CN106511554A - Improved paste preparation capable of nourishing stomach and intestine, and preparation method and applications thereof - Google Patents
Improved paste preparation capable of nourishing stomach and intestine, and preparation method and applications thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
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- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The invention provides an improved paste preparation capable of nourishing stomach and intestine. The improved paste preparation comprises following raw materials: water extract of fructus aurantii stir-baked with bran, water extract of dandelion, water extract of peach kernel, water extract of radix pseudostellariae, water extract of fried semen raphani, water extract of radix astragali, ethanol extract of radix paeoniae rubra, ethanol extract of perilla stem, volatile oil of radix aucklandiae, rheum officinale, and processed honey. The improved paste preparation is capable of realizing transferring of formula medicinal material active sites effectively, and possesses clinical effects which are obviously better than that of other commercially available preparations in treating chronic constipation and belly postoperative complications.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, more specifically to a kind of gastrointestine recovery cream improvement preparation, preparation method
And its application.
Technical background
Due to interference of the abdominal operation to abdominal visceral browser, the inflammation of anesthesia and celiac disease itself, damage, bleeding etc. because
The impact of element, postoperative certainty occur gastrointestinal dysfunction and enteroparalysis to some extent, cause fibrin to be more easy in intestinal tube table
Face deposit adherent, increases the chance that postoperative intestinal adhesion, intestinal obstruction occur.And the increase of enterokinesia can destroy established fiber and glue
Connecting, therefore increase enterokinesia to prevent the formation of intestinal adhesion.Simultaneously gastrointestinal function recovery after operation is disorderly, enteroparalysis clinically frequently with
Fasting, gastrointestinal decompression, the method for fluid infusion are treated, and have so both increased the pain of patient, can also be led because of the prolongation of fasting time
The difficulty for causing nutrition to maintain, is also unfavorable for the antisecosises of postoperative patient.Particularly with older, pulmonary insufficiency
The chance that complication in terms of patient, the cardiopulmonary caused by transfusion occurs is greatly increased.Therefore, how abdominal postoperative promotes
Gastrointestinal function early recovery, is increasingly paid attention to by medical circle.
Chinese medicine gastrointestine recovery cream, the semifluid of sepia stiff;Sweet in the mouth, slight bitter.For tonifying recipess, with benefiting QI for activating blood circulation, manage
The effect of gas catharsis.Cure mainly gastrointestinal postoperative abdominal distention, stomachache activity to weaken, symptoms include asthenia shortness of breath, distension and fullness in the abdomen, do not defecate;Also
Can be used for senile constipation and weakness constipation.
The content of the invention
The invention provides a kind of gastrointestine recovery cream improves preparation, the crude drug that the intestinal post-equalization cream improves preparation is parched with bran
Fructus Aurantii, dandelion, Radix Paeoniae Rubra, Semen Persicae, Radix Pseudostellariae, the Radix Aucklandiae, Radix Et Rhizoma Rhei, Caulis Perillae, Semen Raphani (parched), the Radix Astragali and refined honey, Fructus Aurantii reason in side
Gas alleviating distention in middle-JIAO, the stagnant relieving distension of row, wide intestinal purging FU-organs;Radix Aucklandiae warming middle-JIAO to promote flow of QI pain relieving, strengthening the spleen to promote digestion, both share take its qi-regulating invigorating the stomach and promoting digestion it
Work(.Semen Raphani helps digestion de-swelling, and relieving distension is except full, lowering the adverse-rising QI to resolve phlegm;The Radix Astragali, Radix Pseudostellariae are Qi-tonifying drug, and Radix Astragali invigorating QI to consolidate the body surface resistance, poison holding are arranged
Pus, expelling pus and promoting granulation;Radix Paeoniae Rubra clearing away heat and cooling blood, eliminating stasis to stop pain, purging liver-fire;Semen Persicae blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation;Radix Et Rhizoma Rhei purges heat logical
Just, catharsis blood stasis dispelling, with strong discharge function, can make stagnant dampness drop and remove, pyretic toxicity pathogenic fire is solved with stool again;Pu
Herba Taraxaci heat-clearing and toxic substances removing, carbuncle that disappears dissipating bind, inducing diuresis for treating stranguria syndrome;Caulis Perillae pungent-warm dissipates, relieving QI stagnancy in the stomach, qi-regulating the chest stuffiness relieving.All medicines share can benefit
Gas protects unit, blood stasis dispelling detoxification, qi-regulating catharsis.The stir-baked Fructus Aurantii in bran, dandelion, Radix Paeoniae Rubra, Semen Persicae, Radix Pseudostellariae, the Radix Aucklandiae, Radix Et Rhizoma Rhei, Folium Perillae
The weight ratio of stalk, Semen Raphani (parched), the Radix Astragali and refined honey is:2:6:3:3:2:2:2:3:4:3:20;Wherein, stir-baked Fructus Aurantii in bran, dandelion,
The agents area of Semen Persicae, Radix Pseudostellariae, Semen Raphani (parched) and the Radix Astragali is carried for ethanol for the agents area of water extract, Radix Paeoniae Rubra and Caulis Perillae
Thing is taken, the agents area of the Radix Aucklandiae is used as medicine for whole for the agents area of volatile oil, Radix Et Rhizoma Rhei and refined honey.
Gastrointestine recovery cream improves the preparation method of preparation, comprises the following steps:
1) weight ratio according to claim 1 weighs medical material;
2) decocting of 5 times of Fructus Aurantii, Radix Pseudostellariae, dandelion, Semen Raphani, the Radix Astragali and Semen Persicae dosing material weight is boiled into secondary, often
Secondary 2 hours, filtration, merging filtrate obtained Aqueous extracts;
3) Radix Aucklandiae is extracted into volatile oil with the way of distillation, obtains volatile oil of Radix Aucklandiae;
4) Radix Paeoniae Rubra and Caulis Perillae are pulverized and mixed, are extracted 3 times with 60% ethanol of 5 times of weight of medical material, each 1h, merging are carried
Liquid is taken, alcohol extract is obtained;
5) by Aqueous extracts and alcohol extract;Concentrating under reduced pressure becomes the extractum of density 1.15~1.25 respectively, is mixed to get mixing
Extractum;
6) Radix Et Rhizoma Rhei is crushed into into micropowder;
7) Radix et Rhizoma Rhei micropowder and volatile oil of Radix Aucklandiae are mixed in mixing extractum, obtain gastrointestine recovery cream and improve system.
Gastrointestine recovery cream improve preparation preparation method, step 4) described in 60% ethanol extract 3 times be in 45 ± 2 DEG C of bars
Under part, warm macerating is extracted.
Gastrointestine recovery cream improves the preparation method of preparation, and in step 5, Aqueous extracts concentrating under reduced pressure is 60 DEG C into the temperature of extractum,
Alcohol extract concentrating under reduced pressure is 50 DEG C into the temperature of extractum.
Described gastrointestine recovery cream improves preparation in the gastrointestinal peristalsiss deficiency medicine that treatment chronic constipation causes is prepared
Using.
Described gastrointestine recovery cream improves preparation in treatment abdominal post-operation gastrointestinal dysfunction and enteroparalysis medicine is prepared
Application.
The method have the benefit that:The gastrointestine recovery cream that the present invention is provided improves that preparation is significantly more efficient realizes
The transfer at prescription activity of drug ingredients position, the preparation of acquisition are obvious in the clinical effectiveness for the treatment of chronic constipation and abdominal post-operation complication
Better than other commercially available gastrointestine recovery paste formulations.
Specific embodiment
Gastrointestine recovery paste formulation prepared by 1 different extraction processes of embodiment is investigated to the activity of chronic constipation
1. the preparation of sample
(1) Fructus Aurantii (parched with bran) 100g, Radix Pseudostellariae 100g, Radix Et Rhizoma Rhei 150g, dandelion 300g, Radix Aucklandiae 100g, Semen Raphani are weighed
(stir-fry) 200g, Radix Paeoniae Rubra 150g, Caulis Perillae 100g, Radix Astragali 150g, Semen Persicae 150g, refined honey 1000g.Ten taste of the above, except Radix Et Rhizoma Rhei is crushed
Into outside fine powder, nine taste such as remaining Fructus Aurantii, the decocting of 5 times of dosing material weight boil secondary, 2 hours every time, and filtration, merging filtrate subtract
Pressure is concentrated into the clear paste that relatively close 1.15~1.25 (60 DEG C) are surveyed.Plus refined honey and Radix Et Rhizoma Rhei powder, heating mixing, the technological procedure of the group
It is identical with the gastrointestine recovery paste formulation of States Pharmacopoeia specifications, obtain final product water extraction experimental group.
(2) Fructus Aurantii (parched with bran) 100g, dandelion 300g, Radix Paeoniae Rubra 150g, Semen Persicae 150g, Radix Pseudostellariae 100g, the Radix Aucklandiae are weighed
100g, Caulis Perillae 100g, Radix Et Rhizoma Rhei 150g, Semen Raphani (stir-fry) 200g, Radix Astragali 150g, refined honey 1000g.By Fructus Aurantii, Radix Pseudostellariae, Bao Gong
The decocting of 5 times of English, Semen Raphani, the Radix Astragali and Semen Persicae dosing material weight boils secondary, 2 hours every time, filtration, and merging filtrate reduces pressure dense
The clear paste that relatively close 1.15~1.25 (60 DEG C) are surveyed is reduced to, water extraction cream is obtained.The Radix Aucklandiae extracts volatile oil with the way of distillation, obtains the Radix Aucklandiae
Volatile oil;Radix Paeoniae Rubra and Caulis Perillae are pulverized and mixed, and extract 3 with 60% ethanol of 5 times of weight of medical material for (25 ± 2 DEG C) under normal temperature condition
Secondary, each 1h, united extraction liquid are evaporated to the clear paste that 1.15~1.25 (50 DEG C) are surveyed, obtain alcohol extraction cream;Radix Et Rhizoma Rhei powder particle
The micropowder that 1 μm of footpath >, obtains Radix Et Rhizoma Rhei powder.Mixing alcohol extraction cream, water extraction cream, volatile oil of Radix Aucklandiae and refined honey obtain experimental group A.
(3) Fructus Aurantii (parched with bran) 100g, Radix Pseudostellariae 100g, Radix Et Rhizoma Rhei 150g, dandelion 300g, Radix Aucklandiae 100g, Semen Raphani are weighed
(stir-fry) 200g, Radix Paeoniae Rubra 150g, Caulis Perillae 100g, Radix Astragali 150g, Semen Persicae 150g, refined honey 1000g.By Fructus Aurantii, Radix Pseudostellariae, Bao Gong
The decocting of 5 times of English, Semen Raphani, the Radix Astragali and Semen Persicae dosing material weight boils secondary, 2 hours every time, filtration, and merging filtrate reduces pressure dense
The clear paste that relatively close 1.15~1.25 (60 DEG C) are surveyed is reduced to, water extraction cream is obtained.The Radix Aucklandiae extracts volatile oil with the way of distillation, obtains the Radix Aucklandiae
Volatile oil;Radix Paeoniae Rubra and Caulis Perillae are pulverized and mixed, and with 60% ethanol of 5 times of weight of medical material, under the conditions of 45 ± 2 DEG C, warm macerating extracts 3
Secondary, each 1h, united extraction liquid are evaporated to the clear paste that 1.15~1.25 (50 DEG C) are surveyed, obtain alcohol extraction cream;Radix Et Rhizoma Rhei powder particle
The micropowder that 1 μm of footpath >, obtains Radix Et Rhizoma Rhei powder.Mixing alcohol extraction cream, water extraction cream, volatile oil of Radix Aucklandiae and refined honey obtain experimental group B.
(4) Fructus Aurantii (parched with bran) 100g, Radix Pseudostellariae 100g, Radix Et Rhizoma Rhei 150g, dandelion 300g, Radix Aucklandiae 100g, Semen Raphani are weighed
(stir-fry) 200g, Radix Paeoniae Rubra 150g, Caulis Perillae 100g, Radix Astragali 150g, Semen Persicae 150g, refined honey 1000g.By Fructus Aurantii, Radix Pseudostellariae, Bao Gong
The decocting of 5 times of English, Semen Raphani, the Radix Astragali and Semen Persicae dosing material weight boils secondary, 2 hours every time, filtration, and merging filtrate reduces pressure dense
The clear paste that relatively close 1.15~1.25 (60 DEG C) are surveyed is reduced to, water extraction cream is obtained.The Radix Aucklandiae extracts volatile oil with the way of distillation, obtains the Radix Aucklandiae
Volatile oil;Radix Paeoniae Rubra and Caulis Perillae are pulverized and mixed, and with 60% alcohol reflux 3 times of 5 times of weight of medical material, each 1h, merging are carried
Liquid is taken, the clear paste that 1.15~1.25 (50 DEG C) are surveyed is evaporated to, is obtained alcohol extraction cream;The micropowder of 1 μm of Radix Et Rhizoma Rhei powder particle diameter >, obtains
To Radix Et Rhizoma Rhei powder.Mixing alcohol extraction cream, water extraction cream, volatile oil of Radix Aucklandiae and refined honey obtain experimental group C.
2nd, impact of the different preparation methoies to gastrointestine recovery paste formulation activity
After 140 mices raise and train one week, fed in two batches and observed.Wherein selection 70 is randomly divided into sky after weighing
White group, model group, plus Fructus Cannabis Bolus group, water extraction experimental group, experimental group A, experimental group B and experimental group C, are 10 per component, by female
Male each point of half, this batch of mice are used for observing the duplication of Constipated mice.Other 70 mices are chosen with group technology ibid,
For observing the ink progradation of Constipation Model mice.Mice freely ingests, natural lighting, and timing cleaning, sterilization.
The daily gavage of blank group gives normal saline 0.2ml/10g, and the daily gavage of remaining each group gives Compound Di Fen Nuo Zhi
10mg/kg.d, continuous gavage 7 days is 1 course for the treatment of, stopping a day between the course for the treatment of, 2 course for the treatment of 30min blank groups after last dose
With model group mice respectively with the prepared Chinese ink gavage of 0.2ml/20g, from the first grain melena for starting two groups of mices of record to prepared Chinese ink
Defecation grain number and stool in efflux time, 6h, records result, and SPSS11.5 statistical softwares are analyzed, and establishes constipation
The modeling success of model.
After determining modeling success, positive drug control group (commercially available Chinese medicine Fructus Cannabis Bolus, Chinese medicines quasi-word:Z50020517)) and administration
Gavage once, is administered 3g/kg.d to group (water extraction experimental group, experimental group A, experimental group B and experimental group C) daily, is within 7 days a course for the treatment of,
It is discontinued 1 day between the course for the treatment of, after 2 courses for the treatment of, animal is put to death.
Before mice modeling, each group mice fur color gloss is white, and spirit is good, active active, and feed, drinking-water are normal, and body weight increases
It is long normal;After modeling, the jaundice of mice dry skin and hair, asthenia lazy move, ingest, drinking times are substantially reduced, during whole modeling
None is dead for each group mice;Blank group is without exception because of the ordinary circumstance of not modeling mice.After treatment gastric infusion, Fructus Cannabis Bolus
Group mice and water extraction experimental mice substantially increase after the initial stage activity of administration is compared with modeling, and spirit occurs in water extraction experimental mice
Restless performance, and two groups of Mouse Weights increases slowly, in whole therapeutic process, Fructus Cannabis Bolus group mice none dead, water
Carry experimental mice administration the 7th, 10 day early morning find it is dead, dead 2 altogether;Experimental group A, B, C are at the drug treatment initial stage
The activity of mice compared with increased after modeling, with the increase for the treatment of process, just Sai Tonggao, the activity of middle dose group mice, take the photograph
Compared with substantially increasing after modeling, body weight is without being decreased obviously for the ordinary circumstances such as food, drinking-water;Just fill in the activity of logical low dose group mice, take the photograph
The ordinary circumstances such as food, drinking-water are compared with after modeling, without substantially change, body weight is without being decreased obviously.None example for the treatment of group in whole therapeutic process
It is dead.
1 gastrointestine recovery cream of table improves impact of the preparation to model mice small intestinal peristalsis function
Group | Dosage | Ink progradation (%) |
Blank group | - | 54.6±7.2 |
Model group | 10mg/kg | 44.3±2.2 |
Fructus Cannabis Bolus group | 3g/kg | 58.9±7.1 |
Water extraction experimental group | 4g/kg | 57.6±6.8 |
Experimental group A | 3.5g/kg | 68.4±7.2 |
Experimental group B | 3.5g/kg | 86.1±8.2 |
Experimental group C | 3.5g/kg | 64.5±6.5 |
The ink progradation of mice can reflect the power of Mouse Stomach Intestinal motility.Table 1 is visible, compared with blank group, mould
Type group mice ink progradation significantly reduces (P<0.01), illustrate that the slow model of mouse small intestine propulsion functions is set up.With model group
Compare, the mice ink progradation for just filling in logical mixture amount each group significantly increases (P<0.01), Fructus Cannabis Bolus group and water extraction experimental group are little
The ink progradation of Mus is also obviously improved (P compared with model group<0.05).In addition to blank group and model group, between the group of remaining each group
Relatively show;The impact of experimental group A, C to mouse small intestine wriggling function is more than Fructus Cannabis Bolus group and water extraction experimental group to mouse small intestine
Impact (the P of wriggling function<0.05).Impacts of the experimental group B to mouse small intestine wriggling function is more than Fructus Cannabis Bolus group and water extraction is tested
Impact (P of the group to mouse small intestine wriggling function<0.01).The experimental data of analytical table 1 to may determine that and extract red using alcohol extracting method
Chinese herbaceous peony and Caulis Perillae are better than water extraction to the rate of transform of active component, and the pharmacologically active of experimental group B is better than experimental group A, C, its reason
It is liposoluble substance probably as the main active Radix Paeoniae Rubra total glycosidess and perilla ketone of the treatment constipation of Radix Paeoniae Rubra and Caulis Perillae, but
It is that its heat stability is poor, makes active component receive destruction using alcohol reflux.
Gastrointestine recovery cream after the improvement of embodiment 2 is investigated for the effect of abdominal post-operation complication
Abdominal post-operation gastrointestinal dysfunction, enteroparalysis are surgery common complications.Case totally 213, wherein man 98, female
117;54 ± 2.4 years old mean age.It is randomly divided into 2 groups of Experimental agents group and control drug, Experimental agents group 105, control
Medicine group 108.The preparation of the experimental group B prepared in experimental group administration embodiment 1;Matched group is administered commercially available gastrointestine recovery
Cream (Chinese medicines quasi-word Z37020407);Type of surgery with Subtotal gastrectomy, Bowel resection, Abdomen Trauma, gallbladder and operation on biliary tract is
It is main.
The oral or stomach tube administration in preoperative 1 day of experimental group and matched group, each 20~30g of consumption are taken with warm water dilution, often
Day totally 3 times.Then from the beginning of postoperative 6 hours, every 8 hours 1 time, to aerofluxuss or defecation.With borborygmus, postoperative bowel and
Observation index of the gastrointestinal decompression amount as postoperative intestinal function recovery.
1. postoperative borborygmus recovery situation:To starting to the time for hearing borborygmus to be compared from postoperative, as a result treat
Group Mean Time To Recovery 11.2 ± 1.82 hours;Matched group is 13.2 ± 1.73 hours.Two groups of controls are statistically significant
(P<0.05), illustrate that the gastrointestine recovery cream for carrying out changing technique carries out promoting postoperative borborygmus to comparing with commercially available gastrointestine recovery cream
The recovery of sound has remarkable effect.
2. postoperative bowel situation:To starting to the time for aerofluxuss occur to be compared from postoperative, as a result treatment group averagely arranges
Time gas time is 16.4 ± 1.42 hours;Matched group is 29.6 ± 1.48 hours.Two groups of controls are statistically significant (P<
0.05), explanation carries out the gastrointestine recovery cream of change technique and commercially available gastrointestine recovery cream carries out promoting postoperative row to comparing
Gas has remarkable effect.
3. postoperative gastrointestinal decompression amount situation:First post-operative day, 24 hours second day gastrointestinal decompression amounts are compared, as a result
Treatment group's gastrointestinal decompression flow control one day is 294 ± 5.4ml, is within second day 92 ± 4.5ml;Matched group respectively 312 ± 6.3ml,
133 ± 5.3ml, two groups of controls are statistically significant (P in postoperative 1st, 2 days<0.05), explanation carries out change technique
Gastrointestine recovery cream carry out contrast with commercially available gastrointestine recovery cream and significantly reduce can postoperative gastrointestinal decompression amount.
Claims (6)
1. a kind of gastrointestine recovery cream improves preparation, and the crude drug that the intestinal post-equalization cream improves preparation is stir-baked Fructus Aurantii in bran, dandelion, red
Chinese herbaceous peony, Semen Persicae, Radix Pseudostellariae, the Radix Aucklandiae, Radix Et Rhizoma Rhei, Caulis Perillae, Semen Raphani (parched), the Radix Astragali and refined honey, it is characterised in that:The stir-baked Fructus Aurantii in bran,
The weight ratio of dandelion, Radix Paeoniae Rubra, Semen Persicae, Radix Pseudostellariae, the Radix Aucklandiae, Radix Et Rhizoma Rhei, Caulis Perillae, Semen Raphani (parched), the Radix Astragali and refined honey is:2:6:3:
3:2:2:2:3:4:3:20;Wherein, the agents area of stir-baked Fructus Aurantii in bran, dandelion, Semen Persicae, Radix Pseudostellariae, Semen Raphani (parched) and the Radix Astragali is
The agents area of water extract, Radix Paeoniae Rubra and Caulis Perillae is ethanol extraction, and the agents area of the Radix Aucklandiae is volatile oil, Radix Et Rhizoma Rhei and refined honey
Agents area for being all used as medicine.
2. gastrointestine recovery cream according to claim 1 improves the preparation method of preparation, it is characterised in that:Including following step
Suddenly:
1)Weight ratio according to claim 1 weighs medical material;
2)The decocting of 5 times of Fructus Aurantii, Radix Pseudostellariae, dandelion, Semen Raphani, the Radix Astragali and Semen Persicae dosing material weight is boiled into secondary, every time 2
Hour, filtration, merging filtrate obtain Aqueous extracts;
3)The Radix Aucklandiae is extracted into volatile oil with the way of distillation, volatile oil of Radix Aucklandiae is obtained;
4)Radix Paeoniae Rubra and Caulis Perillae are pulverized and mixed, are extracted 3 times with 60% ethanol of 5 times of weight of medical material, each 1h, united extraction liquid,
Obtain alcohol extract;
5)By Aqueous extracts and alcohol extract;Concentrating under reduced pressure becomes the extractum of density 1.15~1.25 respectively, is mixed to get mixing leaching
Cream;
6)Radix Et Rhizoma Rhei is crushed into into micropowder;
7)Radix et Rhizoma Rhei micropowder and volatile oil of Radix Aucklandiae are mixed in mixing extractum, gastrointestine recovery cream are obtained and is improved system.
3. gastrointestine recovery cream according to claim 2 improves the preparation method of preparation, it is characterised in that:Step 4)Described
It is that warm macerating is extracted under the conditions of 45 ± 2 DEG C that 60% ethanol extracts 3 times.
4. gastrointestine recovery cream according to claim 2 improves the preparation method of preparation, it is characterised in that:Water extraction in step 5
Liquid concentrating under reduced pressure is 60 DEG C into the temperature of extractum, and alcohol extract concentrating under reduced pressure is 50 DEG C into the temperature of extractum.
5. the gastrointestine recovery cream described in claim 1 improves preparation and is preparing the gastrointestinal peristalsiss deficiency medicine that treatment chronic constipation causes
Application in thing.
6. gastrointestine recovery cream according to claim 1 improves preparation and is preparing treatment abdominal post-operation gastrointestinal dysfunction and intestinal
Application in paralysis medicine.
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1686278A (en) * | 2005-04-05 | 2005-10-26 | 周亚球 | Medicine for treating heart brain embulus disease and its preparation method |
CN102861124A (en) * | 2012-10-29 | 2013-01-09 | 重庆师范大学 | Costus root combination medicine and application thereof |
CN102895416A (en) * | 2012-11-12 | 2013-01-30 | 马强 | Acupoint application preparation for treating flatulence |
-
2016
- 2016-11-03 CN CN201610956284.0A patent/CN106511554A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1686278A (en) * | 2005-04-05 | 2005-10-26 | 周亚球 | Medicine for treating heart brain embulus disease and its preparation method |
CN102861124A (en) * | 2012-10-29 | 2013-01-09 | 重庆师范大学 | Costus root combination medicine and application thereof |
CN102895416A (en) * | 2012-11-12 | 2013-01-30 | 马强 | Acupoint application preparation for treating flatulence |
Non-Patent Citations (2)
Title |
---|
丘晨波: "《中药浸提制剂技术和质量监控》", 31 August 1995, 中国医药科技出版社 * |
杨建新等: ""胃肠复元汤促进腹部手术后胃肠功能恢复132例"", 《内蒙古中医药》 * |
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