CN106574225B - 用于样品分配和分析的装置和方法 - Google Patents
用于样品分配和分析的装置和方法 Download PDFInfo
- Publication number
- CN106574225B CN106574225B CN201580044618.0A CN201580044618A CN106574225B CN 106574225 B CN106574225 B CN 106574225B CN 201580044618 A CN201580044618 A CN 201580044618A CN 106574225 B CN106574225 B CN 106574225B
- Authority
- CN
- China
- Prior art keywords
- cover film
- substrate
- compartments
- pressure sensitive
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title claims abstract description 99
- 238000004458 analytical method Methods 0.000 title claims description 15
- 238000009826 distribution Methods 0.000 title claims description 8
- 239000013039 cover film Substances 0.000 claims abstract description 198
- 239000000758 substrate Substances 0.000 claims abstract description 178
- 239000007788 liquid Substances 0.000 claims abstract description 149
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims abstract description 94
- 230000001070 adhesive effect Effects 0.000 claims abstract description 72
- 239000000853 adhesive Substances 0.000 claims abstract description 70
- 239000010408 film Substances 0.000 claims abstract description 46
- 239000002131 composite material Substances 0.000 claims abstract description 37
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000005977 Ethylene Substances 0.000 claims abstract description 18
- 229920005684 linear copolymer Polymers 0.000 claims abstract description 18
- 150000001336 alkenes Chemical class 0.000 claims abstract description 17
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims abstract description 16
- 239000005038 ethylene vinyl acetate Substances 0.000 claims abstract description 15
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims abstract description 15
- 238000004891 communication Methods 0.000 claims abstract description 9
- 239000011248 coating agent Substances 0.000 claims description 59
- 238000000576 coating method Methods 0.000 claims description 59
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 38
- 238000011084 recovery Methods 0.000 claims description 31
- 229920000642 polymer Polymers 0.000 claims description 25
- -1 polypropylene Polymers 0.000 claims description 24
- 239000011888 foil Substances 0.000 claims description 17
- 239000004743 Polypropylene Substances 0.000 claims description 15
- 229920001155 polypropylene Polymers 0.000 claims description 15
- 238000000151 deposition Methods 0.000 claims description 14
- 238000004451 qualitative analysis Methods 0.000 claims description 14
- 238000004445 quantitative analysis Methods 0.000 claims description 14
- 239000002245 particle Substances 0.000 claims description 13
- 239000003795 chemical substances by application Substances 0.000 claims description 12
- 229920001296 polysiloxane Polymers 0.000 claims description 12
- 229920002367 Polyisobutene Polymers 0.000 claims description 10
- 229920002396 Polyurea Polymers 0.000 claims description 10
- 239000004200 microcrystalline wax Substances 0.000 claims description 10
- 235000019808 microcrystalline wax Nutrition 0.000 claims description 10
- 150000003097 polyterpenes Chemical class 0.000 claims description 10
- 229910052751 metal Inorganic materials 0.000 claims description 9
- 239000002184 metal Substances 0.000 claims description 9
- 239000011247 coating layer Substances 0.000 claims 1
- 244000005700 microbiome Species 0.000 abstract description 64
- 229920006254 polymer film Polymers 0.000 abstract description 18
- 238000012258 culturing Methods 0.000 abstract description 8
- 239000000523 sample Substances 0.000 description 149
- 230000012010 growth Effects 0.000 description 46
- 238000012360 testing method Methods 0.000 description 34
- 239000010410 layer Substances 0.000 description 33
- 238000001514 detection method Methods 0.000 description 31
- 239000012790 adhesive layer Substances 0.000 description 23
- 239000000463 material Substances 0.000 description 22
- 239000002609 medium Substances 0.000 description 20
- 239000011521 glass Substances 0.000 description 19
- 239000000126 substance Substances 0.000 description 19
- 235000015097 nutrients Nutrition 0.000 description 18
- 230000001580 bacterial effect Effects 0.000 description 17
- 125000006850 spacer group Chemical group 0.000 description 15
- ARQXEQLMMNGFDU-JHZZJYKESA-N 4-methylumbelliferone beta-D-glucuronide Chemical compound C1=CC=2C(C)=CC(=O)OC=2C=C1O[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O ARQXEQLMMNGFDU-JHZZJYKESA-N 0.000 description 13
- 238000011534 incubation Methods 0.000 description 13
- 229920003023 plastic Polymers 0.000 description 12
- 239000004033 plastic Substances 0.000 description 12
- 241000588724 Escherichia coli Species 0.000 description 11
- 239000001963 growth medium Substances 0.000 description 11
- 238000003556 assay Methods 0.000 description 10
- 238000006243 chemical reaction Methods 0.000 description 10
- 238000011081 inoculation Methods 0.000 description 10
- 230000000813 microbial effect Effects 0.000 description 10
- 239000007787 solid Substances 0.000 description 10
- 230000008901 benefit Effects 0.000 description 9
- 239000003153 chemical reaction reagent Substances 0.000 description 9
- 239000012528 membrane Substances 0.000 description 8
- 239000012085 test solution Substances 0.000 description 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 7
- 239000012472 biological sample Substances 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 229920001971 elastomer Polymers 0.000 description 7
- 230000002209 hydrophobic effect Effects 0.000 description 7
- 239000001301 oxygen Substances 0.000 description 7
- 229910052760 oxygen Inorganic materials 0.000 description 7
- 239000000843 powder Substances 0.000 description 7
- 235000013305 food Nutrition 0.000 description 6
- 238000002156 mixing Methods 0.000 description 6
- 230000002093 peripheral effect Effects 0.000 description 6
- 238000007789 sealing Methods 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 238000003892 spreading Methods 0.000 description 6
- 230000007480 spreading Effects 0.000 description 6
- 102000004190 Enzymes Human genes 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 5
- 229910052782 aluminium Inorganic materials 0.000 description 5
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 5
- 229920006378 biaxially oriented polypropylene Polymers 0.000 description 5
- 239000011127 biaxially oriented polypropylene Substances 0.000 description 5
- 239000012620 biological material Substances 0.000 description 5
- 230000032823 cell division Effects 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 235000018102 proteins Nutrition 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 4
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 4
- 239000000806 elastomer Substances 0.000 description 4
- 230000005284 excitation Effects 0.000 description 4
- 230000014509 gene expression Effects 0.000 description 4
- 238000002955 isolation Methods 0.000 description 4
- 239000000155 melt Substances 0.000 description 4
- 239000002207 metabolite Substances 0.000 description 4
- 239000004005 microsphere Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 229920000573 polyethylene Polymers 0.000 description 4
- 238000003825 pressing Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 239000004793 Polystyrene Substances 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 229940024606 amino acid Drugs 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 239000012736 aqueous medium Substances 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000012787 coverlay film Substances 0.000 description 3
- 239000000975 dye Substances 0.000 description 3
- 230000005670 electromagnetic radiation Effects 0.000 description 3
- 230000007613 environmental effect Effects 0.000 description 3
- 239000003269 fluorescent indicator Substances 0.000 description 3
- 239000006260 foam Substances 0.000 description 3
- 230000002906 microbiologic effect Effects 0.000 description 3
- 239000002773 nucleotide Substances 0.000 description 3
- 125000003729 nucleotide group Chemical group 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 239000002985 plastic film Substances 0.000 description 3
- 229920006255 plastic film Polymers 0.000 description 3
- 229920000139 polyethylene terephthalate Polymers 0.000 description 3
- 239000005020 polyethylene terephthalate Substances 0.000 description 3
- 229920002223 polystyrene Polymers 0.000 description 3
- 229920002635 polyurethane Polymers 0.000 description 3
- 239000004814 polyurethane Substances 0.000 description 3
- 238000011002 quantification Methods 0.000 description 3
- 239000005060 rubber Substances 0.000 description 3
- 238000000638 solvent extraction Methods 0.000 description 3
- HXVZGASCDAGAPS-UHFFFAOYSA-N 4-methylumbelliferyl acetate Chemical compound CC1=CC(=O)OC2=CC(OC(=O)C)=CC=C21 HXVZGASCDAGAPS-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- 239000004642 Polyimide Substances 0.000 description 2
- PLXBWHJQWKZRKG-UHFFFAOYSA-N Resazurin Chemical compound C1=CC(=O)C=C2OC3=CC(O)=CC=C3[N+]([O-])=C21 PLXBWHJQWKZRKG-UHFFFAOYSA-N 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- 229910000831 Steel Inorganic materials 0.000 description 2
- 230000000712 assembly Effects 0.000 description 2
- 238000000429 assembly Methods 0.000 description 2
- 230000005587 bubbling Effects 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000012512 characterization method Methods 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 238000012864 cross contamination Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 229920005570 flexible polymer Polymers 0.000 description 2
- 229920002313 fluoropolymer Polymers 0.000 description 2
- 239000004811 fluoropolymer Substances 0.000 description 2
- 230000009477 glass transition Effects 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 238000005286 illumination Methods 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 239000000123 paper Substances 0.000 description 2
- 238000005192 partition Methods 0.000 description 2
- 150000002978 peroxides Chemical class 0.000 description 2
- 239000004417 polycarbonate Substances 0.000 description 2
- 229920000515 polycarbonate Polymers 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 229920001721 polyimide Polymers 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000010959 steel Substances 0.000 description 2
- 238000002834 transmittance Methods 0.000 description 2
- 230000009105 vegetative growth Effects 0.000 description 2
- 238000011179 visual inspection Methods 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 239000002351 wastewater Substances 0.000 description 2
- QIJRTFXNRTXDIP-UHFFFAOYSA-N (1-carboxy-2-sulfanylethyl)azanium;chloride;hydrate Chemical compound O.Cl.SCC(N)C(O)=O QIJRTFXNRTXDIP-UHFFFAOYSA-N 0.000 description 1
- BCHIXGBGRHLSBE-UHFFFAOYSA-N (4-methyl-2-oxochromen-7-yl) dihydrogen phosphate Chemical compound C1=C(OP(O)(O)=O)C=CC2=C1OC(=O)C=C2C BCHIXGBGRHLSBE-UHFFFAOYSA-N 0.000 description 1
- FUYLLJCBCKRIAL-UHFFFAOYSA-N 4-methylumbelliferone sulfate Chemical compound C1=C(OS(O)(=O)=O)C=CC2=C1OC(=O)C=C2C FUYLLJCBCKRIAL-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241000193403 Clostridium Species 0.000 description 1
- 241000193470 Clostridium sporogenes Species 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
- 102000053187 Glucuronidase Human genes 0.000 description 1
- 108010060309 Glucuronidase Proteins 0.000 description 1
- 238000012369 In process control Methods 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 241001148470 aerobic bacillus Species 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 229920006125 amorphous polymer Polymers 0.000 description 1
- 230000004099 anaerobic respiration Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000012062 aqueous buffer Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 238000012742 biochemical analysis Methods 0.000 description 1
- 238000010876 biochemical test Methods 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000022131 cell cycle Effects 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000012468 concentrated sample Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000011889 copper foil Substances 0.000 description 1
- 229960001305 cysteine hydrochloride Drugs 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000005489 elastic deformation Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000009459 flexible packaging Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 229910000037 hydrogen sulfide Inorganic materials 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000005661 hydrophobic surface Effects 0.000 description 1
- 230000003100 immobilizing effect Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000010965 in-process control Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 229910000358 iron sulfate Inorganic materials 0.000 description 1
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 238000012543 microbiological analysis Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 239000002362 mulch Substances 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000012454 non-polar solvent Substances 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 238000000059 patterning Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000036417 physical growth Effects 0.000 description 1
- 238000003752 polymerase chain reaction Methods 0.000 description 1
- 229920006327 polystyrene foam Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000012254 powdered material Substances 0.000 description 1
- 238000004886 process control Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000012205 qualitative assay Methods 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 238000012372 quality testing Methods 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 238000010079 rubber tapping Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000012898 sample dilution Substances 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000007655 standard test method Methods 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 239000001974 tryptic soy broth Substances 0.000 description 1
- 108010050327 trypticase-soy broth Proteins 0.000 description 1
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/34—Internal compartments or partitions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/38—Caps; Covers; Plugs; Pouring means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/06—Plates; Walls; Drawers; Multilayer plates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
- C12M37/04—Seals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
- C12Q1/06—Quantitative determination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- Clinical Laboratory Science (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462039638P | 2014-08-20 | 2014-08-20 | |
| US62/039,638 | 2014-08-20 | ||
| PCT/US2015/045786 WO2016028834A1 (en) | 2014-08-20 | 2015-08-19 | Devices and methods for sample partitioning and analysis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106574225A CN106574225A (zh) | 2017-04-19 |
| CN106574225B true CN106574225B (zh) | 2019-12-17 |
Family
ID=54066188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580044618.0A Active CN106574225B (zh) | 2014-08-20 | 2015-08-19 | 用于样品分配和分析的装置和方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20170240949A1 (enExample) |
| EP (1) | EP3183335B1 (enExample) |
| JP (1) | JP6722657B2 (enExample) |
| CN (1) | CN106574225B (enExample) |
| WO (1) | WO2016028834A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018039186A1 (en) | 2016-08-26 | 2018-03-01 | Avery Dennison Corporation | Silicone based pressure sensitive adhesive tapes |
| WO2019017030A1 (ja) * | 2017-07-19 | 2019-01-24 | ソニー株式会社 | センサデバイス、検出装置 |
| LT3732482T (lt) | 2017-12-28 | 2022-04-11 | Delaval Holding Ab | Pieno mėginio biožymens analizės juosta |
| KR102384408B1 (ko) * | 2018-05-18 | 2022-04-19 | 주식회사 더웨이브톡 | 미생물 개체수의 계수 방법 및 미생물 개체수의 계수 시스템 |
| KR102113311B1 (ko) * | 2018-05-18 | 2020-05-20 | 주식회사 더웨이브톡 | 미생물 개체수의 계수 방법 및 미생물 개체수의 계수 시스템 |
| US11156541B2 (en) | 2018-05-18 | 2021-10-26 | The Wave Talk, Inc. | Optical detecting system |
| US11391659B2 (en) | 2018-05-18 | 2022-07-19 | The Wave Talk, Inc. | Optical detecting system |
| CN109759152A (zh) * | 2019-02-11 | 2019-05-17 | 湖北伽诺美生物科技有限公司 | 一种单孔径或多孔径围栏装置 |
| SI25919A (sl) | 2019-11-04 | 2021-05-31 | Microbium D.O.O. | Metoda za določitev najverjetnejšega števila bakterij v tekočih vzorcih in model za porazdelitev vzorcev, uporaben za to metodo |
| KR102453456B1 (ko) * | 2020-05-07 | 2022-10-14 | 주식회사 더웨이브톡 | 미생물 개체수의 계수 방법 및 미생물 개체수의 계수 시스템 |
| WO2022043815A1 (en) * | 2020-08-25 | 2022-03-03 | Politecnico Di Milano | Device for biological cultures |
| US20220410160A1 (en) * | 2021-06-09 | 2022-12-29 | Beijing Boe Technology Development Co., Ltd. | Microfluidic chip and microfluidic device |
| KR102436854B1 (ko) * | 2021-12-07 | 2022-08-26 | (주) 제타푸드랩 | 바이오 센싱 전처리 방법 |
| US12228511B1 (en) * | 2023-09-25 | 2025-02-18 | Craig Ellins | Organic plant material microbial test kit devices and processing method |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3338794A (en) * | 1964-11-23 | 1967-08-29 | Swift & Co | Culturing anaerobic bacteria |
| US4425268A (en) * | 1980-02-02 | 1984-01-10 | Bemis Company, Inc. | Polymer blend composition for stretch wrap film |
| JPS5817599B2 (ja) | 1980-10-03 | 1983-04-08 | 出光興産株式会社 | 金属加工油中の硫酸還元菌の迅速検出法 |
| US4775626A (en) | 1986-05-23 | 1988-10-04 | Syntex (U.S.A.) Inc. | Method and compositions for protecting anerobic microorganisms |
| US5214119A (en) | 1986-06-20 | 1993-05-25 | Minnesota Mining And Manufacturing Company | Block copolymer, method of making the same, dimaine precursors of the same, method of making such diamines and end products comprising the block copolymer |
| DE3732142C2 (de) * | 1987-09-24 | 1995-12-21 | Heraeus Instr Gmbh | Verfahren zur Herstellung einer mit einer Maske versehenen Glasplatte sowie Stempelkörper zur Durchführung des Verfahrens |
| JP2672845B2 (ja) | 1988-09-27 | 1997-11-05 | 旭化成工業株式会社 | Ｌ−アラニンデヒドロゲナーゼの製造法 |
| JP3163422B2 (ja) | 1990-04-25 | 2001-05-08 | 栄研化学株式会社 | 嫌気性細菌用の嫌気的環境保持組成物並びにこれを用いた輸送・保存器具 |
| JPH0641885B2 (ja) | 1991-10-07 | 1994-06-01 | 工業技術院長 | 気体ビームを用いた超短レーザーパルス測定方法 |
| US5518892A (en) | 1994-02-23 | 1996-05-21 | Idexx Laboratories, Inc. | Apparatus and method for quantification of biological material in a liquid sample |
| DE69623456T2 (de) | 1995-04-25 | 2003-08-07 | Minnesota Mining And Mfg. Co., Saint Paul | Segmentierte polydiorganosiloxan-polyharnstoffcopolymere sowie verfahren zu deren herstellung |
| WO1996035458A2 (en) | 1995-04-25 | 1996-11-14 | Minnesota Mining And Manufacturing Company | Tackified polydiorganosiloxane polyurea segmented copolymers and a process for making same |
| WO1996034028A1 (en) | 1995-04-25 | 1996-10-31 | Minnesota Mining And Manufacturing Company | Tackified polydiorganosiloxane oligourea segmented copolymers and a process for making same |
| US5700655A (en) | 1995-11-14 | 1997-12-23 | Idexx Laboratories, Inc. | Method for quantification of biological material in a sample |
| US6696286B1 (en) | 1997-04-09 | 2004-02-24 | 3M Innovative Properties Company | Method and devices for detecting and enumerating microorganisms |
| US6391578B2 (en) | 1997-04-09 | 2002-05-21 | 3M Innovative Properties Company | Method and devices for partitioning biological sample liquids into microvolumes |
| AU8595798A (en) * | 1997-08-01 | 1999-02-22 | Minnesota Mining And Manufacturing Company | Method and devices for detecting and enumerating microorganisms |
| US6007914A (en) | 1997-12-01 | 1999-12-28 | 3M Innovative Properties Company | Fibers of polydiorganosiloxane polyurea copolymers |
| US5976827A (en) | 1997-12-12 | 1999-11-02 | Akzo Nobel, N.V. | Sensor device for detecting microorganisms and method therefor |
| US5912115A (en) | 1997-12-12 | 1999-06-15 | Akzo Nobel, N.V. | Evacuated sensor device for detecting microorganisms in blood samples, and method thereof |
| US6458533B1 (en) | 1997-12-19 | 2002-10-01 | High Throughput Genomics, Inc. | High throughput assay system for monitoring ESTs |
| AU744534B2 (en) * | 1997-12-23 | 2002-02-28 | Minnesota Mining And Manufacturing Company | Disc assay devices and methods of use |
| US6322750B1 (en) | 1998-12-30 | 2001-11-27 | Robert L. Kimbell | Gas detector indicator strip providing enhanced dynamic range |
| US6649406B1 (en) | 1999-11-23 | 2003-11-18 | 3M Innovative Properties Company | Device for propagation and storage of microorganisms |
| US6627159B1 (en) | 2000-06-28 | 2003-09-30 | 3M Innovative Properties Company | Centrifugal filling of sample processing devices |
| US7811783B2 (en) | 2001-12-14 | 2010-10-12 | Colifast As | Rapid method of detection and enumeration of sulfide-producing bacteria in food products |
| US6632632B1 (en) | 2001-12-14 | 2003-10-14 | Colifast As | Rapid method of detection and enumeration of sulfide-producing bacteria in food products |
| US7012110B2 (en) * | 2001-12-18 | 2006-03-14 | 3M Innovative Properties Company | Silicone pressure sensitive adhesives prepared using processing aids, articles, and methods |
| JPWO2003102224A1 (ja) * | 2002-05-30 | 2005-09-29 | 富士電機ホールディングス株式会社 | 微生物または細胞の計数方法 |
| US7582472B2 (en) | 2003-08-26 | 2009-09-01 | Smith Kenneth E | Apparatus and method for liquid sample testing |
| US20050239200A1 (en) * | 2004-04-23 | 2005-10-27 | Beckwith Scott W | Devices for culturing anaerobic microorganisms and methods of using the same |
| EP3913375A1 (en) | 2006-01-11 | 2021-11-24 | Bio-Rad Laboratories, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
| JP5083807B2 (ja) | 2006-06-29 | 2012-11-28 | 学校法人東日本学園・北海道医療大学 | 嫌気性細菌培養キット用容器および嫌気性細菌培養キット、並びに嫌気性細菌培養方法および嫌気性細菌の生育判別方法 |
| WO2008006848A1 (en) | 2006-07-13 | 2008-01-17 | Galderma Research & Development | Composition comprising a retinoid and benzoyl peroxide |
| JP2010124806A (ja) * | 2008-12-01 | 2010-06-10 | Oji Paper Co Ltd | 生物試料保存容器 |
| RU2408734C1 (ru) | 2009-05-28 | 2011-01-10 | Владимир Михайлович Воробейчиков | Способ и устройство для обнаружения патогенных микроорганизмов |
| CN102665681A (zh) | 2009-12-16 | 2012-09-12 | 厦桑医药有限公司 | 右布洛芬透皮水凝胶的新颖组合物 |
| US8753834B2 (en) | 2009-12-30 | 2014-06-17 | 3M Innovative Properties Company | Microbial detection article |
| EP4484577A3 (en) | 2010-02-12 | 2025-03-26 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| ES2646413T3 (es) | 2010-06-03 | 2017-12-13 | Basf Se | Detección y recuento de microorganismos |
| US8846335B2 (en) | 2010-06-30 | 2014-09-30 | 3M Innovative Properties Company | Device for rapidly detecting microorganisms |
| US20140287423A1 (en) | 2011-10-28 | 2014-09-25 | Life Technologies Corporaton | Device and method for apportionment and manipulation of sample volumes |
| JP2013202032A (ja) * | 2012-03-29 | 2013-10-07 | Railway Technical Research Institute | 滅菌装置の評価方法及び滅菌方法の評価方法 |
| EP2844296B1 (en) | 2012-05-02 | 2019-03-13 | Capsugel Belgium NV | Aqueous dispersions of hydroxypropyl methylcellulose acetate succinate (hpmcas) |
-
2015
- 2015-08-19 JP JP2017509686A patent/JP6722657B2/ja active Active
- 2015-08-19 WO PCT/US2015/045786 patent/WO2016028834A1/en not_active Ceased
- 2015-08-19 US US15/503,496 patent/US20170240949A1/en not_active Abandoned
- 2015-08-19 CN CN201580044618.0A patent/CN106574225B/zh active Active
- 2015-08-19 EP EP15760542.9A patent/EP3183335B1/en active Active
-
2020
- 2020-09-03 US US17/011,259 patent/US12054766B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2017525366A (ja) | 2017-09-07 |
| EP3183335B1 (en) | 2021-05-26 |
| WO2016028834A1 (en) | 2016-02-25 |
| US20200399674A1 (en) | 2020-12-24 |
| JP6722657B2 (ja) | 2020-07-15 |
| EP3183335A1 (en) | 2017-06-28 |
| US20170240949A1 (en) | 2017-08-24 |
| US12054766B2 (en) | 2024-08-06 |
| CN106574225A (zh) | 2017-04-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106574225B (zh) | 用于样品分配和分析的装置和方法 | |
| AU735311B2 (en) | Method and devices for partitioning biological sample liquids into microvolumes | |
| AU756412B2 (en) | Device and methods for determination of analyte in a solution | |
| US6696286B1 (en) | Method and devices for detecting and enumerating microorganisms | |
| CN103608658B (zh) | 利用微结构化表面检测样品中的所关注分析物的系统和方法 | |
| JP4217378B2 (ja) | 微生物の検知および計数の方法および器具 | |
| US9404911B2 (en) | Integrated assay device and housing | |
| US20010024805A1 (en) | Method and devices for partitioning biological sample liquids into microvolumes | |
| CN111514950A (zh) | 使用分离液进行样品浓缩和检测的系统和方法 | |
| WO2010129727A1 (en) | Coated substrates comprising a cell extractant and biodetection methods thereof | |
| JP4488628B2 (ja) | 接種パッドの付いたディスクアッセイ装置および使用方法 | |
| US20200088615A1 (en) | Systems and methods for rapid detection of an analyte of interest | |
| EP1040181A1 (en) | Disc assay devices and methods of use | |
| JP2022525087A (ja) | 高密度増殖プラットフォーム上の微生物分離株の選択方法 | |
| AU728129B2 (en) | Apparatus and method for quantification of biological material in a liquid sample | |
| MXPA99009030A (en) | Method and devices for partitioning biological sample liquids into microvolumes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |