CN105920724A - Device adopting intraperitoneal perfusion of liquid metal and electrochemotherapy - Google Patents
Device adopting intraperitoneal perfusion of liquid metal and electrochemotherapy Download PDFInfo
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- CN105920724A CN105920724A CN201610343177.0A CN201610343177A CN105920724A CN 105920724 A CN105920724 A CN 105920724A CN 201610343177 A CN201610343177 A CN 201610343177A CN 105920724 A CN105920724 A CN 105920724A
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- liquid metal
- therapeutic electrode
- transfusion bag
- intraperitoneal
- computer system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/12—Devices for heating or cooling internal body cavities
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0001—Body part
- A61F2007/0018—Trunk or parts thereof
- A61F2007/0022—Abdomen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/05—General characteristics of the apparatus combined with other kinds of therapy
- A61M2205/054—General characteristics of the apparatus combined with other kinds of therapy with electrotherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1021—Abdominal cavity
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- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Vascular Medicine (AREA)
- External Artificial Organs (AREA)
Abstract
The invention discloses a device adopting intraperitoneal perfusion of liquid metal and electrochemotherapy. The device comprises an intraperitoneal perfusion end, an intraperitoneal extraction end, a positive therapeutic electrode, a negative therapeutic electrode, an external power supply, a temperature control unit, a computer system and a liquid metal infusion bag, wherein the intraperitoneal perfusion end and the intraperitoneal extraction end are connected with the liquid metal infusion bag, and the temperature control unit is arranged outside the liquid metal infusion bag and connected with the computer system; the positive therapeutic electrode and the negative therapeutic electrode are connected with the external power supply, and the external power supply is connected with the computer system. According to the device, thermotherapy of the peritoneal cavity is completed through intraperitoneal perfusion of the liquid metal, the therapy area of the therapeutic electrodes is greatly increased in an electrochemotherapy process, and large-area electrochemotherapy of tumors can be rapidly completed.
Description
Technical field
The invention belongs to medical instruments field, be specifically related to the device of a kind of oncotherapy and answer
With.
Background technology
The health of the mankind in tumor serious threat, and the main method for the treatment of tumor has surgery hands at present
Art method, radiotherapy, amic therapy method, heating therapy and the most emerging electrochemotherapy method.Outward
Section's often wound of performing the operation is excessive, and healing is slow, and patient is long for recovery time, and the risk that operation exists is big.
Radiotherapy, while killing tumor cell, is easily reduced the immunity of patient self.Amic therapy method
Side effect relatively big, the most easily develop immunity to drugs.Heating therapy utilizes normal cell and tumor cell
Different to the tolerance of temperature, reach to kill tumor cell, normal cell is not made simultaneously
Become damage effect, even can significance strengthen patient's body immunity.Electrochemotherapy
Tumor, utilizes the ion in tissue fluid that redox reaction occurs near electrode, makes anode attached
Nearly PH reduces into acidity, makes the pH near negative electrode raise into alkalescence.Mainly utilize acid-base value
Change, kills tumor cell.
But, the treatment problem that present electrochemistry is run into is, the change of the acid-base value of local is only
It is present in the range of the surrounding about 2cm of electrode, and practical situation, the size of tumor is often
This numerical value can be exceeded, carry out reasonably so the treatment situation of reality is the size according to tumor
Cloth pin, the treatment of the tumor of a 5cm*5cm often to insert the therapeutic electrode of about ten
Can reach to fully treat effect, add more extra misery to patient.Along with liquid is soft
The appearance of property electronics, by the form of intraperitoneal perfusion, can greatly increase therapeutic electrode and group
The contact surface knitted, increases treatment area, without inserting the most unnecessary electrode.
Summary of the invention
In place of the deficiencies in the prior art, a kind of device is proposed.It is an object of the invention to:
By means of liquid metal intraperitoneal perfusion and electrochemotherapy means, it is provided that a kind of novel can be used for
The device of rapid large-area electrochemical treatment of tumors.
It is another object of the present invention to propose the application of described device.
The technical scheme realizing above-mentioned purpose of the present invention is:
A kind of liquid metal intraperitoneal perfusion and the device of electrochemotherapy, including intraperitoneal perfusion end,
Abdominal cavity extraction end, therapeutic electrode positive pole, therapeutic electrode negative pole, extracorporeal power source, temperature regulating device,
Computer system, liquid metal transfusion bag；Described intraperitoneal perfusion end and abdominal cavity extraction end are with described
Liquid metal transfusion bag connects, and arranges described temperature regulating device outside liquid metal transfusion bag, described
Temperature regulating device is connected with described computer system；Described therapeutic electrode positive pole and therapeutic electrode negative pole
Being connected with described extracorporeal power source, described extracorporeal power source is connected with described computer system.
Wherein, described intraperitoneal perfusion end is by priming line with described liquid metal transfusion bag even
Connecing, the material of described priming line is rubber or silica gel, is provided with the first pump on priming line
Send equipment；
Wherein, described abdominal cavity extraction end is by extraction pipeline with described liquid metal transfusion bag even
Connecing, the material of described extraction pipeline is rubber or silica gel, is provided with the second pump on extraction pipeline
Send equipment.
Preferably, described temperature regulating device is water bath equipment or electrical heating wire.
It is highly preferred that described therapeutic electrode the most extremely platinum filament or filamentary silver are made, a length of
10～20cm, a diameter of 0.5～1.2mm；Described therapeutic electrode negative pole is platinum filament or filamentary silver is made,
A length of 10～20cm, a diameter of 0.5～1.2mm.
Wherein, being loaded with liquid metal in described liquid metal transfusion bag, described liquid metal is
One in gallium, indium, stannum or its alloy.
Wherein, described extracorporeal power source is DC source, and supply voltage is 2～10V.
When the device that the present invention proposes uses, positive pole and negative pole are inserted in the target area needing treatment
Territory, in the current loop that positive pole, negative pole, target area are constituted, circuit not should be greater than 10mA.
The device that the present invention proposes application in oncotherapy.
The system that the device that the present invention proposes combines with Sonography devices.In this system, control
Treat electrode and can insert treated position accurately under the ultrasonic guiding waiting instrument.
The beneficial effects of the present invention is:
The device that the present invention proposes, utilizes liquid metal intraperitoneal perfusion to complete the thermotherapy to abdominal cavity,
During electrochemotherapy, substantially increase the treatment area of therapeutic electrode, can be rapid
Complete large-area tumor electrochemotherapy.
The present invention provides a kind of novel dress that can be used for rapid large-area electrochemical treatment of tumors
Put, the method using liquid metal intraperitoneal perfusion, by therapeutic electrode and liquid metal infusion liquid
Contact, it is possible to increase the treatment area of therapeutic electrode, or therapeutic electrode is not straight with liquid metal
Contact, also can the distribution of minor betterment therapeutic electrode surrounding electric field, it is possible to achieve only rely on two
Root therapeutic electrode just reaches large area and kills the effect of tumor cell.Meanwhile, by heating
Liquid metal intraperitoneal perfusion liquid, also can reach the effect of thermotherapy.
Accompanying drawing explanation
The liquid metal intraperitoneal perfusion of the figure present invention and the structure chart of the device of electrochemotherapy.
In figure, 1 is intraperitoneal perfusion end；2 extract end for abdominal cavity；3 is therapeutic electrode positive pole；4
For therapeutic electrode negative pole；5 is extracorporeal power source；6 is temperature regulating device；7 is computer system；8
For circulation line, 9 is pumping equipment, and 10 is liquid metal transfusion bag.
Detailed description of the invention
Now with following most preferred embodiment, the present invention is described, but is not limited to the model of the present invention
Enclose.
Embodiment 1:
Such as Fig. 1, a kind of liquid metal intraperitoneal perfusion and the device of electrochemotherapy, including abdominal cavity
Perfusion end 1, abdominal cavity extraction end 2, therapeutic electrode positive pole 3, therapeutic electrode negative pole 3, external electricity
Source 5, temperature regulating device 6, computer system 7, liquid metal transfusion bag 10；Wherein abdominal cavity fills
Note end 1 and abdominal cavity extraction end 2 are connected with described liquid metal transfusion bag, with perfusion liquid metal
Abdominal cavity constitute closed circuit 8 together, closed circuit is provided with two pumping equipments 9, point
Yong Yu be to Peritoneal Infusions liquid metal with outwards extract liquid metal out.In the present embodiment, pump
Sending equipment is peristaltic pump, and flow is adjustable；The material of the pipeline on closed circuit is rubber, uses
Front sterilization.
Temperature regulating device 6 is set outside liquid metal transfusion bag, this temperature regulating device and computer system
7 connect；Described temperature regulating device is that electrical heating wire is integrated.Therapeutic electrode positive pole 3 and therapeutic electrode
Negative pole 4 is connected with extracorporeal power source 5, and extracorporeal power source 5 is connected with described computer system.At electricity
In chemotherapy course, owing to there being the good liquid metal of a lot of electric conductivity around therapeutic electrode,
Being likely to cause short circuit, now, computer control system can automatically cut off power supply to ensure disease
People and the safety of therapeutic process.
Wherein, therapeutic electrode positive pole 3 is made for platinum filament, a length of 10cm, a diameter of 0.5mm；
Therapeutic electrode negative pole 4 is made for platinum filament, a length of 10cm, a diameter of 0.5mm.
Being loaded with liquid metal in liquid metal transfusion bag 10, described liquid metal is that gallium indium closes
Gold (GaIn24.5, fusing point is 15.5 DEG C).
The application of the device that the present invention proposes, comprises the following steps:
1. clinician does conventional Preoperative Method, does sterilization of instruments, to operation region of interest make-game
Portion anaesthetizes, and completes the heating of liquid metal transfusion bag, and wholly liquid state metal perfusion circulation loop
Sterilization and build.
2., according to the operation plan being pre-designed, determine on position and the electrification of intraperitoneal perfusion
Learn the implantation scheme of therapeutic electrode, and continue to monitor the body temperature of patient and various physical signs.
3., according to the operation plan being pre-designed, first insert the injection end of liquid metal intraperitoneal perfusion
With extraction end.Liquid metal circumfusion pattern is opened after all going well.
4., according to the operation plan being pre-designed, insert the therapeutic electrode of electrochemistry, and calculating
Machine inputs suitable therapeutic scheme.As 5V DC voltage stimulates, stimulation time 10min.
5. need by the temperature of computer system monitoring input liquid metal during whole treatment,
The stimulation process of pump speed and electrochemotherapy.
In a word, the accurate liquid metal intraperitoneal perfusion electrochemotherapy device that the present invention provides, be
A kind of deep destination organization can be implemented large-area electrochemical stimulation the treatment side of invasive
Method, it is contemplated that pivotal role can be played in oncotherapy.
Embodiment 2:
A kind of liquid metal intraperitoneal perfusion and the device of electrochemotherapy, including intraperitoneal perfusion end 1,
Abdominal cavity extraction end 2, therapeutic electrode positive pole 3, therapeutic electrode negative pole 3, extracorporeal power source 5, temperature control
Device 6, computer system 7, liquid metal transfusion bag 10；Wherein intraperitoneal perfusion end 1 and abdomen
Chamber extraction end 2 is connected with described liquid metal transfusion bag, together with the abdominal cavity of perfusion liquid metal
Constitute closed circuit 8, closed circuit is provided with two pumping equipments 9, is respectively used to abdomen
Intra-bladder instillation liquid metal and outwards extract liquid metal out.In the present embodiment, pumping equipment is compacted
Dynamic pump, flow is adjustable.The material of the pipeline on closed circuit is silica gel, uses front sterilization.
Temperature regulating device 6 is set outside liquid metal transfusion bag, this temperature regulating device and computer system
7 connect；Described temperature regulating device is that electrical heating wire is integrated.Therapeutic electrode positive pole 3 and therapeutic electrode
Negative pole 4 is connected with extracorporeal power source 5, and extracorporeal power source 5 is connected with described computer system.At electricity
In chemotherapy course, owing to there being the good liquid metal of a lot of electric conductivity around therapeutic electrode,
Being likely to cause short circuit, now, computer control system can automatically cut off power supply to ensure disease
People and the safety of therapeutic process.
Wherein, therapeutic electrode positive pole 3 is made for platinum filament, a length of 15cm, a diameter of 0.8mm；
Therapeutic electrode negative pole 4 is made for platinum filament, a length of 15cm, a diameter of 0.8mm.
Being loaded with liquid metal in liquid metal transfusion bag 10, described liquid metal is that gallium indium closes
Gold (GaIn24.5, fusing point is 15.5 DEG C).
Other arrange same embodiment 1.
Above embodiment is only to be described the preferred embodiment of the present invention, not to this
The scope of invention is defined, and on the premise of designing spirit without departing from the present invention, this area is general
Lead to various modification and improvement that technical scheme is made by engineers and technicians, all should fall
Enter in the protection domain that claims of the present invention determines.
Claims (9)
1. a liquid metal intraperitoneal perfusion and the device of electrochemotherapy, it is characterised in that
Including intraperitoneal perfusion end, abdominal cavity extraction end, therapeutic electrode positive pole, therapeutic electrode negative pole, external
Power supply, temperature regulating device, computer system, liquid metal transfusion bag；Described intraperitoneal perfusion end and
Abdominal cavity extraction end is connected with described liquid metal transfusion bag, arranges institute outside liquid metal transfusion bag
Stating temperature regulating device, described temperature regulating device is connected with described computer system；Described therapeutic electrode is just
Pole and therapeutic electrode negative pole are connected with described extracorporeal power source, described extracorporeal power source and described computer
System connects.
Device the most according to claim 1, it is characterised in that described intraperitoneal perfusion end
Being connected with described liquid metal transfusion bag by priming line, the material of described priming line is rubber
Glue or silica gel, be provided with the first pumping equipment on priming line.
Device the most according to claim 1, it is characterised in that described abdominal cavity extraction end
Being connected with described liquid metal transfusion bag by extraction pipeline, the material of described extraction pipeline is rubber
Glue or silica gel, be provided with the second pumping equipment on extraction pipeline.
Device the most according to claim 1, it is characterised in that described temperature regulating device is
Water bath equipment or electrical heating wire.
Device the most according to claim 1, it is characterised in that described therapeutic electrode is just
Extremely platinum filament or filamentary silver is made, a length of 10～20cm, a diameter of 0.5～1.2mm；Described control
Treat Electrode Negative and be platinum filament or filamentary silver is made, a length of 10～20cm, a diameter of 0.5～1.2mm.
6. the arbitrary described device of Claims 1 to 5, it is characterised in that described liquid metal
Be loaded with liquid metal in transfusion bag, described liquid metal be the one in gallium, indium, stannum or its
Alloy.
7. the arbitrary described device of Claims 1 to 5, it is characterised in that described extracorporeal power source
For DC source, supply voltage is 2～10V.
8. claim 1～7 arbitrary described device application in oncotherapy.
9. the system that the arbitrary described device of claim 1～7 combines with Sonography devices.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610343177.0A CN105920724B (en) | 2016-05-23 | 2016-05-23 | A kind of device of liquid metal intraperitoneal perfusion and electrochemotherapy |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610343177.0A CN105920724B (en) | 2016-05-23 | 2016-05-23 | A kind of device of liquid metal intraperitoneal perfusion and electrochemotherapy |
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| Publication Number | Publication Date |
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| CN105920724A true CN105920724A (en) | 2016-09-07 |
| CN105920724B CN105920724B (en) | 2019-02-26 |
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| CN201610343177.0A Active CN105920724B (en) | 2016-05-23 | 2016-05-23 | A kind of device of liquid metal intraperitoneal perfusion and electrochemotherapy |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108525128A (en) * | 2018-03-26 | 2018-09-14 | 清华大学 | Application of the liquid metal as tumour magnetic thermotherapy medium |
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| CN2788837Y (en) * | 2005-05-10 | 2006-06-21 | 杨明章 | Bipole gun type electrode for hemangiona therapeutical instrument |
| CN1961987A (en) * | 2005-11-08 | 2007-05-16 | 中国科学院理化技术研究所 | Electrode plate array heating device for whole body or local tumor thermotherapy |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108525128A (en) * | 2018-03-26 | 2018-09-14 | 清华大学 | Application of the liquid metal as tumour magnetic thermotherapy medium |
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| CN105920724B (en) | 2019-02-26 |
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