CN106617262A - Tobacco buccal tablet and preparation method thereof - Google Patents
Tobacco buccal tablet and preparation method thereof Download PDFInfo
- Publication number
- CN106617262A CN106617262A CN201611153239.8A CN201611153239A CN106617262A CN 106617262 A CN106617262 A CN 106617262A CN 201611153239 A CN201611153239 A CN 201611153239A CN 106617262 A CN106617262 A CN 106617262A
- Authority
- CN
- China
- Prior art keywords
- tobacco
- powder
- ethanol
- buccal tablet
- root
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 235000002637 Nicotiana tabacum Nutrition 0.000 title claims abstract description 67
- 239000006189 buccal tablet Substances 0.000 title claims abstract description 37
- 229940046011 buccal tablet Drugs 0.000 title claims abstract description 36
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 244000061176 Nicotiana tabacum Species 0.000 title 1
- 241000208125 Nicotiana Species 0.000 claims abstract description 66
- 239000000843 powder Substances 0.000 claims abstract description 38
- 238000000034 method Methods 0.000 claims abstract description 18
- 239000000463 material Substances 0.000 claims abstract description 14
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 12
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims abstract description 11
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims abstract description 11
- 235000009685 Crataegus X maligna Nutrition 0.000 claims abstract description 11
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims abstract description 11
- 235000009486 Crataegus bullatus Nutrition 0.000 claims abstract description 11
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims abstract description 11
- 235000009682 Crataegus limnophila Nutrition 0.000 claims abstract description 11
- 235000004423 Crataegus monogyna Nutrition 0.000 claims abstract description 11
- 235000002313 Crataegus paludosa Nutrition 0.000 claims abstract description 11
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims abstract description 11
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 10
- 239000003826 tablet Substances 0.000 claims abstract description 8
- 229920001353 Dextrin Polymers 0.000 claims abstract description 7
- 239000004375 Dextrin Substances 0.000 claims abstract description 7
- 235000019425 dextrin Nutrition 0.000 claims abstract description 7
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 6
- 238000001694 spray drying Methods 0.000 claims abstract description 6
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 5
- 229930195725 Mannitol Natural products 0.000 claims abstract description 4
- 239000000594 mannitol Substances 0.000 claims abstract description 4
- 235000010355 mannitol Nutrition 0.000 claims abstract description 4
- 229920002774 Maltodextrin Polymers 0.000 claims abstract description 3
- 239000005913 Maltodextrin Substances 0.000 claims abstract description 3
- 229940035034 maltodextrin Drugs 0.000 claims abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 113
- 235000019441 ethanol Nutrition 0.000 claims description 39
- 239000000243 solution Substances 0.000 claims description 22
- 241000050051 Chelone glabra Species 0.000 claims description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 238000004821 distillation Methods 0.000 claims description 17
- 239000000706 filtrate Substances 0.000 claims description 15
- 230000008030 elimination Effects 0.000 claims description 13
- 238000003379 elimination reaction Methods 0.000 claims description 13
- 239000012535 impurity Substances 0.000 claims description 13
- 238000005119 centrifugation Methods 0.000 claims description 11
- 239000012153 distilled water Substances 0.000 claims description 11
- 241001092040 Crataegus Species 0.000 claims description 10
- 239000006286 aqueous extract Substances 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 10
- XDQITMCFPPPMBC-TUANDBMESA-N scutelloside Natural products OC[C@H]1O[C@@H](O[C@@H]2O[C@@H]3C[C@H]4[C@H](O)[C@@H](O)[C@@](O)(CO3)[C@@H]24)[C@H](O)[C@@H](O)[C@@H]1O XDQITMCFPPPMBC-TUANDBMESA-N 0.000 claims description 10
- 239000006228 supernatant Substances 0.000 claims description 10
- 241000723353 Chrysanthemum Species 0.000 claims description 9
- 235000007516 Chrysanthemum Nutrition 0.000 claims description 9
- 238000002137 ultrasound extraction Methods 0.000 claims description 8
- 238000005406 washing Methods 0.000 claims description 8
- 239000002245 particle Substances 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 claims description 6
- 240000005250 Chrysanthemum indicum Species 0.000 claims description 6
- 235000018959 Chrysanthemum indicum Nutrition 0.000 claims description 6
- 238000001556 precipitation Methods 0.000 claims description 6
- 238000001953 recrystallisation Methods 0.000 claims description 6
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 5
- 230000006837 decompression Effects 0.000 claims description 5
- 238000000605 extraction Methods 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 238000002390 rotary evaporation Methods 0.000 claims description 5
- 238000005469 granulation Methods 0.000 claims description 4
- 230000003179 granulation Effects 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 4
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 3
- 239000000853 adhesive Substances 0.000 claims description 3
- 230000001070 adhesive effect Effects 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 238000009835 boiling Methods 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 claims description 3
- 230000006835 compression Effects 0.000 claims description 3
- 238000007906 compression Methods 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 235000013399 edible fruits Nutrition 0.000 claims description 3
- 238000009313 farming Methods 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 238000000746 purification Methods 0.000 claims description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 3
- 238000005507 spraying Methods 0.000 claims description 3
- 238000002604 ultrasonography Methods 0.000 claims description 3
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 claims description 2
- 239000013049 sediment Substances 0.000 claims description 2
- 238000004062 sedimentation Methods 0.000 claims description 2
- 235000009508 confectionery Nutrition 0.000 claims 1
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims 1
- 235000019504 cigarettes Nutrition 0.000 abstract description 16
- 230000000391 smoking effect Effects 0.000 abstract description 4
- 240000004670 Glycyrrhiza echinata Species 0.000 abstract description 2
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 abstract description 2
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract description 2
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 abstract description 2
- 229940010454 licorice Drugs 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract description 2
- 240000000171 Crataegus monogyna Species 0.000 abstract 1
- IPQKDIRUZHOIOM-UHFFFAOYSA-N Oroxin A Natural products OC1C(O)C(O)C(CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IPQKDIRUZHOIOM-UHFFFAOYSA-N 0.000 abstract 1
- IKIIZLYTISPENI-ZFORQUDYSA-N baicalin Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IKIIZLYTISPENI-ZFORQUDYSA-N 0.000 abstract 1
- 229960003321 baicalin Drugs 0.000 abstract 1
- AQHDANHUMGXSJZ-UHFFFAOYSA-N baicalin Natural products OC1C(O)C(C(O)CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 AQHDANHUMGXSJZ-UHFFFAOYSA-N 0.000 abstract 1
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 abstract 1
- 229960004873 levomenthol Drugs 0.000 abstract 1
- IQPNAANSBPBGFQ-UHFFFAOYSA-N luteolin Chemical compound C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(O)C(O)=C1 IQPNAANSBPBGFQ-UHFFFAOYSA-N 0.000 abstract 1
- LRDGATPGVJTWLJ-UHFFFAOYSA-N luteolin Natural products OC1=CC(O)=CC(C=2OC3=CC(O)=CC(O)=C3C(=O)C=2)=C1 LRDGATPGVJTWLJ-UHFFFAOYSA-N 0.000 abstract 1
- 235000009498 luteolin Nutrition 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 8
- 206010062717 Increased upper airway secretion Diseases 0.000 description 5
- 208000026435 phlegm Diseases 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 229960002715 nicotine Drugs 0.000 description 4
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 4
- 230000001953 sensory effect Effects 0.000 description 4
- 206010011224 Cough Diseases 0.000 description 3
- 208000006673 asthma Diseases 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 239000007937 lozenge Substances 0.000 description 3
- 235000019505 tobacco product Nutrition 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000002738 anti-smoking effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 2
- 238000007542 hardness measurement Methods 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 244000025254 Cannabis sativa Species 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- CAMXVZOXBADHNJ-UHFFFAOYSA-N ammonium nitrite Chemical compound [NH4+].[O-]N=O CAMXVZOXBADHNJ-UHFFFAOYSA-N 0.000 description 1
- 230000000954 anitussive effect Effects 0.000 description 1
- 230000001088 anti-asthma Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000469 ethanolic extract Substances 0.000 description 1
- 238000013210 evaluation model Methods 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000005453 pelletization Methods 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229960003531 phenolsulfonphthalein Drugs 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 238000011895 specific detection Methods 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B13/00—Tobacco for pipes, for cigars, e.g. cigar inserts, or for cigarettes; Chewing tobacco; Snuff
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
- A24B15/26—Use of organic solvents for extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
Abstract
The invention provides a tobacco buccal tablet and a preparation method thereof. The tobacco buccal tablet is prepared from, by mass, 1-20% of tobacco leaf powder, 1-5% of licorice powder, 1-3% of L-mentha camphor, 1-5% of hawthorn powder, 1-5% of honeysuckle powder, 0.1-1% of luteolin, 0.1-1% of baicalin, 20-60% of maltodextrin, 5-40% of resistant dextrin, 10-40% of mannitol and 1-5% of magnesium stearate. The preparation method uses the one-step granulating method, and comprises the steps of adding the components into a spray-drying granulator to produce the granulated powdery material with 20-40 mesh, using press machine to press the powdery material into tablets to acquire the tobacco buccal tablets of 0.2-1.2g per tablet. The tobacco substance in the tablet prepared by using the method can bring the joy and satisfaction of smoking a cigarette, improve the mouthfeel of the tobacco tablet, and exert a positive protection function to the bodily health of consumers.
Description
Technical field
The invention belongs to technical field of cigarettes, and in particular to one grows tobacco buccal tablet and preparation method thereof.
Background technology
In the world the earliest cigarette do not smoldered is the buccal cigarette (SNUS) of Sweden, first-class before originating from 1 hundred 30
Pipe tobacco and spices reconcile after grinding plus water, are mounted in into a quarter tea bag size with very thin paper bag after being processed further
Sell in delicately packed can or plastic casing one by one.Now SNUS is taken as food selling, retail stall Li You Sweden match
The thermal insulation cabinet that company gives, it is ensured that product quality and taste are constant, people increasingly tend under the pressure of anti-smoking campaign
Consumption buccal cigarette, because without second-hand-cigarette, without disaster hidden-trouble, government revenue be not relatively low, price is relatively cheap, young man and operation
Workman enjoys a lot to suck, and at present increasing cigarette consumption person switchs to suck SNUS.Because the product is strictly in accordance with food
Safety requirement and produce, anti-smoking campaign person cannot prove so far whether suck SNUS can give people to bring harm, therefore be only
One tobacco product that need not stamp Smoking is harmful to your health epigram of Denging, wherein only containing 0.8% nicotine, other compositions are below
Required standard, such as nitrous acid ammonia, content of beary metal, but demand of the consumer to tobacco can be met.
At present, in the world the more popular country of buccal cigarette has：Sweden, Norway, the U.S., Russia, Denmark, Canada,
Malaysia, Israel etc..Several forms of buccal cigarette point：1. buccal cigarette in bulk, is sold in capsule (about 40g) mode in bulk, is inhaled
One little group is kneaded into finger during food, then fills in upper lip rear.2. inner wrapping buccal cigarette, buccal cigarette of each parcel equipped with about 1g
Grass, 20-25 parcels are equipped with per box, and moist not as cigarette is dissipated, the absorption of nicotine is also more slow.
But the formal cause moisture content of this buccal cigarette is high, and product easily goes mouldy, storage is difficult, in addition because tobacco component
Content it is larger, therefore excitant is big, and ordinary consumer be can not accept, and these all have impact on the popularization of this form that grows tobacco.
The content of the invention
For the above-mentioned deficiency of prior art, the technical problem to be solved in the present invention is to provide a system for growing tobacco buccal tablet
Preparation Method, the tobacco buccal tablet of preparation can bring to consumer to be enjoyed and satisfaction such as smoking, while and energy pharynx-clearing throat-benefiting,
Making up nicotine stimulates throat, brings the consumption pattern of tobacco product into a brand-new field.
The present invention provide technical scheme be：A kind of tobacco buccal tablet with pharynx-clearing throat-benefiting effect, its feature exists
In the tobacco buccal tablet be by the material composition of following percentage by weight：
The gross mass percentage of above-mentioned substance is 100%；
Wherein, described tobacco leaf, Radix Glycyrrhizae, hawthorn, Honeysuckle Flower particle diameter are 1000～1500 mesh；
Described L-menthol purity 98%～99.5%, cyanidenon purity 85%～99%, scutelloside purity 75%
～99%.
The present invention preferably technical scheme：The first-class tobacco leaf of the tobacco leaf picking Turkish tobaccos, burley tobaccos.The malt paste
Essence, resistant dextrin, mannitol and magnesium stearate are food-grade.
The preparation method of a kind of tobacco buccal tablet with pharynx-clearing throat-benefiting effect that the present invention is provided, it is characterised in that concrete
Step is as follows：
(1) to take be put into after cleaned Dendranthema indicum, impurity elimination, drying in pulverizer and crush, adopt concentration for 90%～
Carry at the beginning of 99.9% ethanol, take filtrate and add distillation water sedimentation, then filter to take supernatant centrifugation revolving in vacuum revolving instrument, it
Distillation water washing is added afterwards, sediment anhydrous alcohol solution is collected, and takes supernatant and revolving, distillation water washing, weight is centrifuged again
Obtain aqueous extract multiple 1～2 time, finally aqueous extract is purified with molecularly distilled, 5～10Pa of distillation pressure, material flow 1
～2d/s, scraper plate 300～500r/min of rotating speed, 60～80 DEG C of temperature, collection light component, Jing ethyl alcohol recrystallizations, obtaining purity is
85% -99% cyanidenon；
(2) take be put into after cleaned root of large-flowered skullcap rhizome, impurity elimination, drying in pulverizer crush, adopt concentration for 70% ethanol it is molten
Liquid is concentrated into and obtains Baical Skullcap root P.E without ethanol in ultrasonic extraction 2～3 times, merging filtrate decompression rotary evaporation, then using point
Son distillation is purified to Baical Skullcap root P.E, 5～8Pa of distillation pressure, 1～2d/s of material flow, scraper plate 400～600r/ of rotating speed
Min, 35～55 DEG C of temperature collects light component, and Jing ethyl alcohol recrystallizations obtain the scutelloside that purity is 75% -99%；
(3) raw medicinal material of tobacco leaf, Radix Glycyrrhizae, hawthorn, honeysuckle is taken respectively through cleaning, after impurity elimination, it is high at 90～100 degree
Middle benefit gas boiling 0.5～2 hour, is then dried, and it is 1000～1500 mesh to be crushed using ZKY serial air separate types micronizer
Powder；
(4) mouth containing tablet raw material is prepared according to the formula of following mass percent：Tobacco leaf powder 1～20% in step (3),
Radix Glycyrrhizae powder 1～5% in step (3), L-menthol 1～3%, hawthorn fruit 1～5% in step (3), gold and silver in step (3)
The scutelloside 0.1～1% extracted in the cyanidenon 0.1～1% extracted in pollen end 1～5%, step (1), step (2), wheat
Bud dextrin 20～60%, resistant dextrin 5～40%, mannitol 10～40%, magnesium stearate 1～5%；
(5) marumerization is adopted, all components prepared in step (4) PGL-B that inserts added together is spray-dried
In granulator, make the granular powder that particle diameter is 20～40 mesh, be then molded using tabletting machine, obtain weight 0.2～
The tobacco buccal tablet with pharynx-clearing throat-benefiting effect of 1.2g/.
The present invention preferably technical scheme：The concrete extracting method of legendary god of farming's chrysanthemum aqueous extract is in the step (2)：By the legendary god of farming
Fragrant chrysanthemum is cleaned, impurity elimination, cross 20 mesh sieves after drying, and chrysanthemum powder is obtained, and is immersed in 30 DEG C in 90% -99.9% ethanol
～50 DEG C of closings are stirred 1～3 hour, and ethanol is 1 with the mass ratio of chrysanthemum powder:1～1:2；Solution cooling is placed 1～2 hour
Afterwards, filter and remove filter residue and obtain ethanol solution, then stir ethanol solution, be slowly added to distilled water while stirring, distilled water with
The mass ratio of ethanol solution is 1:1～2:1 so as to filter to take supernatant after precipitation is complete, using vacuum revolving instrument centrifugation revolving,
Take filtrate and add distillation water washing, take precipitation anhydrous alcohol solution, take supernatant, centrifugation again rotates, takes filtrate and add and steam
Distilled water is washed, and is repeated 1～2 and is obtained aqueous extract；Every time the condition of centrifugation revolving is in said process：Rotating speed 4000～
6000r/min, temperature 45 C～60 DEG C, distilled water is 8 with the mass ratio of filtrate:1～10:1.
The present invention preferably technical scheme：The concrete extraction process of Baical Skullcap root P.E is as follows in the step (3)：Take the root of large-flowered skullcap
Rhizome is cleaned, impurity elimination, be put in pulverizer after drying and crush, and crosses 20 mesh sieves, obtains root of large-flowered skullcap powder, adds 70% ethanol solution,
Ethanol is 1 with the mass ratio of root of large-flowered skullcap powder:1～3:1, using Ultrasound Instrument ultrasonic extraction 0.5～2 hour, supersonic frequency 30～
50KHz, filters after the completion of extraction, takes 70% ethanol of filter residue and repeats ultrasonic extraction once under identical condition, merging filtrate,
Decompression rotary evaporation concentration, rotate 0.6～0.9 atmospheric pressure of pressure, rotating speed be 3000～5000r/min, temperature 30 DEG C～50
DEG C, it is concentrated into and obtains Baical Skullcap root P.E without ethanol.
The present invention preferably technical scheme：Molecular clock purification in the step (2) and step (3) uses U.S. POPE
Two inches of molecule distillation apparatus of company's production.
The present invention preferably technical scheme：Spray drying granulation is with sodium carboxymethylcellulose (CMC) in the step (4)
The aqueous solution be adhesive, solution concentration be 2%～10%, liquid supply speed be 10～30ml/min, 40～70 DEG C of bed temperature,
0.15～0.25MPa of compression gas-pressure.
The granulation process is：Insert all components are added together in PGL-B spray-drying pelleting machines, fluidized simultaneously
Realize powder mix, sprayer unit starts, in the continuous spray process of 20-100min, droplet occurs on powder condense with
Growth process, until required particle size stops spraying.Finally, all granular products proceed to fluidize in same container and do
It is dry, so as to the end-product for obtaining pelletizing.
Advantages of the present invention：Tobacco material in tobacco mouth containing slice prescription prepared by the present invention can be brought as taken out to consumer
Enjoyment and satisfaction as cigarette, Radix Glycyrrhizae therein, menthol, hawthorn, honeysuckle composition have pharynx-clearing throat-benefiting, make up nicotine to larynx
The effect that portion stimulates, and the mouthfeel of tobacco lozenge can be improved, the higher cyanidenon of especially contained purity, scutelloside even more have
There is the active component of notable functions of relieving cough and reducing phlegm, the healthy of consumer is played a very good protection, the functional form cigarette
Careless buccal tablet brings the consumption pattern of tobacco product into a brand-new field.
Specific embodiment
The specific embodiment of the present invention is described in further detail with reference to embodiment.
Cyanidenon in the embodiment of the present invention is to extract to obtain according to following steps：Take cleaned Dendranthema indicum, impurity elimination,
20 mesh sieves are crossed after drying, chrysanthemum powder are obtained, be immersed in 90% -99.9% ethanol 30 DEG C～50 DEG C closing stirrings 1～
3 hours, ethanol was 1 with the mass ratio of chrysanthemum powder:1～1:2；After solution cooling is placed 1～2 hour, filter removal filter residue and obtain
To ethanol solution, ethanol solution is then stirred, distilled water is slowly added to while stirring, distilled water is with the mass ratio of ethanol solution
1:1～2:1 so as to filter to take supernatant after precipitation is complete, using vacuum revolving instrument centrifugation revolving, take filtrate and add and distill washing
Wash, take precipitation anhydrous alcohol solution, take supernatant, centrifugation again rotates, takes filtrate and add and distill water washing, repeats 1
～2 obtain Dendranthema indicum aqueous extract；Every time the condition of centrifugation revolving is in said process：4000～6000r/min of rotating speed, temperature
45 DEG C～60 DEG C, distilled water is 8 with the mass ratio of filtrate:1～10:1；Finally Dendranthema indicum aqueous extract is entered with molecularly distilled
Row purification, the two inches of molecule distillation apparatus produced using POPE companies of the U.S., 5～10Pa of distillation pressure, 1～2d/ of material flow
S, scraper plate 300～500r/min of rotating speed, 60～80 DEG C of temperature collects light component, Jing ethyl alcohol recrystallizations, obtain purity for 85%-
99% cyanidenon.
Scutelloside in the embodiment of the present invention is to extract to obtain according to following steps：Take cleaned root of large-flowered skullcap rhizome, impurity elimination, do
It is put into after dry in pulverizer and crushes, cross 20 mesh sieves, obtain root of large-flowered skullcap powder, adds the quality of 70% ethanol solution, ethanol and root of large-flowered skullcap powder
Than for 1:1～3:1, using Ultrasound Instrument ultrasonic extraction 0.5～2 hour, 30～50KHz of supersonic frequency, filter after the completion of extraction, take
70% ethanol of filter residue repeats ultrasonic extraction once under identical condition, merging filtrate, decompression rotary evaporation concentration, revolving pressure
0.6～0.9 atmospheric pressure of power, rotating speed is 3000～5000r/min, and 30 DEG C～50 DEG C of temperature is concentrated into and obtains the root of large-flowered skullcap without ethanol
Extract；Then Baical Skullcap root P.E is purified using molecular clock, molecular clock is using the two of the production of POPE companies of the U.S.
Inch molecule distillation apparatus, 5～8Pa of distillation pressure, 1～2d/s of material flow, scraper plate 400～600r/min of rotating speed, temperature 35～
55 DEG C, light component is collected, Jing ethyl alcohol recrystallizations obtain the scutelloside that purity is 75% -99%.
Tobacco leaf powder, licorice powder in the embodiment of the present invention, hawthorn powder, honeysuckle powder be respectively by tobacco leaf, Radix Glycyrrhizae, hawthorn,
After raw medicinal material over cleaning, the impurity elimination of honeysuckle, boiling 0.5～2 hour, is then dried in 90～100 degree of high temperature, utilizes
ZKY serial air separate type micronizers are ground into the powder of 1000～1500 mesh.
Prepare the raw material of buccal tablet according to the formula in table 1, its formula is to carry out proportioning according to mass percent：
The tobacco of table 1 sucks slice prescription
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | |
| Tobacco leaf powder | 20% | 15% | 10% | 5% | 5% |
| Radix Glycyrrhizae powder | 1% | 2% | 2% | 4% | 2% |
| L-menthol | 1% | 2% | 2% | 3% | 3% |
| Hawthorn fruit | 1% | 2% | 2% | 4% | 2% |
| Honeysuckle Flower | 1% | 2% | 2% | 4% | 2% |
| Cyanidenon | 0.2% | 0.5% | 0.8% | 1% | 0.1% |
| Scutelloside | 0.2% | 0.5% | 0.8% | 1% | 0.1% |
| Maltodextrin | 58% | 50% | 40% | 30% | 20% |
| Resistant dextrin | 5% | 10% | 20% | 30% | 40% |
| Mannitol | 10% | 12% | 18% | 15% | 22% |
| Magnesium stearate | 2.6% | 4% | 2.4% | 3% | 3.8% |
After raw material components in above-mentioned each embodiment are mixed respectively, PGL-B spray-drying pelleting machines are added
In, fluidized and realized that powder mixes, sprayer unit is opened, with the sodium carboxymethylcellulose (CMC) that concentration is 2%～10%
The aqueous solution be adhesive, liquid supply speed be 10～30ml/min, 40～70 DEG C of bed temperature, compression gas-pressure 0.15～
0.25MPa；In the continuous spray process of 20～100min, there is cohesion and growth process in droplet, on powder until making
Stop spraying during 20～40 mesh particle, finally, all granular products proceed fluidized drying in same container, so as to obtain
Particle diameter is the granular powder of 20～40 mesh, is then molded using tabletting machine, obtains weight and has at 0.2～1.2g/
The tobacco buccal tablet of pharynx-clearing throat-benefiting effect.
Tobacco buccal tablet will be made in above-mentioned four or five embodiments carries out sensory evaluation using the sensory evaluating smoking personnel of specialty,
Concrete Analyses Methods for Sensory Evaluation Results such as table 2：
The tobacco buccal tablet Analyses Methods for Sensory Evaluation Results of table 2
Hardness-testing device is respectively adopted to detect the hardness for preparing tobacco buccal tablet in above-mentioned five embodiments, by cigarette
Careless buccal tablet facade is positioned on Meng Shan all hardness testers, after zero progressively, be slowly increased pressure, until tablet is crushed, read
Dial reading, as tablet hardness；Can also be detected using self-action hardness-testing device.
The result of specific detection is as shown in table 3：
The tobacco buccal tablet hardness of table 3
| Lozenge hardness | |
| Embodiment 1 | 10N |
| Embodiment 2 | 9N |
| Embodiment 3 | 5N |
| Embodiment 4 | 6N |
| Embodiment 5 | 4N |
Reference《Pharmacological experimental methodology》Classical pharmacology is exhaled in 3rd edition (Xu Shuyun is edited, and People's Health Publisher publishes)
Road functional evaluation model is inhaled, the antitussive effect of tobacco buccal tablet is evaluated using ammonia induced cough in mice, the phenol red excretion method of mouse is commented
The phlegm-dispelling functions of valency tobacco buccal tablet, Guinea pig isolated trachea spiral strip method evaluates the antiasthmatic effect of tobacco buccal tablet, concrete to evaluate
The results are shown in Table 4.
The antibechic of the tobacco buccal tablet active ingredient of table 4, phlegm-dispelling functions and evaluation of effect of relievining asthma (x ± s)
*P<0.05,**P<0.01 compares with blank control group
From animal data as can be seen that the tobacco buccal tablet that done of embodiment 3 and embodiment 4 is to mouse and the town of cavy
Cough, eliminating the phlegm, the effect relievingd asthma it is the most notable, the effect that the tobacco buccal tablet of embodiment 1 and 2 has certain antibechic, eliminating the phlegm, relievings asthma
Really, the tobacco buccal tablet of embodiment 5 is slightly better than traditional tobacco lozenge in terms of pharynx-clearing throat-benefiting.
Claims (8)
1. one grow tobacco buccal tablet, it is characterised in that the tobacco buccal tablet is by the material composition of following percentage by weight：
Wherein, described tobacco leaf, Radix Glycyrrhizae, hawthorn, Honeysuckle Flower particle diameter are 1000～1500 mesh；
Described L-menthol purity 98%～99.5%, cyanidenon purity 85%～99%, scutelloside purity 75%～
99%.
2. according to claim 1 one grow tobacco buccal tablet, it is characterised in that：The tobacco leaf picking Turkish tobaccos, burley tobaccos
First-class tobacco leaf.
3. according to claim 1 one grow tobacco buccal tablet, it is characterised in that：The maltodextrin, resistant dextrin, sweet dew
Alcohol and magnesium stearate are food-grade.
4. the preparation method of the tobacco buccal tablet described in a kind of claim 1, it is characterised in that comprise the following steps that：
(1) to take be put into after cleaned Dendranthema indicum, impurity elimination, drying in pulverizer and crush, adopt concentration for 90%～99.9%
Ethanol is just carried, and is taken filtrate and is added distillation water sedimentation, then filters to take supernatant centrifugation revolving in vacuum revolving instrument, adds steam afterwards
Distilled water is washed, and collects sediment anhydrous alcohol solution, takes supernatant and revolving, distillation water washing is centrifuged again, is repeated 1～2 time
Aqueous extract is obtained, finally aqueous extract is purified with molecularly distilled, 5～10Pa of distillation pressure, 1～2d/s of material flow,
Scraper plate 300～500r/min of rotating speed, 60～80 DEG C of temperature collects light component, Jing ethyl alcohol recrystallizations, obtain purity for 85%-
99% cyanidenon；
(2) to take be put into after cleaned root of large-flowered skullcap rhizome, impurity elimination, drying in pulverizer and crush, adopt concentration and exist for 70% ethanol solution
Ultrasonic extraction 2～3 times, merging filtrate decompression rotary evaporation is concentrated into and obtains Baical Skullcap root P.E without ethanol, is then steamed using molecule
Evaporate and Baical Skullcap root P.E is purified, 5～8Pa of distillation pressure, 1～2d/s of material flow, scraper plate 400～600r/min of rotating speed,
35～55 DEG C of temperature, collects light component, and Jing ethyl alcohol recrystallizations obtain the scutelloside that purity is 75% -99%；
(3) raw medicinal material of tobacco leaf, Radix Glycyrrhizae, hawthorn, honeysuckle is taken respectively through cleaning, after impurity elimination, in 90～100 degree of high temperature
Boiling 0.5～2 hour, is then dried, and using ZKY serial air separate types micronizer the powder for 1000～1500 mesh is crushed
End；The first-class tobacco leaf of the tobacco leaf picking Turkish tobaccos, burley tobaccos；
(4) mouth containing tablet raw material is prepared according to the formula of following mass percent：Tobacco leaf powder 1～20% in step (3), step
(3) Radix Glycyrrhizae powder 1～5% in, L-menthol 1～3%, hawthorn fruit 1～5% in step (3), honeysuckle powder in step (3)
The scutelloside 0.1～1% extracted in the cyanidenon 0.1～1% extracted in end 1～5%, step (1), step (2), malt paste
Essence 20～60%, resistant dextrin 5～40%, mannitol 10～40%, magnesium stearate 1～5%；
(5) marumerization is adopted, PGL-B spray-drying processes is inserted by all components prepared in step (4) are added together
In machine, the granular powder that particle diameter is 20～40 mesh is made, be then molded using tabletting machine, obtain weight in 0.2～1.2g/
Tobacco buccal tablet.
5. the preparation method of the tobacco buccal tablet described in a kind of claim 1 according to claim 4, it is characterised in that
The concrete extracting method of legendary god of farming's chrysanthemum aqueous extract is in the step (1)：By Dendranthema indicum is cleaned, impurity elimination, cross 20 mesh after drying
Sieve, is obtained chrysanthemum powder, is immersed in 90% -99.9% ethanol 30 DEG C～50 DEG C closing stirrings 1～3 hour, ethanol with
The mass ratio of chrysanthemum powder is 1:1～1:2；After solution cooling is placed 1～2 hour, filter removal filter residue and obtain ethanol solution, so
After stir ethanol solution, be slowly added to distilled water while stirring, distilled water is 1 with the mass ratio of ethanol solution:1～2:1 so as to
Supernatant is filtered to take after precipitation is complete, using vacuum revolving instrument centrifugation revolving, filtrate is taken and is added and distill water washing, take precipitation nothing
Water-ethanol dissolves, and takes supernatant, and centrifugation again rotates, takes filtrate and add and distill water washing, repeats 1～2 and obtains aqueous extract；
Every time the condition of centrifugation revolving is in said process：4000～6000r/min of rotating speed, temperature 45 C～60 DEG C, distilled water and filter
The mass ratio of liquid is 8:1～10:1.
6. the preparation method of the tobacco buccal tablet described in a kind of claim 1 according to claim 4, it is characterised in that
The concrete extraction process of Baical Skullcap root P.E is as follows in the step (2)：Take and be put into powder after cleaned root of large-flowered skullcap rhizome, impurity elimination, drying
Crush in broken machine, cross 20 mesh sieves, obtain root of large-flowered skullcap powder, add 70% ethanol solution, ethanol is 1 with the mass ratio of root of large-flowered skullcap powder:1～3:
1, using Ultrasound Instrument ultrasonic extraction 0.5～2 hour, 30～50KHz of supersonic frequency, filter after the completion of extraction, take filter residue and use 70%
Ethanol repeats ultrasonic extraction once under identical condition, merging filtrate, decompression rotary evaporation concentration, rotates pressure 0.6～0.9
Individual atmospheric pressure, rotating speed is 3000～5000r/min, and 30 DEG C～50 DEG C of temperature is concentrated into and obtains Baical Skullcap root P.E without ethanol.
7. the preparation method of the tobacco buccal tablet described in a kind of claim 1 according to claim 4, it is characterised in that
Molecular clock purification is using two inches of molecule distillation apparatus of POPE companies of U.S. production in the step (1) and step (2).
8. the preparation method of the tobacco buccal tablet described in a kind of claim 1 according to claim 4, it is characterised in that
In the step (5) spray drying granulation be with the aqueous solution of sodium carboxymethylcellulose as adhesive, solution concentration be 2%～
10%, liquid supply speed be 10～30ml/min, 40～70 DEG C of bed temperature, 0.15～0.25MPa of compression gas-pressure, during spraying granulation
Between be 20-100min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611153239.8A CN106617262B (en) | 2016-12-14 | 2016-12-14 | One grows tobacco buccal tablet and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611153239.8A CN106617262B (en) | 2016-12-14 | 2016-12-14 | One grows tobacco buccal tablet and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106617262A true CN106617262A (en) | 2017-05-10 |
| CN106617262B CN106617262B (en) | 2017-11-07 |
Family
ID=58822072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611153239.8A Active CN106617262B (en) | 2016-12-14 | 2016-12-14 | One grows tobacco buccal tablet and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106617262B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023073922A1 (en) * | 2021-10-29 | 2023-05-04 | 日本たばこ産業株式会社 | Oral product containing indigestible dextrin and composition for said product |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1555840A (en) * | 2003-12-31 | 2004-12-22 | 贵阳医学院 | Chinese medicinal preparation for treating pharyngolaryngitis and its manufacturing method |
| CN101928642A (en) * | 2010-06-22 | 2010-12-29 | 武汉神农天香生物科技有限公司 | Method for extracting and separating spice and medicinal components from whole plants of Dendranthema indicum |
| CN102715647A (en) * | 2012-07-02 | 2012-10-10 | 湖北中烟工业有限责任公司 | Novel buccal cigarette |
| CN103783524A (en) * | 2014-01-04 | 2014-05-14 | 左权县桐峪镇嘉百岁农民专业合作社 | Fructus forsythiae leaf buccal tablets and preparation method thereof |
| CN104432483A (en) * | 2014-12-15 | 2015-03-25 | 湖北中烟工业有限责任公司 | Smokeless tobacco product with crackling taste and preparation method of smokeless tobacco product |
| CN104522873A (en) * | 2014-12-15 | 2015-04-22 | 湖北中烟工业有限责任公司 | Soft snus and preparation method thereof |
| CN104905405A (en) * | 2015-06-17 | 2015-09-16 | 湖北中烟工业有限责任公司 | Preparation method and application of tobacco tip bar containing plant flavone essence |
| CN105154227A (en) * | 2015-06-17 | 2015-12-16 | 湖北中烟工业有限责任公司 | Plant flavone essence cigarette bead for cigarette, and preparation method and application thereof |
| CN106038686A (en) * | 2016-07-20 | 2016-10-26 | 深圳神农春天植物活性物质开发有限公司 | Anti-influenza-virus buccal tablet and preparation method thereof |
-
2016
- 2016-12-14 CN CN201611153239.8A patent/CN106617262B/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1555840A (en) * | 2003-12-31 | 2004-12-22 | 贵阳医学院 | Chinese medicinal preparation for treating pharyngolaryngitis and its manufacturing method |
| CN101928642A (en) * | 2010-06-22 | 2010-12-29 | 武汉神农天香生物科技有限公司 | Method for extracting and separating spice and medicinal components from whole plants of Dendranthema indicum |
| CN102715647A (en) * | 2012-07-02 | 2012-10-10 | 湖北中烟工业有限责任公司 | Novel buccal cigarette |
| CN103783524A (en) * | 2014-01-04 | 2014-05-14 | 左权县桐峪镇嘉百岁农民专业合作社 | Fructus forsythiae leaf buccal tablets and preparation method thereof |
| CN104432483A (en) * | 2014-12-15 | 2015-03-25 | 湖北中烟工业有限责任公司 | Smokeless tobacco product with crackling taste and preparation method of smokeless tobacco product |
| CN104522873A (en) * | 2014-12-15 | 2015-04-22 | 湖北中烟工业有限责任公司 | Soft snus and preparation method thereof |
| CN104905405A (en) * | 2015-06-17 | 2015-09-16 | 湖北中烟工业有限责任公司 | Preparation method and application of tobacco tip bar containing plant flavone essence |
| CN105154227A (en) * | 2015-06-17 | 2015-12-16 | 湖北中烟工业有限责任公司 | Plant flavone essence cigarette bead for cigarette, and preparation method and application thereof |
| CN106038686A (en) * | 2016-07-20 | 2016-10-26 | 深圳神农春天植物活性物质开发有限公司 | Anti-influenza-virus buccal tablet and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023073922A1 (en) * | 2021-10-29 | 2023-05-04 | 日本たばこ産業株式会社 | Oral product containing indigestible dextrin and composition for said product |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106617262B (en) | 2017-11-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7393318B2 (en) | smokeless tobacco tablets | |
| CN105595404B (en) | Tobacco buccal tablet and preparation method thereof | |
| CN100398018C (en) | Smokeless tobacco product | |
| US11612183B2 (en) | Protein-enriched tobacco composition | |
| CN105286080B (en) | Buccal smokeless tobacco product and preparation method thereof | |
| JP2017505629A (en) | Tobacco-containing gel composition | |
| CN105163607A (en) | Sugar-enriched extract derived from tobacco | |
| CN102499447A (en) | Chinese style smoke-free tobacco product containing corsvenor momordica fruits | |
| CN105852193A (en) | Fructus phyllanthi flavored bagged oral cigarette and preparation method thereof | |
| CN100593373C (en) | Bagging mouth-sucked drying tobacco products and method of preparing the same | |
| CN111418892A (en) | Cigarette filter stick additive and application thereof | |
| CN105614567B (en) | A kind of water east leaf mustard deep processed product | |
| CN101355885A (en) | Nicotine with a reduced content of nitrosamines | |
| CN106617262B (en) | One grows tobacco buccal tablet and preparation method thereof | |
| CN103494317A (en) | Smoke-free tobacco based on fresh tobacco preparing | |
| CN102406871A (en) | Smoking cessation tea and preparation method thereof | |
| CN110313597A (en) | One kind is instant to be exempted to rush throat soothing particle and preparation method thereof | |
| CN106389776B (en) | A kind of trollius chinensis granular agent and preparation method thereof | |
| CN103976066A (en) | Processing method of pistacia chinensis bunge green tea | |
| CN107224005B (en) | One kind drinks formula tobacco product | |
| CN106617273B (en) | A kind of cloves mouth containing tobacco product and preparation method thereof | |
| CN105614944A (en) | Kudzuvine root-flavor chewing tobacco and preparation method thereof | |
| CN109123294A (en) | A kind of straight drinking particle of broken wall improving oropharynx microenvironment | |
| CN105768195B (en) | Using the buccal cigarette and preparation method thereof of large scale tobacco-containing material | |
| CN101671696A (en) | Pilocarpus plant extract for reducing smoke dry sensation of cigarettes and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |