CN106579540A - Ointment type past cigarette and preparation method - Google Patents

Abstract

The present invention belongs to the tobacco product field and discloses an ointment type smokeless cigarette and a preparation method thereof. The ointment type smokeless cigarette is made from the following materials in mass percentage: 40% to 45% of paraffin; 15% to 20% of vaseline; 2% to 3% of penetration enhancer; 6% to 8% of nicotine; 1.5% to 2.8% of cotinine; 2% to 5% of neophytadiene; 0.4% to 0.6% of furfural; 0.5% to 0.9% of ionol; 0.4% to 0.6% of megastigmatrienone; 1.3% to 2.7% of solanone; 0.2% to 0.6% of geranyl acetone; 1.3% to 2.4% of catechol; 0.2% to 0.4% of D-phellandrene; 1.2% to 2.3% of geraniolene; 0.3% to 0.4% of pyridine; 0.01% to 0.015% of preservative; and stearic acid adopted as the balance. The ointment type smokeless cigarette of the present invention is a substitute for conventional cigarettes and has a similar aroma, strength and taste with the aroma, strength and taste of the conventional cigarettes. The ointment type smokeless cigarette is small in size, so that ointment type smokeless cigarette is easy to carry; the ointment type smokeless cigarette is not needed be lit, so that fires can be avoided; and the ointment type smokeless cigarette generates no smoke, and therefore, people around will not be affected, and second-hand smoking can be avoided. The ointment type smokeless cigarette has a wide application range.

Description

A kind of ointment type smears cigarette and preparation method thereof

Technical field

The invention belongs to tobacco product field, more particularly, to a kind of ointment type cigarette and preparation method thereof is smeared.

Background technology

At present the smokeless tobacco articles on overseas market mostly are tobacco powder product, more with packed buccal cigarette, bulk form The form such as buccal cigarette, snuff exist.Tobacco chewing gum as smokeless tobacco articles a kind of important supplement form, by chew Process, improves the uniformity of nicotine release, improves the mouthfeel harmony of smokeless tobacco articles, meets the physiology need of tobacco consumer While asking, increase the process enjoying sense that tobacco consumer eats, while also cleanable tooth, fresh breath, pre- anti-caries.

However, tobacco extract is typically directly added in the form of paste or powder in existing smokeless tobacco articles.But In smokeless tobacco articles, due to change of the consumer to the absorption mode of the materials such as nicotine in product, if by tobacco extract In being directly added into product, can cause the materials such as nicotine discharge in consumer oral cavity soon, the duration is short, mouthfeel excitement strong, As entrance thick taste, strength, excitant are excessive, a few minutes taste is thin out, and hamony is deteriorated, and process enjoying sense is poor, serious shadow Ring consumer to require smokeless tobacco articles comfortableness.

Existing sustained release tobacco microcapsules or micro- smoked sheet are generally simply using coating material to tobacco extract or tobacco leaf Coated.However, existing product also just loses the function of sustained release after coating dissolving.Containing above-mentioned microcapsules or micro- The smokeless tobacco articles of smoked sheet, in the starting stage of edible process, in product the content of microcapsules or micro- smoked sheet still than larger, It is also larger with the contact area of oral cavity or saliva, therefore, the material such as nicotine of starting stage release is more, and mouthfeel still compares thorn Swash, after eating a period of time, diminish with the volume of microcapsules or micro- smoked sheet, quantity is also reduced, and then the rate of release of nicotine, Burst size also reduces therewith, and consumer remains to significantly experience the decline of mouthfeel and quality in use, do not reach with Smoking identical is experienced.

The content of the invention

The technical problem to be solved in the present invention is the defect for overcoming prior art, there is provided a kind of ointment at nasal cavity Type smears cigarette.

Another object of the present invention is to provide the preparation method that a kind of ointment type smears cigarette.

The present invention is achieved through the following technical solutions：

A kind of ointment type smears cigarette, is made up of the material of following mass percent：

Paraffin 40%～45%, vaseline 15%～20%, penetrating agent 2% ~ 3%, nicotine 6% ~ 8%, cotinine 1.5% ~ 2.8%, planting two Alkene 2% ~ 5%, furfural 0.4% ~ 0.6%, ionol 0.5% ~ 0.9%, Megastigmatrienone 0.4% ~ 0.6%, solanone 1.3% ~ 2.7%, perfume Phyllopodium acetone 0.2% ~ 0.6%, catechol 1.3% ~ 2.4%, D- phellandrenes 0.2% ~ 0.4%, myrcene 1.2% ~ 2.3%, pyridine 0.3% ~ 0.4%th, preservative 0.01% ~ 0.015%, sodium glycocholate 0.03 ~ 0.11%, appropriate pH value regulator, balance of stearic acid；It is described soft It is 4.7 ~ 5.9 that cream type smears the pH of cigarette.

The invention provides a kind of substitute of conventional cigarette, takes granule and be put in nasal cavity, using having crowd on bronchia mucosal Many trickle fine hair, greatly increases the effective surface area for smearing cigarette absorption, it is upper it is subcutaneous have an abundant capillary, pharynx nasalis enriches Lymphatic vessel the ingredient draws for smearing cigarette are also played an important role, ingredient draws are rapid.Smear after cigarette absorbs and be directly entered body Circulate, not trans-portal vein, without liver first-pass effect, bronchia mucosal is atomic to drug metabolism weak, and bioavilability is high.

Just because of the olfactive characteristics and absorption characteristic at nasal cavity position are very special and sensitivity, the present invention is put in nasal cavity Smear cigarette strictly to control composition and ratio, just with qualities such as similar fragrance, strength, the tastes to conventional cigarette.

Because nasal cavity, nasal sinus and cranium brain relation are extremely close, not only there are potential fine channel, and 12 between nose cranium To having 3 to be distributed in bronchia mucosal to (trifacial ramus ophthalmicus and ramus maxillaris, olfactory nerve and Branches of facial nerve) in cranial nerve.Cause This, can stimulate intranasal nerve after the composition intranasal such as nicotine so as to produce reflectivity regulation, adjust brain and viscera function, so as to Therapeutic action is played to brain and whole body.

Preferably, ointment type smears cigarette and can add appropriate pH value regulator, such as citric acid, lactic acid, tartaric acid, carbonic acid One or more in sodium, sodium acid carbonate, disodium hydrogen phosphate etc..

Preferably, the neophytadiene, furfural, solanone, the mass ratio of myrcene are 3:0.4:2.4:1.5.With with perfume (or spice) Cigarette identical fragrance.

Preferably, the nicotine, cotinine, the mass ratio of Megastigmatrienone are 7：2.5：0.5.

Preferably, a kind of ointment type is smeared cigarette and is made up of the material of following mass percent：

Paraffin 40%, vaseline 18%, penetrating agent 3%, nicotine 7%, cotinine 2.5%, neophytadiene 3%, furfural 0.4%, ionol 0.9%th, Megastigmatrienone 0.5%, solanone 2.4%, geranyl acetone 0.6%, catechol 2.4%, D- phellandrenes 0.3%, myrcene 1.5%th, pyridine 0.4%, preservative 0.01%, sodium glycocholate 0.09%, appropriate pH value regulator, balance of stearic acid；The ointment It is 4.9 that type smears the pH of cigarette.

Preferably, a kind of ointment type is smeared cigarette and is made up of the material of following mass percent：

Paraffin 40%, vaseline 16%, penetrating agent 2%, nicotine 7%, cotinine 2.5%, neophytadiene 3%, furfural 0.4%, ionol 0.8%th, Megastigmatrienone 0.5%, solanone 2.4%, geranyl acetone 0.6%, catechol 1.3%, D- phellandrenes 0.2%, myrcene 1.5%th, pyridine 0.3%, preservative 0.01%, sodium glycocholate 0.11%, appropriate pH value regulator, balance of stearic acid；The ointment It is 5.7 that type smears the pH of cigarette.

Preferably, penetrating agent is azone, and preservative is nipagin esters and its sodium salt.

A kind of ointment type smears the preparation method of cigarette, comprises the following steps：

S1. weighing paraffin, vaseline, stearic acid and preservative and being put in melt pot adds heat fusing to be in a liquid state, after stirring, It is filtrated to get mixed-matrix；

S2. mixed-matrix is put in blending tank, adds remaining component, seal blending tank, stirred at being heated to 90 DEG C ~ 100 DEG C After uniform, both obtain after cooling.

Compared with prior art, the invention has the advantages that：

The present invention's smears cigarette as the substitute of conventional cigarette for ointment type at nasal cavity, with similar to conventional cigarette The qualities such as fragrance, strength, taste.

Cigarette is smeared for the ointment type at nasal cavity have the advantages that ingredient draws are rapid, bioavilability is high, Er Qieyan Intranasal nerve can be stimulated after the composition intranasal such as alkali so as to produce reflectivity regulation, brain and viscera function are adjusted, so as to brain Therapeutic action is played with whole body.

The ointment type of the present invention smears cigarette small volume and is easy to carry and is avoided that fire, non smoke will not without the need for burning Have influence on the people of surrounding, it is to avoid second-hand-cigarette, it is applied widely.

Specific embodiment

The present invention is further illustrated with reference to specific embodiment.Unless stated otherwise, adopt in the embodiment of the present invention Raw material, apparatus and method are routinely commercial raw material, the conventional use of apparatus and method in this area.

Embodiment 1

A kind of ointment type smears cigarette, is made up of the material of following quality：

Paraffin 40g, vaseline 18g, azone 3g, nicotine 7g, cotinine 2.5g, neophytadiene 3g, furfural 0.4g, ionol 0.9g, Megastigmatrienone 0.5g, solanone 2.4g, geranyl acetone 0.6g, catechol 2.4g, D- phellandrene 0.3g, myrcene 1.5g, pyridine 0.4g, nipagin esters 0.01g, sodium glycocholate 0.09g, stearic acid 16.0g, sodium acid carbonate 0.1g, obtained ointment It is 4.9 that type smears the pH of cigarette.

Ointment type smears the preparation method of cigarette, comprises the following steps：

S1. paraffin, vaseline, stearic acid and the preservative for weighing above-mentioned metering is put in melt pot plus heat fusing is in a liquid state, and stirs After mixing uniformly, mixed-matrix is filtrated to get；

S2. mixed-matrix is put in blending tank, adds remaining component, seal blending tank, stirred at being heated to 90 DEG C ~ 100 DEG C After uniform, both obtain after cooling.

Embodiment 2 ~ 5

Embodiment 2 ~ 5 is substantially the same manner as Example 1, and difference is that the content proportioning of each component is as shown in table 1：

Table 1（Unit：g）

	Embodiment 2	Embodiment 3	Embodiment 4	Embodiment 5
					Paraffin	40	42	43	45
Vaseline	16	20	15	18
					Azone	2	3	3	2
Nicotine	7	8	7	6
					Cotinine	2.5	2.0	2.4	2.8
Neophytadiene	3	2	5	4
					Furfural	0.4	0.6	0.5	0.4
Ionol	0.8	0.5	0.7	0.9
					Megastigmatrienone	0.5	0.6	0.4	0.5
Solanone	2.4	1.3	2.7	1.7
					Geranyl acetone	0.6	0.4	0.2	0.5
Catechol	1.3	2.4	1.8	2.0
					D- phellandrenes	0.2	0.4	0.4	0.3
Myrcene	1.5	1.2	1.9	2.3
					Pyridine	0.3	0.4	0.4	0.4
Nipagin esters	0.01	0.012	0.015	0.01
					Sodium glycocholate	0.11	0.04	0.08	0.10
Stearic acid	20.75	16.048	15.005	12.8
					PH value regulator	Sodium carbonate, 0.63	Sodium acid carbonate, 1.1	Disodium hydrogen phosphate, 0.5	Lactic acid, 0.29
pH	4.7	5.2	5.6	5.9

Comparative example 1

Paraffin 40g, vaseline 18g, azone 3g, nipagin esters 0.01g, tobacco smoke oil extractum 12g, stearic acid 26.99g.

The preparation method of tobacco smoke oil extractum：To pulverize after Tobacco drying, tobacco powder is obtained, take tobacco powder and be placed in burning In cup, distilled water, stirring is added to run through, tobacco powder is 35-45 with the weight proportion of distilled water:600-1000, soaks 1-2 After hour, ultrasonic wave extraction separation is carried out, after extracting 25-35 minutes, filtered, it is (relative that filtrate is condensed into tobacco tobacco tar liquid extract Density, 1mL is equivalent to tobacco 1g), re-dry is obtained tobacco tobacco tar thick medicinal extract (0.6mL is equivalent to tobacco 1g).

Ointment type smears the preparation method of cigarette, comprises the following steps：

S1. paraffin, vaseline, stearic acid and the preservative for weighing above-mentioned metering is put in melt pot plus heat fusing is in a liquid state, and stirs After mixing uniformly, mixed-matrix is filtrated to get；

S2. mixed-matrix is put in blending tank, adds tobacco smoke oil extractum, seal blending tank, be heated at 90 DEG C ~ 100 DEG C After stirring, both obtain after cooling.

Comparative example 2

Paraffin 40g, vaseline 18g, azone 3g, nipagin esters 0.01g, tobacco extract 32g, stearic acid 6.99g.

The preparation method of tobacco extract：

S11. the flue-cured tobacco that absolute dry mass is 100g is taken, adds 1400g water to carry out in 60 DEG C after immersion 25min, be cooled to 20 DEG C of left sides The right side, the ultrasonic extraction 60min under the conditions of 25 ± 2 DEG C, the power of ultrasonic wave is 300W, and then vacuum draw is filtered, and obtains filter residue a With filtrate a；

S12. after the ethanol of 7 times of absolute dry mass of filter residue a is added in the filter residue a of S11, the ultrasonic extraction under the conditions of 25 ± 2 DEG C 30min, the power of ultrasonic wave is 300W, and then vacuum draw is filtered, and obtains filter residue b and filtrate b；

S13. filtrate a and filtrate b is mixed, it is 15% that solid content is concentrated in vacuo under the conditions of 25 DEG C, obtains the tobacco and carries Take thing.

Ointment type smears the preparation method of cigarette, comprises the following steps：

S1. paraffin, vaseline, stearic acid and the preservative for weighing above-mentioned metering is put in melt pot plus heat fusing is in a liquid state, and stirs After mixing uniformly, mixed-matrix is filtrated to get；

S2. mixed-matrix is put in blending tank, adds tobacco extract, seal blending tank, stirred at being heated to 90 DEG C ~ 100 DEG C After mixing uniformly, both obtain after cooling.

Comparative example 3 ~ 6

Comparative example 3 ~ 6 is substantially the same manner as Example 1, and difference is that the content proportioning of each component is as shown in table 2：

Table 2（Unit：g）

	Comparative example 3	Comparative example 4	Comparative example 5	Comparative example 6
					Paraffin	40	42	43	45
Vaseline	16	20	15	18
					Azone	2	3	3	2
Nicotine	7	7	7	6
					Cotinine	2.5	2.5	-	2.8
Neophytadiene	3	2	5	4
					Furfural	0.7	0.3	0.5	0.4
Ionol	0.8	0.5	0.7	0.9
					Megastigmatrienone	0.5	0.5	0.4	0.5
Solanone	3.5	1.0	2.7	1.7
					Geranyl acetone	0.6	0.4	0.2	0.5
Catechol	1.3	2.4	1.8	2.0
					D- phellandrenes	0.2	0.4	0.4	0.3
Myrcene	1.0	2.5	1.9	2.3
					Pyridine	0.3	0.4	0.4	-
Nipagin esters	0.01	0.012	0.015	0.01
					Stearic acid	21.19	17.388	17.945	13.29
Sodium glycocholate	-	0.1	0.02	0.15
					pH	4.8	6.0	4.8	5.3

The evaluation of effect

10 criticism persons for having smoking habit usually are chosen, everyone takes equivalent sample and is put in nasal cavity, and according to ointment type cigarette is smeared The index such as fragrance, strength, outward appearance given a mark, and try to achieve mean value and record in the following table.

Evaluation criterion：

Fragrance：Fragrance is dense（10～8 points）, fragrance it is thin（6～4 points）, fragrance it is light（2～1 points）

Strength：Strength is moderate（10～8 points）, strength it is big（6～4 points）, strength it is little（2～1 points）

Excitant：It is little（10～8 points）, in（6～4 points）, it is big（2～1 points）

Miscellaneous taste：Nothing（10～8 points）, it is heavier（6～4 points）, it is serious（2～1 points）

Outward appearance：Quality and color are uniform（10～8 points）, quality and colour-difference（6～4 points）, quality and color it is very poor（2～1 points）

Evaluation result is as follows：

	Fragrance	Strength	Excitant	Miscellaneous taste	Outward appearance	It is total
							Embodiment 1	10	10	10	10	10	50
Embodiment 2	10	10	10	10	10	50
							Embodiment 3	9	8	9	8	10	44
Embodiment 4	8	9	8	8	10	43
							Embodiment 5	9	9	9	8	10	45
Comparative example 1	2	1	2	2	2	9
							Comparative example 2	2	2	5	4	4	17
Comparative example 3	2	4	5	6	7	24
							Comparative example 4	4	6	6	5	8	29
Comparative example 5	2	4	8	4	8	26
							Comparative example 6	4	6	3	5	6	24

It can be seen from above-mentioned evaluation result, embodiment 1～5 prepare ointment type smear cigarette, on the whole the selection of component and Reasonable mixture ratio, product has the advantage of excellent fragrance, strength, excitant and miscellaneous taste very little, and product provides one to consumer Plant the experience similar to conventional cigarette.Neophytadiene, furfural, solanone, myrcene are added with specific ratio in embodiment 1 ~ 2, There is provided a kind of most widely suited fragrance, while the ratio combination of nicotine, cotinine, Megastigmatrienone ensure that the strength of product And absorbing state, the quality of product is more excellent.Knowable to comparative example 1 ~ 2, from tobacco extract tobacco tobacco tar thick medicinal extract or Tobacco extract is used as tobacco ingredient, and its fragrance for obtaining and strength etc. are all very poor, is especially the absence of the generation of cigarette extracting combustion Fragrance；Its composition complex stimulus is very strong, the shortcomings of miscellaneous taste is dense.Comparative example 3 ~ 6 understands the usage ratio of each material, pH, sweet The factors such as sodium taurocholate smear the fragrance of cigarette, strength, excitant to ointment type very big negative effect.

Claims (7)

1. a kind of ointment type smears cigarette, it is characterised in that be made up of the material of following mass percent：

Paraffin 40%～45%, vaseline 15%～20%, penetrating agent 2% ~ 3%, nicotine 6% ~ 8%, cotinine 1.5% ~ 2.8%, planting two Alkene 2% ~ 5%, furfural 0.4% ~ 0.6%, ionol 0.5% ~ 0.9%, Megastigmatrienone 0.4% ~ 0.6%, solanone 1.3% ~ 2.7%, perfume Phyllopodium acetone 0.2% ~ 0.6%, catechol 1.3% ~ 2.4%, D- phellandrenes 0.2% ~ 0.4%, myrcene 1.2% ~ 2.3%, pyridine 0.3% ~ 0.4%th, preservative 0.01% ~ 0.015%, sodium glycocholate 0.03 ~ 0.11%, appropriate pH value regulator, balance of stearic acid；It is described soft It is 4.7 ~ 5.9 that cream type smears the pH of cigarette.

2. according to claim 1 ointment type smears cigarette, it is characterised in that the neophytadiene, furfural, solanone, myrcene Mass ratio be 3:0.4:2.4:1.5.

3. according to claim 2 ointment type smears cigarette, it is characterised in that the nicotine, cotinine, the matter of Megastigmatrienone Amount is than being 7：2.5：0.5.

4. according to claim 1 ointment type smears cigarette, it is characterised in that be made up of the material of following mass percent：

Paraffin 40%, vaseline 18%, penetrating agent 3%, nicotine 7%, cotinine 2.5%, neophytadiene 4%, furfural 0.5%, ionol 0.9%th, Megastigmatrienone 0.5%, solanone 1.7%, geranyl acetone 0.6%, catechol 2.4%, D- phellandrenes 0.3%, myrcene 2.0%th, pyridine 0.4%, preservative 0.01%, sodium glycocholate 0.09%, appropriate pH value regulator, balance of stearic acid；The ointment It is 4.9 that type smears the pH of cigarette.

5. according to claim 1 ointment type smears cigarette, it is characterised in that be made up of the material of following mass percent：

Paraffin 40%, vaseline 16%, penetrating agent 2%, nicotine 7%, cotinine 2.5%, neophytadiene 3%, furfural 0.4%, ionol 0.8%th, Megastigmatrienone 0.5%, solanone 2.4%, geranyl acetone 0.6%, catechol 1.3%, D- phellandrenes 0.2%, myrcene 1.5%th, pyridine 0.3%, preservative 0.01%, sodium glycocholate 0.11%, appropriate pH value regulator, balance of stearic acid；The ointment It is 5.7 that type smears the pH of cigarette.

6. the ointment type according to Claims 1 to 5 any one smears cigarette, it is characterised in that penetrating agent is azone, preservative For nipagin esters and its sodium salt.

7. a kind of ointment type according to claim 6 smears the preparation method of cigarette, it is characterised in that comprise the following steps：

S1. weighing paraffin, vaseline, stearic acid and preservative and being put in melt pot adds heat fusing to be in a liquid state, after stirring, It is filtrated to get mixed-matrix；

S2. mixed-matrix is put in blending tank, adds remaining component, seal blending tank, stirred at being heated to 90 DEG C ~ 100 DEG C After uniform, both obtain after cooling.