CN106619886A - 含毛茛草提取物的治疗肝炎的中西药组合物及其制备方法 - Google Patents
含毛茛草提取物的治疗肝炎的中西药组合物及其制备方法 Download PDFInfo
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- CN106619886A CN106619886A CN201611117904.8A CN201611117904A CN106619886A CN 106619886 A CN106619886 A CN 106619886A CN 201611117904 A CN201611117904 A CN 201611117904A CN 106619886 A CN106619886 A CN 106619886A
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Abstract
本发明公开了一种含毛茛草提取物的治疗肝炎的中西药组合物及其制备方法,由以下重量份的原料组成:兰索拉唑、毛茛草提取物、中药浸膏粉;所述中药浸膏粉由以下重量份的原料组成:树舌、煅青凡、当归、竹黄、绵茵陈、木蹄、土鳖虫、牡丹皮、半枝莲、桃仁、炙甘草、虎杖、冷水花、柴胡。本发明能够缩短疗程、增强疗效,采用兰索拉唑、毛茛草提取物和中药浸膏粉为原料,即将中医药结合起来,起到协同作用,解决了西药和中药在辅助治疗各种类型肝炎中各自存在的问题,同时产生协同治疗效果。
Description
技术领域
本发明涉及一种药物,具体是一种含毛茛草提取物的治疗肝炎的中西药组合物及其制备方法。
背景技术
肝炎在临床上有多种分类方法,如(1)病原学分类:可将病毒性肝炎分为五型即甲、乙、丙、丁、戊。(2)临床分类可分为以下儿型:①急性无黄疸型肝炎,这是病毒性肝炎中最常见的类烈,以乙烈、丙烈、丁烈肝炎多见,一般此类肝炎临床症状较少,转氨酶升高水平较低,组织学改变轻,死亡率较低,但病程可迁延较长时间,有“三慢”特点,发病慢、恢复慢、迁延也慢(慢指长的意思);②急性黄疸型肝炎,比起无黄疸型肝炎来说相对较少,病情常为自限性,预后多良好,但少数可发展成重型肝炎;③慢性肝炎:1994年有关专家又提出慢性肝炎的命名与建议,以病原为基础确定慢性肝炎的诊断命名,同时根据肝炎炎症的坏死严重程度订了分级标准,又根据肝纤维化程度制定了分期标准;④重型肝炎,又可分为急性重型、亚急性重型和慢性重型;⑤淤胆型肝炎。
目前用于治疗急慢性肝损害的药物,较常用的有葡醛内酯、甘草酸二按等。这些化学药物普遍有一定的副作用,并导致远期治疗效果差、病毒株产生耐药现象、停药后复发率高等问题。
中医药治疗乙肝的疗效已被大量的临床试验所证明。中药在抗病毒、调节机体免疫力、保护肝细胞等方面都可发挥较好的疗效。但是目前中药制剂普遍存在起效缓慢,需要长期使用等问题。
毛茛草生命力旺盛,愈合能力强。喜温暖湿润和阳光充足环境,较耐寒,不耐高温和干旱,但耐水淹,萌发力强,枝条密集。在深水区域及河岸上没有毛茛草生长,在河谷滨水区域分布最多,且生长最旺盛;毛茛草中含有果胶8.5%,树皮含鞣质,在球状花果序中还分出熊果酸、β-谷甾醇、土当归酸等。花、果序经预试含儿茶素类化合物;能够清热解毒,散瘀止痛。
目前尚无单独使用毛茛草或其提取物与西药配合治疗胃溃疡的相关报道。
发明内容
本发明的目的在于提供一种安全可靠、疗效确切的含毛茛草提取物的治疗肝炎的中西药组合物及其制备方法,以解决上述背景技术中提出的问题。
为实现上述目的,本发明提供如下技术方案:
一种含毛茛草提取物的治疗肝炎的中西药组合物,由以下重量份的原料组成:兰索拉唑3-5份、毛茛草提取物2-4份、中药浸膏粉10-20份;所述中药浸膏粉由以下重量份的原料组成:树舌20-30份、煅青凡20-40份、当归5-10份、竹黄6-8份、绵茵陈6-10份、木蹄3-5份、土鳖虫1-3份、牡丹皮2-4份、半枝莲6-8份、桃仁4-6份、炙甘草3-5份、虎杖1-3份、冷水花1-2份、柴胡1-2份。
作为本发明进一步的方案:所述含毛茛草提取物的治疗肝炎的中西药组合物,由以下重量份的原料组成:兰索拉唑3.5-4.5份、毛茛草提取物2.5-3.5份、中药浸膏粉12-18份;所述中药浸膏粉由以下重量份的原料组成:树舌22-28份、煅青凡25-35份、当归6-9份、竹黄6.5-7.5份、绵茵陈7-9份、木蹄3.5-4.5份、土鳖虫1.5-2.5份、牡丹皮2.5-3.5份、半枝莲6.5-7.5份、桃仁4.5-5.5份、炙甘草3.5-4.5份、虎杖1.5-2.5份、冷水花1.2-1.8份、柴胡1.2-1.8份。
作为本发明进一步的方案:所述含毛茛草提取物的治疗肝炎的中西药组合物,由以下重量份的原料组成:兰索拉唑4份、毛茛草提取物3份、中药浸膏粉15份;所述中药浸膏粉由以下重量份的原料组成:树舌25份、煅青凡30份、当归8份、竹黄7份、绵茵陈8份、木蹄7份、土鳖虫2份、牡丹皮3份、半枝莲7份、桃仁5份、炙甘草4份、虎杖2份、冷水花1.5份、柴胡1.5份。
作为本发明进一步的方案:所述毛茛草提取物毛茛草水提取物或毛茛草挥发油、或毛茛草水提取物和毛茛草挥发油的混合物。
作为本发明进一步的方案:所述的混合物是由毛茛草提取物、毛茛草挥发油为活性成分按下述重量配比制备而成:毛茛草提取物1.8-3.5份、毛茛草挥发油0.2-0.5份。
作为本发明进一步的方案:所述的混合物是由毛茛草提取物、毛茛草挥发油为活性成分按下述重量配比制备而成:毛茛草提取物2.7份、毛茛草挥发油0.3份。
所述含毛茛草提取物的治疗肝炎的中西药组合物的制备方法,具体步骤如下:
(1)按照重量份称取各原料;
(2)按配方称取新鲜的半枝莲、炙甘草和冷水花,入榨机榨出汁液,冷藏,过滤,除去杂质和沉淀,脱色处理,浓缩至含水量为45-55%,再加入0.1-0.2%的抗氧化剂,得到纯净药液,为成分A备用;
(3)按配方称取树舌、煅青凡、当归、竹黄、绵茵陈、木蹄、土鳖虫、牡丹皮、虎杖、柴胡、桃仁、分别制成中药饮片,粉碎后过50-60目筛,加相对于所获得的混合物4-6倍重量的纯净水,浸泡10-14h,再加入3-4倍重量的纯净水,置于锅炉中煎煮提取1-3次,每次提取0.5-1h,过滤,合并滤液得到成分B备用;
(4)将成分A和成分B混合均匀后浓缩成稠膏,再喷雾干燥得到中药浸膏粉;
(5)将兰索拉唑、毛茛草提取物和中药浸膏粉混合后制成中西药组合物制剂。
作为本发明进一步的方案:所述抗氧化剂为抗坏血酸棕搁酸酯、没食子酸丙酯、焦亚硫酸钠、丁基羟基茴香醚中的一种或几种。
作为本发明进一步的方案:所述中西药组合物制剂为片剂、胶囊或颗粒剂。
作为本发明再进一步的方案:所述中西药组合物在制备治疗肝炎药物中的应用。
药理作用研究:
木发明药用组合物的主要药效学研究证实了其具有较强降低转氨酶作用,即保肝降酶作用。
参照张均田主编,《现代药理试验方法》(下册),北京医科大学中国协和医科大学联合出版社,第1397-1398页,“第一节小鼠急性化学性肝损伤模型”中公开的方法,建立小鼠四氯化碳急性化学肝损伤模型,进行本发明的药用组合物抗肝损伤的药效学试验。
试验分组:
(1)正常对照组:动物未作任何处理,正常生理盐水灌胃;
(2)模型对照组:动物模型造模成功后,正常生理盐水灌胃;
(3)纯中药组:如上文所述的中药浸膏粉0.45g/kg体重灌胃;
(4)兰索拉唑组:如上文所述的兰索拉唑9mg/kg体重灌胃;
(5)毛茛草提取物组:如上文所述的毛茛草提取物9mg/kg体重灌胃;
(6)兰索拉唑和毛茛草提取物混合物组:4.5mg/kg体重兰索拉唑+4.5mg/kg体重各采用灌胃;
(7)中西药组合物组:4.5mg/kg体重兰索拉唑+4.5mg/kg体重毛茛草提取物+0.45g/kg体重中药浸膏粉灌胃。
下表显示了各组对小鼠肝功能主要指标GOT、GPT的影响。
表1:各组对小鼠肝功能主要指标GOT、GPT的影响
组别 | 动物数 | GOT(活性单位) | GPT(活性单位) |
正常对照组 | 10 | 22.43±12.69 | 51.78±16.98 |
模型对照组 | 10 | 256.78±72.54 | 318.74±58.42 |
纯中药组 | 10 | 188.76±66.31 | 221.41±55.97 |
兰索拉唑组 | 10 | 127.32±56.53 | 196.38±25.11 |
毛茛草提取物组 | 10 | 134.12±79.45 | 186.47±26.13 |
兰索拉唑和毛茛草提取物混合物组 | 10 | 158.63±72.18 | 190.43±29.72 |
中西药组合物组 | 10 | 81.22±21.29 | 102.01±28.64 |
该表显示治疗各组(纯中药组、兰索拉唑组、毛茛草提取物组、兰索拉唑和毛茛草提取物混合物组、中西药组合物组)均与模型对照组存在显著性差异(P<0.05),而中西药组合物组与纯中药组、中西药组合物组与兰索拉唑组、中西药组合物组与毛茛草提取物组、中西药组合物组与兰索拉唑和毛茛草提取物混合物组均存在显著性差异(P<0.05)。显示组合物组中的兰索拉唑、毛茛草提取物与中药组分相互之间存在协同效应。
与现有技术相比,本发明的有益效果是:
本发明能够缩短疗程、增强疗效,采用兰索拉唑、毛茛草提取物和中药浸膏粉为原料,即将中医药结合起来,起到协同作用,解决了西药和中药在辅助治疗各种类型肝炎中各自存在的问题,同时产生协同治疗效果。
具体实施方式
下面结合具体实施方式对本专利的技术方案作进一步详细地说明。
实施例1
一种含毛茛草提取物的治疗肝炎的中西药组合物,由以下重量份的原料组成:兰索拉唑3份、毛茛草提取物2份、中药浸膏粉10份;所述中药浸膏粉由以下重量份的原料组成:树舌20份、煅青凡20份、当归5份、竹黄6份、绵茵陈6份、木蹄3份、土鳖虫1份、牡丹皮2份、半枝莲6份、桃仁4份、炙甘草3份、虎杖1份、冷水花1份、柴胡1份。
所述含毛茛草提取物的治疗肝炎的中西药组合物的制备方法,具体步骤如下:
(1)按照重量份称取各原料;
(2)按配方称取新鲜的半枝莲、炙甘草和冷水花,入榨机榨出汁液,冷藏,过滤,除去杂质和沉淀,脱色处理,浓缩至含水量为45%,再加入0.1%的抗氧化剂,得到纯净药液,为成分A备用;
(3)按配方称取树舌、煅青凡、当归、竹黄、绵茵陈、木蹄、土鳖虫、牡丹皮、虎杖、柴胡、桃仁、分别制成中药饮片,粉碎后过50目筛,加相对于所获得的混合物4倍重量的纯净水,浸泡10h,再加入3倍重量的纯净水,置于锅炉中煎煮提取1次,每次提取0.5h,过滤,合并滤液得到成分B备用;
(4)将成分A和成分B混合均匀后浓缩成稠膏,再喷雾干燥得到中药浸膏粉;
(5)将兰索拉唑、毛茛草提取物和中药浸膏粉混合后制成中西药组合物制剂。
实施例2
一种含毛茛草提取物的治疗肝炎的中西药组合物,由以下重量份的原料组成:兰索拉唑3.5份、毛茛草提取物2.5份、中药浸膏粉12份;所述中药浸膏粉由以下重量份的原料组成:树舌22份、煅青凡25份、当归6份、竹黄6.5份、绵茵陈7份、木蹄3.5份、土鳖虫1.5份、牡丹皮2.5份、半枝莲6.5份、桃仁4.5份、炙甘草3.5份、虎杖1.5份、冷水花1.2份、柴胡1.2份。
所述含毛茛草提取物的治疗肝炎的中西药组合物的制备方法,具体步骤如下:
(1)按照重量份称取各原料;
(2)按配方称取新鲜的半枝莲、炙甘草和冷水花,入榨机榨出汁液,冷藏,过滤,除去杂质和沉淀,脱色处理,浓缩至含水量为48%,再加入0.12%的抗氧化剂,得到纯净药液,为成分A备用;
(3)按配方称取树舌、煅青凡、当归、竹黄、绵茵陈、木蹄、土鳖虫、牡丹皮、虎杖、柴胡、桃仁、分别制成中药饮片,粉碎后过52目筛,加相对于所获得的混合物4.5倍重量的纯净水,浸泡11h,再加入3.2重量的纯净水,置于锅炉中煎煮提取2次,每次提取0.6h,过滤,合并滤液得到成分B备用;
(4)将成分A和成分B混合均匀后浓缩成稠膏,再喷雾干燥得到中药浸膏粉;
(5)将兰索拉唑、毛茛草提取物和中药浸膏粉混合后制成中西药组合物制剂。
作为本发明进一步的方案:所述抗氧化剂为抗坏血酸棕搁酸酯、没食子酸丙酯、焦亚硫酸钠、丁基羟基茴香醚中的一种或几种。
实施例3
所述含毛茛草提取物的治疗肝炎的中西药组合物,由以下重量份的原料组成:兰索拉唑4份、毛茛草提取物3份、中药浸膏粉15份;所述中药浸膏粉由以下重量份的原料组成:树舌25份、煅青凡30份、当归8份、竹黄7份、绵茵陈8份、木蹄7份、土鳖虫2份、牡丹皮3份、半枝莲7份、桃仁5份、炙甘草4份、虎杖2份、冷水花1.5份、柴胡1.5份。
所述含毛茛草提取物的治疗肝炎的中西药组合物的制备方法,具体步骤如下:
(1)按照重量份称取各原料;
(2)按配方称取新鲜的半枝莲、炙甘草和冷水花,入榨机榨出汁液,冷藏,过滤,除去杂质和沉淀,脱色处理,浓缩至含水量为50%,再加入0.15%的抗氧化剂,得到纯净药液,为成分A备用;
(3)按配方称取树舌、煅青凡、当归、竹黄、绵茵陈、木蹄、土鳖虫、牡丹皮、虎杖、柴胡、桃仁、分别制成中药饮片,粉碎后过55目筛,加相对于所获得的混合物5倍重量的纯净水,浸泡12h,再加入3.5倍重量的纯净水,置于锅炉中煎煮提取2次,每次提取0.8h,过滤,合并滤液得到成分B备用;
(4)将成分A和成分B混合均匀后浓缩成稠膏,再喷雾干燥得到中药浸膏粉;
(5)将兰索拉唑、毛茛草提取物和中药浸膏粉混合后制成中西药组合物制剂。
实施例4
一种含毛茛草提取物的治疗肝炎的中西药组合物,由以下重量份的原料组成:兰索拉唑4.5份、毛茛草提取物3.5份、中药浸膏粉18份;所述中药浸膏粉由以下重量份的原料组成:树舌28份、煅青凡35份、当归9份、竹黄7.5份、绵茵陈9份、木蹄4.5份、土鳖虫2.5份、牡丹皮3.5份、半枝莲7.5份、桃仁5.5份、炙甘草4.5份、虎杖2.5份、冷水花1.8份、柴胡1.8份。
所述含毛茛草提取物的治疗肝炎的中西药组合物的制备方法,具体步骤如下:
(1)按照重量份称取各原料;
(2)按配方称取新鲜的半枝莲、炙甘草和冷水花,入榨机榨出汁液,冷藏,过滤,除去杂质和沉淀,脱色处理,浓缩至含水量为52%,再加入0.18%的抗氧化剂,得到纯净药液,为成分A备用;
(3)按配方称取树舌、煅青凡、当归、竹黄、绵茵陈、木蹄、土鳖虫、牡丹皮、虎杖、柴胡、桃仁、分别制成中药饮片,粉碎后过58目筛,加相对于所获得的混合物5.5倍重量的纯净水,浸泡13h,再加入3.8重量的纯净水,置于锅炉中煎煮提取3次,每次提取0.9h,过滤,合并滤液得到成分B备用;
(4)将成分A和成分B混合均匀后浓缩成稠膏,再喷雾干燥得到中药浸膏粉;
(5)将兰索拉唑、毛茛草提取物和中药浸膏粉混合后制成中西药组合物制剂。
作为本发明进一步的方案:所述抗氧化剂为抗坏血酸棕搁酸酯、没食子酸丙酯、焦亚硫酸钠、丁基羟基茴香醚中的一种或几种。
实施例5
一种含毛茛草提取物的治疗肝炎的中西药组合物,由以下重量份的原料组成:兰索拉唑5份、毛茛草提取物4份、中药浸膏粉20份;所述中药浸膏粉由以下重量份的原料组成:树舌30份、煅青凡40份、当归10份、竹黄8份、绵茵陈10份、木蹄5份、土鳖虫3份、牡丹皮4份、半枝莲8份、桃仁6份、炙甘草5份、虎杖3份、冷水花2份、柴胡2份。
所述含毛茛草提取物的治疗肝炎的中西药组合物的制备方法,具体步骤如下:
(1)按照重量份称取各原料;
(2)按配方称取新鲜的半枝莲、炙甘草和冷水花,入榨机榨出汁液,冷藏,过滤,除去杂质和沉淀,脱色处理,浓缩至含水量为55%,再加入0.2%的抗氧化剂,得到纯净药液,为成分A备用;
(3)按配方称取树舌、煅青凡、当归、竹黄、绵茵陈、木蹄、土鳖虫、牡丹皮、虎杖、柴胡、桃仁、分别制成中药饮片,粉碎后过60目筛,加相对于所获得的混合物6倍重量的纯净水,浸泡14h,再加入4倍重量的纯净水,置于锅炉中煎煮提取3次,每次提取1h,过滤,合并滤液得到成分B备用;
(4)将成分A和成分B混合均匀后浓缩成稠膏,再喷雾干燥得到中药浸膏粉;
(5)将兰索拉唑、毛茛草提取物和中药浸膏粉混合后制成中西药组合物制剂。
实施例6
实施例3制备的含毛茛草提取物的治疗肝炎的中西药组合物对HbsAg和HbeAg两种抗原的分泌的抑制作用试验:
将对数生长期的HepG2.2.15按104/ml接种于96孔细胞培养板中,每孔180μl;待细胞贴壁后(24h)加药,实验分为5个小组,(1)中西药组合物组:600、300、150、75mg/L;(2)空白对照组:8%FBS的RPMI1640培养基;37℃,5%CO2分别孵育60h、84h后测定培养基上清液中HBsAg与HBeAg的表达。
试验表明:本发明中西药组合物对HBsAg和HBeAg两种抗原的分泌均有抑制作用,且在实验的84h达高峰。说明本发明中西药组合物抗乙肝作用确切而且毒性较低。
表2:本发明的中西药组合物对HepG2.2.15细胞株HBsAg分泌的影响(n=3,x±s)
*P<0.05**P<0.01。
表3:本发明的中西药组合物对HepG2.2.15细胞株HBeAg分泌的影响(n=3,x±s)
*P<0.05**P<0.01
本发明能够缩短疗程、增强疗效,采用兰索拉唑、毛茛草提取物和中药浸膏粉为原料,即将中医药结合起来,起到协同作用,解决了西药和中药在辅助治疗各种类型肝炎中各自存在的问题,同时产生协同治疗效果。
上面对本专利的较佳实施方式作了详细说明,但是本专利并不限于上述实施方式,在本领域的普通技术人员所具备的知识范围内,还可以在不脱离本专利宗旨的前提下作出各种变化。
Claims (10)
1.一种含毛茛草提取物的治疗肝炎的中西药组合物,其特征在于,由以下重量份的原料组成:兰索拉唑3-5份、毛茛草提取物2-4份、中药浸膏粉10-20份;所述中药浸膏粉由以下重量份的原料组成:树舌20-30份、煅青凡20-40份、当归5-10份、竹黄6-8份、绵茵陈6-10份、木蹄3-5份、土鳖虫1-3份、牡丹皮2-4份、半枝莲6-8份、桃仁4-6份、炙甘草3-5份、虎杖1-3份、冷水花1-2份、柴胡1-2份。
2.根据权利要求1所述的含毛茛草提取物的治疗肝炎的中西药组合物,其特征在于,由以下重量份的原料组成:兰索拉唑3.5-4.5份、毛茛草提取物2.5-3.5份、中药浸膏粉12-18份;所述中药浸膏粉由以下重量份的原料组成:树舌22-28份、煅青凡25-35份、当归6-9份、竹黄6.5-7.5份、绵茵陈7-9份、木蹄3.5-4.5份、土鳖虫1.5-2.5份、牡丹皮2.5-3.5份、半枝莲6.5-7.5份、桃仁4.5-5.5份、炙甘草3.5-4.5份、虎杖1.5-2.5份、冷水花1.2-1.8份、柴胡1.2-1.8份。
3.根据权利要求1所述的含毛茛草提取物的治疗肝炎的中西药组合物,其特征在于,由以下重量份的原料组成:兰索拉唑4份、毛茛草提取物3份、中药浸膏粉15份;所述中药浸膏粉由以下重量份的原料组成:树舌25份、煅青凡30份、当归8份、竹黄7份、绵茵陈8份、木蹄7份、土鳖虫2份、牡丹皮3份、半枝莲7份、桃仁5份、炙甘草4份、虎杖2份、冷水花1.5份、柴胡1.5份。
4.根据权利要求1-3任一所述的含毛茛草提取物的治疗肝炎的中西药组合物,其特征在于,所述毛茛草提取物毛茛草水提取物或毛茛草挥发油、或毛茛草水提取物和毛茛草挥发油的混合物。
5.根据权利要求4所述的含毛茛草提取物的治疗肝炎的中西药组合物,其特征在于,所述的混合物是由毛茛草提取物、毛茛草挥发油为活性成分按下述重量配比制备而成:毛茛草提取物1.8-3.5份、毛茛草挥发油0.2-0.5份。
6.根据权利要求4所述的含毛茛草提取物的治疗肝炎的中西药组合物,其特征在于,所述的混合物是由毛茛草提取物、毛茛草挥发油为活性成分按下述重量配比制备而成:毛茛草提取物2.7份、毛茛草挥发油0.3份。
7.一种如权利要求1-3任一所述的含毛茛草提取物的治疗肝炎的中西药组合物的制备方法,其特征在于,具体步骤如下:
(1)按照重量份称取各原料;
(2)按配方称取新鲜的半枝莲、炙甘草和冷水花,入榨机榨出汁液,冷藏,过滤,除去杂质和沉淀,脱色处理,浓缩至含水量为45-55%,再加入0.1-0.2%的抗氧化剂,得到纯净药液,为成分A备用;
(3)按配方称取树舌、煅青凡、当归、竹黄、绵茵陈、木蹄、土鳖虫、牡丹皮、虎杖、柴胡、桃仁、分别制成中药饮片,粉碎后过50-60目筛,加相对于所获得的混合物4-6倍重量的纯净水,浸泡10-14h,再加入3-4倍重量的纯净水,置于锅炉中煎煮提取1-3次,每次提取0.5-1h,过滤,合并滤液得到成分B备用;
(4)将成分A和成分B混合均匀后浓缩成稠膏,再喷雾干燥得到中药浸膏粉;
(5)将兰索拉唑、毛茛草提取物和中药浸膏粉混合后制成中西药组合物制剂。
8.根据权利要求7所述的含毛茛草提取物的治疗肝炎的中西药组合物的制备方法,其特征在于,所述抗氧化剂为抗坏血酸棕搁酸酯、没食子酸丙酯、焦亚硫酸钠、丁基羟基茴香醚中的一种或几种。
9.根据权利要求7所述的含毛茛草提取物的治疗肝炎的中西药组合物的制备方法,其特征在于,所述中西药组合物制剂为片剂、胶囊或颗粒剂。
10.一种如权利要求1-3任一所述的中西药组合物在制备治疗肝炎药物中的应用。
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CN114224888A (zh) * | 2021-01-03 | 2022-03-25 | 中以海德人工智能药物研发股份有限公司 | 兰索拉唑在制备治疗或预防病毒性肝炎用药物中的用途 |
CN114515338A (zh) * | 2022-03-04 | 2022-05-20 | 中以海德人工智能药物研发股份有限公司 | 一种用于治疗病毒性肝炎的药物组合物 |
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CN114209844A (zh) * | 2022-01-27 | 2022-03-22 | 中以海德人工智能药物研发股份有限公司 | 一种用于治疗病毒性肝炎的药物组合物 |
CN114515338A (zh) * | 2022-03-04 | 2022-05-20 | 中以海德人工智能药物研发股份有限公司 | 一种用于治疗病毒性肝炎的药物组合物 |
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