CN106617263A - Ointment-form snuff and preparation method thereof - Google Patents

Ointment-form snuff and preparation method thereof Download PDF

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Publication number
CN106617263A
CN106617263A CN201611257416.7A CN201611257416A CN106617263A CN 106617263 A CN106617263 A CN 106617263A CN 201611257416 A CN201611257416 A CN 201611257416A CN 106617263 A CN106617263 A CN 106617263A
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China
Prior art keywords
snuff
ointment
ointment type
furfural
type snuff
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CN201611257416.7A
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Chinese (zh)
Inventor
陈泽鹏
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China National Tobacco Corp Guangdong Branch
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China National Tobacco Corp Guangdong Branch
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Priority to CN201611257416.7A priority Critical patent/CN106617263A/en
Publication of CN106617263A publication Critical patent/CN106617263A/en
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Classifications

    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B13/00—Tobacco for pipes, for cigars, e.g. cigar inserts, or for cigarettes; Chewing tobacco; Snuff
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

Abstract

The invention belongs to the field of tobacco products, and discloses ointment-form snuff and a preparation method thereof. The ointment-form snuff is prepared from the following materials in percentage by mass: 43-44% of paraffin wax, 17-21% of petroleum jelly, 2.4-3% of penetration enhancer, 6.2-7.8% of nicotine, 1.9-2.5% of cotinine, 2.3-5.1% of neophytadiene, 0.34-0.49% of furfural, 0.5-0.9% of ionol, 0.43-0.56% of megastigmatrienone and the like; and the pH value of the ointment-form snuff is 4.7-5.9. The ointment-form snuff provided by the invention, as a substitute of conventional cigarettes, is similar with the conventional cigarettes in such qualities as aroma, strength, taste and the like. The ointment-form snuff is relatively small in size, convenient to carry and broad in application scope, and the ointment-form snuff, which does not need to be burned, can avoid fire disaster, avoid influence of smoke to people around and avoid secondhand smoking.

Description

A kind of ointment type snuff and preparation method thereof
Technical field
The invention belongs to tobacco product field, more particularly, to a kind of ointment type snuff and preparation method thereof.
Background technology
At present the smokeless tobacco articles on overseas market mostly are tobacco powder product, more with packed buccal cigarette, bulk form The form such as buccal cigarette, snuff exist.Tobacco chewing gum as smokeless tobacco articles a kind of important supplement form, by chew Process, improves the uniformity of nicotine release, improves the mouthfeel harmony of smokeless tobacco articles, meets the physiology need of tobacco consumer While asking, increase the process enjoying sense that tobacco consumer eats, while also cleanable tooth, fresh breath, pre- anti-caries.
However, tobacco extract is typically directly added into the form of paste or powder in existing smokeless tobacco articles.But In smokeless tobacco articles, due to change of the consumer to the absorption mode of the materials such as nicotine in product, if by tobacco extract In being directly added into product, can cause the materials such as nicotine discharge in consumer oral cavity soon, the duration is short, mouthfeel excitement strong, As entrance thick taste, strength, excitant are excessive, a few minutes taste is thin out, and hamony is deteriorated, and process enjoying sense is poor, serious shadow Ring consumer to require smokeless tobacco articles comfortableness.
Existing sustained release tobacco microcapsules or micro- smoked sheet are generally simply using coating material to tobacco extract or tobacco leaf Coated.However, existing product also just loses the function of sustained release after coating dissolving.Containing above-mentioned microcapsules or micro- The smokeless tobacco articles of smoked sheet, in the starting stage of edible process, in product the content of microcapsules or micro- smoked sheet still than larger, It is also larger with the contact area of oral cavity or saliva, therefore, the material such as nicotine of starting stage release is more, and mouthfeel still compares thorn Swash, after eating a period of time, diminish with the volume of microcapsules or micro- smoked sheet, quantity is also reduced, and then the rate of release of nicotine, Burst size also reduces therewith, and consumer remains to significantly experience the decline of mouthfeel and quality in use, do not reach with Smoking identical is experienced.
The content of the invention
The technical problem to be solved in the present invention is the defect for overcoming prior art, there is provided a kind of ointment at nasal cavity Type snuff.
Another object of the present invention is to provide a kind of preparation method of the ointment type snuff.
The present invention is achieved through the following technical solutions：
A kind of ointment type snuff, is made up of the material of following mass percent：
Paraffin 43%～44%, vaseline 17%～21%, penetrating agent 2.4% ~ 3%, nicotine 6.2% ~ 7.8%, cotinine 1.9% ~ 2.5%, Neophytadiene 2.3% ~ 5.1%, furfural 0.34% ~ 0.49%, ionol 0.5% ~ 0.9%, Megastigmatrienone 0.43% ~ 0.56%, eggplant Ketone 2.3% ~ 2.7%, geranyl acetone 0.25% ~ 0.62%, catechol 3.3% ~ 4.24%, D- phellandrenes 1.2% ~ 1.4%, myrcene 1.2% ~ 2.3%, pyridine 0.37% ~ 0.41%, preservative 0.01% ~ 0.015%, sodium glycocholate 0.03 ~ 0.11%, 5 hydroxymethyl furfural 0.12 ~ 0.15%, irisone 0.3 ~ 0.6%, violaxanthin 0.17 ~ 0.30%, appropriate pH value regulator, balance of stearic acid；It is described The pH of ointment type snuff is 4.7 ~ 5.9.
The invention provides a kind of substitute of conventional cigarette, takes granule and be put into nasal cavity, using having crowd on bronchia mucosal Many trickle fine hair, greatly increases the effective surface area for smearing cigarette absorption, it is upper it is subcutaneous have an abundant capillary, pharynx nasalis enriches Lymphatic vessel the ingredient draws for smearing cigarette are also played an important role, ingredient draws are rapid.Smear after cigarette absorbs and be directly entered body Circulate, not trans-portal vein, without liver first-pass effect, bronchia mucosal is atomic to drug metabolism weak, and bioavilability is high.
Just because of the olfactive characteristics and absorption characteristic at nasal cavity position are very special and sensitivity, the present invention is put into nasal cavity Smear cigarette strictly to control composition and ratio, just with qualities such as similar fragrance, strength, the tastes to conventional cigarette.
Because nasal cavity, nasal sinus and cranium brain relation are extremely close, not only there are potential fine channel, and 12 between nose cranium To having 3 to be distributed in bronchia mucosal to (trifacial ramus ophthalmicus and ramus maxillaris, olfactory nerve and Branches of facial nerve) in cranial nerve.Cause This, can stimulate intranasal nerve after the composition intranasal such as nicotine so as to produce reflectivity regulation, adjust brain and viscera function, so as to Therapeutic action is played to brain and whole body.
Preferably, ointment type snuff can add appropriate pH value regulator, such as citric acid, lactic acid, tartaric acid, sodium carbonate, One or more in sodium acid carbonate, disodium hydrogen phosphate etc..
Preferably, the neophytadiene, furfural, solanone, the mass ratio of myrcene are 3:0.4:2.4:1.5；The 5- hydroxyls Methyl furfural, irisone, the mass ratio 13 of violaxanthin:44:23.With with cigarette identical fragrance.
Preferably, the nicotine, cotinine, the mass ratio of Megastigmatrienone are 7：2.3：0.45.
Preferably, a kind of ointment type snuff is made up of the material of following mass percent：
Paraffin 43%, vaseline 18%, penetrating agent 3%, nicotine 7%, cotinine 2.3%, neophytadiene 4%, furfural 0.5%, ionol 0.9%th, Megastigmatrienone 0.45%, solanone 2.4%, geranyl acetone 0.6%, catechol 3.4%, D- phellandrenes 1.3%, myrcene 2.0%th, pyridine 0.4%, preservative 0.01%, sodium glycocholate 0.09%, 5 hydroxymethyl furfural 0.13%, irisone 0.44%, purple Huang Matter 0.23%, appropriate pH value regulator, balance of stearic acid；The pH of the ointment type snuff is 4.9.
Preferably, a kind of ointment type snuff is made up of the material of following mass percent：
Paraffin 44%, vaseline 18%, penetrating agent 2.6%, nicotine 7%, cotinine 2.3%, neophytadiene 3%, furfural 0.4%, violet Alcohol 0.8%, Megastigmatrienone 0.45%, solanone 2.4%, geranyl acetone 0.6%, catechol 3.8%, D- phellandrenes 1.3%, myrcene 1.5%th, pyridine 0.39%, preservative 0.01%, sodium glycocholate 0.11%, 5 hydroxymethyl furfural 0.13%, irisone 0.44%, purple Huang Matter 0.23%, appropriate pH value regulator, balance of stearic acid；The pH of the ointment type snuff is 5.7.
Preferably, penetrating agent is azone, and preservative is nipagin esters and its sodium salt.
A kind of preparation method of the ointment type snuff, comprises the following steps：
S1. weighing paraffin, vaseline, stearic acid and preservative and being put into melt pot adds heat fusing to be in a liquid state, after stirring, It is filtrated to get mixed-matrix；
S2. mixed-matrix is put into blending tank, adds remaining component, seal blending tank, stirred at being heated to 90 DEG C ~ 100 DEG C After uniform, both obtain after cooling.
Compared with prior art, the invention has the advantages that：
The present invention for ointment type snuff at nasal cavity as conventional cigarette substitute, with the similar perfume (or spice) to conventional cigarette The qualities such as gas, strength, taste.
Have the advantages that ingredient draws are rapid, bioavilability is high for the ointment type snuff at nasal cavity, and nicotine Deng intranasal nerve can be stimulated after composition intranasal so as to produce reflectivity regulation, adjust brain and viscera function, so as to brain and Whole body plays therapeutic action.
The ointment type snuff small volume of the present invention is easy to carry and is avoided that fire, non smoke will not shadows without the need for burning Ring the people to surrounding, it is to avoid second-hand-cigarette, it is applied widely.
Specific embodiment
The present invention is further illustrated with reference to specific embodiment.Unless stated otherwise, adopt in the embodiment of the present invention Raw material, apparatus and method are routinely commercial raw material, the conventional use of apparatus and method in this area.
Embodiment 1
A kind of ointment type snuff, is made up of the material of following quality：
Paraffin 43g, vaseline 18g, azone 3g, nicotine 7g, cotinine 2.3g, neophytadiene 4g, furfural 0.5g, ionol 0.9g, Megastigmatrienone 0.45g, solanone 2.4g, geranyl acetone 0.6g, catechol 3.4g, D- phellandrene 1.3g, myrcene 2.0g, pyridine 0.4g, nipagin esters 0.01g, sodium glycocholate 0.09g, 5 hydroxymethyl furfural 0.13g, irisone 0.44g, purple Yellow matter 0.23g, stearic acid 9.78g, sodium acid carbonate 0.12g, the pH of obtained ointment type snuff is 4.9.
The preparation method of ointment type snuff, comprises the following steps：
S1. paraffin, vaseline, stearic acid and the preservative for weighing above-mentioned metering is put into melt pot plus heat fusing is in a liquid state, and stirs After mixing uniformly, mixed-matrix is filtrated to get；
S2. mixed-matrix is put into blending tank, adds remaining component, seal blending tank, stirred at being heated to 90 DEG C ~ 100 DEG C After uniform, both obtain after cooling.
Embodiment 2 ~ 5
Embodiment 2 ~ 5 is substantially the same manner as Example 1, and difference is that the content proportioning of each component is as shown in table 1：
Table 1（Unit：g）
Embodiment 2 Embodiment 3 Embodiment 4 Embodiment 5
Paraffin 44 43 43 44
Vaseline 18 21 17 20
Azone 2.6 2.4 3 2
Nicotine 7 6.2 7 7.8
Cotinine 2.3 1.9 2.2 2.5
Neophytadiene 3 5.1 5 2.3
Furfural 0.4 0.34 0.49 0.4
Ionol 0.8 0.5 0.7 0.9
Megastigmatrienone 0.45 0.56 0.4 0.5
Solanone 2.4 2.3 2.7 2.5
Geranyl acetone 0.6 0.4 0.25 0.35
Catechol 3.8 4.2 3.3 4
D- phellandrenes 1.3 1.4 1.2 1.3
Myrcene 1.5 1.2 1.9 2.3
Pyridine 0.39 0.41 0.35 0.4
Nipagin esters 0.01 0.012 0.015 0.01
Sodium glycocholate 0.11 0.03 0.08 0.1
5 hydroxymethyl furfural 0.13 0.15 0.12 0.14
Irisone 0.44 0.6 0.3 0.53
Violaxanthin 0.23 0.25 0.17 0.3
Stearic acid 9.94 6.948 10.325 7.38
PH value regulator Sodium carbonate, 0.6 Sodium acid carbonate, 1.1 Disodium hydrogen phosphate, 0.5 Lactic acid, 0.29
pH 4.7 5.2 5.6 5.9
Comparative example 1
Paraffin 43g, vaseline 18g, azone 3g, nipagin esters 0.01g, tobacco smoke oil extractum 12g, stearic acid 23.99g.
The preparation method of tobacco smoke oil extractum：To pulverize after Tobacco drying, tobacco powder is obtained, take tobacco powder and be placed in burning In cup, distilled water, stirring is added to run through, tobacco powder is 35-45 with the weight proportion of distilled water:600-1000, soaks 1-2 After hour, ultrasonic wave extraction separation is carried out, after extracting 25-35 minutes, filtered, it is (relative that filtrate is condensed into tobacco tobacco tar liquid extract Density, 1mL is equivalent to tobacco 1g), re-dry is obtained tobacco tobacco tar thick medicinal extract (0.6mL is equivalent to tobacco 1g).
The preparation method of ointment type snuff, comprises the following steps：
S1. paraffin, vaseline, stearic acid and the preservative for weighing above-mentioned metering is put into melt pot plus heat fusing is in a liquid state, and stirs After mixing uniformly, mixed-matrix is filtrated to get；
S2. mixed-matrix is put into blending tank, adds tobacco smoke oil extractum, seal blending tank, be heated at 90 DEG C ~ 100 DEG C After stirring, both obtain after cooling.
Comparative example 2
Paraffin 44g, vaseline 18g, azone 3g, nipagin esters 0.01g, tobacco extract 32g, stearic acid 2.99g.
The preparation method of tobacco extract：
S11. the flue-cured tobacco that absolute dry mass is 100g is taken, adds 1400g water to carry out in 60 DEG C after immersion 25min, be cooled to 20 DEG C of left sides The right side, the ultrasonic extraction 60min under the conditions of 25 ± 2 DEG C, the power of ultrasonic wave is 300W, and then vacuum draw is filtered, and obtains filter residue a With filtrate a；
S12. after the ethanol of 7 times of absolute dry mass of filter residue a is added in the filter residue a of S11, the ultrasonic extraction under the conditions of 25 ± 2 DEG C 30min, the power of ultrasonic wave is 300W, and then vacuum draw is filtered, and obtains filter residue b and filtrate b；
S13. filtrate a and filtrate b is mixed, it is 15% that solid content is concentrated in vacuo under the conditions of 25 DEG C, obtains the tobacco and carries Take thing.
The preparation method of ointment type snuff, comprises the following steps：
S1. paraffin, vaseline, stearic acid and the preservative for weighing above-mentioned metering is put into melt pot plus heat fusing is in a liquid state, and stirs After mixing uniformly, mixed-matrix is filtrated to get；
S2. mixed-matrix is put into blending tank, adds tobacco extract, seal blending tank, stirred at being heated to 90 DEG C ~ 100 DEG C After mixing uniformly, both obtain after cooling.
Comparative example 3 ~ 6
Comparative example 3 ~ 6 is substantially the same manner as Example 1, and difference is that the content proportioning of each component is as shown in table 2：
Table 2（Unit：g）
Comparative example 3 Comparative example 4 Comparative example 5 Comparative example 6
Paraffin 44 43 43 44
Vaseline 18 21 17 20
Azone 2.6 2.4 3 2
Nicotine 7 6.2 7 7.8
Cotinine 2.3 1.9 - 2.5
Neophytadiene 2 5.1 5 2.3
Furfural 0.5 0.34 0.49 0.4
Ionol 0.8 0.5 0.7 0.9
Megastigmatrienone 0.45 0.56 0.4 0.5
Solanone 2.8 2.3 2.7 2.5
Geranyl acetone 0.6 0.4 0.25 0.35
Catechol 3.8 4.2 3.3 4
D- phellandrenes 1.3 1.4 1.2 1.3
Myrcene 1.5 1.2 1.9 2.3
Pyridine 0.39 0.41 0.35 0.4
Nipagin esters 0.01 0.012 0.015 0.01
Sodium glycocholate 0.11 0.03 0.08 -
5 hydroxymethyl furfural 0.11 0.15 0.12 0.14
Irisone 0.44 0.6 0.3 0.53
Violaxanthin 0.15 - 0.17 0.3
PH value regulator Sodium carbonate 0.53 Sodium acid carbonate 2.7 Disodium hydrogen phosphate 1.2 Tartaric acid 0.97
Stearic acid 10.61 5.598 11.825 6.8
pH 4.7 5.2 5.6 5.9
The evaluation of effect
10 criticism persons for having smoking habit usually are chosen, everyone takes equivalent sample and is put into nasal cavity, according to ointment type snuff The indexs such as fragrance, strength, outward appearance are given a mark, and try to achieve mean value record in the following table.
Evaluation criterion：
Fragrance：Fragrance is dense（10～8 points）, fragrance it is thin（6～4 points）, fragrance it is light（2～1 points）
Strength：Strength is moderate（10～8 points）, strength it is big（6～4 points）, strength it is little（2～1 points）
Excitant：It is little（10～8 points）, in（6～4 points）, it is big（2～1 points）
Miscellaneous taste：Nothing（10～8 points）, it is heavier（6～4 points）, it is serious（2～1 points）
Outward appearance：Quality and color are uniform（10～8 points）, quality and colour-difference（6～4 points）, quality and color it is very poor（2～1 points）
Evaluation result is as follows：
Fragrance Strength Excitant Miscellaneous taste Outward appearance It is total
Embodiment 1 10 10 10 10 10 50
Embodiment 2 10 10 10 10 10 50
Embodiment 3 8 9 9 9 8 43
Embodiment 4 9 9 8 9 10 45
Embodiment 5 8 9 9 8 10 44
Comparative example 1 1 1 2 1 2 7
Comparative example 2 3 1 2 3 5 14
Comparative example 3 2 3 1 6 8 20
Comparative example 4 4 3 5 4 8 24
Comparative example 5 3 4 8 4 8 27
Comparative example 6 6 3 4 6 6 25
It can be seen from above-mentioned evaluation result, ointment type snuff prepared by embodiment 1～5 selection of component and is matched somebody with somebody on the whole Than reasonable, product has the advantage of excellent fragrance, strength, excitant and miscellaneous taste very little, and product provides one kind to consumer The experience similar to conventional cigarette.Neophytadiene, furfural, solanone, myrcene are added with specific ratio in embodiment 1 ~ 2, are carried Supplied a kind of most widely suited fragrance, at the same nicotine, cotinine, Megastigmatrienone ratio combination ensure that product strength and Absorbing state, the quality of product is more excellent.Knowable to comparative example 1 ~ 2, the tobacco tobacco tar thick medicinal extract or cigarette of extraction from tobacco Careless extract is used as tobacco ingredient, and its fragrance for obtaining and strength etc. are all very poor, is especially the absence of the generation of cigarette extracting combustion Fragrance；Its composition complex stimulus is very strong, the shortcomings of miscellaneous taste is dense.Comparative example 3 ~ 6 understands usage ratio, pH, the sweet courage of each material The factors such as sour sodium have very big negative effect to the fragrance of ointment type snuff, strength, excitant.

Claims (7)

1. a kind of ointment type snuff, it is characterised in that be made up of the material of following mass percent：
Paraffin 43%～44%, vaseline 17%～21%, penetrating agent 2.4% ~ 3%, nicotine 6.2% ~ 7.8%, cotinine 1.9% ~ 2.5%, Neophytadiene 2.3% ~ 5.1%, furfural 0.34% ~ 0.49%, ionol 0.5% ~ 0.9%, Megastigmatrienone 0.43% ~ 0.56%, eggplant Ketone 2.3% ~ 2.7%, geranyl acetone 0.25% ~ 0.62%, catechol 3.3% ~ 4.24%, D- phellandrenes 1.2% ~ 1.4%, myrcene 1.2% ~ 2.3%, pyridine 0.37% ~ 0.41%, preservative 0.01% ~ 0.015%, sodium glycocholate 0.03 ~ 0.11%, 5 hydroxymethyl furfural 0.12 ~ 0.15%, irisone 0.3 ~ 0.6%, violaxanthin 0.17 ~ 0.30%, appropriate pH value regulator, balance of stearic acid；It is described The pH of ointment type snuff is 4.7 ~ 5.9.
2. ointment type snuff according to claim 1, it is characterised in that the neophytadiene, furfural, solanone, myrcene Mass ratio is 3:0.4:2.4:1.5；The 5 hydroxymethyl furfural, irisone, the mass ratio 13 of violaxanthin:44:23.
3. ointment type snuff according to claim 2, it is characterised in that the nicotine, cotinine, the quality of Megastigmatrienone Than for 7：2.3：0.45.
4. ointment type snuff according to claim 1, it is characterised in that be made up of the material of following mass percent：
Paraffin 43%, vaseline 18%, penetrating agent 3%, nicotine 7%, cotinine 2.3%, neophytadiene 4%, furfural 0.5%, ionol 0.9%th, Megastigmatrienone 0.45%, solanone 2.4%, geranyl acetone 0.6%, catechol 3.4%, D- phellandrenes 1.3%, myrcene 2.0%th, pyridine 0.4%, preservative 0.01%, sodium glycocholate 0.09%, 5 hydroxymethyl furfural 0.13%, irisone 0.44%, purple Huang Matter 0.23%, appropriate pH value regulator, balance of stearic acid；The pH of the ointment type snuff is 4.9.
5. ointment type snuff according to claim 1, it is characterised in that be made up of the material of following mass percent：
Paraffin 44%, vaseline 18%, penetrating agent 2.6%, nicotine 7%, cotinine 2.3%, neophytadiene 3%, furfural 0.4%, violet Alcohol 0.8%, Megastigmatrienone 0.45%, solanone 2.4%, geranyl acetone 0.6%, catechol 3.8%, D- phellandrenes 1.3%, myrcene 1.5%th, pyridine 0.39%, preservative 0.01%, sodium glycocholate 0.11%, 5 hydroxymethyl furfural 0.13%, irisone 0.44%, purple Huang Matter 0.23%, appropriate pH value regulator, balance of stearic acid；The pH of the ointment type snuff is 5.7.
6. the ointment type snuff according to Claims 1 to 5 any one, it is characterised in that penetrating agent is azone, and preservative is Nipagin esters and its sodium salt.
7. a kind of preparation method of the snuff of ointment type according to claim 6, it is characterised in that comprise the following steps：
S1. weighing paraffin, vaseline, stearic acid and preservative and being put into melt pot adds heat fusing to be in a liquid state, after stirring, It is filtrated to get mixed-matrix；
S2. mixed-matrix is put into blending tank, adds remaining component, seal blending tank, stirred at being heated to 90 DEG C ~ 100 DEG C After uniform, both obtain after cooling.
CN201611257416.7A 2016-12-30 2016-12-30 Ointment-form snuff and preparation method thereof Pending CN106617263A (en)

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* Cited by examiner, † Cited by third party
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CN108968165A (en) * 2018-10-10 2018-12-11 湖北中烟工业有限责任公司 A method of improving electronic cigarette and aspirates strength

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Application publication date: 20170510