CN101120891A - Multifunctional tumor insertion thermotherapy machine - Google Patents
Multifunctional tumor insertion thermotherapy machine Download PDFInfo
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- CN101120891A CN101120891A CNA200710025446XA CN200710025446A CN101120891A CN 101120891 A CN101120891 A CN 101120891A CN A200710025446X A CNA200710025446X A CN A200710025446XA CN 200710025446 A CN200710025446 A CN 200710025446A CN 101120891 A CN101120891 A CN 101120891A
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Abstract
The present invention is a tumor interventional thermal therapy machine with multiple functions, which is characterized in that a blocking perfusion loop is arranged. The blocking perfusion loop is a fluid-conveying pipe arranged between a storage liquid bag and an introduction tube. An introduction pump and a heating unit are arranged in series connection in the fluid-conveying pipe. The heating unit is a hot water bath groove. Middle section of the fluid-conveying pipe is a heat exchange tube arranged in the hot water bath groove. The present invention possesses advantages of reasonable structure, safe application, low application cost and reliable treatment effect. The present invention can realize multiple function therapies of ''thermal perfusion chemotherapy in target tumor artery through an artery catheter'', ''thermal perfusion chemotherapy in thoracoabdominal cavity'' and ''thermal perfusion chemotherapy in bladder'', respectively.
Description
Technical field
The present invention relates to medical apparatus and instruments, a kind of tumor insertion thermotherapy machine of more specifically saying so, be used for of " target artery thermochemotherapy ", " thermocoagulation " of various malignant solid tumors through the ductus arteriosus tumor, be used for " the splanchnocoel thermochemotherapy " of pernicious ascites pleural fluid and splanchnocoel malignant tumor, and be used for tumor of bladder " through the catheter thermochemotherapy ".
Background technology
Get involved thermochemotherapy through ductus arteriosus and treat various malignant solid tumors, the splanchnocoel hyperthermic perfusion chemotherapy is treated pernicious ascites pleural fluid, treatment splanchnocoel malignant tumor, belly cavity tumor, the early stage hyperthermic perfusion chemotherapy in tumor of pelvic cavity operation back, tumor of bladder is through catheter hyperthermic perfusion chemotherapy treatment tumor of bladder, and its curative effect is generally acknowledged by domestic and international tumor expert.
At present, for the concrete enforcement that gets involved the thermochemotherapy technology, be to pour into by means of the high capacity high pressure injector, the problem that this mode exists mainly comprises:
1, in that injection may be brought pollution during the suction high pressure injector from the liquid bag, there is insecurity.
2, the high-pressure injection tube is a consumptive material, disposable use, and the use cost height has increased medical expense to the patient.
3, chemotherapeutics and solution selectively do not heat jointly, thereby unavoidably make some chemotherapeutics loss of stability.
4, getting involved in the thermochemotherapy through ductus arteriosus, be heat-exchange tube to be set and to adopt heating in water bath, temperature sensor is arranged on the exit of heat-exchange tube, but owing to the difference of ambient temperature, the difference of flow, thermal loss on the infusion pipeline is difficult to prediction, make the intravital fluid temperature of the actual patient of injection be difficult to accurate control, can not reach optimum therapeuticing effect.
5, in breast, abdominal thermal infusion chemotherapy, be to adopt microwave heating for liquid storing bag, have microwave pollution, and may impact pharmaceutical properties.
6, at the intervention thermochemotherapy of tumor of bladder, need the control treatment during intravesical pressure greater than patient's diastolic pressure, but also be not exclusively used in the intervention thermochemotherapy machine of tumor of bladder treatment at present.
Summary of the invention
The present invention is for avoiding above-mentioned existing in prior technology weak point, provide a kind of reasonable in design, safe in utilization, use cost is low, curative effect multifunctional tumor insertion thermotherapy machine more reliably, by different configurations, realize " through ductus arteriosus tumor target artery hyperthermic perfusion chemotherapy ", " splanchnocoel hyperthermic perfusion chemotherapy " and " bladder hyperthermic perfusion chemotherapy " respectively.
The technical scheme that technical solution problem of the present invention is adopted is:
Multifunctional tumor insertion thermotherapy machine of the present invention, its construction features is that sealing perfusion loop is set, described sealing perfusion loop is between liquid storing bag and ingress pipe liquid-transport pipe-line to be set, series connection is provided with and imports pump and heating unit on described liquid-transport pipe-line, described heating unit is the hot water bath, and the stage casing of liquid-transport pipe-line is arranged on the heat-exchange tube in the hot water bath.
Construction features of the present invention also is the porch at described ingress pipe, and the importing temperature sensor is set, and the control of the temperature of hot water bath is to be controlled temperature detection signal with the output signal that imports temperature sensor.
Construction features of the present invention also is to constitute through ductus arteriosus tumor target artery hyperthermic perfusion chemotherapy machine by following structure configuration:
A, described liquid storing bag be not for containing the solution bag of chemotherapeutics, the independent medicinal liquid input circuit that is made of chemotherapy medicinal fluid bag, medicinal liquid input pipe and spray pump that is provided with;
B, described ingress pipe are ductus arteriosus;
C, between the output mouth of pipe and ingress pipe of described heat-exchange tube, the three way cock is set, the chemotherapy medicinal fluid bag inserts the three way cock by the medicinal liquid input pipe, in described medicinal liquid input pipe, series connection is provided with spray pump.
Construction features of the present invention also is to constitute splanchnocoel hyperthermic perfusion chemotherapy machine by following structure configuration:
A, described liquid storing bag are the medicinal fluid bag that contains chemotherapeutics, and described ingress pipe is breast, abdominal cavity ingress pipe, breast, abdominal cavity delivery line are set and derive pump, derive liquid and insert medicinal fluid bag by breast, abdominal cavity delivery line and the circulation of derivation pump;
B, in the exit of breast, abdominal cavity delivery line, the derivation temperature sensor is set, the flow-control in the sealing perfusion loop is to be controlled detection signal with the output signal that derives temperature sensor.
Construction features of the present invention also is to constitute bladder hyperthermic perfusion chemotherapy machine by following structure configuration:
A, described liquid storing bag are the medicinal fluid bag that contains chemotherapeutics, and described ingress pipe is the bladder ingress pipe, the bladder delivery line is set and derives pump, and described bladder delivery line inserts liquid storing bag by deriving the pump circulation;
B, in the exit of described bladder delivery line, being provided with respectively derives temperature sensor and outlet pressure sensor, the flow-control in the described sealing perfusion loop is to be controlled detection signal with the output signal that derives temperature sensor and outlet pressure sensor.。
Compared with the prior art, beneficial effect of the present invention is embodied in:
1, the present invention is provided with sealing perfusion loop, replaces the high capacity high pressure injector with " importing pump ", liquid is completely enclosed within the liquid-transport pipe-line flows, and uses safelyr, and consumptive material value is low, greatly reduces use cost.
2, the present invention adopts heating in water bath, has avoided microwave pollution, the influence of also having avoided microwave heating to cause pharmaceutical properties.
3, the present invention's importing temperature sensor that will be used to control the hot water bath temperature is arranged on the porch of ingress pipe, eliminated the temperature deviation of the actual injection patient body inner liquid medicine that thermal loss causes on ambient temperature and the infusion pipeline, provide favourable assurance for guaranteeing therapeutic effect.
4, the present invention can realize respectively multiple treatment function at " through ductus arteriosus tumor target artery hyperthermic perfusion chemotherapy ", " splanchnocoel hyperthermic perfusion chemotherapy " and " bladder hyperthermic perfusion chemotherapy " by different configurations, realize a tractor serves several purposes, greatly reduce the equipment configuration cost of medical institutions, improve capacity utilization, reduce medical expense.
5, the present invention can make chemotherapeutics not participate in heating in different treatment occasions selectively, greatly helps the maintenance of drug effectiveness energy.
6, the present invention is in the intervention thermochemotherapy at tumor of bladder, can control treatment effectively during intravesical pressure greater than patient's diastolic pressure, thereby guarantee therapeutic effect.
Description of drawings
Fig. 1 is configured to through ductus arteriosus tumor target artery hyperthermic perfusion chemotherapy machine structural representation for the present invention.
Label among Fig. 1: 1 liquid-transport pipe-line, 2 import pumps, 3 hot water baths, 4 heat-exchange tubes, 5 medicinal liquid input pipes, 6 spray pumps, 7 three way cock, S1 be solution bag, S2 be medicinal fluid bag, T1 bath temperature pick off, T2 for import temperature sensor, A is a ductus arteriosus.
Fig. 2 is configured to splanchnocoel hyperthermic perfusion chemotherapy machine structural representation for the present invention.
Label among Fig. 2: it is that breast, abdominal cavity ingress pipe, f2 are breast, abdominal cavity delivery line for deriving temperature sensor, f1 that 1 liquid-transport pipe-line, 2 imports pumps, 3 hot water baths, 4 heat-exchange tubes, 5 to derive pumps, S2 be medicinal fluid bag, T1 bath temperature pick off, T2 to importing temperature sensor, T3.
Fig. 3 is configured to bladder hyperthermic perfusion chemotherapy machine structural representation for the present invention.
Label among Fig. 3: 1 liquid-transport pipe-line, 2 imports pumps, 3 hot water baths, 4 heat-exchange tubes, 5, and to derive pumps, 6 bladder ingress pipes, 7 bladder delivery lines, S2 be that medicinal fluid bag, T1 bath temperature pick off, T2 are for importing temperature sensor, T3 for deriving temperature sensor.
Below, in conjunction with the accompanying drawings the present invention is further described by the specific embodiment:
The specific embodiment
Embodiment 1:
Referring to Fig. 1, constitute through ductus arteriosus tumor target artery hyperthermic perfusion chemotherapy machine by following structure configuration:
Sealing perfusion loop is set, this sealing perfusion loop is that liquid-transport pipe-line 1 is set between liquid storing bag and ingress pipe, series connection is provided with and imports pump 2 and heating unit on liquid-transport pipe-line 1, and heating unit is a hot water bath 3, and the stage casing of liquid-transport pipe-line 1 is arranged on the heat-exchange tube 4 in the hot water bath 3; Porch at ingress pipe; be provided with and import temperature sensor T2; the control of the temperature of hot water bath 3 is to be controlled temperature detection signal with the output signal that imports temperature sensor T2; T1 preheats and overtemperature protection the water in the hot water bath 3 according to the bath temperature pick off, by the specification circuit structure control circuit G is set.
In concrete the enforcement, the corresponding structure setting comprises:
Liquid storing bag is not for containing the solution bag S1 of chemotherapeutics, the independent medicinal liquid input circuit that is made of chemotherapy medicinal fluid bag S2, medicinal liquid input pipe 5 and spray pump 6 that is provided with; Ingress pipe is ductus arteriosus A; Between the output mouth of pipe and ductus arteriosus A of heat-exchange tube 4, three way cock 7 is set, chemotherapy medicinal fluid bag S2 inserts three way cock 7 by medicinal liquid input pipe 5, and in medicinal liquid input pipe 4, series connection is provided with spray pump 6.
Embodiment 2: referring to Fig. 2, constitute splanchnocoel hyperthermic perfusion chemotherapy machine by following structure configuration:
Identical with embodiment 1 is, sealing perfusion loop is set, this sealing perfusion loop is that liquid-transport pipe-line 1 is set between liquid storing bag and ingress pipe, series connection is provided with and imports pump 2 and heating unit on liquid-transport pipe-line 1, heating unit is a hot water bath 3, and the stage casing of liquid-transport pipe-line 1 is arranged on the heat-exchange tube 4 in the hot water bath 3; Porch at ingress pipe; be provided with and import temperature sensor T2; the control of the temperature of hot water bath 3 is to be controlled temperature detection signal with the output signal that imports temperature sensor T2; T1 preheats and overtemperature protection the water in the hot water bath 3 according to the bath temperature pick off, by the specification circuit structure control circuit G is set.
In concrete the enforcement, the corresponding structure setting comprises:
Liquid storing bag is the medicinal fluid bag S2 that contains chemotherapeutics, and ingress pipe is breast, abdominal cavity ingress pipe f1, breast, abdominal cavity delivery line f2 is set and derives pump 5, derives liquid and inserts medicinal fluid bag S2 by breast, abdominal cavity delivery line f2 and 5 circulations of derivation pump;
In the exit of breast, abdominal cavity delivery line f2, being provided with derives temperature sensor T3, and the flow-control in the sealing perfusion loop is to be controlled detection signal with the output signal that derives temperature sensor T3.
Shown in Figure 2, series connection is provided with two hot water baths 3, and two sections heat-exchange tubes 4 that series connection is provided with place two hot water baths 3 respectively, increase heat exchange area with this, reduces programming rate, helps keeping the stability of chemotherapeutics.
In the present embodiment,, adjust the medicinal liquid flow in the sealing perfusion loop, the temperature that derives medicinal liquid is remained on about 42.5-43 ℃, thereby make curative effect more definite stable according to the detected temperatures value that derives temperature sensor T3.
During treatment,, and, carry out circumfusion subsequently by desired temperature advancing irrigation at first according to the consumption of thoracic cavity 800-1000ml, abdominal cavity 1500-2000ml.
Embodiment 3: referring to Fig. 3, constitute bladder hyperthermic perfusion chemotherapy machine by following structure configuration:
Identical with embodiment 1 is, sealing perfusion loop is set, this sealing perfusion loop is that liquid-transport pipe-line 1 is set between liquid storing bag and ingress pipe, series connection is provided with and imports pump 2 and heating unit on liquid-transport pipe-line 1, heating unit is a hot water bath 3, and the stage casing of liquid-transport pipe-line 1 is arranged on the heat-exchange tube 4 in the hot water bath 3; Porch at ingress pipe; be provided with and import temperature sensor T2; the control of the temperature of hot water bath 3 is to be controlled temperature detection signal with the output signal that imports temperature sensor T2; T1 preheats and overtemperature protection the water in the hot water bath 3 according to the bath temperature pick off, by the specification circuit structure control circuit G is set.
In concrete the enforcement, the corresponding structure setting comprises:
Liquid storing bag is the medicinal fluid bag S2 that contains chemotherapeutics, and ingress pipe is a bladder ingress pipe 6, bladder delivery line 7 is set and derives pump 5, and derivation liquid is by bladder delivery line 7 and derive pump 5 circulation access medicinal fluid bag S2;
In the exit of bladder delivery line 7, being provided with respectively derives temperature sensor T3 and outlet pressure sensor P, and the flow-control in the sealing perfusion loop is to be controlled detection signal with the output signal that derives temperature sensor T3 and outlet pressure sensor P.Intravesical pressure is greater than patient's diastolic pressure in the maintenance therapeutic process, the blocking-up tumor blood flow makes tumor tissues ischemia, anoxia, the chemotherapeutics penetration is strengthened under the effect of heating power and pressure, and the chemotherapeutics that enters in the tumor cell increases, and can further improve the curative effect of bladder thermochemotherapy.
During treatment, at first folder closes bladder and derives the mouth of pipe, pours into certain amount of fluid in advance to intravesical, makes the diastolic pressure of intravesical pressure greater than the patient, and open subsequently bladder is derived the mouth of pipe and carried out circumfusion.
Claims (6)
1. multifunctional tumor insertion thermotherapy machine, it is characterized in that being provided with sealing perfusion loop, described sealing perfusion loop is that liquid-transport pipe-line (1) is set between liquid storing bag and ingress pipe, go up series connection at described liquid-transport pipe-line (1) importing pump (2) and heating unit are set, described heating unit is hot water bath (3), and the stage casing of liquid-transport pipe-line (1) is arranged on the heat-exchange tube (4) in the hot water bath (3).
2. multifunctional tumor insertion thermotherapy machine according to claim 1, it is characterized in that porch at described ingress pipe, be provided with and import temperature sensor (T2), the temperature control of hot water bath (3) is to be controlled temperature detection signal with the output signal that imports temperature sensor (T2).
3. multifunctional tumor insertion thermotherapy machine according to claim 2 is characterized in that constituting through ductus arteriosus tumor target artery hyperthermic perfusion chemotherapy machine by following structure configuration:
A, described liquid storing bag be not for containing the solution bag (S1) of chemotherapeutics, the independent medicinal liquid input circuit that is made of chemotherapy medicinal fluid bag (S2), medicinal liquid input pipe (5) and spray pump (6) that is provided with;
B, described ingress pipe are ductus arteriosus (A);
C, between the output mouth of pipe and ingress pipe of described heat-exchange tube (4), three way cock (7) is set, chemotherapy medicinal fluid bag (S2) inserts three way cock (7) by medicinal liquid input pipe (5), in described medicinal liquid input pipe (5), series connection is provided with spray pump (6).
4. multifunctional tumor insertion thermotherapy machine according to claim 2 is characterized in that constituting splanchnocoel hyperthermic perfusion chemotherapy machine by following structure configuration:
A, described liquid storing bag are the medicinal fluid bag (S2) that contains chemotherapeutics, described ingress pipe is breast, abdominal cavity ingress pipe (f1), breast, abdominal cavity delivery line (f2) are set and derive pump (5), derive liquid and insert medicinal fluid bag (S2) by breast, abdominal cavity delivery line (f2) and derivation pump (5) circulation;
B, in the exit of described breast, abdominal cavity delivery line (f2), being provided with derives temperature sensor (T3), the flow-control in the described sealing perfusion loop is to be controlled detection signal with the output signal that derives temperature sensor (T3).
5. multifunctional tumor insertion thermotherapy machine according to claim 4 is characterized in that series connection is provided with two hot water baths (3), and the heat-exchange tube (4) of two sections series connection settings places two hot water baths (3) respectively.
6. multifunctional tumor insertion thermotherapy machine according to claim 2 is characterized in that constituting bladder hyperthermic perfusion chemotherapy machine by following structure configuration:
A, described liquid storing bag are the medicinal fluid bag (S2) that contains chemotherapeutics, and described ingress pipe is bladder ingress pipe (6), bladder delivery line (7) is set and derives pump (5), derive liquid and insert medicinal fluid bag (S2) by bladder delivery line (7) and derivation pump (5) circulation;
B, in the exit of described bladder delivery line (7), being provided with respectively derives temperature sensor (T3) and outlet pressure sensor (P), and the flow-control in the described sealing perfusion loop is that the output signal with derivation temperature sensor (T3) and outlet pressure sensor (P) is controlled detection signal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200710025446XA CN101120891A (en) | 2007-07-25 | 2007-07-25 | Multifunctional tumor insertion thermotherapy machine |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200710025446XA CN101120891A (en) | 2007-07-25 | 2007-07-25 | Multifunctional tumor insertion thermotherapy machine |
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| CN101120891A true CN101120891A (en) | 2008-02-13 |
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| CNA200710025446XA Pending CN101120891A (en) | 2007-07-25 | 2007-07-25 | Multifunctional tumor insertion thermotherapy machine |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101897636A (en) * | 2010-08-06 | 2010-12-01 | 上海交通大学 | Intraperitoneal hyperthermic perfusion chemotherapy instrument in operation |
| CN103519931A (en) * | 2013-10-30 | 2014-01-22 | 安徽英特电子有限公司 | Automatic water inflowing and draining structure of water bath |
| CN106492331A (en) * | 2016-11-24 | 2017-03-15 | 江苏省人民医院 | A kind of drug cycles formula irrigation of bladder device |
| CN106540347A (en) * | 2016-12-19 | 2017-03-29 | 复旦大学附属肿瘤医院 | A kind of abdominal thermal infusion equipment and abdominal thermal infusion treat the method for building up of animal model |
| CN107261307A (en) * | 2017-07-26 | 2017-10-20 | 珠海富伊特科技有限公司 | A kind of constant temperature abdominal thermal infusion treatment system |
| CN107736933A (en) * | 2017-11-29 | 2018-02-27 | 朱新福 | Abdominal thermal infusion apparatus for controlling connection |
| CN110237412A (en) * | 2019-07-22 | 2019-09-17 | 上海市第一人民医院 | On Irrigation of Bladder Chemotherapy instrument |
| CN110393627A (en) * | 2019-08-29 | 2019-11-01 | 吉林省迈达医疗器械股份有限公司 | A kind of perfusion unit in use for thermochemical therapeutics for abdominal cavity |
-
2007
- 2007-07-25 CN CNA200710025446XA patent/CN101120891A/en active Pending
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101897636A (en) * | 2010-08-06 | 2010-12-01 | 上海交通大学 | Intraperitoneal hyperthermic perfusion chemotherapy instrument in operation |
| CN101897636B (en) * | 2010-08-06 | 2012-08-22 | 上海交通大学 | Intraperitoneal hyperthermic perfusion chemotherapy instrument in operation |
| CN103519931A (en) * | 2013-10-30 | 2014-01-22 | 安徽英特电子有限公司 | Automatic water inflowing and draining structure of water bath |
| CN103519931B (en) * | 2013-10-30 | 2015-03-11 | 安徽英特电子有限公司 | Automatic water inflowing and draining structure of water bath |
| CN106492331A (en) * | 2016-11-24 | 2017-03-15 | 江苏省人民医院 | A kind of drug cycles formula irrigation of bladder device |
| CN106492331B (en) * | 2016-11-24 | 2022-08-26 | 江苏省人民医院 | Medicine circulation type bladder perfusion device |
| CN106540347A (en) * | 2016-12-19 | 2017-03-29 | 复旦大学附属肿瘤医院 | A kind of abdominal thermal infusion equipment and abdominal thermal infusion treat the method for building up of animal model |
| CN107261307A (en) * | 2017-07-26 | 2017-10-20 | 珠海富伊特科技有限公司 | A kind of constant temperature abdominal thermal infusion treatment system |
| CN107736933A (en) * | 2017-11-29 | 2018-02-27 | 朱新福 | Abdominal thermal infusion apparatus for controlling connection |
| CN107736933B (en) * | 2017-11-29 | 2019-12-13 | 陈贵敏 | Abdominal cavity hot perfusion joint control device |
| CN110237412A (en) * | 2019-07-22 | 2019-09-17 | 上海市第一人民医院 | On Irrigation of Bladder Chemotherapy instrument |
| CN110393627A (en) * | 2019-08-29 | 2019-11-01 | 吉林省迈达医疗器械股份有限公司 | A kind of perfusion unit in use for thermochemical therapeutics for abdominal cavity |
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