CN106540347A - A kind of abdominal thermal infusion equipment and abdominal thermal infusion treat the method for building up of animal model - Google Patents
A kind of abdominal thermal infusion equipment and abdominal thermal infusion treat the method for building up of animal model Download PDFInfo
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- CN106540347A CN106540347A CN201611177389.2A CN201611177389A CN106540347A CN 106540347 A CN106540347 A CN 106540347A CN 201611177389 A CN201611177389 A CN 201611177389A CN 106540347 A CN106540347 A CN 106540347A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M3/00—Medical syringes, e.g. enemata; Irrigators
- A61M3/02—Enemata; Irrigators
- A61M3/0233—Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs
- A61M3/025—Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs supplied directly from the pressurised water source, e.g. with medicament supply
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/12—Devices for heating or cooling internal body cavities
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M3/00—Medical syringes, e.g. enemata; Irrigators
- A61M3/02—Enemata; Irrigators
- A61M3/0233—Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs
- A61M3/0254—Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs the liquid being pumped
- A61M3/0258—Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs the liquid being pumped by means of electric pumps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/05—General characteristics of the apparatus combined with other kinds of therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/12—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
- A61M2205/127—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit with provisions for heating or cooling
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Vascular Medicine (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The present invention relates to a kind of abdominal thermal infusion equipment and abdominal thermal infusion treat the method for building up of animal model.Described abdominal thermal infusion equipment is provided with the system of pumping into, pumping out system and thermocouple, the described system that pumps into includes medicine storage bag, the first silica gel tube, the first peristaltic pump, tube for transfusion, first puncture needle and heat-exchange device, described pumping out system is provided with medicine reclaiming bag, the second silica gel tube, the second peristaltic pump, drain pipe and second puncture needle, and described thermocouple is used for the temperature for monitoring infusion liquid abdominal cavity entry and outlet.The abdominal thermal infusion equipment of the present invention is applied to sets up abdominal thermal infusion treatment animal model, can significantly reduce infection rate, and better tolerance, feasibility are high, significantly improve therapeutic effect, and simple structure, using convenient, are adapted for scientific research.
Description
Technical field
The present invention relates to medical domain, specifically, be related to a kind of abdominal thermal infusion equipment for being applied to animal model with
And abdominal thermal infusion treats the method for building up of animal model.
Background technology
Abdominal thermal infusion treatment (HIPEC) is by the infusion liquid containing chemotherapeutics full abdominal cavity, accurate constant temperature constant speed and follows
Ring irrigates certain hour, and intraperitoneal chemotherapy is combined with thermotherapy, by high temperature to the direct killing effect of cancer cells of tumor, high temperature and chemotherapeutic
Thing anti-tumor synergetic is acted on and mechanical flushing action, removes free intraperitoneal cancer cells, subclinical focus and small to reach
The therapeutical effect of cancerous node, so as to play a part of prevention and treatment to the transfer of colon cancer peritoneum.High accuracy temperature control and high accuracy
Control rate of flooding is the key problem in technology of HIPEC, has collaboration to increase when temperature maintains 42～43 DEG C to chemotherapeutic anticancer toxicity
Use is pretended, treatment time is advisable for 60～90min.
Clinically existing more ripe technology is applied to abdominal thermal infusion treatment, and some abdomens are also disclosed that in prior art
The hot perfusion equipment in chamber.Such as Chinese patent literature CN200510037071.X, publication date 2006.05.31 disclose a kind of abdominal cavity
Thermal infusion therapeutic equipment, which includes a heating chamber, at least two peristaltic pumps, a medicine storage bag, a perfusion infusion pipeline, drawing liquid transfusion
Pipeline, a circulation line, a control system and a display device；The perfusion infusion pipeline, drawing liquid infusion pipeline and circulation line
On respectively have a threeway and a temperature sensor；At least two peristaltic pump, display device and each temperature sensor are all connected to control
System processed, the perfusion infusion pipeline, drawing liquid infusion pipeline and circulation line are all connected to medicine storage bag.
In order to carry out the basic research of abdominal thermal infusion treatment, to verify its therapy mechanism and improve Therapeutic Method, generally
It is the abdominal thermal infusion treatment model for setting up toy, is tested on this basis.And by abdominal thermal infusion equipment application in
During animal, due to humans and animals volume difference it is big, direct application certainly will cause cannot it is anticipated that normal work and studied,
And have not yet to see feasibility height, better tolerance, therapeutic effect can be significantly improved, and application is easily suitable for animal model
Abdominal thermal infusion treatment system.
The content of the invention
The purpose of the present invention is for deficiency of the prior art, there is provided a kind of abdominal thermal infusion equipment.
Another purpose of the present invention is to provide the method for building up that a kind of abdominal thermal infusion treats animal model.
To realize above-mentioned first purpose, the present invention is adopted the technical scheme that：
A kind of abdominal thermal infusion equipment, is provided with the system of pumping into and pumping out system, is additionally provided with thermocouple；Described pumps into system
Including medicine storage bag, the first silica gel tube, the first peristaltic pump, tube for transfusion, first puncture needle and heat-exchange device, the first described silica gel
Pipe one end connects medicine storage bag, and the other end is connected with an end of tube for transfusion, the other end connection first puncture needle of tube for transfusion,
The centre portion of the first silica gel tube is installed on the first peristaltic pump, and described heat-exchange device is used for the infusion liquid of heated transportation；
Described pumping out system is provided with medicine reclaiming bag, the second silica gel tube, the second peristaltic pump, drain pipe and second puncture needle, described
Second silica gel tube one end connects medicine reclaiming bag, and the other end is connected with an end of drain pipe, and the other end of drain pipe connects
Second puncture needle is connect, the centre portion of the second silica gel tube is installed on the second peristaltic pump；Described thermocouple is used to monitor perfusion
Liquid abdominal cavity entry and the temperature of outlet.
Preferably, the first silica gel tube between described heat-exchange device and the first peristaltic pump and medicine storage bag contacts to heat
The infusion liquid of conveying.
Preferably, described thermocouple is provided with two thermocouple wires, and described two thermocouple wires one go out liquid by tube for transfusion
The through hole of end is inserted in the cavity of tube for transfusion, and another through hole by drain pipe feed liquor end is inserted in the chamber of drain pipe
In vivo.
Preferably, described heat-exchange device is the constant temperature water bath apparatus with having heaters.
Preferably, described heat-exchange device is Shanghai Rong Feng digital display thermostatic water-circulator bath pot 501A types.
To realize above-mentioned second purpose, the present invention is adopted the technical scheme that：
A kind of to set up the method that abdominal thermal infusion treats animal model, described method has used as above arbitrary described abdomen
The hot perfusion equipment in chamber.
Preferably, described method is carried out in gnotobasiss.
Preferably, infusion liquid temperature-controlled precision≤0.6 DEG C of abdominal cavity entry.
Preferably, in filling process Intraabdominal constant temperature between 42 DEG C to 43 DEG C.
Preferably, normal saline is irrigated before irrigating pastille infusion liquid makes temperature in peritoneal cavity reach between 42 DEG C to 43 DEG C.
The invention has the advantages that：
1st, abdominal thermal infusion equipment of the invention is applied to animal, using connection abdominal cavity is punctured, can significantly reduce infection rate,
Better tolerance, and avoid the impact that modus operandi causes animal uncomfortable for experimental result is produced；
2nd, abdominal thermal infusion equipment of the invention adopts open perfusion system, fully can remove free cancerous cell and
Material of tumor microenvironment release etc., is remarkably improved therapeutic effect, can more accurately investigate medicinal liquid or abdominal thermal infusion treatment
The therapeutic effect of pattern, additionally, the cancerous cell that open perfusion system is dissociated in can obviously improve closed circulation perfusion loop
The problem of blocking pipeline；
3rd, abdominal thermal infusion equipment of the invention can high accuracy temperature control and control infusion liquid flow velocity, feasibility is high, significantly
Improve therapeutic effect；
4th, the abdominal thermal infusion treatment animal model that the present invention sets up is limited using the cytotoxic drug of superthermal state
Penetration depth, therefore drug accumulation is in intraperitoneal, by the control of endoperitoneal metastasis in bottom line；
5th, abdominal thermal infusion device structure of the invention is simple, using convenient, is convenient for scientific research.
Description of the drawings
Fig. 1. the part composition schematic diagram of the abdominal thermal infusion equipment of the present invention.
Fig. 2. the abdominal thermal infusion equipment working state schematic diagram of the present invention.
Fig. 3. fluorescence intensity change situation before and after living imaging observation and treatment.Group I matched group control, organize II tail veins
Administration group t1, dosage are 2mg/m2, 37 DEG C of intraperitoneal perfusion standard dose t2 of III are organized, dosage is 3.75mg/m2, organize 37 DEG C of abdomens of IV
Chamber irrigates high dose t3, and dosage is 7.5mg/m2, 43 DEG C of abdominal thermal infusion standard dose t4 of V groups, dosage is 3.75mg/m2, VI groups
43 DEG C of abdominal thermal infusion high dose t5, dosage is 7.5mg/m2。
Fig. 4. Anatomical Observation respectively constitutes tumor situation.Group I matched group control, organize II tail vein administration groups t1, agent
Measure as 2mg/m2, 37 DEG C of intraperitoneal perfusion standard dose t2 of III are organized, dosage is 3.75mg/m2, the high agent of group 37 DEG C of intraperitoneal perfusions of IV
Amount t3, dosage is 7.5mg/m2, 43 DEG C of abdominal thermal infusion standard dose t4 of V groups, dosage is 3.75mg/m2, 43 DEG C of abdominal cavity heat of VI groups
Perfusion high dose t5, dosage is 7.5mg/m2。
Specific embodiment
Below in conjunction with the accompanying drawings the specific embodiment that the present invention is provided is elaborated.
Present inventor possesses abundant research experience in abdominal thermal infusion clinical treatment and basic research field, especially
During which reports still few abdominal thermal infusion basic research in currently available technology, inventor attempts to establish abdominal thermal infusion and controls
Animal model is treated, and notes observing and thinking deeply summary, it is appreciated that problems with：(1) animal model (such as tumor bearing nude mice) body constitution
Weakness, is not suitable for carrying out laparotomy ventrotomy, and Infection in operation probability is high, and the rate that causes death is higher, affects the accurate of experimental result statistics
Degree；(2) clinical abdominal thermal infusion equipment adopts closed loop, the filling for having membrane filtration to pump out in closed loop
Fluid injection, and the cancerous cell and liquid mass-energy actually in metastasis is cut, but the thing of part cancerous cell and tumor microenvironment release
Matter differs, and abdominal cavity is still entered after circumfusion, and the material of remaining may further promote transfer.It is based on
Problem above etc., present inventor have developed the abdominal thermal infusion equipment suitable for lotus knurl model mice, and carry out treatment
The foundation of model and correlational study.
Reference is as follows：
1. system pumped into, 11. medicine storage bags, 12. first silica gel tubes, 13. first peristaltic pumps, 14. tube for transfusions, 15. first wear
Pricker, 16. heat-exchange devices
2. pumping out system, 21. reclaiming bags, 22. second silica gel tubes, 23. second peristaltic pumps, 24. drain pipes, 25. second wear
Pricker
3. thermocouple, 31. thermocouple wires
Embodiment 1
Fig. 1 is referred to, Fig. 1 is the part composition schematic diagram of the abdominal thermal infusion equipment of the present invention.Described abdominal cavity heat is filled
Note equipment is provided with the system of pumping into 1, pumping out system 2 and thermocouple 3.The described system 1 that pumps into includes medicine storage bag 11, the first silica gel tube
12nd, the first peristaltic pump 13, tube for transfusion 14, first puncture needle 15 and heat-exchange device 16, described 12 one end of the first silica gel tube connect
Medicine storage bag 11 is connect, the other end is connected with an end of tube for transfusion 14, the other end connection first puncture needle 15 of tube for transfusion 14,
The centre portion of the first described silica gel tube 12 is installed on the first peristaltic pump 13, and described heat-exchange device 16 and first is wriggled
The first silica gel tube 12 between pump 13 and medicine storage bag 11 contacts the infusion liquid with heated transportation.Described pumping out system 2 is provided with medicine
Thing reclaiming bag 21, the second silica gel tube 22, the second peristaltic pump 23, drain pipe 24 and second puncture needle 25, the second described silica gel tube
22 one end connect medicine reclaiming bag 21, and the other end is connected with an end of drain pipe 24, the other end connection of drain pipe 24
Second puncture needle 25, the centre portion of the second described silica gel tube 22 are installed on the second peristaltic pump 23.Described thermocouple 3 sets
There are two thermocouple wires 31, described two thermocouple wires, 31 through holes by 14 liquid outlet portion of tube for transfusion are inserted in tube for transfusion 14
Cavity in, another through hole by 24 feed liquor end of drain pipe is inserted in the cavity of drain pipe 24.
The present invention abdominal thermal infusion equipment operation principle and process be：Fig. 2 is referred to, Fig. 2 is the abdominal cavity of the present invention
Hot perfusion equipment working state schematic representation.Before the treatment starts, connecting components, are entered to animal using 1% pentobarbital sodium
Row anesthesia, dorsal positions are fixed on operating-table, clean abdominal part with 75% ethanol.First puncture needle 15 and second puncture needle 25 are worn
Lunge into animal intraperitoneal, site of puncture is located at the left end and right-hand member in abdominal cavity respectively, to simulate its process rinsed in intraperitoneal.
Heat-exchange device 16, the first peristaltic pump 13, the second peristaltic pump 23, thermocouple 3 are then turned on, infusion liquid first passes through heat-exchange device
16 heating, pump into tube for transfusion 14 by 13 the first silica gel tubes of Jing 12 of the first peristaltic pump, then hot at the liquid outlet of tube for transfusion 14
31 thermometric of thermocouple wire of galvanic couple 3, then Jing first puncture needles 15 are into animal abdominal cavity, then together with free cancerous cell and liquid matter Jing
Second puncture needle 25, drain pipe 24 enter the first silica gel tube 22, and by 31 thermometric of thermocouple wire of thermocouple 3, in the second peristaltic pump
It is pumped out in the presence of 23 to medicine reclaiming bag 21, to play therapeutic effect.Above procedure should be carried out in sterilizing room, environment
It is stable, and before the infusion liquid treatment of perfusion pastille should irrigate normal saline makes temperature in peritoneal cavity reach 43 DEG C or so for 10 minutes, with
Play optimum therapeuticing effect.
It should be noted that abdominal thermal infusion is treated by the present invention and place transfusion using laparotomy ventrotomy or go out the silica gel of liquid
Pipe is changed to be irrigated using lancet puncture abdominal cavity, this has broken normal mode, it is contemplated that the tumor bearing nude mice having a delicate constitution
Deng toy not tolerating for operation technique, and operation technique is for the harmful effect that experimental result accuracy is produced, energy
The probability of postoperative infection is effectively reduced, experiment result accuracy is improved.Irrigated using closed loop in prior art, and
The present invention breaks the normal procedure, and has used open perfusion system, and this kind of pattern can fully remove free cancerous cell and tumor is micro-
Material of Environment release etc., significantly improves therapeutic effect, in order to more objectively investigate medicinal liquid or abdominal thermal infusion Therapeutic mode
Therapeutic effect, additionally, open perfusion system can obviously improve closed circulation perfusion loop in dissociate cancerous cell blocking
The problem of pipeline.The first described peristaltic pump 13 and the second peristaltic pump 23 are a kind of liquid transporting apparatus of controllable flow velocity,
The filling process of stable low speed can be maintained after flow velocity is set, it is ensured that stable experiment is lasting.It is right that described heat-exchange device 16 is used for
Infusion liquid is heated, can be using the constant temperature water bath apparatus with having heaters, and its heat up rapid, safety, thermal efficiency are high, while energy
There is provided effective heat storage function sustainable constant temperature, and specifically, it is preferable to Shanghai Rong Feng digital display thermostatic water-circulator bath pot 501A types are adopted,
There is adjutage on the left of its water-bath, be electric box on the right side of water-bath, open equipped with temperature control instrument, power supply on electric box front panel
Close, in electric box, have electric heating tube and temperature sensor, its temperature control system employs high-quality electronic component, temperature control is sensitive,
Dependable performance, easy to use, operation principle is：The temperature transition of water trough inner water is resistance value by temperature sensor, through integrated
The amplification of amplifier, compare after, output control signal efficiently controls the average heating power of electric heating tube, makes in tank
Water keeps constant temperature.Can high accuracy temperature control using this heat-exchange device.Described thermocouple 3 is for infusion liquid abdominal cavity entry and going out
The temperature of mouth is monitored, and persistently records temperature change over the course for the treatment of, and abdominal cavity entry temperature-controlled precision≤0.6 DEG C realizes
High accuracy temperature control.
Embodiment 2
Nude mice abdominal cavity injection cell suspension builds peritoneum metastasis model.By colon cancer 116-luc cell with 2.5*106It is individual thin
The amount of born of the same parents/only is inoculated in BALB/c nude mice abdominal cavity.After tumour growth 10 days, nude mice is randomly divided into into 6 groups, 6 per group are moved
Thing：Group I matched groups (n=6), group II tail vein administration groups (n=6), dosage is 2mg/m2, organize 37 DEG C of intraperitoneal perfusion standards of III
Dosage (n=6), dosage is 3.75mg/m2, 37 DEG C of intraperitoneal perfusion high doses (n=6) of IV are organized, dosage is 7.5mg/m2, V groups 43
DEG C abdominal thermal infusion standard dose (n=6), dosage is 3.75mg/m2, 43 DEG C of abdominal thermal infusion high doses (n=6) of VI groups, agent
Measure as 7.5mg/m2.Adjustment perfusion flow velocity is 6mL/min.
Abdominal thermal infusion equipment of the equipment using embodiment 1.Intraabdominal constant temperature is between 42 DEG C to 43 DEG C.Filling
After the temperature of fluid injection reaches the temperature of needs, Continuous Perfusion 30min.After perfusion terminates, saline infusions abdominal cavity is used
10min, removes device for casting.Living imaging is shot at inoculation 1 week, 2 weeks, 3 weeks respectively, fluorescence intensity and regional change is observed
Situation, the drug effect of the different therapeutic modalities of comparison.
Before and after treatment fluorescence intensity change situation and into tumor situation respectively as shown in Figure 3 and Figure 4, and in whole experiment process
Without animal dead.Result above shows that the abdominal thermal infusion equipment of the present invention is used to set up thermo-chemotherapy animal model feasibility
Height, animal are tolerated, and this kind of thermo-chemotherapy method significantly suppress the growth of intraperitoneal tumor, are achieved and excellent are controlled curative effect
Really.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
Member, on the premise of without departing from the inventive method, can also make some improvement and supplement, and these improve and supplement also should be regarded as
Protection scope of the present invention.
Claims (10)
1. a kind of abdominal thermal infusion equipment, is provided with the system of pumping into and pumping out system, it is characterised in that be additionally provided with thermocouple；It is described
The system that pumps into include medicine storage bag, the first silica gel tube, the first peristaltic pump, tube for transfusion, first puncture needle and heat-exchange device, it is described
First silica gel tube one end connection medicine storage bag, the other end is connected with an end of tube for transfusion, and the other end of tube for transfusion connects
First puncture needle, the centre portion of the first silica gel tube are installed on the first peristaltic pump, and described heat-exchange device is defeated for heating
The infusion liquid sent；Described pumping out system is provided with medicine reclaiming bag, the second silica gel tube, the second peristaltic pump, drain pipe and second and wears
Pricker, described second silica gel tube one end connection medicine reclaiming bag, the other end are connected with an end of drain pipe, drain pipe
The other end connects second puncture needle, and the centre portion of the second silica gel tube is installed on the second peristaltic pump；Described thermocouple is used
In monitoring infusion liquid abdominal cavity entry and the temperature of outlet.
2. abdominal thermal infusion equipment according to claim 1, it is characterised in that described heat-exchange device and first is wriggled
The first silica gel tube between pump and medicine storage bag is contacted with the infusion liquid of heated transportation.
3. abdominal thermal infusion equipment according to claim 1, it is characterised in that described thermocouple is provided with two galvanic couples
Silk, described piece through hole by tube for transfusion liquid outlet portion of two thermocouple wires are inserted in the cavity of tube for transfusion, and another leads to
The through hole for crossing drain pipe feed liquor end is inserted in the cavity of drain pipe.
4. abdominal thermal infusion equipment according to claim 1, it is characterised in that described heat-exchange device is with heating
The constant temperature water bath apparatus of device.
5. abdominal thermal infusion equipment according to claim 4, it is characterised in that described heat-exchange device is Shanghai Rong Feng
Digital display thermostatic water-circulator bath pot 501A types.
6. it is a kind of to set up the method that abdominal thermal infusion treats animal model, it is characterised in that described method has used right to want
Seek the arbitrary described abdominal thermal infusion equipment of 1-5.
7. method according to claim 6, it is characterised in that described method is carried out in gnotobasiss.
8. method according to claim 6, it is characterised in that infusion liquid temperature-controlled precision≤0.6 DEG C of abdominal cavity entry.
9. method according to claim 6, it is characterised in that Intraabdominal constant temperature is at 42 DEG C to 43 in filling process
Between DEG C.
10. method according to claim 6, it is characterised in that irrigating normal saline before perfusion pastille infusion liquid makes abdominal cavity
Temperature is reached between 42 DEG C to 43 DEG C.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108795867A (en) * | 2018-06-05 | 2018-11-13 | 华东理工大学 | The method for shifting external threedimensional model for building colon cancer cell peritonaeum |
| CN109893334A (en) * | 2019-04-29 | 2019-06-18 | 河南中医药大学 | Abdominal thermal infusion chemotherapy device |
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| CN106540347A8 (en) | 2017-05-10 |
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Inventor after: Cai Guoxiang Inventor after: Liu Jianwen Inventor after: Li Yueqi Inventor after: Qiu Cen Inventor after: Xu Ye Inventor after: Cai Sanjun Inventor before: Cai Guoxiang Inventor before: Liu Jianwen Inventor before: Li Yueqi Inventor before: Qiu Cheng Inventor before: Xu Ye Inventor before: Cai Sanjun |
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Correction item: Inventor Correct: Cai Guoxiang|Liu Jianwen|Li Yueqi|Qiu Cen|Xu Ye|Cai Sanjun False: Cai Guoxiang|Liu Jianwen|Li Yueqi|Qiu Cheng|Xu Ye|Cai Sanjun Number: 13 Volume: 33 |
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Correction item: Inventor Correct: Cai Guoxiang|Liu Jianwen|Li Yueqi|Qiu Cen|Xu Ye|Cai Sanjun False: Cai Guoxiang|Liu Jianwen|Li Yueqi|Qiu Cheng|Xu Ye|Cai Sanjun Number: 13 Page: The title page Volume: 33 |
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Application publication date: 20170329 |