20 parts.
5. the Chinese medicine as described in Claims 1-4, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Malachitum 12 parts, Semen Cajani 25 parts, Nostoc 18 parts, Radix vignae sinensis 16 parts, Caulis et Folium Fici beecheyanae 10 parts, Semen Mume 28 parts, Herba Salviae Scapiformis 14 parts, Herba Phaenospermatis globosae 20 parts, Herba lysimachiae capillipedis 15 parts, Radix Loti Corniculati 26 parts, Fructus Dracontomeli Duperreani 10 parts, Potentilla sericea L.(Potentilla poteroides Franch) 26 parts, nine Ns of power 22 parts, Herba Rabdosiae glaucocalycis 20 parts, Rhizoma Humatae Tyermanni 10 parts and Herba Pofhos repensae 22 parts.
6. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, the first step is obtained powder and add in cold water and soak 6 hours ~ 12 hours, with slow fire boiling, decocting time is 3 hours ~ 5 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 2 ~ 4 times of the powder quality that the first step obtains;
3rd step, filters second step the filtering residue obtained and again adds in cold water, with slow fire boiling 2 hours ~ 4 hours, filters acquisition second filtrate, and the quality of the water added is 2 ~ 4 times of the filtering residue quality that second step obtains;
4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 80 ~ 120 orders;
5th step, in the powder that described 4th step obtains, add starch, the percentage by weight of described starch in described powder is 15% ~ 30%, and by the material pouch after mixing or packing box subpackage, every 5 ~ 10 grams is one bag or a box subpackage.
7. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
8. the preparation method of Chinese medicine as described in claim 1 to 5, it is characterized in that, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, the first step is obtained powder and add in cold water and soak 6 hours ~ 12 hours, with slow fire boiling, decocting time is 3 hours ~ 5 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 2 ~ 4 times of the powder quality that the first step obtains;
3rd step, filters second step the filtering residue obtained and again adds in cold water, with slow fire boiling 2 hours ~ 4 hours, filters acquisition second filtrate, and the quality of the water added is 2 ~ 4 times of the filtering residue quality that second step obtains;
4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 80 ~ 120 orders;
5th step, in the powder that described 4th step obtains, add starch, the percentage by weight of described starch in described powder is 15% ~ 30%, and by the material pouch after mixing or packing box subpackage, every 5 ~ 10 grams is one bag or a box subpackage.
9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
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| CN106236957A (en) * | 2016-08-30 | 2016-12-21 | 罗嘉辉 | A kind of Chinese medicine for treating rhinitis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1751730A (en) * | 2004-09-20 | 2006-03-29 | 曹蛟 | Traditional Chinese medicine for treating anaphylactic rhinitis and its prepn. method |
| CN1872280A (en) * | 2005-05-30 | 2006-12-06 | 成都华神集团股份有限公司制药厂 | Composition of Chinese traditional medicine for treating allergic rhinitis, and preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1751730A (en) * | 2004-09-20 | 2006-03-29 | 曹蛟 | Traditional Chinese medicine for treating anaphylactic rhinitis and its prepn. method |
| CN1872280A (en) * | 2005-05-30 | 2006-12-06 | 成都华神集团股份有限公司制药厂 | Composition of Chinese traditional medicine for treating allergic rhinitis, and preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106236957A (en) * | 2016-08-30 | 2016-12-21 | 罗嘉辉 | A kind of Chinese medicine for treating rhinitis |
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