CN106619177A - Whitening and moisturizing cosmetic of white yak bone collagen protein peptide and preparation method of whitening and moisturizing cosmetic - Google Patents

Whitening and moisturizing cosmetic of white yak bone collagen protein peptide and preparation method of whitening and moisturizing cosmetic Download PDF

Info

Publication number
CN106619177A
CN106619177A CN201611054737.7A CN201611054737A CN106619177A CN 106619177 A CN106619177 A CN 106619177A CN 201611054737 A CN201611054737 A CN 201611054737A CN 106619177 A CN106619177 A CN 106619177A
Authority
CN
China
Prior art keywords
white
collagen peptide
bone collagen
yak bone
whitening
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201611054737.7A
Other languages
Chinese (zh)
Inventor
肖建喜
么林妍
付彩虹
朱沛贤
韦文凡
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lanzhou University
Original Assignee
Lanzhou University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lanzhou University filed Critical Lanzhou University
Priority to CN201611054737.7A priority Critical patent/CN106619177A/en
Publication of CN106619177A publication Critical patent/CN106619177A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/673Vitamin B group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Cosmetics (AREA)

Abstract

The invention discloses a whitening and moisturizing cosmetic of white yak bone collagen protein peptide. The whitening and moisturizing cosmetic is prepared from the following raw materials in percentage by weight: 8%-18% of white yak bone collagen protein peptide, 4%-8% of a snail slime extract, 7%-15% of a botanic effective component additive, 4%-8% of jojoba oil, 15%-39% of an additive and the balance of deionized water, wherein the sum of the percentages of the raw materials is 100%. The invention further discloses a preparation method of the whitening and moisturizing cosmetic of the white yak bone collagen protein peptide. The cosmetic prepared by the formula and the preparation method disclosed by the invention has the advantages of whitening and moisturizing, a moisturizing barrier can be formed on the skin, and moisture evaporation of the skin is reduced, so that natural moisturizing, whitening, wrinkle-removing and spot-removing effects are achieved.

Description

A kind of white Yak Bone collagen peptide skin whitening, moisturizing cosmetics and preparation method thereof
Technical field
The present invention relates to cosmetic technical field, it is more particularly related to a kind of white Yak Bone collagen peptide Skin whitening, moisturizing cosmetics and preparation method thereof.
Background technology
Collagen is a kind of structural protein for being present in cytoplasm, and it is distributed widely in animal connective tissue, Collagen as functional biomacromolecules, with multifrequency nature:Such as without cytotoxicity, regulatable biodegradable speed Degree, can specifically promote or suppress the biochemistry compatibility of the interaction of cell-material, physiological condition excellent etc. many excellent Point.Collagen is hydrolyzed in the presence of acid, alkali, heat, enzyme, can be produced amino acid and be constituted similar collagen hydrolysate. Collagen and its hydrolysate is similar to the structure of application on human skin collagen, compatibility is good, has the interaction such as ionic bond, hydrogen bond, pole Easily absorbed and utilized by the skin of human body, hair etc..The collagen water entered in skin epithelial cell by Transdermal absorption Solution product promotes the activity of hyaluronic acid synthetase, meanwhile, it is also beneficial to by the collagen hydrolysate of skin absorption The collagen metabolism of sub-surface porosity connective tissue, so as to improving the ability of skin adsorption moisture and strengthening the elasticity of skin, and And because it does not have stimulation to skin, frequently as cosmetic additive agent or raw material.According to U.S. CTFA cosmetic material handbooks The natural materials employed and《Functional cosmetics raw material》In introduction, have collagen or its water in the natural materials of selection Solution product (such as hydroxyproline, proline and serine).
White yak growth reproduction under the adverse circumstances of plateau, its evolutionary process gives it and resists the evil such as anoxic and high ultraviolet Bad condition, the gene for keeping own health strong.It is embodied on its bone, the density of Yak Bone is big, and collagen content is high, its In it is amino acid contained abundant and comprehensively, be extremely excellent collagen raw material.Common ox is compared, white yak freely grows In the prairie environment of more than 3000 meters green ecologicals of height above sea level, the green forage of pollution-free growth naturally is eaten, with higher Biological safety and excellent biological characteristics, have in the exploitation of superior cosmetics or functional cosmetics greatly latent Power.
The content of the invention
It is an object of the invention to solve at least the above, and provide the advantage that at least will be described later.
It is a still further object of the present invention to provide a kind of white Yak Bone collagen peptide skin whitening, moisturizing cosmetics, the cosmetic Product can be face cream type, or emulsion types, it can form moisture barrier on skin, reduce moisture of skin and steam Send out, reach natural moisture preserving, whitening, wrinkle resistant, nti-freckle effect.
It is a still further object of the present invention to provide a kind of preparation of white Yak Bone collagen peptide skin whitening, moisturizing cosmetics Method, the preparation method is simple, can realize industrialized production.
To achieve these goals, the invention provides a kind of white Yak Bone collagen peptide skin whitening, moisturizing cosmetics, its It is made up of the raw material of following percentage by weight:
White Yak Bone collagen peptide 8~18%, snail pituitary extract 4~8%, effective ingredients in plant additive 7~ 15%, jojoba oil 4~8%, additive 15~39%, remainder is deionized water;Wherein, the percentage sum of each raw material For 100%.
Preferably, in described white Yak Bone collagen peptide skin whitening, moisturizing cosmetics, the additive includes fourth two Alcohol, dimethyl silicone polymer, saualane, trehalose, panthenol, Sodium Hyaluronate, niacinamide, methyl hydroxybenzoate, propylben, Stearic acid, bisabolol and auxiliary additive, the auxiliary additive is cetostearyl alcohol or Jojoba wax PEG-120 ester Class.
Preferably, in described white Yak Bone collagen peptide skin whitening, moisturizing cosmetics, each group in the additive The content in cosmetics is divided to be respectively:
Butanediol 5~8%, dimethyl silicone polymer 4~8%, saualane 2~5%, trehalose 2~5%, panthenol 1~ 4%, Sodium Hyaluronate 0.1~0.5%, niacinamide 1~3%, methyl hydroxybenzoate 0.2~0.4%, propylben 0.2~ 0.4%, stearic acid 1~4%, bisabolol 0.2~0.5%, auxiliary additive 0.4~0.6%.
Preferably, in described white Yak Bone collagen peptide skin whitening, moisturizing cosmetics, the effective ingredients in plant adds Plus agent includes 4~8% licorice, 2~5% aloe barbadensis Miller leaf juice powder and 1~2% gadol extract.
Preferably, in described white Yak Bone collagen peptide skin whitening, moisturizing cosmetics, the white Yak Bone collagen egg White peptide is to extract to obtain from the bone of white yak.
Present invention also offers a kind of preparation method of white Yak Bone collagen peptide skin whitening, moisturizing cosmetics, including it is following Step:
Step one, in percentage by weight, stearic acid is well mixed with deionized water, then be added sequentially butanediol, Panthenol, aloe barbadensis Miller leaf juice powder, Sodium Hyaluronate, trehalose, white Yak Bone collagen peptide and saualane, obtain solid-liquid and mix Compound, 50~65 DEG C are heated to solid dissolving by solidliquid mixture, and are incubated 30 minutes, are subsequently cooled to add Buddhist nun after room temperature Pool tortoise beetle ester, obtains the first solution after stirring;
Step 2, in percentage by weight, by auxiliary additive, dimethyl silicone polymer, jojoba oil, snail mucus Extract, licorice, gadol extract, bisabolol and niacinamide are mixed, heat the mixture to 50~ 65 DEG C, and 30 minutes are incubated, it is cooled to add propylben after room temperature, obtain the second solution;
Step 3, homogeneous will be carried out after the first solution and the mixing of the second solution, the mixed solution after homogeneous is placed in into 90~ It is incubated in 100 DEG C of water-bath, is cooled to be carried out during uniform temperature aseptic subpackaged, is obtained white Yak Bone collagen peptide Skin whitening, moisturizing cosmetics;For example, 95 DEG C of water-bath, is carried out aseptic subpackaged when being cooled to close room temperature;
Wherein, in the step one and the step 2 heating and insulating process is performed both by stirring operation.For example, walk Rapid one and step 2 in heating-up temperature be 60 DEG C.
Preferably, in the preparation method of described white Yak Bone collagen peptide skin whitening, moisturizing cosmetics, the white yak The extracting method of ox bone collagen protein peptides includes:
Pretreatment:The bone of white yak carries out removal of impurities and drying, the bone of dried white yak is crushed to into 30~ 150 mesh, obtain bone meal;
High pressure is digested:Bone meal is dispersed in enzyme solutions, and add cushioning liquid to pH be 4~9, in temperature be 30~70 DEG C, pressure be 100~700Mpa under conditions of digest 0.1~36h;
Post processing:Separation of solid and liquid is carried out to enzymolysis product, collagen liquid and solid residue is obtained, to the collagen Liquid is concentrated and freezed, and obtains white Yak Bone collagen peptide;
Wherein, in the high pressure enzymolysis process, the quality of bone meal and the volume ratio 1 of enzyme solutions:1~1:15.
Preferably, in the preparation method of described white Yak Bone collagen peptide skin whitening, moisturizing cosmetics, the enzyme is molten Enzyme in liquid is at least one in bromelain, papain, pepsin and trypsase, in the enzyme solutions The addition of enzyme is 1000~7000U/g.
Preferably, in the preparation method of described white Yak Bone collagen peptide skin whitening, moisturizing cosmetics, the high pressure The temperature of enzymolysis processing is 40~50 DEG C, and pressure is 150~700Mpa, and enzymolysis time is 0.2~24h.
Preferably, in the preparation method of described white Yak Bone collagen peptide skin whitening, moisturizing cosmetics, the high pressure During enzymolysis processing, the quality of the bone meal is 1 with the ratio of the volume of the enzyme solutions:2~1:7;And adjusted with cushioning liquid Section pH value is 5~7.
The present invention at least includes following beneficial effect:
1st, white Yak Bone collagen peptide skin whitening, moisturizing cosmetics of the present invention have the function of moisturizing and reparation:In vain Yak Bone collagen peptide can go deep into deep skin tissue, can nutrition, moisten, repair, it is moist, assign living cells, adjust intracellular Environment, strengthens body immunity, purifies blood, stimulates circulation, and snail pituitary extract promotes the guarantor of cosmetics Wet effect.
2nd, white Yak Bone collagen peptide skin whitening, moisturizing cosmetics of the present invention have and moisten and crease resistant functions:White yak Ox bone collagen protein peptides hydrolysate has stronger skin permeability and absorption characteristic easy to digest, and can effectively provide skin Amino acid required for metabolism, can promote SF to break up, and strengthen cell propagation, promote collagen and transparent Matter acid synthesis;Improve skin elasticity, improve the function of dermis of skin and epidermis.
3rd, white Yak Bone collagen peptide skin whitening, moisturizing cosmetics of the present invention have whitening and sunscreen function:White yak Ox bone collagen protolysate can effective direct irradiation of the shielding of ultraviolet to skin, and effectively absorb ultraviolet, reduce purple Stimulation of the outside line to melanocyte, fundamentally suppresses or reduces melanic formation, prevents melanin deposition;Radix Glycyrrhizae is extracted Thing more promotes the suppression melanin effect of cosmetics of the present invention as natural plant whitening agent.
4th, the white Yak Bone collagen peptide of white Yak Bone collagen peptide skin whitening, moisturizing cosmetics of the present invention with it is saturating The compound use of bright matter acid, niacinamide etc. can strengthen the moisturizing anti-senescence function of cosmetics;White Yak Bone collagen peptide with suddenly Suddenly bar oil, the compound use of gadol extract can strengthen the moisturizing anti-oxidation function of cosmetics.
5th, the white Yak Bone collagen peptide skin whitening, moisturizing cosmetics remarkable advantage that the present invention is provided is formed on skin Moisture barrier, reduces moisture of skin evaporation, and Glycerin, Sage Extract helps the reconstruction of skin collagen and elastic collagen The regeneration and renewal of albumen, and direct irradiation of the shielding of ultraviolet to skin, delay skin aging, suppress and reduce melanic Formed, strengthen skin elasticity.
6th, the preparation method of the white Yak Bone collagen peptide skin whitening, moisturizing cosmetics that the present invention is provided is simple, and face can be obtained White type skin whitening, moisturizing cosmetics and emulsion-type skin whitening, moisturizing cosmetics, can realize industrialized production.
The further advantage of the present invention, target and feature embody part by description below, and part will also be by this The research of invention and practice and be understood by the person skilled in the art.
Specific embodiment
With reference to embodiment, the present invention is described in further detail, to make those skilled in the art with reference to specification Word can be implemented according to this.
It should be appreciated that it is used herein such as " have ", "comprising" and " including " term are not precluded from one or many The presence or addition of individual other elements or its combination.
The preparation method of white Yak Bone collagen peptide is in skin whitening, moisturizing cosmetics of the present invention:
The foreign matter on the bone of white yak being removed first, being dried, is crushed, smashing fineness was 40~150 mesh sieves;Again will be white The powder of Yak Bone is scattered in pepsin solution, and the quality of the powder of white Yak Bone is 1 with the ratio of the volume of enzyme:2~1: 7, preferably 1:5;
Then plus cushioning liquid adjust to pH be 5~7, in the condition that temperature is 40~50 DEG C, pressure is 150~700Mpa 0.2~24h of lower enzymolysis;
Again enzymolysis product is carried out into separation of solid and liquid, obtain collagen peptide liquid and solid residue, then concentration, freeze-drying, system Into white Yak Bone collagen protein peptide powder.
By the following examples 1~3 the present invention will be described, wherein, the raw material of the cosmetics in embodiment 1~3 and Raw material composition refers to table 1.
Cosmetic formulations in the embodiment 1~3 of table 1
The preparation method of the skin whitening, moisturizing cosmetics described in embodiment 1~3 is specially:
(1) after, stearic acid is well mixed with deionized water, butanediol, panthenol, aloe barbadensis Miller leaf juice are added sequentially Powder, Sodium Hyaluronate, trehalose, white Yak Bone collagen peptide, saualane, dissolve on mixer, are heated up to 60 DEG C, maintain 30 minutes, it is cooled to after room temperature and adds methyl hydroxybenzoate, stir, obtains the first solution;
(2), sequentially add cetostearyl alcohol, dimethyl silicone polymer, jojoba oil, snail in another container to extract Thing, licorice, gadol extract, bisabolol, niacinamide, are warming up to 60 DEG C, 30 points of stirring insulation on mixer Clock, is cooled to after room temperature and adds propylben to obtain the second solution;
(3), the first solution is mixed with the second solution, with homogenizer homogeneous after, in 95 DEG C of water-baths be incubated 15 minutes, It is cooled to close room temperature, aseptic subpackaged prepared product.Cetostearyl alcohol can also be replaced with Jojoba wax PEG-120 esters.
After testing, the moisture-holding capacity of the white Yak Bone collagen peptide skin whitening, moisturizing face cream in embodiment 1,2,3 reaches 85%.
Emulsion can be prepared using identical method:The white Yak Bone collagen moisturizing anti-aging emulsion that will be prepared 7ml samples to be tested are poured in 10ml centrifuge tubes, are stoppered with cork, put the electric heating constant temperature training that people is pre-adjusted (38 ± 1) DEG C In foster case, after being kept for 1 hour, during the centrifuge that room temperature is placed is moved into immediately, it is centrifuged under conditions of rotating speed is 3000r/min 30min, takes out centrifuge tube, does not find lamination.
Although embodiment of the present invention is disclosed as above, it is not restricted to listed in specification and embodiment With, it can be applied to completely various suitable the field of the invention, for those skilled in the art, can be easily Other modification is realized, therefore under the universal limited without departing substantially from claim and equivalency range, the present invention is not limited In specific details.

Claims (10)

1. a kind of white Yak Bone collagen peptide skin whitening, moisturizing cosmetics, it is characterised in that by the raw material of following percentage by weight Make:
White Yak Bone collagen peptide 8~18%, snail pituitary extract 4~8%, effective ingredients in plant additive 7~15%, Jojoba oil 4~8%, additive 15~39%, remainder is deionized water;Wherein, the percentage sum of each raw material is 100%.
2. Yak Bone collagen peptide skin whitening, moisturizing cosmetics as claimed in claim 1 white, it is characterised in that the additive Including butanediol, dimethyl silicone polymer, saualane, trehalose, panthenol, Sodium Hyaluronate, niacinamide, methyl hydroxybenzoate, Buddhist nun The golden propyl ester of pool, stearic acid, bisabolol and auxiliary additive, the auxiliary additive is cetostearyl alcohol or Jojoba wax PEG-120 esters.
3. Yak Bone collagen peptide skin whitening, moisturizing cosmetics as claimed in claim 2 white, it is characterised in that the additive In content of each component in cosmetics be respectively:
Butanediol 5~8%, dimethyl silicone polymer 4~8%, saualane 2~5%, trehalose 2~5%, panthenol 1~4%, thoroughly Bright matter acid sodium 0.1~0.5%, niacinamide 1~3%, methyl hydroxybenzoate 0.2~0.4%, propylben 0.2~0.4%, firmly Resin acid 1~4%, bisabolol 0.2~0.5%, auxiliary additive 0.4~0.6%.
4. Yak Bone collagen peptide skin whitening, moisturizing cosmetics as claimed in claim 1 white, it is characterised in that the plant has Effect component additive agent includes 4~8% licorice, 2~5% aloe barbadensis Miller leaf juice powder and 1~2% rhodiola root Extract.
5. Yak Bone collagen peptide skin whitening, moisturizing cosmetics as claimed in claim 1 white, it is characterised in that the white yak Bone collagen peptide is to extract to obtain from the bone of white yak.
6. a kind of side of the white Yak Bone collagen peptide skin whitening, moisturizing cosmetics prepared as described in any one of Claims 1 to 5 Method, it is characterised in that comprise the following steps:
Step one, in percentage by weight, stearic acid is well mixed with deionized water, then be added sequentially butanediol, panthenol, Aloe barbadensis Miller leaf juice powder, Sodium Hyaluronate, trehalose, white Yak Bone collagen peptide and saualane, obtain solidliquid mixture, Solidliquid mixture is heated to into 50~65 DEG C to solid dissolving, and is incubated 30 minutes, be subsequently cooled to add nipalgin after room temperature Methyl esters, obtains the first solution after stirring;
Step 2, in percentage by weight, auxiliary additive, dimethyl silicone polymer, jojoba oil, snail mucus are extracted Thing, licorice, gadol extract, bisabolol and niacinamide are mixed, and heat the mixture to 50~65 DEG C, And 30 minutes are incubated, and it is cooled to add propylben after room temperature, obtain the second solution;
Step 3, will the first solution and the second solution mixing after carry out homogeneous, the mixed solution after homogeneous is placed in into 90~100 DEG C Water-bath in be incubated, be cooled to be carried out during uniform temperature aseptic subpackaged, obtain white Yak Bone collagen peptide whitening Moisture-keeping cosmetics;
Wherein, in the step one and the step 2 heating and insulating process is performed both by stirring operation.
7. the preparation method of Yak Bone collagen peptide skin whitening, moisturizing cosmetics as claimed in claim 6 white, it is characterised in that The extracting method of the white Yak Bone collagen peptide includes:
Pretreatment:The bone of white yak carries out removal of impurities and drying, and the bone of dried white yak is crushed to into 30~150 Mesh, obtains bone meal;
High pressure is digested:Bone meal is dispersed in enzyme solutions, and add cushioning liquid to pH be 4~9, in temperature be 30~70 DEG C, Pressure is that 0.1~36h is digested under conditions of 100~700Mpa;
Post processing:Separation of solid and liquid is carried out to enzymolysis product, collagen liquid and solid residue is obtained, the collagen liquid is entered Row is concentrated and lyophilized, obtains white Yak Bone collagen peptide;
Wherein, in the high pressure enzymolysis process, the quality of bone meal and the volume ratio 1 of enzyme solutions:1~1:15.
8. the preparation method of Yak Bone collagen peptide skin whitening, moisturizing cosmetics as claimed in claim 7 white, it is characterised in that Enzyme in the enzyme solutions is at least one in bromelain, papain, pepsin and trypsase, described The addition of enzyme is 1000~7000U/g in enzyme solutions.
9. the preparation method of Yak Bone collagen peptide skin whitening, moisturizing cosmetics as claimed in claim 7 white, it is characterised in that The temperature of the high pressure enzymolysis processing is 40~50 DEG C, and pressure is 150~700Mpa, and enzymolysis time is 0.2~24h.
10. the preparation method of Yak Bone collagen peptide skin whitening, moisturizing cosmetics as claimed in claim 7 white, its feature exists During the high pressure enzymolysis processing, the quality of the bone meal is 1 with the ratio of the volume of the enzyme solutions:2~1:7;It is used in combination It is 5~7 that cushioning liquid adjusts pH value.
CN201611054737.7A 2016-11-25 2016-11-25 Whitening and moisturizing cosmetic of white yak bone collagen protein peptide and preparation method of whitening and moisturizing cosmetic Pending CN106619177A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201611054737.7A CN106619177A (en) 2016-11-25 2016-11-25 Whitening and moisturizing cosmetic of white yak bone collagen protein peptide and preparation method of whitening and moisturizing cosmetic

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201611054737.7A CN106619177A (en) 2016-11-25 2016-11-25 Whitening and moisturizing cosmetic of white yak bone collagen protein peptide and preparation method of whitening and moisturizing cosmetic

Publications (1)

Publication Number Publication Date
CN106619177A true CN106619177A (en) 2017-05-10

Family

ID=58812032

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201611054737.7A Pending CN106619177A (en) 2016-11-25 2016-11-25 Whitening and moisturizing cosmetic of white yak bone collagen protein peptide and preparation method of whitening and moisturizing cosmetic

Country Status (1)

Country Link
CN (1) CN106619177A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107375173A (en) * 2017-07-29 2017-11-24 北京健旭康技术有限公司 Purposes of the special cultivation animal in cosmetics are prepared
CN108309919A (en) * 2018-05-08 2018-07-24 王清秀 Goat Placenta-peptide-bone collagen peptide composition, the facial mask liquid containing the composition
CN109846739A (en) * 2019-03-18 2019-06-07 惠州市旭东实业有限公司 A kind of moisturizing facial soap
CN111631969A (en) * 2020-07-08 2020-09-08 华南农业大学 Repair liquid with blue light resisting effect and cosmetic thereof
CN113520905A (en) * 2021-03-25 2021-10-22 甘肃天际生物科技有限公司 Instant collagen microneedle and preparation method thereof
CN113520900A (en) * 2021-04-13 2021-10-22 甘肃天际生物科技有限公司 Hypoallergenic and anti-aging yak collagen composition and application thereof
CN113546161A (en) * 2020-11-20 2021-10-26 甘肃天际生物科技有限公司 Yak I type collagen product for repairing skin photodamage

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103284912A (en) * 2013-05-31 2013-09-11 吴克 Sensitive skin cream
CN103783254A (en) * 2013-07-02 2014-05-14 吴长海 Preparation method of yak bone collagen peptide
CN103830153A (en) * 2014-03-27 2014-06-04 广东伊茗药业有限公司 Emollient cosmetic and preparation method thereof
CN103932969A (en) * 2014-04-16 2014-07-23 法国奢蔻化妆品有限公司 Deep-sea fish skin collagen peptide cosmetic capable of delaying ageing, firming skin, brightening and moisturizing and preparation method thereof
CN104413406A (en) * 2013-09-09 2015-03-18 西南民族大学 Processing craft for extracting composite bone collagen from yak bone
CN105112484A (en) * 2015-09-21 2015-12-02 杨德庆 Method for preparing collagen through high-pressure enzymolysis
CN105385737A (en) * 2015-12-09 2016-03-09 青海北极牦牛生物科技有限公司 Preparation technology of yak bone collagen oligopeptide
CN105853250A (en) * 2016-05-13 2016-08-17 诺斯贝尔化妆品股份有限公司 Cosmetic composition containing gold collagen
CN106011208A (en) * 2016-06-29 2016-10-12 肖建喜 Method for preparing small-molecular weight collagen active peptide through enzymolysis of yak bone and skin

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103284912A (en) * 2013-05-31 2013-09-11 吴克 Sensitive skin cream
CN103783254A (en) * 2013-07-02 2014-05-14 吴长海 Preparation method of yak bone collagen peptide
CN104413406A (en) * 2013-09-09 2015-03-18 西南民族大学 Processing craft for extracting composite bone collagen from yak bone
CN103830153A (en) * 2014-03-27 2014-06-04 广东伊茗药业有限公司 Emollient cosmetic and preparation method thereof
CN103932969A (en) * 2014-04-16 2014-07-23 法国奢蔻化妆品有限公司 Deep-sea fish skin collagen peptide cosmetic capable of delaying ageing, firming skin, brightening and moisturizing and preparation method thereof
CN105112484A (en) * 2015-09-21 2015-12-02 杨德庆 Method for preparing collagen through high-pressure enzymolysis
CN105385737A (en) * 2015-12-09 2016-03-09 青海北极牦牛生物科技有限公司 Preparation technology of yak bone collagen oligopeptide
CN105853250A (en) * 2016-05-13 2016-08-17 诺斯贝尔化妆品股份有限公司 Cosmetic composition containing gold collagen
CN106011208A (en) * 2016-06-29 2016-10-12 肖建喜 Method for preparing small-molecular weight collagen active peptide through enzymolysis of yak bone and skin

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
国家食品药品监督管理局: "《化妆品安全技术规范》", 23 December 2015 *
王建新: "《化妆品植物原料大全》", 30 June 2012, 中国纺织出版社 *
钟振声等: "《表面活性剂在化妆品中的应用》", 31 August 2003, 化学工业出版社 *
龚泉福等: "《蜗牛养殖技术》", 30 June 2016, 上海科学技术出版社 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107375173A (en) * 2017-07-29 2017-11-24 北京健旭康技术有限公司 Purposes of the special cultivation animal in cosmetics are prepared
CN108309919A (en) * 2018-05-08 2018-07-24 王清秀 Goat Placenta-peptide-bone collagen peptide composition, the facial mask liquid containing the composition
CN109846739A (en) * 2019-03-18 2019-06-07 惠州市旭东实业有限公司 A kind of moisturizing facial soap
CN111631969A (en) * 2020-07-08 2020-09-08 华南农业大学 Repair liquid with blue light resisting effect and cosmetic thereof
CN113546161A (en) * 2020-11-20 2021-10-26 甘肃天际生物科技有限公司 Yak I type collagen product for repairing skin photodamage
CN113520905A (en) * 2021-03-25 2021-10-22 甘肃天际生物科技有限公司 Instant collagen microneedle and preparation method thereof
CN113520900A (en) * 2021-04-13 2021-10-22 甘肃天际生物科技有限公司 Hypoallergenic and anti-aging yak collagen composition and application thereof

Similar Documents

Publication Publication Date Title
CN106619177A (en) Whitening and moisturizing cosmetic of white yak bone collagen protein peptide and preparation method of whitening and moisturizing cosmetic
CN102462640B (en) Ocean fish skin collagen hydrating and anti-aging cosmetic and preparation method thereof
CN106214535B (en) Anti-aging composition containing sponge microneedle capable of activating cells
CN106265360B (en) A kind of facial cleanser of the product containing fermentation of seaweed and preparation method thereof
CN109512691A (en) A kind of indigo plant copper peptide freeze-dried powder preparation and preparation method thereof
CN102178617A (en) Protein skin care products having function of skin repair and care
KR101897401B1 (en) Cosmetic composition for skin desquamation comprising powder of captured spicule using ultra high pressure as effective component
CN109276515B (en) Composition containing bioactive collagen peptide and preparation method and application thereof
CN105687081A (en) Anti-aging and moisture preserving gel and method for preparing same
CN112043621A (en) Preservative-free polypeptide composition with anti-aging effect
CN109199964A (en) One kind to peptide quintessence dew and preparation method thereof
CN109363990A (en) A kind of old skin care compositions of removing wrinkle and resisting aging and its preparation method and application
CN107411998B (en) Antioxidant mask containing active peptide of hairtail
CN103720612B (en) Brown-sugar-containing mask cosmetic
CN101249059A (en) Moisture-keeping face pack and method of preparing the same
KR102076334B1 (en) cosmetic composition having collagen derived from salmon skin
CN105147575A (en) Hair restorer containing stem cells and preparation method thereof
CN107890455A (en) A kind of preparation method of the reparation anti-wrinkle facial mask liquid containing snail mucus and sodium hyaluronate
CN107320357A (en) A kind of cosmetics containing polysaccharide
CN111358710A (en) Moisture-preserving and soothing donkey-hide gelatin face cream and preparation method thereof
CN113768862B (en) Anti-wrinkle composition, preparation method and application thereof
CN113730289B (en) Eye and lip care composition with multiple repairing effects and application thereof
WO2018048028A1 (en) Soap composition containing cynoglosus semilaevis skin component and production method thereof
CN110025515B (en) Anti-allergy polysaccharide compound composition and application thereof in cosmetics
KR20220096379A (en) Method for preparing antler extract and kyung-ok-go containing antler extract

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20170510

RJ01 Rejection of invention patent application after publication