CN106540313A - A kind of superabsorbent water hemostatic material in medical use and its preparation technology - Google Patents
A kind of superabsorbent water hemostatic material in medical use and its preparation technology Download PDFInfo
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- CN106540313A CN106540313A CN201611118872.3A CN201611118872A CN106540313A CN 106540313 A CN106540313 A CN 106540313A CN 201611118872 A CN201611118872 A CN 201611118872A CN 106540313 A CN106540313 A CN 106540313A
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- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
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- A—HUMAN NECESSITIES
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- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/108—Specific proteins or polypeptides not covered by groups A61L24/102 - A61L24/106
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/112—Phosphorus-containing compounds, e.g. phosphates, phosphonates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/202—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with halogen atoms, e.g. triclosan, povidone-iodine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Abstract
The invention discloses a kind of superabsorbent water hemostatic material in medical use and its preparation technology, its hemostatic material includes following components：Shitosan, cross linked polyacrylate, starch acrylic acid graft copolymer, plant polyose, cervus and cucumis polypeptide, sephadex, aluminum phosphate, coir fibre, bamboo powder, bata-carotene, Vitwas E, PVP-I, trihydroxymethylpropanyltri diglycidyl ether, expoxy propane, granatenine, humic acid, mabi saponin(e, ethyl ester benzyl ester, azone.The haemostatic effect of hemostatic material in medical use prepared by the present invention is good and speed is fast；Simultaneously the absorptivity of hemostatic material in medical use is high, and uptake is big, and it is larger compared with depth and the big situation of amount of bleeding is used to be especially suitable for wound, is also beneficial to the recovery of wound.
Description
Technical field
The invention belongs to medical material tech field, and in particular to a kind of superabsorbent water hemostatic material in medical use and its preparation work
Skill.
Background technology
Hemostasis is an important step of emergency medical treatment, sudden wound occurs in corrective surgery treatment, daily life
When hindering, it is both needed to carry out quick-acting haemostatic powder, especially during emergency treatment in prominent event, realization is fast and effectively stopped blooding to patient
Life security it is most important.At present, the wide variety of hemostatic material, common are powder, spongy, foam-like, film
Shape, flake, tabular, plain weave are netted, non-woven fabric-like etc., wherein spongiform hemostatic material is most wide in clinical practice, but
Which absorbs the combination properties such as the attaching performance of tissue of sepage ability, absorptivity, mechanical property, anthemorrhagic speed and bleeding site
Also undesirable, haemostatic effect is not good.Experimental study shows that the Water absorption and water retention of hemostatic material in medical use is bigger, absorb and
Keep the effect of body fluid stronger, be more conducive to the recovery of wound or the control of amount of bleeding in surgical procedure, can reach good
Good haemostatic effect.Thus, we research and develop a kind of superabsorbent water hemostatic material in medical use of quick-acting haemostatic powder, to meet various clinical practices
Demand.
The content of the invention
For this purpose, the present invention provides a kind of superabsorbent water hemostatic material in medical use and its preparation technology, in solution prior art at least
A kind of technical problem.
For this purpose, the present invention provides a kind of superabsorbent water hemostatic material in medical use, including the component of following weight portion：Shitosan 28-
36 parts, cross linked polyacrylate 8-14 parts, starch acrylic acid graft copolymer 5-10 parts, plant polyose 3-7 parts, cervus and cucumis polypeptide 3-6
Part, sephadex 4-9 parts, aluminum phosphate 5-11 parts, coir fibre 3-8 parts, bamboo powder 1-4 part, beta carotene 2-6 parts, dimension
Raw element E acetate 1-4 parts, PVP-I 0.5-2 parts, trihydroxymethylpropanyltri diglycidyl ether 2-5 parts, expoxy propane 0.6-
1.3 parts, granatenine 1.2-3.5 parts, humic acid 2.4-5 parts, mabi saponin(e 3.6-5 parts, ethyl ester benzyl ester 6-9 part, azone 5-10
Part.
An embodiment of the invention, wherein, the plant polyose is white dextrin, cellulose, locust bean gum, melon
In that bean gum and pectin at least two.
An embodiment of the invention, wherein, including the component of following weight portion：Shitosan 29-34 parts, crosslinking
Polyacrylic acid 10-13 parts, starch acrylic acid graft copolymer 6-9.5 parts, plant polyose 3.8-6.2 parts, cervus and cucumis polypeptide 3.5-5.3
Part, sephadex 4.2-8 parts, aluminum phosphate 5.5-9 parts, coir fibre 3.6-7.4 parts, bamboo powder 1.8-3.5 part, β-Hu Luo
Bu Su 2.4-5.3 parts, Vitwas E 1.8-3.6 parts, PVP-I 0.7-1.6 parts, trimethylolpropane tris glycidol
Ether 2.5-4.2 parts, expoxy propane 0.8-1.1 parts, granatenine 1.6-3.2 parts, humic acid 2.8-4.3 parts, mabi saponin(e 3.8-
4.6 parts, ethyl ester benzyl ester 6.5-8 part, azone 6.2-9 parts.
An embodiment of the invention, wherein, including the component of following weight portion：33 parts of shitosan, crosslinking are poly-
11.5 parts of acrylic acid, 7.8 parts of starch acrylic acid graft copolymer, 4.6 parts of plant polyose, 4 parts of cervus and cucumis polypeptide, sephadex
6 parts of glue, 6.3 parts of aluminum phosphate, 4.5 parts of coir fibre, 2.2 parts of bamboo powder, 3.6 parts of beta carotene, 2.4 parts of Vitwas E,
1.2 parts of PVP-I, 2.8 parts of trihydroxymethylpropanyltri diglycidyl ether, expoxy propane 0.9, granatenine 2.4, humic acid 3.5
Part, 4 parts of mabi saponin(e, 7.4 parts of ethyl ester benzyl ester, 8.2 parts of azone.
For this purpose, the present invention provides the preparation technology of superabsorbent water hemostatic material in medical use, including following preparation processes：
Step 1）Shitosan, cross linked polyacrylate and starch acrylic acid graft copolymer are added in half acetic acid, stirring and dissolving,
Mixed solution is made, it is standby；Coir fibre, bamboo powder are placed in crucible, in an inert atmosphere, 2-4 are calcined at 300-500 DEG C
Hour, it is standby；
Step 2）Plant polyose, sephadex, granatenine and humic acid are added in second half acetic acid, at 0-5 DEG C
Under, with the speed stirring 40-80min of 300-800rpm, it is subsequently adding Vitwas E, ethyl ester benzyl ester, azone, aluminum phosphate
With step 1）In calcined powder, be warming up to 40-70 DEG C, with the speed of 300-800rpm stirring 50-120min；
Step 3）By step 1）In mixed solution and step 2）The solution ultrasonic mixing of preparation is uniform, then sequentially adds mabi
Saponin(e, beta carotene, cervus and cucumis polypeptide, PVP-I, expoxy propane, trihydroxymethylpropanyltri diglycidyl ether, continue ultrasound
15-40min, pours in grinding tool；
Step 4）Freeze-drying obtains freeze-dried powder, and Jing Co radiation sterilization is processed, and obtains final product superabsorbent water hemostatic material in medical use.
An embodiment of the invention, wherein, in step 1）In, calcine 3 hours at 350 DEG C.
An embodiment of the invention, wherein, in step 2）In, at 0-5 DEG C, stirred with the speed of 550rpm
60min；In step 2）In, 60 DEG C are warming up to, with the speed stirring 100min of 500rpm.
An embodiment of the invention, wherein, in step 3）In, ultrasonic power is 80-200W, and ultrasonic temperature is
40-60℃。
Beneficial effects of the present invention are：
The gross hemostasis rate of hemostatic material in medical use prepared by the present invention is up to 98.3%, and bleeding stopping period is 65 ± 2 ~ 72 ± 2s, haemostatic effect
Get well and speed is fast；The absorptivity of hemostatic material in medical use is high simultaneously, is up to more than 125g/g to the absorbency of physiological saline, to people
The absorbency of work blood is up to 105g/g, and uptake is big, and it is larger compared with depth and the big situation of amount of bleeding is used to be especially suitable for wound,
It is also beneficial to the recovery of wound.
Specific embodiment
With reference to embodiment, the present invention is described in further detail.Following examples are used to illustrate the present invention, but not
For limiting the scope of the present invention.
Embodiment 1
A kind of superabsorbent water hemostatic material in medical use, including the component of following weight portion：28 parts of shitosan, 8 parts of cross linked polyacrylate, shallow lake
5 parts of powder acrylic acid graft copolymer, 3 parts of plant polyose, 3 parts of cervus and cucumis polypeptide, 4 parts of sephadex, 5 parts of aluminum phosphate, coconut palm
3 parts of case fibre, 1 part of bamboo powder, 2 parts of beta carotene, 1 part of Vitwas E, 0.5 part of PVP-I, trimethylolpropane tris
2 parts of glycidol ether, 0.6 part of expoxy propane, 1.2 parts of granatenine, 2.4 parts of humic acid, 3.6 parts of mabi saponin(e, ethyl ester benzyl ester 6
Part, 5 parts of azone.
The plant polyose is white dextrin, the mixture of cellulose, and both weight ratios are 3:1.
The preparation technology of the superabsorbent water hemostatic material in medical use, including following preparation processes：
Step 1）Shitosan, cross linked polyacrylate and starch acrylic acid graft copolymer are added in half acetic acid, stirring and dissolving,
Mixed solution is made, it is standby；Coir fibre, bamboo powder are placed in crucible, in an inert atmosphere, are calcined 2 hours at 300 DEG C,
It is standby；
Step 2）Plant polyose, sephadex, granatenine and humic acid are added in second half acetic acid, at 0-5 DEG C
Under, with the speed stirring 40min of 300pm, it is subsequently adding Vitwas E, ethyl ester benzyl ester, azone, aluminum phosphate and step 1）
In calcined powder, be warming up to 40 DEG C, with the speed of 300rpm stirring 50min；
Step 3）By step 1）In mixed solution and step 2）The solution ultrasonic mixing of preparation is uniform, then sequentially adds mabi
Saponin(e, beta carotene, cervus and cucumis polypeptide, PVP-I, expoxy propane, trihydroxymethylpropanyltri diglycidyl ether, continue ultrasound
15min, pours in grinding tool, and wherein ultrasonic power is 80W, and ultrasonic temperature is 40 DEG C；
Step 4）Freeze-drying obtains freeze-dried powder, and Jing Co radiation sterilization is processed, and obtains final product superabsorbent water hemostatic material in medical use.
Embodiment 2
A kind of superabsorbent water hemostatic material in medical use, including the component of following weight portion：36 parts of shitosan, 14 parts of cross linked polyacrylate,
0 part of starch acrylic acid graft copolymer 1,7 parts of plant polyose, 6 parts of cervus and cucumis polypeptide, 9 parts of sephadex, aluminum phosphate 11
Part, 8 parts of coir fibre, 4 parts of bamboo powder, 6 parts of beta carotene, 4 parts of Vitwas E, 2 parts of PVP-I, trimethylolpropane
5 parts of triglycidyl ether, 1.3 parts of expoxy propane, 3.5 parts of granatenine, 5 parts of humic acid, 5 parts of mabi saponin(e, ethyl ester benzyl ester 9
Part, 10 parts of azone.
Mixture of the plant polyose for locust bean gum, guar gum and pectin, and the weight ratio of three is 4:2:1.
The preparation technology of the superabsorbent water hemostatic material in medical use, including following preparation processes：
Step 1）Shitosan, cross linked polyacrylate and starch acrylic acid graft copolymer are added in half acetic acid, stirring and dissolving,
Mixed solution is made, it is standby；Coir fibre, bamboo powder are placed in crucible, in an inert atmosphere, are calcined 4 hours at 500 DEG C,
It is standby；
Step 2）Plant polyose, sephadex, granatenine and humic acid are added in second half acetic acid, at 0-5 DEG C
Under, with the speed stirring 80min of 800rpm, it is subsequently adding Vitwas E, ethyl ester benzyl ester, azone, aluminum phosphate and step 1）
In calcined powder, be warming up to 70 DEG C, with the speed of 800rpm stirring 120min；
Step 3）By step 1）In mixed solution and step 2）The solution ultrasonic mixing of preparation is uniform, then sequentially adds mabi
Saponin(e, beta carotene, cervus and cucumis polypeptide, PVP-I, expoxy propane, trihydroxymethylpropanyltri diglycidyl ether, continue ultrasound
40min, pours in grinding tool, and wherein ultrasonic power is 200W, and ultrasonic temperature is 60 DEG C；
Step 4）Freeze-drying obtains freeze-dried powder, and Jing Co radiation sterilization is processed, and obtains final product superabsorbent water hemostatic material in medical use.
Embodiment 3
A kind of superabsorbent water hemostatic material in medical use, including the component of following weight portion：29 parts of shitosan, 10 parts of cross linked polyacrylate,
6 parts of starch acrylic acid graft copolymer, 3.8 parts of plant polyose, 3.5 parts of cervus and cucumis polypeptide, 4.2 parts of sephadex, phosphoric acid
5.5 parts of aluminium, 3.6 parts of coir fibre, 1.8 parts of bamboo powder, 2.4 parts of beta carotene, 1.8 parts of Vitwas E, PVP-I 0.7
Part, 2.5 parts of trihydroxymethylpropanyltri diglycidyl ether, 0.8 part of expoxy propane, 1.6 parts of granatenine, 2.8 parts of humic acid, mabi
3.8 parts of saponin(e, 6.5 parts of ethyl ester benzyl ester, 6.2 parts of azone.
Mixture of the plant polyose for white dextrin, locust bean gum and pectin, and the weight ratio of three is 1:3:2.
The preparation technology of the superabsorbent water hemostatic material in medical use, including following preparation processes：
Step 1）Shitosan, cross linked polyacrylate and starch acrylic acid graft copolymer are added in half acetic acid, stirring and dissolving,
Mixed solution is made, it is standby；Coir fibre, bamboo powder are placed in crucible, in an inert atmosphere, are calcined 3 hours at 380 DEG C,
It is standby；
Step 2）Plant polyose, sephadex, granatenine and humic acid are added in second half acetic acid, at 0-5 DEG C
Under, with the speed stirring 60min of 500rpm, it is subsequently adding Vitwas E, ethyl ester benzyl ester, azone, aluminum phosphate and step 1）
In calcined powder, be warming up to 60 DEG C, with the speed of 700rpm stirring 90min；
Step 3）By step 1）In mixed solution and step 2）The solution ultrasonic mixing of preparation is uniform, then sequentially adds mabi
Saponin(e, beta carotene, cervus and cucumis polypeptide, PVP-I, expoxy propane, trihydroxymethylpropanyltri diglycidyl ether, continue ultrasound
25min, pours in grinding tool, and wherein ultrasonic power is 150W, and ultrasonic temperature is 50 DEG C；
Step 4）Freeze-drying obtains freeze-dried powder, and Jing Co radiation sterilization is processed, and obtains final product superabsorbent water hemostatic material in medical use.
Embodiment 4
A kind of superabsorbent water hemostatic material in medical use, including the component of following weight portion：34 parts of shitosan, 13 parts of cross linked polyacrylate,
9.5 parts of starch acrylic acid graft copolymer, 6.2 parts of plant polyose, 5.3 parts of cervus and cucumis polypeptide, 8 parts of sephadex, phosphoric acid
9 parts of aluminium, 7.4 parts of coir fibre, 3.5 parts of bamboo powder, 5.3 parts of beta carotene, 3.6 parts of Vitwas E, PVP-I 1.6
Part, 4.2 parts of trihydroxymethylpropanyltri diglycidyl ether, 1.1 parts of expoxy propane, 3.2 parts of granatenine, 4.3 parts of humic acid, mabi
4.6 parts of saponin(e, 8 parts of ethyl ester benzyl ester, 9 parts of azone.
The plant polyose is cellulose, locust bean gum, the mixture of guar gum, and the weight ratio of three is 5:3:1.
The preparation technology of the superabsorbent water hemostatic material in medical use, including following preparation processes：
Step 1）Shitosan, cross linked polyacrylate and starch acrylic acid graft copolymer are added in half acetic acid, stirring and dissolving,
Mixed solution is made, it is standby；Coir fibre, bamboo powder are placed in crucible, in an inert atmosphere, are calcined 3 hours at 420 DEG C,
It is standby；
Step 2）Plant polyose, sephadex, granatenine and humic acid are added in second half acetic acid, at 0-5 DEG C
Under, with the speed stirring 75min of 650rpm, it is subsequently adding Vitwas E, ethyl ester benzyl ester, azone, aluminum phosphate and step 1）
In calcined powder, be warming up to 60 DEG C, with the speed of 450rpm stirring 90min；
Step 3）By step 1）In mixed solution and step 2）The solution ultrasonic mixing of preparation is uniform, then sequentially adds mabi
Saponin(e, beta carotene, cervus and cucumis polypeptide, PVP-I, expoxy propane, trihydroxymethylpropanyltri diglycidyl ether, continue ultrasound
25min, pours in grinding tool, and wherein ultrasonic power is 160W, and ultrasonic temperature is 55 DEG C；
Step 4）Freeze-drying obtains freeze-dried powder, and Jing Co radiation sterilization is processed, and obtains final product superabsorbent water hemostatic material in medical use.
Embodiment 5
A kind of superabsorbent water hemostatic material in medical use, including the component of following weight portion：33 parts of shitosan, cross linked polyacrylate 11.5
Part, 7.8 parts of starch acrylic acid graft copolymer, 4.6 parts of plant polyose, 4 parts of cervus and cucumis polypeptide, 6 parts of sephadex, phosphoric acid
6.3 parts of aluminium, 4.5 parts of coir fibre, 2.2 parts of bamboo powder, 3.6 parts of beta carotene, 2.4 parts of Vitwas E, PVP-I 1.2
Part, 2.8 parts of trihydroxymethylpropanyltri diglycidyl ether, expoxy propane 0.9, granatenine 2.4,3.5 parts of humic acid, mabi saponin(e
4 parts, 7.4 parts of ethyl ester benzyl ester, 8.2 parts of azone.
Mixture of the plant polyose for cellulose, locust bean gum, guar gum and pectin, and four weight ratio is
4:1:2:1。
The preparation technology of the superabsorbent water hemostatic material in medical use, including following preparation processes：
Step 1）Shitosan, cross linked polyacrylate and starch acrylic acid graft copolymer are added in half acetic acid, stirring and dissolving,
Mixed solution is made, it is standby；Coir fibre, bamboo powder are placed in crucible, in an inert atmosphere, are calcined 3 hours at 350 DEG C,
It is standby；
Step 2）Plant polyose, sephadex, granatenine and humic acid are added in second half acetic acid, at 0-5 DEG C
Under, with the speed stirring 60min of 550rpm, it is subsequently adding Vitwas E, ethyl ester benzyl ester, azone, aluminum phosphate and step 1）
In calcined powder, be warming up to 60 DEG C, with the speed of 500rpm stirring 100min；
Step 3）By step 1）In mixed solution and step 2）The solution ultrasonic mixing of preparation is uniform, then sequentially adds mabi
Saponin(e, beta carotene, cervus and cucumis polypeptide, PVP-I, expoxy propane, trihydroxymethylpropanyltri diglycidyl ether, continue ultrasound
30min, pours in grinding tool, and wherein ultrasonic power is 100W, and ultrasonic temperature is 60 DEG C；
Step 4）Freeze-drying obtains freeze-dried powder, and Jing Co radiation sterilization is processed, and obtains final product superabsorbent water hemostatic material in medical use.
Comparative example 1
In place of this comparative example and the difference of embodiment 1 it is：Without granatenine and starch acrylic acid graft copolymer.
Comparative example 2
In place of this comparative example and the difference of embodiment 1 it is：Without mabi saponin(e, ethyl ester benzyl ester and beta carotene.
Performance test
Correlated performance test is carried out to the hemostatic material in medical use prepared by embodiment 1-5 and comparative example 1,2, and test result is：
| Numbering | Gross hemostasis rate/% | Bleeding stopping period/s（Mouse femoral artery wound） | Absorbency/g/g（Physiological saline） | Absorbency/g/g（Artificial blood） |
| Embodiment 1 | 98.3 | 72±2 | 125.3 | 105.8 |
| Embodiment 2 | 98.7 | 70±3 | 131.2 | 111.3 |
| Embodiment 3 | 99.1 | 68±3 | 135.4 | 114.2 |
| Embodiment 4 | 99.3 | 66±3 | 138.9 | 115.9 |
| Embodiment 5 | 99.4 | 65±2 | 141.2 | 117.3 |
| Comparative example 1 | 95.2 | 93±4 | 98.7 | 82.5 |
| Comparative example 2 | 92.7 | 105±4 | 106.8 | 94.6 |
The gross hemostasis rate of the hemostatic material in medical use prepared from above test result, the present invention is up to 98.3%, and bleeding stopping period is 65
± 2 ~ 72 ± 2s, haemostatic effect is good and speed is fast；The absorptivity of hemostatic material in medical use is high simultaneously, the absorbency to physiological saline
Up to more than 125g/g, is up to 105g/g to the absorbency of artificial blood, and uptake is big, be especially suitable for wound it is larger relatively deep and
The big situation of amount of bleeding is used, and is also beneficial to the recovery of wound.
Claims (8)
1. a kind of superabsorbent water hemostatic material in medical use, it is characterised in that including the component of following weight portion：Shitosan 28-36 parts, friendship
Connection polyacrylic acid 8-14 parts, starch acrylic acid graft copolymer 5-10 parts, plant polyose 3-7 parts, cervus and cucumis polypeptide 3-6 parts, crosslinking
Sephadex 4-9 parts, aluminum phosphate 5-11 parts, coir fibre 3-8 parts, bamboo powder 1-4 part, beta carotene 2-6 parts, vitamin E vinegar
Acid esters 1-4 parts, PVP-I 0.5-2 parts, trihydroxymethylpropanyltri diglycidyl ether 2-5 parts, expoxy propane 0.6-1.3 parts, stone
Pomegranate skin alkali 1.2-3.5 parts, humic acid 2.4-5 parts, mabi saponin(e 3.6-5 parts, ethyl ester benzyl ester 6-9 part, azone 5-10 parts.
2. superabsorbent water hemostatic material in medical use according to claim 1, it is characterised in that the plant polyose be white dextrin,
In cellulose, locust bean gum, guar gum and pectin at least two.
3. superabsorbent water hemostatic material in medical use according to claim 1, it is characterised in that including the component of following weight portion：
Shitosan 29-34 parts, cross linked polyacrylate 10-13 parts, starch acrylic acid graft copolymer 6-9.5 parts, plant polyose 3.8-6.2
Part, cervus and cucumis polypeptide 3.5-5.3 parts, sephadex 4.2-8 parts, aluminum phosphate 5.5-9 parts, coir fibre 3.6-7.4 parts, bamboo
Powder 1.8-3.5 parts, beta carotene 2.4-5.3 parts, Vitwas E 1.8-3.6 parts, PVP-I 0.7-1.6 parts, three hydroxyls
Methylpropane triglycidyl ether 2.5-4.2 part, expoxy propane 0.8-1.1 parts, granatenine 1.6-3.2 parts, humic acid 2.8-
4.3 parts, mabi saponin(e 3.8-4.6 parts, ethyl ester benzyl ester 6.5-8 part, azone 6.2-9 parts.
4. superabsorbent water hemostatic material in medical use according to claim 1, it is characterised in that including the component of following weight portion：
33 parts of shitosan, 11.5 parts of cross linked polyacrylate, 7.8 parts of starch acrylic acid graft copolymer, 4.6 parts of plant polyose, deer melon are more
4 parts of peptide, 6 parts of sephadex, 6.3 parts of aluminum phosphate, 4.5 parts of coir fibre, 2.2 parts of bamboo powder, 3.6 parts of beta carotene, dimension
2.4 parts of raw element E acetates, 1.2 parts of PVP-I, 2.8 parts of trihydroxymethylpropanyltri diglycidyl ether, expoxy propane 0.9, pomegranate
Skin alkali 2.4,3.5 parts of humic acid, 4 parts of mabi saponin(e, 7.4 parts of ethyl ester benzyl ester, 8.2 parts of azone.
5. the preparation technology according to the arbitrary described superabsorbent water hemostatic material in medical use of claim 1-4, it is characterised in that under including
State preparation process：
Step 1）Shitosan, cross linked polyacrylate and starch acrylic acid graft copolymer are added in half acetic acid, stirring and dissolving,
Mixed solution is made, it is standby；Coir fibre, bamboo powder are placed in crucible, in an inert atmosphere, 2-4 are calcined at 300-500 DEG C
Hour, it is standby；
Step 2）Plant polyose, sephadex, granatenine and humic acid are added in second half acetic acid, at 0-5 DEG C
Under, with the speed stirring 40-80min of 300-800rpm, it is subsequently adding Vitwas E, ethyl ester benzyl ester, azone, aluminum phosphate
With step 1）In calcined powder, be warming up to 40-70 DEG C, with the speed of 300-800rpm stirring 50-120min；
Step 3）By step 1）In mixed solution and step 2）The solution ultrasonic mixing of preparation is uniform, then sequentially adds mabi
Saponin(e, beta carotene, cervus and cucumis polypeptide, PVP-I, expoxy propane, trihydroxymethylpropanyltri diglycidyl ether, continue ultrasound
15-40min, pours in grinding tool；
Step 4）Freeze-drying obtains freeze-dried powder, and Jing Co radiation sterilization is processed, and obtains final product superabsorbent water hemostatic material in medical use.
6. the preparation technology of superabsorbent water hemostatic material in medical use according to claim 5, it is characterised in that in step 1）In,
Calcine 3 hours at 350 DEG C.
7. the preparation technology of superabsorbent water hemostatic material in medical use according to claim 5, it is characterised in that in step 2）In,
At 0-5 DEG C, with the speed stirring 60min of 550rpm；In step 2）In, 60 DEG C are warming up to, are stirred with the speed of 500rpm
100min。
8. the preparation technology of superabsorbent water hemostatic material in medical use according to claim 5, it is characterised in that in step 3）In,
Ultrasonic power is 80-200W, and ultrasonic temperature is 40-60 DEG C.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108187132A (en) * | 2018-01-05 | 2018-06-22 | 广州润虹医药科技股份有限公司 | A kind of povidone iodine hydrogel antiseptic dressing and preparation method thereof |
| CN108659248A (en) * | 2017-03-31 | 2018-10-16 | 台湾塑胶工业股份有限公司 | Water-absorbent resin and method for producing same |
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| CN102133421A (en) * | 2011-03-17 | 2011-07-27 | 山东赛克赛斯药业科技有限公司 | Rapidly-hemostatic wound dressing as well as preparation method and application thereof |
| CN102137684A (en) * | 2008-04-25 | 2011-07-27 | 医疗行业产品有限公司 | Haemostatic material |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102137684A (en) * | 2008-04-25 | 2011-07-27 | 医疗行业产品有限公司 | Haemostatic material |
| CN102133421A (en) * | 2011-03-17 | 2011-07-27 | 山东赛克赛斯药业科技有限公司 | Rapidly-hemostatic wound dressing as well as preparation method and application thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108659248A (en) * | 2017-03-31 | 2018-10-16 | 台湾塑胶工业股份有限公司 | Water-absorbent resin and method for producing same |
| CN108659248B (en) * | 2017-03-31 | 2021-07-27 | 台湾塑胶工业股份有限公司 | Water-absorbent resin and method for producing same |
| CN108187132A (en) * | 2018-01-05 | 2018-06-22 | 广州润虹医药科技股份有限公司 | A kind of povidone iodine hydrogel antiseptic dressing and preparation method thereof |
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Application publication date: 20170329 |