CN105920724B - A kind of device of liquid metal intraperitoneal perfusion and electrochemotherapy - Google Patents
A kind of device of liquid metal intraperitoneal perfusion and electrochemotherapy Download PDFInfo
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- CN105920724B CN105920724B CN201610343177.0A CN201610343177A CN105920724B CN 105920724 B CN105920724 B CN 105920724B CN 201610343177 A CN201610343177 A CN 201610343177A CN 105920724 B CN105920724 B CN 105920724B
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- liquid metal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/12—Devices for heating or cooling internal body cavities
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0001—Body part
- A61F2007/0018—Trunk or parts thereof
- A61F2007/0022—Abdomen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/05—General characteristics of the apparatus combined with other kinds of therapy
- A61M2205/054—General characteristics of the apparatus combined with other kinds of therapy with electrotherapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1021—Abdominal cavity
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- Biomedical Technology (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
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- External Artificial Organs (AREA)
Abstract
The present invention proposes that the device of a kind of liquid metal intraperitoneal perfusion and electrochemotherapy, including intraperitoneal perfusion end, abdominal cavity extract end, therapeutic electrode anode, therapeutic electrode cathode, extracorporeal power source, temperature regulating device, computer system, liquid metal infusion bag；The intraperitoneal perfusion end and abdominal cavity are extracted end and are connect with the liquid metal infusion bag, the temperature regulating device are arranged outside liquid metal infusion bag, the temperature regulating device is connect with the computer system；The therapeutic electrode anode and therapeutic electrode cathode are connect with the extracorporeal power source, and the extracorporeal power source is connect with the computer system.Device proposed by the present invention substantially increases the treatment area of therapeutic electrode during electrochemotherapy to the thermotherapy in abdominal cavity using the completion of liquid metal intraperitoneal perfusion, can quickly complete the tumour electrochemotherapy of large area.
Description
Technical field
The invention belongs to medical instruments fields, and in particular to a kind of device of oncotherapy and its application.
Background technique
Tumour seriously threatens the health of the mankind, and the main method for treating tumour at present has surgical method, and radiotherapy is changed
Therapy, heat therapy and electrochemotherapy method emerging at present.Often wound is excessive for surgical operation, and healing is slow, and patient restores
Time is long, and existing risk of performing the operation is big.Radiotherapy is easily reduced the immunity of patient itself while killing tumour cell.
The side effect of amic therapy method is larger, is also easy to produce drug resistance.Heat therapy utilizes the tolerance of normal cell and tumour cell to temperature
Ability is different, reaches kill tumour cell, while not causing the effect of damage to normal cell again, in addition can conspicuousness enhancing
The immunity of patient's body.Using the ion in tissue fluid redox reaction occurs near electrode for electrochemical treatment of tumors,
Make anode PH reduction nearby at acidity, increases the pH near cathode at alkalinity.The main variation for utilizing pH value, kills tumour
Cell.
However, the treatment problem that electrochemistry is encountered now is that the variation of local pH value exists only in the week of electrode
In the range of enclosing about 2cm, and actual conditions, the size of tumour tend to exceed this numerical value, so actual treatment condition
It is reasonable cloth needle is carried out according to the size of tumour, the treatment of the tumour of a 5cm × 5cm will often be inserted into ten or so and control
Treatment electrode, which can be only achieved, fully treats effect, has added more additional pains to patient.With going out for liquid flexible electronics
It is existing, it by way of intraperitoneal perfusion, can greatly increase the contact surface of therapeutic electrode and tissue, increase treatment area, without
It needs to be inserted into again extra electrode.
Summary of the invention
In view of the deficiencies of the prior art, a kind of device is proposed.It is an object of the invention to: by means of liquid metal
Intraperitoneal perfusion and electrochemotherapy means provide a kind of novel device that can be used for rapid large-area electrochemical treatment of tumors.
It is another object of the present invention to propose the application of described device.
Realize the technical solution of above-mentioned purpose of the present invention are as follows:
End, treatment are extracted in the device of a kind of liquid metal intraperitoneal perfusion and electrochemotherapy, including intraperitoneal perfusion end, abdominal cavity
Electrode anode, therapeutic electrode cathode, extracorporeal power source, temperature regulating device, computer system, liquid metal infusion bag；The abdominal cavity fills
Note end and abdominal cavity are extracted end and are connect with the liquid metal infusion bag, and the temperature regulating device is arranged outside liquid metal infusion bag,
The temperature regulating device is connect with the computer system；The therapeutic electrode anode and therapeutic electrode cathode and the extracorporeal power source
Connection, the extracorporeal power source are connect with the computer system.
Wherein, the intraperitoneal perfusion end is connect by priming line with the liquid metal infusion bag, the priming line
Material be rubber or silica gel, the first pumping equipment is provided on priming line；
Wherein, the abdominal cavity is extracted end and is connect by extracting pipeline with the liquid metal infusion bag, the extraction pipeline
Material be rubber or silica gel, the second pumping equipment is provided on extraction tube road.
Preferably, the temperature regulating device is water bath equipment or electric heating wire.
It is highly preferred that the therapeutic electrode just extremely platinum filament or filamentary silver is made, length is 10~20cm, diameter is 0.5~
1.2mm；The therapeutic electrode cathode is made of platinum filament or filamentary silver, and length is 10~20cm, and diameter is 0.5~1.2mm.
Wherein, it is loaded with liquid metal in the liquid metal infusion bag, the liquid metal is gallium, indium, one in tin
Kind or its alloy.
Wherein, the extracorporeal power source is DC power supply, and supply voltage is 2~10V.
Device proposed by the present invention in use, anode and cathode are inserted in target area in need for the treatment of, anode, cathode,
Circuit should not exceed 10mA in the current loop that target area is constituted.
Application of the device proposed by the present invention in oncotherapy.
The system that device proposed by the present invention is combined with Sonography devices.In the system, therapeutic electrode can be super
Treated position is accurately inserted under the guidance of the instruments such as sound.
The beneficial effects of the present invention are:
Device proposed by the present invention completes the thermotherapy to abdominal cavity using liquid metal intraperitoneal perfusion, in electrochemotherapy mistake
Cheng Zhong substantially increases the treatment area of therapeutic electrode, can quickly complete the tumour electrochemotherapy of large area.
The present invention provides a kind of novel device that can be used for rapid large-area electrochemical treatment of tumors, with liquid metal
The method of intraperitoneal perfusion is in contact by therapeutic electrode with liquid metal perfusion liquid, it is possible to increase the treatment area of therapeutic electrode, or
That therapeutic electrode does not contact directly with liquid metal, also can minor betterment therapeutic electrode surrounding electric field distribution, may be implemented only
Just achieve the effect that large area kills tumour cell by two therapeutic electrodes.At the same time, by heating liquid metal abdominal cavity
Perfusion liquid can also achieve the effect that thermotherapy.
Detailed description of the invention
Scheme the structure chart of the device of liquid metal intraperitoneal perfusion and electrochemotherapy of the invention.
In figure, 1 is intraperitoneal perfusion end；2 extract end for abdominal cavity；3 be therapeutic electrode anode；4 be therapeutic electrode cathode；5 are
Extracorporeal power source；6 be temperature regulating device；7 be computer system；8 be circulation line, and 9 be pumping equipment, and 10 are infused for liquid metal
Bag.
Specific embodiment
The present invention is now illustrated with following most preferred embodiment, but is not intended to limit the scope of the invention.
Embodiment 1:
Such as Fig. 1, the device of a kind of liquid metal intraperitoneal perfusion and electrochemotherapy, including intraperitoneal perfusion end 1, abdominal cavity are extracted
End 2, therapeutic electrode anode 3, therapeutic electrode cathode 4, extracorporeal power source 5, temperature regulating device 6, computer system 7, liquid metal infusion
Bag 10；Wherein intraperitoneal perfusion end 1 and abdominal cavity are extracted end 2 and are connect with the liquid metal infusion bag, the abdomen with perfusion liquid metal
Chamber constitutes circulation loop 8 together, and setting is respectively used to there are two pumping equipment 9 to Peritoneal Infusions liquid gold on circulation loop
Belong to and extract out outward liquid metal.In the present embodiment, pumping equipment is peristaltic pump, and flow is adjustable；Pipeline on circulation loop
Material is rubber, uses preceding disinfection.
Temperature regulating device 6 is set outside liquid metal infusion bag, which connect with computer system 7；The temperature control
Device is integrated for electric heating wire.Therapeutic electrode anode 3 and therapeutic electrode cathode 4 are connect with extracorporeal power source 5, extracorporeal power source 5 and institute
State computer system connection.During electrochemotherapy, due to there is many liquid gold with good conductivity around therapeutic electrode
Belong to, it is likely that will cause short circuit, at this point, computer control system can automatically cut off the power the peace to guarantee patient and therapeutic process
Entirely.
Wherein, therapeutic electrode anode 3 is made of platinum filament, length 10cm, diameter 0.5mm；Therapeutic electrode cathode 4 is platinum
Silk is made, length 10cm, diameter 0.5mm.
Liquid metal is loaded in liquid metal infusion bag 10, the liquid metal is gallium-indium alloy (GaIn24.5, fusing point
It is 15.5 DEG C).
The application of device proposed by the present invention, comprising the following steps:
1. clinician does conventional Preoperative Method, sterilization of instruments is done, local anaesthesia is done to operation region of interest, completes liquid
The heating of metal infusion bag and wholly liquid state metal are perfused the disinfection of circulation loop and build.
2. determining the insertion position of intraperitoneal perfusion and the plant of electrochemotherapy electrode according to the operation plan being pre-designed
Enter scheme, and continue to monitor patient body temperature and various physical signs.
3. being first inserted into the injection end of liquid metal intraperitoneal perfusion according to the operation plan being pre-designed and extracting end.All
Liquid metal circumfusion mode is opened after normal.
4. being inserted into the therapeutic electrode of electrochemistry according to the operation plan being pre-designed, and input is suitable in a computer
Therapeutic scheme.If 5V DC voltage stimulates, stimulation time 10min.
5. needing to be monitored the temperature of input liquid metal, pump speed and electrochemical therapeutic during entire treatment by computer system
The stimulation process for the treatment of.
In short, accurate liquid metal intraperitoneal perfusion electrochemotherapy device provided by the invention, be a kind of minimal invasive can
Implement the treatment method of the electrochemical stimulation of large area to deep destination organization, it is contemplated that crucial make can be played in oncotherapy
With.
Embodiment 2:
The device of a kind of liquid metal intraperitoneal perfusion and electrochemotherapy, including intraperitoneal perfusion end 1, abdominal cavity are extracted end 2, are controlled
Treat electrode anode 3, therapeutic electrode cathode 4, extracorporeal power source 5, temperature regulating device 6, computer system 7, liquid metal infusion bag 10；Its
Middle intraperitoneal perfusion end 1 and abdominal cavity are extracted end 2 and are connect with the liquid metal infusion bag, the structure together with the abdominal cavity of perfusion liquid metal
At circulation loop 8, setting is respectively used to Peritoneal Infusions liquid metal and outward there are two pumping equipment 9 on circulation loop
Extract liquid metal out.In the present embodiment, pumping equipment is peristaltic pump, and flow is adjustable.The material of pipeline on circulation loop is silicon
Glue uses preceding disinfection.
Temperature regulating device 6 is set outside liquid metal infusion bag, which connect with computer system 7；The temperature control
Device is integrated for electric heating wire.Therapeutic electrode anode 3 and therapeutic electrode cathode 4 are connect with extracorporeal power source 5, extracorporeal power source 5 and institute
State computer system connection.During electrochemotherapy, due to there is many liquid gold with good conductivity around therapeutic electrode
Belong to, it is likely that will cause short circuit, at this point, computer control system can automatically cut off the power the peace to guarantee patient and therapeutic process
Entirely.
Wherein, therapeutic electrode anode 3 is made of platinum filament, length 15cm, diameter 0.8mm；Therapeutic electrode cathode 4 is platinum
Silk is made, length 15cm, diameter 0.8mm.
Liquid metal is loaded in liquid metal infusion bag 10, the liquid metal is gallium-indium alloy (GaIn24.5, fusing point
It is 15.5 DEG C).
Other are arranged with embodiment 1.
Above embodiment is only that preferred embodiments of the present invention will be described, is not carried out to the scope of the present invention
It limits, without departing from the spirit of the design of the present invention, this field ordinary engineering and technical personnel is to technical solution of the present invention
The all variations and modifications made, should fall within the scope of protection determined by the claims of the present invention.
Claims (8)
1. the device of a kind of liquid metal intraperitoneal perfusion and electrochemotherapy, which is characterized in that taken out including intraperitoneal perfusion end, abdominal cavity
Take end, therapeutic electrode anode, therapeutic electrode cathode, extracorporeal power source, temperature regulating device, computer system, liquid metal infusion bag；Institute
It states intraperitoneal perfusion end and abdominal cavity to extract end and connect with the liquid metal infusion bag, the control is set outside liquid metal infusion bag
Warm device, the temperature regulating device are connect with the computer system；The therapeutic electrode anode and therapeutic electrode cathode with it is described
Extracorporeal power source connection, the extracorporeal power source are connect with the computer system；
Wherein, the therapeutic electrode anode is directly contacted with liquid metal or liquid metal is arranged in around therapeutic electrode anode；
The therapeutic electrode cathode is directly contacted with liquid metal or liquid metal is arranged in around therapeutic electrode cathode.
2. the apparatus according to claim 1, which is characterized in that the intraperitoneal perfusion end passes through priming line and the liquid
The material of the connection of metal infusion bag, the priming line is rubber or silica gel, and the first pumping equipment is provided on priming line.
3. the apparatus according to claim 1, which is characterized in that extract end by extracting pipeline and the liquid in the abdominal cavity
The connection of metal infusion bag, the material for extracting pipeline is rubber or silica gel, and the second pumping equipment is provided on extraction tube road.
4. the apparatus according to claim 1, which is characterized in that the temperature regulating device is water bath equipment or electric heating wire.
5. the apparatus according to claim 1, which is characterized in that the therapeutic electrode just extremely platinum filament or filamentary silver is made, long
Degree is 10~20cm, and diameter is 0.5~1.2mm；The therapeutic electrode cathode is made of platinum filament or filamentary silver, length be 10~
20cm, diameter are 0.5~1.2mm.
6. any device of Claims 1 to 5, which is characterized in that be loaded with liquid gold in the liquid metal infusion bag
Belong to, the liquid metal is one of gallium, indium, tin or its alloy.
7. any device of Claims 1 to 5, which is characterized in that the extracorporeal power source is DC power supply, and supply voltage is
2~10V.
8. the system that any device of claim 1~7 combine with Sonography devices, in the system, treat electric
Treated position is accurately inserted into pole under the guidance of Sonography devices.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610343177.0A CN105920724B (en) | 2016-05-23 | 2016-05-23 | A kind of device of liquid metal intraperitoneal perfusion and electrochemotherapy |
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| CN201610343177.0A CN105920724B (en) | 2016-05-23 | 2016-05-23 | A kind of device of liquid metal intraperitoneal perfusion and electrochemotherapy |
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| CN105920724A CN105920724A (en) | 2016-09-07 |
| CN105920724B true CN105920724B (en) | 2019-02-26 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108525128B (en) * | 2018-03-26 | 2021-02-12 | 清华大学 | Application of liquid metal as tumor magnetic thermal therapy medium |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2788837Y (en) * | 2005-05-10 | 2006-06-21 | 杨明章 | Bipole gun type electrode for hemangiona therapeutical instrument |
| CN1961987A (en) * | 2005-11-08 | 2007-05-16 | 中国科学院理化技术研究所 | Electrode plate array heating device for whole body or local tumor thermotherapy |
| CN102949237A (en) * | 2011-08-24 | 2013-03-06 | 中国科学院理化技术研究所 | Probe heating device based on liquid metal |
| CN103127608A (en) * | 2013-01-22 | 2013-06-05 | 清华大学 | Manufacturing method of inner body injecting and molding type electronic device |
| CN103405289A (en) * | 2013-07-26 | 2013-11-27 | 清华大学 | Device based on liquid metal and used for repairing defective peripheral nerve function |
| CN103432624A (en) * | 2013-08-13 | 2013-12-11 | 清华大学 | Injectable liquid metal bone cement, preparation method of injectable liquid metal bone cement and special injection device for injectable liquid metal bone cement |
| CN105477747A (en) * | 2015-12-31 | 2016-04-13 | 海杰亚（北京）医疗器械有限公司 | Precise quantitative injection instrument with treatment material |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9278209B2 (en) * | 2013-09-06 | 2016-03-08 | Med-El Elektromedizinische Geraete Gmbh | Cochlear implant electrode with liquid metal alloy |
-
2016
- 2016-05-23 CN CN201610343177.0A patent/CN105920724B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2788837Y (en) * | 2005-05-10 | 2006-06-21 | 杨明章 | Bipole gun type electrode for hemangiona therapeutical instrument |
| CN1961987A (en) * | 2005-11-08 | 2007-05-16 | 中国科学院理化技术研究所 | Electrode plate array heating device for whole body or local tumor thermotherapy |
| CN102949237A (en) * | 2011-08-24 | 2013-03-06 | 中国科学院理化技术研究所 | Probe heating device based on liquid metal |
| CN103127608A (en) * | 2013-01-22 | 2013-06-05 | 清华大学 | Manufacturing method of inner body injecting and molding type electronic device |
| CN103405289A (en) * | 2013-07-26 | 2013-11-27 | 清华大学 | Device based on liquid metal and used for repairing defective peripheral nerve function |
| CN103432624A (en) * | 2013-08-13 | 2013-12-11 | 清华大学 | Injectable liquid metal bone cement, preparation method of injectable liquid metal bone cement and special injection device for injectable liquid metal bone cement |
| CN105477747A (en) * | 2015-12-31 | 2016-04-13 | 海杰亚（北京）医疗器械有限公司 | Precise quantitative injection instrument with treatment material |
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