CN106178087A - Human body soft tissue bonding special bio medical material and preparation method thereof - Google Patents
Human body soft tissue bonding special bio medical material and preparation method thereof Download PDFInfo
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- CN106178087A CN106178087A CN201610760860.4A CN201610760860A CN106178087A CN 106178087 A CN106178087 A CN 106178087A CN 201610760860 A CN201610760860 A CN 201610760860A CN 106178087 A CN106178087 A CN 106178087A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
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Abstract
The invention discloses human body soft tissue bonding special bio medical material, with α BCA, vinylpyrrolidone, Hydroxypropyl methacrylate, isopropyl acrylate is main component, by adding citrate, Aloe nano powder, benzoin dimethylether, N, N dimethyl is to aniline, Alamine 304, calcium carbonate, aluminium oxide, wollastonite in powder, alumina-silicate ceramic fibre, degreased pupa powder, squalane, Folium Ginkgo extract, L cysteine, retarder, it is aided with ball milling, ultrasonic disperse, mix and blend, dry, the techniques such as irradiation sterilization, make the human body soft tissue being prepared from bonding special bio medical material in bonding strength, binding speed, the aspects such as bonding persistence have had significant raising, disclosure satisfy that the requirement of industry, there is preferable application prospect.
Description
Technical field
The present invention relates to biomedical materials field, be related specifically to human body soft tissue bonding special bio medical material and
Its preparation method.
Background technology
Along with the progress of medical science, the requirement to surgical technic and auxiliary material result is more and more higher clinically.The reason of modern medicine
Read and be intended to reduce to greatest extent the misery of patient, allow patients ' recovery prestissimo, and recover function farthest
While, it is desirable to outward appearance also can ideally be recovered.Therefore being continuously increased of clinical demand has promoted what adhesive of medical studied to send out
Exhibition and adhering technique are in clinical application.
Adhesive of medical is a branch of medical high polymer, and it is with biological tissue for bonding object, the human body overwhelming majority
Tissue, organ can be applied adhering technique to replace part over the course for the treatment of and sew up, ligation operation, it is not necessary to anesthesia；Wound is more
Automatic-falling after conjunction.With traditional method as sewed up compared with stitching, the use of adhesive of medical can effectively shorten operating time, fall
Low patient pain feels.Therefore, adhesive of medical is increasingly favored by doctor and patient.By its purposes, its adhesive effect exists
Human-body biological cell relates to following youngster aspect: the bonding between (1) cell；(2) inside of human body active mass is with inactive
The bonding of part；(3) bonding between tissue and exterior materials.It is specifically categorized as: soft tissue binding agent, dental
Binding agent, orthopaedics binding agent and skin pressure sensitive adhesive.
Cyanoacrylate medical adhesive just can produce instaneous polymerization reaction in the presence of micro anion, and conglutination reaction is fast
Speed, the heat of polymerization produced during solidification is low, the least to local excitation, chemical stability and good biocompatibility.Through to medical
Glue biological characteristics is long-term and in-depth study show it have hypotoxicity, can vivo degradation, without three causes, and have concurrently certain only
Blood and antibacterial functions, itself is aseptic, and golden yellow and Staphylococcus albus, tetracoccus, bacillus subtilis are all had the most antibacterial work
With, it is adaptable to the bonding etc. of skin, internal organs, nerve, muscle, vascular organs or tissue.In clinical practice, from department of eye, skin
The surgical operations such as skin section solve a difficult problem for many traditional medicines to medical treatment aspect, become an important skill of modern medicine
Art.It can reduce the use of stitching thread, shortens operating time, can after reinforcing for some special these binding agents of identical use
To reduce the generation of postoperative anastomotic position leakage, to reducing, postoperative wound surface is hemorrhage also positive effect, has a good application prospect,
Receive the concern of people.
But, common cyano-acrylate binder is the most all held in bonding strength, binding speed, bonding
The aspects such as long degree also exist deficiency, it is impossible to meet medical demand substantially.
Summary of the invention
For solving above-mentioned technical problem, the present invention provides human body soft tissue bonding special bio medical material and preparation method thereof,
By using specified raw material to be combined, coordinating corresponding production technology, the human body soft tissue bonding special bio obtained is medical
Material has had significant raising at aspects such as bonding strength, binding speed, bonding persistences, it is possible to meet the requirement of industry, tool
There is preferable application prospect.
The purpose of the present invention can be achieved through the following technical solutions:
Human body soft tissue bonding special bio medical material, is prepared by the raw materials in: α-cyanoacrylaten-butyl
50-60 part, vinylpyrrolidone 45-55 part, Hydroxypropyl methacrylate 45-55 part, isopropyl acrylate 40-50 part, Fructus Citri Limoniae
Acid esters 15-25 part, Aloe nano powder 12-16 part, benzoin dimethylether 10-14 part, N, N-dimethyl to aniline 8-10 part,
Alamine 304 7-9 part, calcium carbonate 5-7 part, aluminium oxide 4-6 part, wollastonite in powder 4-6 part, alumina-silicate ceramic fibre 3-5 part, defat
Dried silkworm chrysalis meal 2-4 part, squalane 2-4 part, Folium Ginkgo extract 1-3 part, Cys 1-3 part, retarder 3-5 part.
Preferably, during described citrate is acetyl triethyl citrate, tributyl citrate, tributyl 2-acetylcitrate
Any one.
Preferably, described retarder in carboxymethyl cellulose, sodium gluconate, the zinc oxide any one or several
Kind.
The preparation method of described human body soft tissue bonding special bio medical material, comprises the following steps:
(1) each raw material is weighed according to weight portion；
(2) by calcium carbonate, aluminium oxide, wollastonite in powder, alumina-silicate ceramic fibre mixing, joining in ball mill, ball milling becomes particle diameter
Less than the powder body of 8 μm, subsequently mixed powder is put in baking oven and dry under the conditions of 120-150 DEG C, obtain powder and be dry mixed
Material；
(3) by α-cyanoacrylaten-butyl, vinylpyrrolidone, Hydroxypropyl methacrylate, isopropyl acrylate, citric acid
Ester, Aloe nano powder, benzoin dimethylether, N, N-dimethyl are to aniline, Alamine 304, degreased pupa powder, squalane, slow
Solidifying agent is placed in mixing and blending machine, stirs 40-60min, obtain compound, transfer to ultrasonic after cooling at 120-150 DEG C
In ripple disperser, the glycerol of the quality such as addition, regulate pH to 7.5-8.0, with 25-30kHz's with the NaOH solution of 10% subsequently
Frequency ultrasound dispersion 1-2h, obtains supersound process compound；
(4) the powder dry blend of step (2) and the supersound process compound of step (3) are placed in mixing and blending machine,
Mix homogeneously at a temperature of 160-180 DEG C, adds Folium Ginkgo extract, Cys after being cooled to room temperature, obtains whole batch mixing, subsequently
It is placed in low temperature baking oven drying, and is cooled to room temperature；
(5) finished product is obtained by packing after the irradiated sterilizing of whole batch mixing after cooling.
Preferably, the rotating speed of described ball mill is 220-270 r/min.
Preferably, described irradiation sterilization uses Co60-gamma-rays, and irradiation dose is 10-20kGy.
Compared with prior art, it has the beneficial effect that the present invention
(1) the human body soft tissue bonding special bio medical material of the present invention, with α-cyanoacrylaten-butyl, vinyl pyrrolidine
Ketone, Hydroxypropyl methacrylate, isopropyl acrylate are main component, by adding citrate, Aloe nano powder, resting in peace
Fragrant double methyl ether, N, N-dimethyl is to aniline, Alamine 304, calcium carbonate, aluminium oxide, wollastonite in powder, alumina-silicate ceramic fibre, de-
Fat dried silkworm chrysalis meal, squalane, Folium Ginkgo extract, Cys, retarder, be aided with ball milling, ultrasonic disperse, mix and blend, baking
The techniques such as dry, irradiation sterilization so that the human body soft tissue bonding special bio medical material being prepared from is in bonding strength, bonding
The aspects such as speed, bonding persistence have had significant raising, it is possible to meet the requirement of industry, have preferable application prospect.
(2) the human body soft tissue bonding special bio medical material cheaper starting materials of the present invention, technique simply, are suitable to extensive
Industrialization is used, practical.
Detailed description of the invention
Below in conjunction with specific embodiment, the technical scheme of invention is described in detail.
Embodiment 1
(1) α-cyanoacrylaten-butyl 50 parts, vinylpyrrolidone 45 parts, Hydroxypropyl methacrylate are weighed according to weight portion
45 parts, isopropyl acrylate 40 parts, acetyl triethyl citrate 15 parts, Aloe nano powder 12 parts, benzoin dimethylether 10 parts,
N, N-dimethyl is to aniline 8 parts, Alamine 304 7 parts, calcium carbonate 5 parts, aluminium oxide 4 parts, wollastonite in powder 4 parts, aluminum silicate ceramic fibre
Tie up 3 parts, degreased pupa powder 2 parts, squalane 2 parts, Folium Ginkgo extract 1 part, Cys 1 part, carboxymethyl cellulose 3 parts；
(2) by calcium carbonate, aluminium oxide, wollastonite in powder, alumina-silicate ceramic fibre mixing, join in ball mill, turning of ball mill
Speed is 220 r/min, and ball milling becomes particle diameter to be less than the powder body of 8 μm, is put into by mixed powder in baking oven subsequently under the conditions of 120 DEG C
Dry, obtain powder dry blend；
(3) by α-cyanoacrylaten-butyl, vinylpyrrolidone, Hydroxypropyl methacrylate, isopropyl acrylate, acetyl lemon
Lemon triethylenetetraminehexaacetic acid ester, Aloe nano powder, benzoin dimethylether, N, N-dimethyl are to aniline, Alamine 304, degreased pupa powder, angle
Shark alkane, carboxymethyl cellulose are placed in mixing and blending machine, stir 40 min, obtain compound, shift after cooling at 120 DEG C
In ultrasonic disperser, the glycerol of the quality such as addition, regulate pH to 7.5, with 25kHz's with the NaOH solution of 10% subsequently
Frequency ultrasound dispersion 1h, obtains supersound process compound；
(4) the powder dry blend of step (2) and the supersound process compound of step (3) are placed in mixing and blending machine, 160
Mix homogeneously at a temperature of DEG C, adds Folium Ginkgo extract, Cys after being cooled to room temperature, obtains whole batch mixing, be subsequently placed at low
Temperature baking oven is dried, and is cooled to room temperature；
(5) obtaining finished product by packing after the irradiated sterilizing of whole batch mixing after cooling, irradiation sterilization uses Co60-gamma-rays,
Irradiation dose is 10kGy.
The performance test results of the human body soft tissue bonding special bio medical material prepared is as shown in table 1.
Embodiment 2
(1) α-cyanoacrylaten-butyl 55 parts, vinylpyrrolidone 50 parts, Hydroxypropyl methacrylate are weighed according to weight portion
50 parts, isopropyl acrylate 45 parts, tributyl citrate 20 parts, Aloe nano powder 14 parts, benzoin dimethylether 12 parts, N,
N-dimethyl is to aniline 9 parts, Alamine 304 8 parts, calcium carbonate 6 parts, aluminium oxide 5 parts, wollastonite in powder 5 parts, alumina-silicate ceramic fibre 4
Part, degreased pupa powder 3 parts, squalane 3 parts, Folium Ginkgo extract 2 parts, Cys 2 parts, sodium gluconate 4 parts；
(2) by calcium carbonate, aluminium oxide, wollastonite in powder, alumina-silicate ceramic fibre mixing, join in ball mill, turning of ball mill
Speed is 245 r/min, and ball milling becomes particle diameter to be less than the powder body of 8 μm, is put into by mixed powder in baking oven subsequently under the conditions of 135 DEG C
Dry, obtain powder dry blend；
(3) by α-cyanoacrylaten-butyl, vinylpyrrolidone, Hydroxypropyl methacrylate, isopropyl acrylate, citric acid
Tributyl, Aloe nano powder, benzoin dimethylether, N, N-dimethyl are to aniline, Alamine 304, degreased pupa powder, spiny dogfish
Alkane, sodium gluconate are placed in mixing and blending machine, stir 50 min, obtain compound at 135 DEG C, transfer to after cooling surpass
In sound wave disperser, the glycerol of the quality such as addition, regulate pH to 7.8, with the frequency of 27kHz with the NaOH solution of 10% subsequently
Ultrasonic disperse 1.5h, obtains supersound process compound；
(4) the powder dry blend of step (2) and the supersound process compound of step (3) are placed in mixing and blending machine, 170
Mix homogeneously at a temperature of DEG C, adds Folium Ginkgo extract, Cys after being cooled to room temperature, obtains whole batch mixing, be subsequently placed at low
Temperature baking oven is dried, and is cooled to room temperature；
(5) obtaining finished product by packing after the irradiated sterilizing of whole batch mixing after cooling, irradiation sterilization uses Co60-gamma-rays,
Irradiation dose is 15kGy.
The performance test results of the human body soft tissue bonding special bio medical material prepared is as shown in table 1.
Embodiment 3
(1) α-cyanoacrylaten-butyl 60 parts, vinylpyrrolidone 55 parts, Hydroxypropyl methacrylate are weighed according to weight portion
55 parts, isopropyl acrylate 50 parts, tributyl 2-acetylcitrate 25 parts, Aloe nano powder 16 parts, benzoin dimethylether 14 parts,
N, N-dimethyl is to aniline 10 parts, Alamine 304 9 parts, calcium carbonate 7 parts, aluminium oxide 6 parts, wollastonite in powder 6 parts, aluminum silicate ceramic
Fiber 5 parts, degreased pupa powder 4 parts, squalane 4 parts, Folium Ginkgo extract 3 parts, Cys 3 parts, zinc oxide 5 parts；
(2) by calcium carbonate, aluminium oxide, wollastonite in powder, alumina-silicate ceramic fibre mixing, join in ball mill, turning of ball mill
Speed is 270 r/min, and ball milling becomes particle diameter to be less than the powder body of 8 μm, is put into by mixed powder in baking oven subsequently under the conditions of 150 DEG C
Dry, obtain powder dry blend；
(3) by α-cyanoacrylaten-butyl, vinylpyrrolidone, Hydroxypropyl methacrylate, isopropyl acrylate, acetyl lemon
Lemon acid tributyl, Aloe nano powder, benzoin dimethylether, N, N-dimethyl are to aniline, Alamine 304, degreased pupa powder, angle
Shark alkane, zinc oxide are placed in mixing and blending machine, stir 60min, obtain compound, transfer to ultrasonic after cooling at 150 DEG C
In ripple disperser, the glycerol of the quality such as addition, regulate pH to 8.0 with the NaOH solution of 10% subsequently, surpass with the frequency of 30kHz
Sound dispersion 2h, obtains supersound process compound；
(4) the powder dry blend of step (2) and the supersound process compound of step (3) are placed in mixing and blending machine, 180
Mix homogeneously at a temperature of DEG C, adds Folium Ginkgo extract, Cys after being cooled to room temperature, obtains whole batch mixing, be subsequently placed at low
Temperature baking oven is dried, and is cooled to room temperature；
(5) obtaining finished product by packing after the irradiated sterilizing of whole batch mixing after cooling, irradiation sterilization uses Co60-gamma-rays,
Irradiation dose is 20kGy.
The performance test results of the human body soft tissue bonding special bio medical material prepared is as shown in table 1.
Embodiment 4
(1) α-cyanoacrylaten-butyl 60 parts, vinylpyrrolidone 45 parts, Hydroxypropyl methacrylate are weighed according to weight portion
55 parts, isopropyl acrylate 40 parts, acetyl triethyl citrate 25 parts, Aloe nano powder 12 parts, benzoin dimethylether 14 parts,
N, N-dimethyl is to aniline 8 parts, Alamine 304 9 parts, calcium carbonate 5 parts, aluminium oxide 6 parts, wollastonite in powder 4 parts, aluminum silicate ceramic fibre
Tie up 5 parts, degreased pupa powder 2 parts, squalane 4 parts, Folium Ginkgo extract 1 part, Cys 3 parts, sodium gluconate 3 parts；
(2) by calcium carbonate, aluminium oxide, wollastonite in powder, alumina-silicate ceramic fibre mixing, join in ball mill, turning of ball mill
Speed is 270 r/min, and ball milling becomes particle diameter to be less than the powder body of 8 μm, is put into by mixed powder in baking oven subsequently under the conditions of 120 DEG C
Dry, obtain powder dry blend；
(3) by α-cyanoacrylaten-butyl, vinylpyrrolidone, Hydroxypropyl methacrylate, isopropyl acrylate, acetyl lemon
Lemon triethylenetetraminehexaacetic acid ester, Aloe nano powder, benzoin dimethylether, N, N-dimethyl are to aniline, Alamine 304, degreased pupa powder, angle
Shark alkane, sodium gluconate are placed in mixing and blending machine, stir 40 min, obtain compound, transfer to after cooling at 150 DEG C
In ultrasonic disperser, the glycerol of the quality such as addition, regulate pH to 8.0, with the frequency of 25kHz with the NaOH solution of 10% subsequently
Rate ultrasonic disperse 2h, obtains supersound process compound；
(4) the powder dry blend of step (2) and the supersound process compound of step (3) are placed in mixing and blending machine, 160
Mix homogeneously at a temperature of DEG C, adds Folium Ginkgo extract, Cys after being cooled to room temperature, obtains whole batch mixing, be subsequently placed at low
Temperature baking oven is dried, and is cooled to room temperature；
(5) obtaining finished product by packing after the irradiated sterilizing of whole batch mixing after cooling, irradiation sterilization uses Co60-gamma-rays,
Irradiation dose is 20kGy.
The performance test results of the human body soft tissue bonding special bio medical material prepared is as shown in table 1.
Comparative example 1
(1) α-cyanoacrylaten-butyl 50 parts, vinylpyrrolidone 45 parts, Hydroxypropyl methacrylate are weighed according to weight portion
45 parts, isopropyl acrylate 40 parts, acetyl triethyl citrate 15 parts, Aloe nano powder 12 parts, N, N-dimethyl is to aniline
8 parts, Alamine 304 7 parts, calcium carbonate 5 parts, aluminium oxide 4 parts, wollastonite in powder 4 parts, alumina-silicate ceramic fibre 3 parts, degreased pupa powder 2
Part, Folium Ginkgo extract 1 part, Cys 1 part, carboxymethyl cellulose 3 parts；
(2) by calcium carbonate, aluminium oxide, wollastonite in powder, alumina-silicate ceramic fibre mixing, join in ball mill, turning of ball mill
Speed is 220 r/min, and ball milling becomes particle diameter to be less than the powder body of 8 μm, is put into by mixed powder in baking oven subsequently under the conditions of 120 DEG C
Dry, obtain powder dry blend；
(3) by α-cyanoacrylaten-butyl, vinylpyrrolidone, Hydroxypropyl methacrylate, isopropyl acrylate, acetyl lemon
Aniline, Alamine 304, degreased pupa powder, carboxymethyl cellulose are put by lemon triethylenetetraminehexaacetic acid ester, Aloe nano powder, N, N-dimethyl
In mixing and blending machine, at 120 DEG C, stir 40 min, obtain compound, transfer to after cooling, in ultrasonic disperser, add
The glycerol of quality such as enter, regulate pH to 7.5 with the NaOH solution of 10% subsequently, disperse 1h with the frequency ultrasound of 25kHz, obtain
Supersound process compound；
(4) the powder dry blend of step (2) and the supersound process compound of step (3) are placed in mixing and blending machine, 160
Mix homogeneously at a temperature of DEG C, adds Folium Ginkgo extract, Cys after being cooled to room temperature, obtains whole batch mixing, be subsequently placed at low
Temperature baking oven is dried, and is cooled to room temperature；
(5) obtaining finished product by packing after the irradiated sterilizing of whole batch mixing after cooling, irradiation sterilization uses Co60-gamma-rays,
Irradiation dose is 10kGy.
The performance test results of the human body soft tissue bonding special bio medical material prepared is as shown in table 1.
Comparative example 2
(1) α-cyanoacrylaten-butyl 60 parts, vinylpyrrolidone 55 parts, Hydroxypropyl methacrylate are weighed according to weight portion
55 parts, isopropyl acrylate 50 parts, tributyl 2-acetylcitrate 25 parts, Aloe nano powder 16 parts, benzoin dimethylether 14 parts,
N, N-dimethyl is to aniline 10 parts, calcium carbonate 7 parts, aluminium oxide 6 parts, wollastonite in powder 6 parts, alumina-silicate ceramic fibre 5 parts, defat
Dried silkworm chrysalis meal 4 parts, squalane 4 parts, Cys 3 parts, zinc oxide 5 parts；
(2) by calcium carbonate, aluminium oxide, wollastonite in powder, alumina-silicate ceramic fibre mixing, join in ball mill, turning of ball mill
Speed is 270 r/min, and ball milling becomes particle diameter to be less than the powder body of 8 μm, is put into by mixed powder in baking oven subsequently under the conditions of 150 DEG C
Dry, obtain powder dry blend；
(3) by α-cyanoacrylaten-butyl, vinylpyrrolidone, Hydroxypropyl methacrylate, isopropyl acrylate, acetyl lemon
Lemon acid tributyl, Aloe nano powder, benzoin dimethylether, N, N-dimethyl are to aniline, degreased pupa powder, squalane, oxidation
Zinc is placed in mixing and blending machine, stirs 60min, obtain compound, transfer to ultrasonic disperser after cooling at 150 DEG C
In, the glycerol of the quality such as addition, regulate pH to 8.0 with the NaOH solution of 10% subsequently, disperse 2h with the frequency ultrasound of 30kHz,
Obtain supersound process compound；
(4) the powder dry blend of step (2) and the supersound process compound of step (3) are placed in mixing and blending machine, 180
Mix homogeneously at a temperature of DEG C, adds Cys after being cooled to room temperature, obtains whole batch mixing, be subsequently placed in low temperature baking oven drying,
And it is cooled to room temperature；
(5) obtaining finished product by packing after the irradiated sterilizing of whole batch mixing after cooling, irradiation sterilization uses Co60-gamma-rays,
Irradiation dose is 20kGy.
The performance test results of the human body soft tissue bonding special bio medical material prepared is as shown in table 1.
The human body soft tissue the prepared bonding special bio medical material of embodiment 1-4 and comparative example 1-2 is carried out respectively
Bonding strength, bonding strength rate of descent, these several performance tests of anaphylaxis after hardening time, 6 months.
Table 1
| Bonding strength (N) | Hardening time (S) | Bonding strength rate of descent (%) after 6 months | Scratch test | |
| Embodiment 1 | 86.7 | 9 | 3.7% | Qualified |
| Embodiment 2 | 84.3 | 10 | 4.1% | Qualified |
| Embodiment 3 | 88.6 | 8 | 2.9% | Qualified |
| Embodiment 4 | 81.9 | 10 | 4.6% | Qualified |
| Comparative example 1 | 61.8 | 25 | 15.3% | Qualified |
| Comparative example 2 | 59.9 | 27 | 16.8% | Qualified |
The present invention human body soft tissue bonding special bio medical material with α-cyanoacrylaten-butyl, vinylpyrrolidone,
Hydroxypropyl methacrylate, isopropyl acrylate are main component, by adding citrate, Aloe nano powder, Benzoinum
Double methyl ethers, N, N-dimethyl is to aniline, Alamine 304, calcium carbonate, aluminium oxide, wollastonite in powder, alumina-silicate ceramic fibre, defat
Dried silkworm chrysalis meal, squalane, Folium Ginkgo extract, Cys, retarder, be aided with ball milling, ultrasonic disperse, mix and blend, drying,
The techniques such as irradiation sterilization so that the human body soft tissue bonding special bio medical material being prepared from is in bonding strength, bonding speed
The aspects such as degree, bonding persistence have had significant raising, it is possible to meet the requirement of industry, have preferable application prospect.Meanwhile,
The human body soft tissue bonding special bio medical material cheaper starting materials of the present invention, technique are simple, are suitable to heavy industrialization and use,
Practical.
The foregoing is only embodiments of the invention, not thereby limit the scope of the claims of the present invention, every utilize this
Equivalent structure or equivalence flow process that bright description is made convert, or are directly or indirectly used in other relevant technology necks
Territory, is the most in like manner included in the scope of patent protection of the present invention.
Claims (6)
1. human body soft tissue bonding special bio medical material, it is characterised in that: it is prepared by the raw materials in: alpha-cyano
N-butyl acrylate 50-60 part, vinylpyrrolidone 45-55 part, Hydroxypropyl methacrylate 45-55 part, isopropyl acrylate
40-50 part, citrate 15-25 part, Aloe nano powder 12-16 part, benzoin dimethylether 10-14 part, N, N-dimethyl pair
Aniline 8-10 part, Alamine 304 7-9 part, calcium carbonate 5-7 part, aluminium oxide 4-6 part, wollastonite in powder 4-6 part, alumina-silicate ceramic fibre
3-5 part, degreased pupa powder 2-4 part, squalane 2-4 part, Folium Ginkgo extract 1-3 part, Cys 1-3 part, retarder 3-5
Part.
Human body soft tissue the most according to claim 1 bonding special bio medical material, it is characterised in that: described citric acid
Ester is any one in acetyl triethyl citrate, tributyl citrate, tributyl 2-acetylcitrate.
Human body soft tissue the most according to claim 1 bonding special bio medical material, it is characterised in that: described retarder
Any one or a few in carboxymethyl cellulose, sodium gluconate, zinc oxide.
4., according to the preparation method of the arbitrary described human body soft tissue bonding special bio medical material of claims 1 to 3, it is special
Levy and be, comprise the following steps:
(1) each raw material is weighed according to weight portion；
(2) by calcium carbonate, aluminium oxide, wollastonite in powder, alumina-silicate ceramic fibre mixing, joining in ball mill, ball milling becomes particle diameter
Less than the powder body of 8 μm, subsequently mixed powder is put in baking oven and dry under the conditions of 120-150 DEG C, obtain powder and be dry mixed
Material；
(3) by α-cyanoacrylaten-butyl, vinylpyrrolidone, Hydroxypropyl methacrylate, isopropyl acrylate, citric acid
Ester, Aloe nano powder, benzoin dimethylether, N, N-dimethyl are to aniline, Alamine 304, degreased pupa powder, squalane, slow
Solidifying agent is placed in mixing and blending machine, stirs 40-60min, obtain compound, transfer to ultrasonic after cooling at 120-150 DEG C
In ripple disperser, the glycerol of the quality such as addition, regulate pH to 7.5-8.0, with 25-30kHz's with the NaOH solution of 10% subsequently
Frequency ultrasound dispersion 1-2h, obtains supersound process compound；
(4) the powder dry blend of step (2) and the supersound process compound of step (3) are placed in mixing and blending machine,
Mix homogeneously at a temperature of 160-180 DEG C, adds Folium Ginkgo extract, Cys after being cooled to room temperature, obtains whole batch mixing, subsequently
It is placed in low temperature baking oven drying, and is cooled to room temperature；
(5) finished product is obtained by packing after the irradiated sterilizing of whole batch mixing after cooling.
The preparation method of medical PVC anti-microbial catheter material the most according to claim 4, it is characterised in that: described ball mill
Rotating speed be 220-270 r/min.
The preparation method of medical PVC anti-microbial catheter material the most according to claim 4, it is characterised in that: described irradiation goes out
Bacterium uses Co60-gamma-rays, and irradiation dose is 10-20kGy.
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| CN (1) | CN106178087A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108553409A (en) * | 2018-06-21 | 2018-09-21 | 安徽农业大学 | A kind of Epigallo-catechin gallate (EGCG) nano wire preparation and its preparation method and application |
| CN108904870A (en) * | 2018-08-01 | 2018-11-30 | 浙江派菲特新材料科技有限公司 | A kind of medical adhesive with promotion healing and repair function |
| CN112543653A (en) * | 2018-06-13 | 2021-03-23 | 艾利丹尼森公司 | Medical adhesive for rapid release of antimicrobial agents |
-
2016
- 2016-08-30 CN CN201610760860.4A patent/CN106178087A/en not_active Withdrawn
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112543653A (en) * | 2018-06-13 | 2021-03-23 | 艾利丹尼森公司 | Medical adhesive for rapid release of antimicrobial agents |
| CN108553409A (en) * | 2018-06-21 | 2018-09-21 | 安徽农业大学 | A kind of Epigallo-catechin gallate (EGCG) nano wire preparation and its preparation method and application |
| CN108553409B (en) * | 2018-06-21 | 2021-03-26 | 安徽农业大学 | Epigallocatechin gallate nanowire preparation and preparation method and application thereof |
| CN108904870A (en) * | 2018-08-01 | 2018-11-30 | 浙江派菲特新材料科技有限公司 | A kind of medical adhesive with promotion healing and repair function |
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Application publication date: 20161207 |
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