CN106581552A - Agent for treating coronary heart disease and preparation method of agent - Google Patents
Agent for treating coronary heart disease and preparation method of agent Download PDFInfo
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- CN106581552A CN106581552A CN201510683211.4A CN201510683211A CN106581552A CN 106581552 A CN106581552 A CN 106581552A CN 201510683211 A CN201510683211 A CN 201510683211A CN 106581552 A CN106581552 A CN 106581552A
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Abstract
The invention discloses an agent for treating coronary heart disease and a preparation method of the agent. The agent is prepared from the following raw materials in parts by weight: 15-30 parts of radix angelicae sinensis, 30-55 parts of radix rehmanniae praeparata, 20-35 parts of herba cistanche, 10-55 parts of unprocessed rehmannia root, 10-20 parts of ginseng, 10-30 parts of radix ophiopogonis, 3-12 parts of fruit of Chinese magnoliavine, 7-15 parts of liquorice root, 10-40 parts of radix astragali, 20-30 parts of radix scrophulariae, 20-55 parts of radix salviae miltiorrhizae, 2-15 parts of fructus amomi, 2-15 parts of rhizoma ligustici wallichii and 10-20 parts of honeysuckle flowers. The agent provided by the invention has the characteristics of being gentle in drug property and free from side effects.
Description
Technical field
The present invention relates to a kind of medicament and preparation method for treating heart disease, particularly a kind of hat
Worry healing potion and preparation method.
Background technology
Coronary heart disease, refers to that blood vessel-coronary artery generation of supply cardiotrophin material is serious athero-
Hardening or spasm, close coronary artery stenosis or blocking, and the tube chamber that thrombosis is caused
Plug, causes a kind of heart disease of myocardial ischemia-anoxemia or infraction, also known as ischemic heart disease.
Coronary heart disease is the most common type that atherosclerotic causes organ lesion, is harm person in middle and old age
The common disease of people's health, and rejuvenation tendency is presented.The reason for coronary artery narrows be:In blood
The long-term too high, cholesterol of blood fat be deposited in accumulating over a long period on the inner membrance of coronary artery tube chamber,
Ground pattern patch is formed, make that the inner membrance of otherwise smooth becomes is coarse, and soft tube wall becomes deadlock
Firmly, on this basis, the blood platelet of rupture also condenses adhesion and gets on, and makes coronary lumen narrow,
Even entirely shut.Coronary artery smooth entirely shuts, and causes myocardial blood supply bad, cardiac muscle
Cannot get blood nutrition and necrosis be referred to as myocardial infarction, this is the performance of coronary heart disease most serious.
Modern medicine is broadly divided into two classes under the guidance of this theory to cardiopathic treatment means:
One is to use medicine to include expansion of blood vessels class medicine and the molten lipid drug of thrombolysis；Two it is support, takes
Bridge is performed the operation.In the treatment of coronary heart disease, intervention operation and bypass surgery belong to invasive treatment,
Simultaneously postoperative complication has a strong impact on the healthy of patient.Moreover above-mentioned operation
The precipitation again that the rubbish such as vascular lipids can not be solved from source forms new patch, causes
Make blood vessel restenosis, blocking, the problem of the not smooth old disease recurrence of myocardial blood supply.
The content of the invention
The purpose of the present invention, is to provide a kind of coronary heart disease treatment medicament and preparation method.The present invention
With the property of medicine it is gentle, have no side effect the characteristics of.
What the present invention was realized in.A kind of coronary heart disease treatment medicament, it is matched somebody with somebody with following weight
The raw material of ratio is made,
More preferably, aforesaid coronary heart disease treatment medicament, be made of with the raw material of following weight proportions,
Optimally, aforesaid coronary heart disease treatment medicament, it is with the raw material system of following weight proportions
Into,
In aforesaid coronary heart disease treatment medicament, the formulation of described medicament be powder, tablet,
Oral liquid or capsule.
In the preparation method of aforesaid coronary heart disease treatment medicament, described powder is as follows
Prepare：Each active compound is ground to form and mix in proportion after fine powder and cross 250-400 mesh sieves, as
Powder.
In the preparation method of aforesaid coronary heart disease treatment medicament, described tablet is in the steps below
Prepare：Each active compound is ground to form and mix in proportion after fine powder and cross 300-500 mesh sieves, sieved
It is tabletted afterwards.
In the preparation method of aforesaid coronary heart disease treatment medicament, described oral liquid presses following steps
It is rapid to prepare：Total raw material is pressed into medicine:The volume ratio of water is 1:2-4 soaks at least 1h, then
Plus suitable quantity of water is decocted to consider after 1-3h and removes the dregs of a decoction.
In the preparation method of aforesaid coronary heart disease treatment medicament, described capsule is made in the steps below
It is standby：Total raw material is pressed into medicine:The volume ratio of water is 1:2-10 soaks at least 2h, then adds appropriate
Decocting boils 1-1.5h, filters off the dregs of a decoction, by the Chinese medicine leaching of clarification under conditions of negative pressure, low temperature
Liquid is concentrated into Bomi degree for more than 75%, and by powder spraying apparatus dry powder is made, and the temperature of spout≤
100 DEG C, then make capsule after addition filler in dry powder.
Radix Angelicae Sinensis, it is warm in nature, it is sweet, pungent.Return liver, the heart, the spleen channel.Replenishing and activating blood, menstruction regulating and pain relieving,
Relax bowel.Radix Angelicae Sinensis can improve internal hypercoagulative state, adjust blood lipid metabolism, reduce cholesterol.
Cultivated land, sweet, tepor.Return liver and kidney channel.Enrich blood yin-nourishing, life essence-filling, marrow-benefitting.Prepared rhizome of rehmannia energy
Significantly inhibit liver hemorrhagic necrosis and simple necrosis；The hyperlipemia that high lipid food is caused
The vena hepatica haemorrhage that disease, fatty liver and rat endotoxin cause, there is inhibition thrombosis
Effect；Activation to plasminogen, is antithrombotic mechanism of action.
Saline cistanche, return through is sweet, salty, temperature.Return kidney, large intestine channel.Kidney-replenishing, benefiting essence-blood, profit
Intestines defaecation.《Bencao Jingshu》:The key medicine of nourshing kidney replenishing vital essence and blood, sweet energy heat extraction bowl spares, acid can enter
Liver, salty energy nourshing kidney, kidney liver is the moon, and cloudy gas is grown, then the labor heat of the five internal organs is moved back certainly, penis syncope due to pathogenic cold
Hot pain self-healing.
The dried rhizome of rehmannia, it is sweet, tremble with fear.The thoughts of returning home, liver and kidney channel.Clearing heat and cooling blood, yin-nourishing is promoted the production of body fluid.For
The deep red polydipsia of pyreticosis tongue, yin asthenia generating intrinsic heat, hectic fever due to yin labor heat, Heat Diabetes is spitted blood, and maggot blood sends out spot
Dermexanthesis.
Ginseng, mild-natured, sweet, slight bitter, tepor.Returns spleen, lung channel.Reinforce vital energy, multiple arteries and veins
Gu it is de-, reinforce the spleen to benefit the lung, promote the production of body fluid to quench thirst, tranquilize the mind and promote the intelligence.Ginseng has protective effect to cardiac muscle.People
Ginseng soap two can reduce the lactic acid content of mouse brain and cardiac muscle in the case of severe depletion of oxygen, can recover
Content of cAMP/cGMP ratios during anoxic, and with protection heart muscle capillary endothelial cell and subtract
The effect of light injury of mitochondria.
The tuber of dwarf lilyturf, sweet, slight bitter is slightly cold.The thoughts of returning home, lung, stomach.Nourishing Yin and promoting production of body fluid, moistening lung clears away heart-fire.
For dryness of the lung dry cough.Empty carbuncle cough, injury thirst, vexed insomnia, Heat Diabetes, intestinal dryness is just
It is secret；Pharyngeal diphtheria.The tuber of dwarf lilyturf increases may myocardial alimentary blood flow after infraction, the heart of hypoxic-ischemic
Myocyte comparatively fast obtains reparation with protection, and the release for causing myocardium cGMP and cAMP is reduced, so as to
The content in blood plasma is reduced, and makes both ratio restore balance.
The fruit of Chinese magnoliavine, temperature；It is sour, sweet；Return lung, the heart, kidney channel.Astringent or styptic treatment for spontaneous sweating, nourishing generate fluid is restrained, is mended
Kidney calming heart.The fruit of Chinese magnoliavine has vasodilative effect.Schizandrin, schisandrin C, the deoxidation fruit of Chinese magnoliavine
Elements etc. have inhibitory action in vitro dog mesenteric artery shrinks, and can increase arteries and veins mouse isolated heart
And anesthesia dog CF.The fruit of Chinese magnoliavine is conducive to histiocytic oxygen exchange, can be to heart
Tissue produces protective effect, also gently palmic rate and fibre can solve hypertension.
Radix Glycyrrhizae, mild-natured, sweet, return 12 warps.Have removing toxic substances, eliminating the phlegm, pain relieving, spasmolysis so that
The pharmacological actions such as anticancer.Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain reconciles
All medicines.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, institute's abdomen, four limbs
Contraction urgency pain, carbuncle sore tumefacting virus alleviate drug toxicity, strong.
The Radix Astragali, property is sweet, tepor.Return lung, spleen, liver and kidney channel.There are invigorating qi for consolidating superficies, arrest sweating solid
The effect of de-, torr sore myogenic, inducing diuresis for removing edema.The Radix Astragali can strengthen myocardial contractive power, coronary artery dilating,
Improve myocardial blood flow and myocardial metabolism, improve superoxide dismutase activity, lower lipid peroxy
Compound content, so as to mitigate the damage that free radical is caused.
Radix scrophulariae is sweet, bitter, salty；Cold nature.Return lung, stomach, kidney channel.Warm heresy is joined the army, interior
Sunken pericardium, febrile virulent maculae, the deep red polydipsia of consumption of YIN caused by febrile disease, tongue, Tianjin hinder constipation, hectic fever due to yin labor is coughed, mesh
Red, pharyngalgia, cold carbuncle, diphtheria, carbuncle sore tumefacting virus.
The red sage root, it is bitter, it is slightly cold.The thoughts of returning home, Liver Channel.Promoting blood circulation for regulating menstruation, addiction of dispelling pain relieving, cool blood to disappear carbuncle,
Relieving restlessness that clears away heart-fire, nourishing blood and tranquilization.The red sage root can promoting blood circulation addiction, remove obstruction in channels to relieve pain, blood-nourishing calming heart can increase
Plus coronary heart disease CBF, improve myocardial contractive power, and do not increase myocardial anoxia amount, promote collateral
Circulation and blood flow reallocation.
Fructus amomi, taste is pungent is warm in nature.Returns spleen Jing, stomach, kidney channel.《Medical center bun will》:Profit kidney,
Tonifying liver, mends the gate of vitality, and taste, relieving stagnation.
Ligusticum wallichii, pungent, temperature.Return liver, courage, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.For
Pacify nerve, positive head wind headache, disease addiction stomachache, chest side of body shouting pain, tumbling and swelling, headache, wind
Pain of dampness syndrome.Ligusticum wallichii can expand smooth muscle, improve microcirculation, and have anti-freezing, resistant to aggregation effect,
And be depressured by expanding peripheral vessel.
Honeysuckle flower, it is sweet, cold.Attach to the lung and stomach meridians.Effect:It is clearing heat and detoxicating.With effect for reducing blood fat.
Compared with prior art, medicine of the present invention captures dihuang drink, Shengmai San, cassia twig Radix Glycyrrhizae
The length of all sides such as soup, shenfu decoction, danggui buxue decoction, Danshen, Simiao Yongan Tang, Zengye Tang,
And form with reference to Long-term clinical experience addition or subtraction of changes.The medicine of the present invention cultivated land help kidney of sweet temperature
It is cloudy；Saline cistanche temperature invigorating kidney yang, with this work(of tonifying both YIN and YANG can be played；Shengmai San, with its ginseng sweet temperature
Nourishing generate fluid is with tonifying lung, and the prosperous then all dirty gas of lung qi is all prosperous, the source of the tuber of dwarf lilyturf sweet cold yin-nourishing moisturizing,
Fruit of Chinese magnoliavine acid temperature is astringed the lung and is promoted the production of body fluid, entirely can nourishing generate fluid, astringing YIN to stop sweating；Shenfu decoction invigorates vital energy and reinforce the heart
Establishing-Yang, warm promoting blood circulation, often make heart infarction, the first aid side of heart failure；Cassia twig, Radix Glycyrrhizae are warming heart yang,
Specially control the palpitaition of heart-yang void；Danggui buxue decoction, with the gas of Radix Astragali tonifying spleen lung, as a means of biochemistry, when
Return nourishing blood and promoting blood circulation, play the work(of qi-supplementing, blood-engendering；Danshen in side, the red sage root is promoting blood circulation and removing blood stasis, pain relieving and
Not impairment of QI-blood, santal, fructus amomi middle benefit gas promoting qi circulation and relieving pain, this taste of medicine three, mild in medicine property and, qi and blood simultaneously
Control, both can stagnation resolvation promoting qi circulation and relieving pain, be again the cold disease retardance for the treatment of, the chest impediment and cardialgia of hypofunction of YANG QI in chest
Good recipe, more promoting blood circulation and removing blood stasis with Ligusticum wallichii, mountain quarrel, analgesic effect is more preferably；Honeysuckle flower, radix scrophulariae agree without prior consultation works as
Return, Radix Glycyrrhizae is Simiao Yongan Tang, can clearing heat and detoxicating, promoting blood circulation and stopping pain, then with the red sage root live painstaking effort,
Nourishing heart scattered silt, treatment is pained more to see its work(.
It is simultaneous to suffer from glycosuria patient much during clinical diagnosis is for the patient of coronary heart disease, and diabetes are anti-
Come over and make coronary heart disease to increase, while coronary heart disease is treated, it is necessary to pay attention to the control of diabetes,
The Radix Astragali, the dried rhizome of rehmannia, radix scrophulariae, the red sage root in side, modern medicine study shows all there is drop blood well
Sugar effect.Furthermore, patients with coronary heart disease is particularly senile patients with coronary heart disease and suffers from constipation person much,
Because constipation makes difficult defecation, in straining at stool, the increase of cardiac pressure load, easily induction
Heart infarction die suddenly, therefore, side in the dried rhizome of rehmannia, radix scrophulariae, the tuber of dwarf lilyturf constitute Zengye Tang, work(fluid dryness,
Relax bowel.
With the effect of marking, answer positive evil removing is consolidated, it is to be to nurse one's health renal function to the present invention
The key link for the treatment of, while focusing on the coordination of function of the internal organs such as kidney, the heart, liver, spleen, makes kidney
Cloudy to grow, lower unit obtains that warm, qi and blood must be mended, extravasated blood must be solved, heat toxin can be clear, not only can lipid-loweringing
Anti-freezing, reduction blood viscosity, thrombus can also improve function of vascular endothelium, release
Vasopasm, anti arteriosclerosis, stable vulnerable plaque；Blood, vascular lesion are had dual
Therapeutic action, can effectively treat disease of cardiovascular system.
Applicant carried out following experiments, the provable present invention is with effective effect；
Inventor has successively received thousands of clients, and wherein emr treatment archives are as follows：Patient
1118 people, the wherein people of the male sex 708 altogether, the people of women 410.Age in the 40-55 year people of person 170,
The 56-65 year people of person 594, more than the 66 years old people of person 354.In 1118 clients, the most short person of the course of disease
More than 100 days, most elder was up to 12 years.
Usage and consumption：Oral capsule, a 5-6 grain, every 2g, three times a day, one
It is within individual month a course for the treatment of；
General one course for the treatment of subjective symptoms of patient is obviously improved, three to four courses for the treatment of of Most patients
Reach healing or effective.Detailed observed and recorded during medication, clinical curative effect analysis are shown in Table 1, by
This prescription overall clinical efficacy rate is understood in table 1 up to 96.14%, and this is not found during treating
Medicament has obvious toxic and side effect.
The clinical efficacy of table 1 is counted
| Illness | Number of cases | Recovery from illness | It is effective | Effectively | It is invalid | Always there is rate |
| The stagnation of the heart blood | 295 | 79 | 171 | 35 | 10 | 95.83% |
| Cold solidifying heart arteries and veins | 25 | 3 | 9 | 11 | 2 | 92% |
| The motive is weak | 224 | 56 | 146 | 15 | 7 | 96% |
| Heart-kidney yang deficiency | 287 | 91 | 175 | 14 | 7 | 96.89% |
| Heart kidney-yin deficiency | 287 | 85 | 174 | 22 | 6 | 97.56% |
| Amount to | 1118 | 314 | 675 | 97 | 32 | 96.14% |
Specific embodiment
Embodiment 1.A kind of coronary heart disease treatment medicament, it is with the raw material system of following weight proportions
Into,
Above-mentioned coronary heart disease treatment pharmaceutical formulation is powder, tablet, oral liquid or capsule.
The preparation method of above-mentioned powder is：Each active compound is ground to form and mix in proportion simultaneously after fine powder
Cross 250-400 mesh sieves, as powder.
The usage and consumption of above-mentioned powder：Orally, a 10-15g, a day three times, one
The moon is a course for the treatment of.
The preparation method of above-mentioned tablet is：Each active compound is ground to form and mix in proportion simultaneously after fine powder
300-500 mesh sieves are crossed, it is tabletted after sieving.
The usage of above-mentioned tablet and the same powder of consumption.
The preparation method of above-mentioned oral liquid is：Total raw material is pressed into medicine:The volume ratio of water is
1:2-4 soaks at least 1h, then adds worry after suitable quantity of water decoction 1-3h to remove the dregs of a decoction.
The usage and consumption of above-mentioned oral liquid：Orally, a 60-70mL, a day three times,
The course for the treatment of of January one.
The preparation method of above-mentioned capsule is：Total raw material is pressed into medicine:The volume ratio of water is 1:2-10
Soak at least 2h, then add suitable quantity of water to decoct 1-1.5h, filter off the dregs of a decoction, in negative pressure, low
It is more than 75% that the Chinese medicine leaching liquid of clarification is concentrated into into Bomi degree under conditions of temperature, by dusting
Equipment makes dry powder, temperature≤100 DEG C of spout, then makes after addition filler in dry powder
Capsule.
The usage and consumption of above-mentioned capsule：Orally, a 5-6 grain, every 2g, one day three
It is secondary, it is within one month a course for the treatment of.
Claims (8)
1. a kind of coronary heart disease treatment medicament, it is characterised in that：It is with following weight proportions
Raw material is made,
2. coronary heart disease treatment medicament as claimed in claim 1, it is characterised in that：It is with
The raw material of following weight proportioning is made,
3. coronary heart disease treatment medicament as claimed in claim 2, it is characterised in that：It is with
The raw material of following weight proportioning is made,
4. the coronary heart disease treatment medicament as described in any one of claim 1-3, its feature exists
In：The formulation of described medicament is powder, tablet, oral liquid or capsule.
5. the preparation method of coronary heart disease treatment medicament as claimed in claim 4, its feature exists
In：Described powder is prepared as follows：Each active compound is ground to form and mix in proportion after fine powder
Merged 250-400 mesh sieves, as powder.
6. the preparation method of coronary heart disease treatment medicament as claimed in claim 4, its feature exists
In：Described tablet is prepared according to the following steps：Each active compound is ground to form and mix in proportion after fine powder
Merged 300-500 mesh sieves, it is tabletted after sieving.
7. the preparation method of coronary heart disease treatment medicament as claimed in claim 4, its feature exists
In：Described oral liquid is prepared according to the following steps：Total raw material is pressed into medicine:The volume ratio of water is
1:2-4 soaks at least 1h, then adds worry after suitable quantity of water decoction 1-3h to remove the dregs of a decoction.
8. the preparation method of coronary heart disease treatment medicament as claimed in claim 4, its feature exists
In：Described capsule is prepared according to the following steps：Total raw material is pressed into medicine:The volume ratio of water is
1:2-10 soaks at least 2h, then adds suitable quantity of water to decoct 1-1.5h, filters off the dregs of a decoction,
It is more than 75% that the Chinese medicine leaching liquid of clarification is concentrated into into Bomi degree under conditions of negative pressure, low temperature,
Dry powder, temperature≤100 DEG C of spout are made by powder spraying apparatus, then is added in dry powder and is filled out
Fill after agent and make capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510683211.4A CN106581552A (en) | 2015-10-20 | 2015-10-20 | Agent for treating coronary heart disease and preparation method of agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510683211.4A CN106581552A (en) | 2015-10-20 | 2015-10-20 | Agent for treating coronary heart disease and preparation method of agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106581552A true CN106581552A (en) | 2017-04-26 |
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ID=58555266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510683211.4A Pending CN106581552A (en) | 2015-10-20 | 2015-10-20 | Agent for treating coronary heart disease and preparation method of agent |
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| Country | Link |
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| CN (1) | CN106581552A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112933184A (en) * | 2021-03-01 | 2021-06-11 | 湖南鹍廷科技开发有限责任公司 | Chinese medicinal preparation for treating cardiovascular and cerebrovascular diseases and preparation method thereof |
-
2015
- 2015-10-20 CN CN201510683211.4A patent/CN106581552A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112933184A (en) * | 2021-03-01 | 2021-06-11 | 湖南鹍廷科技开发有限责任公司 | Chinese medicinal preparation for treating cardiovascular and cerebrovascular diseases and preparation method thereof |
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Application publication date: 20170426 |