CN206660201U - A kind of abdominal thermal infusion equipment - Google Patents
A kind of abdominal thermal infusion equipment Download PDFInfo
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- CN206660201U CN206660201U CN201621396419.4U CN201621396419U CN206660201U CN 206660201 U CN206660201 U CN 206660201U CN 201621396419 U CN201621396419 U CN 201621396419U CN 206660201 U CN206660201 U CN 206660201U
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- abdominal
- silicone tube
- thermal infusion
- infusion equipment
- peristaltic pump
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Abstract
It the utility model is related to a kind of abdominal thermal infusion equipment.Described abdominal thermal infusion equipment is provided with and is pumped into system, pumping out system and thermocouple, the described system that is pumped into includes medicine storage bag, the first silicone tube, the first peristaltic pump, woven hose, first puncture needle and heat-exchange device, described pumping out system is provided with medicine collection bag, the second silicone tube, the second peristaltic pump, drain pipe and second puncture needle, and described thermocouple is used for the temperature for monitoring perfusion liquid abdominal cavity entry and outlet.Abdominal thermal infusion equipment of the present utility model is applied to establish abdominal thermal infusion treatment animal model, can significantly reduce infection rate, better tolerance, feasibility is high, significantly improves therapeutic effect, and simple in construction, and application is convenient, is adapted for scientific research.
Description
Technical field
Medical domain is the utility model is related to, specifically, is related to a kind of abdominal thermal infusion applied to animal model and sets
It is standby.
Background technology
Abdominal thermal infusion treatment (HIPEC) is that the perfusion liquid containing chemotherapeutics is filled into abdominal cavity, accurate constant temperature constant speed and followed
Ring irrigates certain time, intraperitoneal chemotherapy is combined with thermotherapy, direct killing effect of cancer cells, high temperature and chemotherapeutic by high temperature to tumour
Thing anti-tumor synergetic acts on and mechanical flushing action, and free intraperitoneal cancer cells, subclinical focus and small are removed to reach
The therapeutic action of cancerous node, so as to play a part of prevention and treatment to the transfer of colon cancer peritonaeum.High accuracy temperature control and high accuracy
Control rate of flooding is HIPEC key problem in technology, has collaboration to increase chemotherapeutic anticancer toxicity when temperature maintains 42~43 DEG C
Use is pretended, treatment time is that 60~90min is advisable.
Clinically existing more ripe technology is treated applied to abdominal thermal infusion, also discloses that some abdomens in the prior art
The hot perfusion equipment of chamber.Such as Chinese patent literature CN200510037071.X, publication date 2006.05.31, disclose a kind of abdominal cavity
Thermal infusion therapeutic equipment, it includes a heating chamber, at least two peristaltic pumps, a medicine storage bag, a perfusion infusion pipeline, drawing liquid transfusion
Pipeline, a circulation line, a control system and a display device；The perfusion infusion pipeline, drawing liquid infusion pipeline and circulation line
On respectively have a threeway and a temperature sensor；At least two peristaltic pump, display device and each temperature sensor are all connected to control
System processed, the perfusion infusion pipeline, drawing liquid infusion pipeline and circulation line are all connected to medicine storage bag.
In order to carry out the basic research of abdominal thermal infusion treatment, to verify its therapy mechanism and improve treatment method, generally
It is the abdominal thermal infusion treatment model for establishing toy, is tested on this basis.And by abdominal thermal infusion equipment application in
During animal, because humans and animals volume difference is big, direct application certainly will cause can not it is anticipated that normal work and studied,
And have not yet to see feasibility height, better tolerance, therapeutic effect can be significantly improved, and application is easily suitable for animal model
Abdominal thermal infusion treatment system.
The content of the invention
The purpose of this utility model is to be directed to deficiency of the prior art, there is provided a kind of abdominal thermal infusion equipment.
To achieve the above object, the utility model adopts the technical scheme that：
A kind of abdominal thermal infusion equipment, provided with system and pumping out system is pumped into, is additionally provided with thermocouple；Described is pumped into system
Including medicine storage bag, the first silicone tube, the first peristaltic pump, woven hose, first puncture needle and heat-exchange device, the first described silica gel
Pipe one end connects medicine storage bag, and the other end is connected with an end of woven hose, the other end connection first puncture needle of woven hose,
The centre portion of first silicone tube is installed on the first peristaltic pump, and described heat-exchange device is used for the perfusion liquid of heated transportation；
Described pumping out system is provided with medicine collection bag, the second silicone tube, the second peristaltic pump, drain pipe and second puncture needle, described
Second silicone tube one end connects medicine collection bag, and the other end is connected with an end of drain pipe, and the other end of drain pipe connects
Second puncture needle is connect, the centre portion of the second silicone tube is installed on the second peristaltic pump；Described thermocouple, which is used to monitor, to be irrigated
Liquid abdominal cavity entry and the temperature of outlet.
Preferably, the first silicone tube between described heat-exchange device and the first peristaltic pump and medicine storage bag is contacted to heat
The perfusion liquid of conveying.
Preferably, described thermocouple is provided with two thermocouple wires, and described two thermocouple wires one go out liquid by woven hose
The through hole of end is inserted in the cavity of woven hose, and another through hole by drain pipe feed liquor end is inserted in the chamber of drain pipe
In vivo.
Preferably, described heat-exchange device is the constant temperature water bath apparatus with having heaters.
Preferably, described heat-exchange device is Shanghai Rong Feng digital display thermostatic water-circulator bath pot 501A types.
The utility model advantage is：
1st, abdominal thermal infusion equipment of the present utility model is applied to animal, connects abdominal cavity using puncturing, can significantly reduce sense
Dye rate, better tolerance, and avoid modus operandi and cause animal discomfort for influence caused by experimental result；
2nd, abdominal thermal infusion equipment of the present utility model uses open perfusion system, and it is thin can fully to remove free cancer
Material of born of the same parents and tumor microenvironment release etc., is remarkably improved therapeutic effect, can more accurately investigate decoction or abdominal thermal infusion
The therapeutic effect of Therapeutic mode, in addition, open perfusion system can obviously improve the cancer dissociated in closed circulation perfusion loop
The problem of cell blocking pipeline；
3rd, abdominal thermal infusion equipment of the present utility model high accuracy temperature control and can control the flow velocity of perfusion liquid, and feasibility is high,
Significantly improve therapeutic effect；
4th, abdominal thermal infusion device structure of the present utility model is simple, and application is convenient, is convenient for scientific research.
Brief description of the drawings
The part composition schematic diagram of Fig. 1 abdominal thermal infusion equipment of the present utility model.
Fig. 2 abdominal thermal infusion equipment working state schematic diagrames of the present utility model.
Fig. 3 living imagings observe pretherapy and post-treatment fluorescence intensity change situation.Group I control group control, organize II tail veins
Administration group t1, dosage 2mg/m2, group III 37 DEG C of intraperitoneal perfusions standard dose t2, dosage 3.75mg/m2, organize 37 DEG C of abdomens of IV
Chamber irrigates high dose t3, dosage 7.5mg/m2, V groups 43 DEG C of abdominal thermal infusions standard dose t4, dosage 3.75mg/m2, VI groups
43 DEG C of abdominal thermal infusions high dose t5, dosage 7.5mg/m2。
Fig. 4 Anatomical Observations respectively form knurl situation.Group I control group control, organize II tail vein administration group t1, agent
Measure as 2mg/m2, group III 37 DEG C of intraperitoneal perfusions standard dose t2, dosage 3.75mg/m2, organize 37 DEG C of high agent of intraperitoneal perfusion of IV
Measure t3, dosage 7.5mg/m2, V groups 43 DEG C of abdominal thermal infusions standard dose t4, dosage 3.75mg/m2, 43 DEG C of abdominal cavity heat of VI groups
Irrigate high dose t5, dosage 7.5mg/m2。
Embodiment
Embodiment provided by the invention is elaborated below in conjunction with the accompanying drawings.
Present inventor possesses abundant research experience in abdominal thermal infusion clinical treatment and basic research field, especially
It is reported in currently available technology in still few abdominal thermal infusion basic research, and inventor, which attempts to establish abdominal thermal infusion, to be controlled
Animal model is treated, and pays attention to observing and thinks deeply summary, it is appreciated that problems with：(1) animal model (such as tumor bearing nude mice) constitution
Weakness, it is not suitable for carrying out laparotomy ventrotomy, Infection in operation probability is high, and the rate that causes death is higher, influences the accurate of experimental result statistics
Degree；(2) clinical abdominal thermal infusion equipment uses closed loop, has the filling that membrane filtration pumps out in closed loop
Fluid injection, and the cancer cell and liquid mass-energy actually in transfer stove are cut, but part cancer cell and the thing of tumor microenvironment release
Matter, which differs, to be surely removed, and still enters abdominal cavity after circumfusion, remaining material may further promote transfer.It is based on
Problem above etc., present inventor have developed the abdominal thermal infusion equipment suitable for lotus knurl model mice, and carry out treatment
The foundation and correlative study of model.
Reference is as follows：
1. being pumped into system, 11. medicine storage bags, 12. first silicone tubes, 13. first peristaltic pumps, 14. woven hoses, 15. first wear
Pricker, 16. heat-exchange devices
2. pumping out system, 21. collection bags, 22. second silicone tubes, 23. second peristaltic pumps, 24. drain pipes, 25. second wear
Pricker
3. thermocouple, 31. thermocouple wires
Embodiment 1
Fig. 1 is referred to, Fig. 1 is the part composition schematic diagram of abdominal thermal infusion equipment of the present utility model.Described abdominal cavity
Hot perfusion equipment is provided with and is pumped into system 1, pumping out system 2 and thermocouple 3.The described system 1 that is pumped into includes medicine storage bag 11, the first silicon
Sebific duct 12, the first peristaltic pump 13, woven hose 14, first puncture needle 15 and heat-exchange device 16, the first described silicone tube 12 1
End connection medicine storage bag 11, the other end are connected with an end of woven hose 14, and the other end connection first of woven hose 14 punctures
Pin 15, the centre portion of the first described silicone tube 12 are installed on the first peristaltic pump 13, described heat-exchange device 16 and
The first silicone tube 12 between one peristaltic pump 13 and medicine storage bag 11 contacts the perfusion liquid with heated transportation.Described pumping out system 2
Provided with medicine collection bag 21, the second silicone tube 22, the second peristaltic pump 23, drain pipe 24 and second puncture needle 25, described second
The one end of silicone tube 22 connection medicine collection bag 21, the other end is connected with an end of drain pipe 24, the other end of drain pipe 24
Portion connects second puncture needle 25, and the centre portion of the second described silicone tube 22 is installed on the second peristaltic pump 23.Described heat
Galvanic couple 3 is provided with two thermocouple wires 31, and 31 through holes by the outlet end portion of woven hose 14 of described two thermocouple wires are inserted in
In the cavity of woven hose 14, another through hole by the feed liquor end of drain pipe 24 is inserted in the cavity of drain pipe 24.
The operation principle and process of abdominal thermal infusion equipment of the present utility model be：Fig. 2 is referred to, Fig. 2 is that this practicality is new
The abdominal thermal infusion equipment working state schematic diagram of type.Before the treatment starts, connecting components, 1% yellow Jackets are used
Animal is anaesthetized, dorsal position is fixed on operating table, and belly is cleaned with 75% alcohol.First puncture needle 15 and second are worn
The puncture of pricker 25 is intraperitoneal into animal, and site of puncture is located at the left end and right-hand member in abdominal cavity respectively, to simulate it in intraperitoneal punching
The process washed.Heat-exchange device 16, the first peristaltic pump 13, the second peristaltic pump 23, thermocouple 3 are then turned on, perfusion liquid first passes through
Heat-exchange device 16 heats, and is pumped into woven hose 14 through the first silicone tube 12 by the first peristaltic pump 13, then going out in woven hose 14
It is then thin together with free cancer by the thermometric of thermocouple wire 31 of thermocouple 3 at liquid mouth, then through first puncture needle 15 into animal abdominal cavity
Born of the same parents and liquid matter enter the first silicone tube 22 through second puncture needle 25, drain pipe 24, and by the thermometric of thermocouple wire 31 of thermocouple 3,
It is pumped out in the presence of second peristaltic pump 23 to medicine collection bag 21, to play therapeutic effect.Above procedure should be in desinfection chamber
Middle progress, ambient stable, and should irrigate physiological saline before perfusion drug containing perfusion liquid treatment reaches temperature in peritoneal cavity in 10 minutes
43 DEG C or so, to play optimum therapeuticing effect.
It should be noted that abdominal thermal infusion treatment is placed transfusion using laparotomy ventrotomy or goes out liquid by the utility model
Silicone tube is changed to be irrigated using lancet puncture abdominal cavity, this has broken normal mode, it is contemplated that the lotus knurl having a delicate constitution
The toys such as nude mice do not tolerate for operation technique, and operation technique is for bad shadow caused by experimental result accuracy
Ring, can effectively reduce the probability of postoperative infection, improve experiment result accuracy.Filled in the prior art using closed loop
Note, and the utility model is broken the normal procedure, and has used open perfusion system, this kind of pattern can fully remove free cancer cell
Material discharged with tumor microenvironment etc., significantly improves therapeutic effect, in order to more objectively investigate decoction or abdominal thermal infusion
The therapeutic effect of Therapeutic mode, in addition, open perfusion system can obviously improve the cancer dissociated in closed circulation perfusion loop
The problem of cell blocking pipeline.Described the first peristaltic pump 13 and the second peristaltic pump 23 is a kind of liquid conveying of controllable flow velocity
Device, the filling process of stable low speed can be maintained after flow velocity is set, ensures that stable experiment continues.Described heat-exchange device 16
For being heated to perfusion liquid, the constant temperature water bath apparatus with having heaters can be used, it heats up, and rapid, safety, the thermal efficiency are high,
It can provide effective heat storage function sustainable constant temperature simultaneously, and specifically, it is preferable to using Shanghai Rong Feng digital display thermostatic water-circulator bath pots
There is adjutage in 501A types, its water-bath left side, is electric boxs on the right side of water-bath, temperature controller is housed on electric box front panel
Table, power switch, there are electric heating tube and temperature sensor in electric box, its temperature control system employs high-quality electronic component,
Temperature control is sensitive, dependable performance, easy to use, and operation principle is：The temperature transition of water trough inner water is resistance value by temperature sensor,
After amplification, comparison by integrated amplifier, output control signal, the average heating power of electric heating tube is efficiently controlled, is made
Water in tank keeps constant temperature.Can high accuracy temperature control using this heat-exchange device.Described thermocouple 3 is used for perfusion liquid abdominal cavity
The temperature of entrance and exit is monitored, and persistently records temperature change, abdominal cavity entry temperature-controlled precision≤0.6 over the course for the treatment of
DEG C, realize high accuracy temperature control.
Embodiment 2
Nude mice abdominal cavity injection cell suspension structure peritonaeum metastasis model.By colon cancer 116-luc cells with 2.5*106It is individual thin
Born of the same parents/only amount be inoculated in BALB/c nude mice abdominal cavities.After tumour growth 10 days, nude mice is randomly divided into 6 groups, every group 6 dynamic
Thing：Group I control groups (n=6), group II tail veins administration group (n=6), dosage 2mg/m2, organize 37 DEG C of intraperitoneal perfusion standards of III
Dosage (n=6), dosage 3.75mg/m2, organize 37 DEG C of intraperitoneal perfusion high doses (n=6) of IV, dosage 7.5mg/m2, V groups 43
DEG C abdominal thermal infusion standard dose (n=6), dosage 3.75mg/m2, 43 DEG C of abdominal thermal infusion high doses (n=6) of VI groups, agent
Measure as 7.5mg/m2.Adjustment perfusion flow velocity is 6mL/min.
Equipment uses the abdominal thermal infusion equipment of embodiment 1.Intraperitoneal constant temperature is between 42 DEG C to 43 DEG C.Filling
After the temperature of fluid injection reaches the temperature of needs, Continuous Perfusion 30min.After perfusion terminates, with saline infusions abdominal cavity
10min, remove device for casting.Living imaging is shot when being inoculated with 1 week, 2 weeks, 3 weeks respectively, observes fluorescence intensity and regional change
Situation, the drug effect of more different therapeutic modalities.
Pretherapy and post-treatment fluorescence intensity change situation and into knurl situation respectively as shown in Figure 3 and Figure 4, and in whole experiment process
Without animal dead.Result above shows that abdominal thermal infusion equipment of the present utility model can for establishing thermo-chemotherapy animal model
Row is high, and animal is resistant to, and this kind of thermo-chemotherapy method significantly suppress the growth of intraperitoneal tumor, achieve excellent control
Therapeutic effect.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
Member, on the premise of the inventive method is not departed from, can also make some improvement and supplement, and these are improved and supplement also should be regarded as
Protection scope of the present invention.
Claims (5)
1. a kind of abdominal thermal infusion equipment, provided with being pumped into system and pumping out system, it is characterised in that be additionally provided with thermocouple；It is described
The system that is pumped into include medicine storage bag, the first silicone tube, the first peristaltic pump, woven hose, first puncture needle and heat-exchange device, it is described
First silicone tube one end connection medicine storage bag, the other end is connected with an end of woven hose, the other end connection of woven hose
First puncture needle, the centre portion of the first silicone tube are installed on the first peristaltic pump, and described heat-exchange device is defeated for heating
The perfusion liquid sent；Described pumping out system is provided with medicine collection bag, the second silicone tube, the second peristaltic pump, drain pipe and second and worn
Pricker, second described silicone tube one end connection medicine collection bag, the other end are connected with an end of drain pipe, drain pipe
The other end connects second puncture needle, and the centre portion of the second silicone tube is installed on the second peristaltic pump；Described thermocouple is used
Temperature in monitoring perfusion liquid abdominal cavity entry and outlet.
2. abdominal thermal infusion equipment according to claim 1, it is characterised in that described heat-exchange device and first is wriggled
The first silicone tube between pump and medicine storage bag is contacted with the perfusion liquid of heated transportation.
3. abdominal thermal infusion equipment according to claim 1, it is characterised in that described thermocouple is provided with two galvanic couples
Silk, a piece through hole by woven hose outlet end portion of described two thermocouple wires are inserted in the cavity of woven hose, and another logical
The through hole for crossing drain pipe feed liquor end is inserted in the cavity of drain pipe.
4. abdominal thermal infusion equipment according to claim 1, it is characterised in that described heat-exchange device is with heating
The constant temperature water bath apparatus of device.
5. abdominal thermal infusion equipment according to claim 4, it is characterised in that described heat-exchange device is Shanghai Rong Feng
Digital display thermostatic water-circulator bath pot 501A types.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201621396419.4U CN206660201U (en) | 2016-12-19 | 2016-12-19 | A kind of abdominal thermal infusion equipment |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201621396419.4U CN206660201U (en) | 2016-12-19 | 2016-12-19 | A kind of abdominal thermal infusion equipment |
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| CN206660201U true CN206660201U (en) | 2017-11-24 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106540347A (en) * | 2016-12-19 | 2017-03-29 | 复旦大学附属肿瘤医院 | A kind of abdominal thermal infusion equipment and abdominal thermal infusion treat the method for building up of animal model |
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2016
- 2016-12-19 CN CN201621396419.4U patent/CN206660201U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106540347A (en) * | 2016-12-19 | 2017-03-29 | 复旦大学附属肿瘤医院 | A kind of abdominal thermal infusion equipment and abdominal thermal infusion treat the method for building up of animal model |
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