CN106520778A - 改造的白介素12及其在制备治疗肿瘤的药物中的用途 - Google Patents

改造的白介素12及其在制备治疗肿瘤的药物中的用途 Download PDF

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Publication number
CN106520778A
CN106520778A CN201510568718.5A CN201510568718A CN106520778A CN 106520778 A CN106520778 A CN 106520778A CN 201510568718 A CN201510568718 A CN 201510568718A CN 106520778 A CN106520778 A CN 106520778A
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tumor
modified interleukin
interleukin
recombinant vector
nucleotide sequence
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CN201510568718.5A
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Chinese (zh)
Inventor
王尧河
王鹏举
高冬玲
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Zhengzhou University
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Zhengzhou University
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Priority to CN201510568718.5A priority Critical patent/CN106520778A/zh
Priority to PCT/CN2016/098527 priority patent/WO2017041739A1/zh
Priority to EP16843677.2A priority patent/EP3348643B1/en
Priority to US15/758,853 priority patent/US11345732B2/en
Priority to CN202311154075.0A priority patent/CN117736296A/zh
Priority to CN202410669656.6A priority patent/CN118852455A/zh
Priority to CN202410669647.7A priority patent/CN118791625A/zh
Priority to CN201680022405.2A priority patent/CN108307642B/zh
Priority to JP2018532498A priority patent/JP7340222B2/ja
Publication of CN106520778A publication Critical patent/CN106520778A/zh
Priority to JP2021215459A priority patent/JP7438552B2/ja
Priority to US17/700,991 priority patent/US20220213161A1/en
Pending legal-status Critical Current

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    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5434—IL-12
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CN201510568718.5A 2015-09-09 2015-09-09 改造的白介素12及其在制备治疗肿瘤的药物中的用途 Pending CN106520778A (zh)

Priority Applications (11)

Application Number Priority Date Filing Date Title
CN201510568718.5A CN106520778A (zh) 2015-09-09 2015-09-09 改造的白介素12及其在制备治疗肿瘤的药物中的用途
CN202410669656.6A CN118852455A (zh) 2015-09-09 2016-09-09 改造的白介素12、包含其的药物及其用途
EP16843677.2A EP3348643B1 (en) 2015-09-09 2016-09-09 Modified interleukin 12 and use thereof in preparing drugs for treating tumours
US15/758,853 US11345732B2 (en) 2015-09-09 2016-09-09 Modified interleukin 12 and use thereof in preparing drugs for treating tumours
CN202311154075.0A CN117736296A (zh) 2015-09-09 2016-09-09 改造的溶瘤病毒及其用途
PCT/CN2016/098527 WO2017041739A1 (zh) 2015-09-09 2016-09-09 改造的白介素12及其在制备治疗肿瘤药物中的用途
CN202410669647.7A CN118791625A (zh) 2015-09-09 2016-09-09 包含改造的白介素12的溶瘤病毒及其用途
CN201680022405.2A CN108307642B (zh) 2015-09-09 2016-09-09 改造的白介素12及其在制备治疗肿瘤药物中的用途
JP2018532498A JP7340222B2 (ja) 2015-09-09 2016-09-09 腫瘍溶解性ウイルス、腫瘍溶解性ウイルスを含む薬物、医薬品の製造における使用、および腫瘍溶解性ウイルスの作製方法
JP2021215459A JP7438552B2 (ja) 2015-09-09 2021-12-29 注射用医薬品、注射用調製物、および注射用医薬品の製造における使用
US17/700,991 US20220213161A1 (en) 2015-09-09 2022-03-22 Modified interleukin 12 and use thereof in preparing drugs for treating tumours

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201510568718.5A CN106520778A (zh) 2015-09-09 2015-09-09 改造的白介素12及其在制备治疗肿瘤的药物中的用途

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CN106520778A true CN106520778A (zh) 2017-03-22

Family

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Family Applications (5)

Application Number Title Priority Date Filing Date
CN201510568718.5A Pending CN106520778A (zh) 2015-09-09 2015-09-09 改造的白介素12及其在制备治疗肿瘤的药物中的用途
CN202410669647.7A Pending CN118791625A (zh) 2015-09-09 2016-09-09 包含改造的白介素12的溶瘤病毒及其用途
CN201680022405.2A Active CN108307642B (zh) 2015-09-09 2016-09-09 改造的白介素12及其在制备治疗肿瘤药物中的用途
CN202410669656.6A Pending CN118852455A (zh) 2015-09-09 2016-09-09 改造的白介素12、包含其的药物及其用途
CN202311154075.0A Pending CN117736296A (zh) 2015-09-09 2016-09-09 改造的溶瘤病毒及其用途

Family Applications After (4)

Application Number Title Priority Date Filing Date
CN202410669647.7A Pending CN118791625A (zh) 2015-09-09 2016-09-09 包含改造的白介素12的溶瘤病毒及其用途
CN201680022405.2A Active CN108307642B (zh) 2015-09-09 2016-09-09 改造的白介素12及其在制备治疗肿瘤药物中的用途
CN202410669656.6A Pending CN118852455A (zh) 2015-09-09 2016-09-09 改造的白介素12、包含其的药物及其用途
CN202311154075.0A Pending CN117736296A (zh) 2015-09-09 2016-09-09 改造的溶瘤病毒及其用途

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US (2) US11345732B2 (https=)
EP (1) EP3348643B1 (https=)
JP (2) JP7340222B2 (https=)
CN (5) CN106520778A (https=)
WO (1) WO2017041739A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018184484A1 (zh) * 2017-04-06 2018-10-11 张晋宇 细胞因子组合
WO2021249035A1 (zh) * 2020-06-10 2021-12-16 广州恩宝生物医药科技有限公司 一种复制型人腺病毒及其应用

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EP3861016A2 (en) 2018-10-03 2021-08-11 Xencor, Inc. Il-12 heterodimeric fc-fusion proteins
CA3124287A1 (en) * 2018-12-21 2020-06-25 Ottawa Hospital Research Institute Modified orthopoxvirus vectors
CN115916233A (zh) 2019-10-03 2023-04-04 Xencor股份有限公司 靶向IL-12异源二聚体Fc融合蛋白
CN119677861A (zh) * 2022-06-10 2025-03-21 特兰斯吉恩股份有限公司 表达白介素-12的重组病毒
WO2025221669A1 (en) * 2024-04-18 2025-10-23 Promab Biotechnologies, Inc. Fusion protein comprising il-12 and gm-csf
WO2026020161A1 (en) 2024-07-19 2026-01-22 Cytomx Therapeutics, Inc. Activatable il-12 constructs and related compositions and methods

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CA2612785A1 (en) 2005-06-30 2007-01-11 Archemix Corp. Polynucleotides and polypeptides of the il-12 family of cytokines
RU2304586C1 (ru) * 2006-03-27 2007-08-20 Михаил Николаевич Смирнов Препарат интерлейкина-2 и способ его получения
CN102174479B (zh) 2011-03-02 2013-04-03 北京锤特生物科技有限公司 靶向性治疗人肿瘤的溶肿瘤腺病毒及其应用
SG11201702295UA (en) * 2014-09-22 2017-04-27 Intrexon Corp Improved therapeutic control of heterodimeric and single chain forms of interleukin-12
AU2016338436B2 (en) * 2015-10-14 2021-09-30 Mighty Oak Medical, Inc. Patient-matched apparatus and methods for performing surgical procedures

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018184484A1 (zh) * 2017-04-06 2018-10-11 张晋宇 细胞因子组合
CN110603048A (zh) * 2017-04-06 2019-12-20 张晋宇 细胞因子组合
US11535656B2 (en) 2017-04-06 2022-12-27 Jinyu Zhang Cytokine combination
US12540167B2 (en) 2017-04-06 2026-02-03 Ningbo Innovative Mechanism Bioscience Llc Cytokine combination
WO2021249035A1 (zh) * 2020-06-10 2021-12-16 广州恩宝生物医药科技有限公司 一种复制型人腺病毒及其应用

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CN117736296A (zh) 2024-03-22
EP3348643A1 (en) 2018-07-18
JP2018533970A (ja) 2018-11-22
JP7340222B2 (ja) 2023-09-07
JP7438552B2 (ja) 2024-02-27
CN118852455A (zh) 2024-10-29
WO2017041739A1 (zh) 2017-03-16
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