CN106511418A - Fresh pseudo-ginseng activity extractive, preparation method thereof, preparation and application - Google Patents
Fresh pseudo-ginseng activity extractive, preparation method thereof, preparation and application Download PDFInfo
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- CN106511418A CN106511418A CN201611189646.4A CN201611189646A CN106511418A CN 106511418 A CN106511418 A CN 106511418A CN 201611189646 A CN201611189646 A CN 201611189646A CN 106511418 A CN106511418 A CN 106511418A
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- 244000131316 Panax pseudoginseng Species 0.000 title claims abstract description 44
- 235000003181 Panax pseudoginseng Nutrition 0.000 title claims abstract description 42
- 230000000694 effects Effects 0.000 title claims abstract description 42
- 238000002360 preparation method Methods 0.000 title claims abstract description 25
- 239000000341 volatile oil Substances 0.000 claims abstract description 20
- 238000000605 extraction Methods 0.000 claims abstract description 18
- 238000000034 method Methods 0.000 claims abstract description 17
- 239000000843 powder Substances 0.000 claims abstract description 17
- 239000002994 raw material Substances 0.000 claims abstract description 14
- 239000003814 drug Substances 0.000 claims abstract description 11
- 239000000463 material Substances 0.000 claims abstract description 9
- 238000002203 pretreatment Methods 0.000 claims abstract description 8
- 238000000926 separation method Methods 0.000 claims abstract description 6
- 235000013305 food Nutrition 0.000 claims abstract description 5
- 239000003826 tablet Substances 0.000 claims abstract description 5
- 239000002775 capsule Substances 0.000 claims abstract description 4
- 239000008187 granular material Substances 0.000 claims abstract description 4
- 230000004089 microcirculation Effects 0.000 claims abstract description 4
- 239000006187 pill Substances 0.000 claims abstract description 4
- 241000180649 Panax notoginseng Species 0.000 claims description 53
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 53
- 239000000284 extract Substances 0.000 claims description 37
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 29
- 238000010992 reflux Methods 0.000 claims description 14
- 238000001035 drying Methods 0.000 claims description 10
- 230000001954 sterilising effect Effects 0.000 claims description 10
- 239000004615 ingredient Substances 0.000 claims description 8
- 239000002002 slurry Substances 0.000 claims description 8
- 238000004108 freeze drying Methods 0.000 claims description 7
- 238000004659 sterilization and disinfection Methods 0.000 claims description 7
- 238000012805 post-processing Methods 0.000 claims description 6
- 150000002632 lipids Chemical class 0.000 claims description 4
- 239000008213 purified water Substances 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 3
- 230000002526 effect on cardiovascular system Effects 0.000 claims description 3
- 235000013402 health food Nutrition 0.000 claims description 3
- 238000004821 distillation Methods 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 238000001704 evaporation Methods 0.000 claims 1
- 230000008020 evaporation Effects 0.000 claims 1
- JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 239000011435 rock Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 abstract description 5
- 238000004458 analytical method Methods 0.000 description 7
- 239000000203 mixture Substances 0.000 description 6
- 238000007710 freezing Methods 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000008176 lyophilized powder Substances 0.000 description 4
- 238000004321 preservation Methods 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 229930182490 saponin Natural products 0.000 description 3
- 150000007949 saponins Chemical class 0.000 description 3
- 235000017709 saponins Nutrition 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 2
- 235000003140 Panax quinquefolius Nutrition 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 230000008014 freezing Effects 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 235000008434 ginseng Nutrition 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 238000004949 mass spectrometry Methods 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 239000007832 Na2SO4 Substances 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 1
- 210000004247 hand Anatomy 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 239000010813 municipal solid waste Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 238000002390 rotary evaporation Methods 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 230000008542 thermal sensitivity Effects 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a fresh pseudo-ginseng activity extractive, a preparation method of the fresh pseudo-ginseng activity extractive, a preparation and an application. The fresh pseudo-ginseng activity extractive is prepared by taking fresh pseudo-ginseng as raw material, and performing pre-treatment, extraction, separation, and post-treatment techniques; the fresh pseudo-ginseng activity extractive is yellow green, wherein the content of the volatile oil is more than 0.1%.. The preparation method comprises pre-treatment, extraction, separation, and post-treatment. The preparation is pure powder of fresh pseudo-ginseng activity extractive, or prepared to be powder, tablet, granule, capsule and pill by adding pharmaceutically acceptable auxiliary materials. The application is the application of fresh pseudo-ginseng activity extractive in preparing drugs, foods and health-care foods for improving angiocarpy and coronary microcirculation. The invention uses the fresh pseudo-ginseng (including preserved fresh pseudo-ginseng) as raw material, and gathers complete active original essence of the concentrated fresh pseudo-ginseng, and realizes the convenience of storage and carrying of the fresh pseudo-ginseng; the fresh pseudo-ginseng can be used efficiently.
Description
Technical field
The invention belongs to Radix Notoginseng deep process technology field, and in particular to a kind of fresh pseudo-ginseng activity extract and its preparation side
Method, preparation and application.
Background technology
The traditional Chinese medical science think health it is most important be QI and blood at all, and Radix Ginseng is the king of QI invigorating, and Radix Notoginseng is the king that enriches blood, three
Seven are also called the king in ginseng.So being a kind of important natural resources of Chinese medicinal materials.
The processing form of Radix Notoginseng product experienced a tortuous process, just start mainly using notoginseng drying root or life
Radix Notoginseng powder, the Radix Notoginseng total arasaponinss of Chinese medicine Western medicineization purification later, with the understanding of application practice, it is believed that the Radix Notoginseng of ecosystem compared with
The effect of Radix Notoginseng total arasaponinss replenishing and activating blood occurs in that more comprehensively, in turn and can retain comprehensive effective ingredient and relative can realize
The superfine notoginseng powder of efficient absorption.In recent years it is found that in fresh Radix Notoginseng effective ingredient be it is most comprehensively complete, particularly three
Seven total saponins are higher by more than 20% compared with the Radix Notoginseng of traditional drying, so and improve drying meanss, using vacuum lyophilization fresh three
Seven.Lyophilizing Radix Notoginseng, the Jing practical applications of several years are occurred in that on the market, it was demonstrated that the replenishing and activating blood effect of lyophilizing Radix Notoginseng is better than common dry
Dry Radix Notoginseng.So the development experience of Radix Notoginseng ecosystem is to Western medicine, ecosystem is then returned again, it is last again with science and technology processing handss
Section remains the process of fresh and alive ecosystem, finally still have followed Chinese tradition traditional Chinese medical science theory, and studying from nature is recovered one's original simplicity.It is high
Science service is in nature, rather than nature remodeling.
People generally acknowledge that the lyophilizing Radix Notoginseng product for retaining the active ingredients of fresh Radix Notoginseng is the optimal product of Radix Notoginseng mostly at present
Product form, not only content of the total saponins in radix notoginseng is higher by more than 20% compared with the Radix Notoginseng of traditional drying to fresh Radix Notoginseng, while the complete knot in Radix Notoginseng
The side that the active polysaccharide of structure, the composition traditional drying of volatile oil component and organized enzyme isoreactivity albumen and conventional high-temperature are extracted
Method is easily lost.So fresh Radix Notoginseng and lyophilizing Radix Notoginseng are the most complete product form of effective ingredient.There is a kind of fresh Radix Notoginseng mouth on market
Take liquid, although raw material is fresh Radix Notoginseng, but extraction process and sterilization process high-temperature heating and high temperature sterilization（Extracting temperature
60 DEG C of ＞, 120 DEG C of sterilization temperature）.Equally destroy the active component such as organized enzyme isoreactivity albumen of fresh Radix Notoginseng, and effectively into
The structural intergrity divided, loses the meaning as raw material with fresh Radix Notoginseng.Therefore, develop it is a kind of can solve the above problems fresh three
Seven processing technique are very important.
The drug activity of Chinese medicine focuses on four natures and five flavors of drug, and does not lie in the height of single certain effective ingredient, but has focused on
The integrity of effect composition, inventor retain a kind of significant composition of four natures and five flavors of drug, reason using volatile oil component as extract
Be volatile oil component be that plant thermal sensitivity in extraction process is most strong and be easiest to the composition for losing, while and being to retain plant four
The standard feature composition of the gas five tastes.
The volatile oil component ＞ 0.1 ‰ of general fresh Radix Notoginseng（That is 10mg/100g）, the Radix Notoginseng extract of traditional method for extracting waves
The equal ＜ 0.1 ‰ of hair oil composition is not detected.
The content of the invention
The first object of the present invention is to provide a kind of fresh pseudo-ginseng activity extract；Second purpose is fresh described in offer
The preparation method of pseudo-ginseng activity extract；3rd purpose is the preparation of the fresh pseudo-ginseng activity extract for providing described；4th mesh
Be the fresh pseudo-ginseng activity extract for providing described application.
The first object of the present invention is achieved in that described fresh pseudo-ginseng activity extract is with fresh Radix Notoginseng or fresh-keeping three
Seven is raw material, and premenstrual process, extracting and developing, aftertreatment technology step are prepared, and described fresh pseudo-ginseng activity extract is Huang
Green, wherein volatile oil content ＞ 0.1 ‰.
The second object of the present invention is achieved in that including pre-treatment, extracting and developing and post-processing step, concrete to wrap
Include：
A, pre-treatment：The water mill slurry of 1 ~ 3 times of fresh three seven weight of raw material is added after raw material fresh Radix Notoginseng is cleaned, is controlled during defibrination
35 DEG C of defibrination temperature ＜, obtains serosity；
B, extraction：Serosity is inserted in cold reflux extraction pot, the pure water of slurry weight 3-15 times is added, below 35 DEG C of temperature
Cold reflux extracts 60 ~ 180 min；
C, separation：Extracting solution is separated into material residue, retains water soluble ingredient and lipid, volatile oil component；
D, post processing：Extracting solution is concentrated, sterilized, the fresh pseudo-ginseng activity extract of object is dried to obtain.
The third object of the present invention is achieved in that the described pure powder of fresh pseudo-ginseng activity extract or adds pharmaceutically
Acceptable adjuvant is prepared into powder, tablet, granule, capsule and pill.
The fourth object of the present invention be achieved in that described fresh pseudo-ginseng activity extract preparation improve cardiovascular and
Application in the medicine of Coronary microcirculation, food and health food.
The present invention utilizes fresh Radix Notoginseng（Including fresh-keeping fresh Radix Notoginseng）For raw material, the primary essence of full activity of enrichment concentration Radix Notoginseng
China, realizes the storage of fresh Radix Notoginseng, the convenience for carrying, and can efficient utilization.Fresh pseudo-ginseng activity extract of the present invention is
Yellow greenish powder, remains the color and luster of fresh Radix Notoginseng ecosystem, and remains the four natures and five flavors of drug of fresh Radix Notoginseng, and entrance returns sweet, volatile oil
Content ＞ 0.1 ‰.Remain active polysaccharide and Radix Notoginseng total arasaponinss in Radix Notoginseng simultaneously（Rg1、Rb1、R1、Deng）Ecosystem structure it is complete
Property, and organized enzyme, the activity of active glucoprotein isoreactivity albumen；And the more traditional extraction of content of the total saponins in radix notoginseng is high by more than 20%.
Description of the drawings
Fig. 1 is the total ion current figure that gas chromatography combined with mass spectrometry of the present invention analyzes volatile oil component.
Specific embodiment
With reference to embodiment, the present invention is further illustrated, but never in any form the present invention is any limitation as,
Based on present invention teach that any conversion for being made or replacement, belong to protection scope of the present invention.
Fresh pseudo-ginseng activity extract of the present invention is premenstrual process, extracting and developing, rear place with fresh Radix Notoginseng as raw material
Reason processing step is prepared, and described fresh pseudo-ginseng activity extract is yellow green, wherein volatile oil content ＞ 0.1 ‰.
The preparation method of fresh pseudo-ginseng activity extract of the present invention, including pre-treatment, extracting and developing and post processing step
Suddenly, specifically include：
A, pre-treatment：The water mill slurry of 1 ~ 3 times of fresh three seven weight of raw material is added after raw material fresh Radix Notoginseng is cleaned, is controlled during defibrination
35 DEG C of defibrination temperature ＜, obtains serosity；
B, extraction：Serosity is inserted in cold reflux extraction pot, the pure water of slurry weight 3-15 times is added, below 35 DEG C of temperature
Cold reflux extracts 60 ~ 180 min；
C, separation：Extracting solution is separated into material residue, retains water soluble ingredient and lipid, volatile oil component；
D, post processing：Extracting solution is concentrated, sterilized, the fresh pseudo-ginseng activity extract of object is dried to obtain.
Described preparation method, the temperature in preparation process are controlled below 35 DEG C.
Extract：Plus 3～10 times of purification water cooled reflux extract 60 ~ 180 minutes, 35 DEG C of extraction process temperature ＜；
Separate：Separating starch, colloid, tannin and fiber, retain water soluble ingredient and lipid, volatile oil component；
Concentration：35 DEG C of cold concentration temperature ＜；
Sterilizing：35 DEG C of cold sterilization temperature ＜；
It is dried：- 40 DEG C of vacuum lyophilization～35 DEG C.
During concentration and sterilizing-drying is extracted, extracting solution and concentrated solution can not produce ebuillition of heated phenomenon, to avoid
The loss of volatile oil component.
The temperature control that step B is extracted is below 35 DEG C.
It is less than 35 DEG C cold concentration in temperature that concentration described in D steps is, the temperature control of described sterilizing is at 35 DEG C
Cold sterilization is carried out below；Described drying is lyophilization.
The preparation of fresh pseudo-ginseng activity extract of the present invention is the described pure powder of fresh pseudo-ginseng activity extract or adds
Enter pharmaceutically acceptable adjuvant and be prepared into powder, tablet, granule, capsule and pill.
The application of fresh pseudo-ginseng activity extract of the present invention is that described fresh pseudo-ginseng activity extract is preparing improvement
Application in the medicine of cardiovascular and Coronary microcirculation, food and health food.
To be embodied as case, the present invention will be further described below：
Embodiment 1
Fresh Radix Notoginseng 12kg is taken, the net fresh Radix Notoginseng of 10kg is obtained after cleaning, defibrination after 2 times of pure water is subsequently adding, then grinding slurry is put
Enter in cold reflux extraction element, add 10 times of pure water of serosity cold reflux in the case where 35 DEG C of ＜ to extract 120 minutes, then filter and extract
Liquid separates material residue, then extracting solution is obtained after separating liquid is centrifuged, and extracting solution Jing after 35 DEG C of cryoconcentration of ＜ carries out ultrahigh-pressure cold and kills
Bacterium, then quick-freezing are put into Freezing room cold preservation to less than -20 DEG C.Then it is cooled to freezing ice cube broken less than -40 DEG C in advance and inserts again
Lyophilization storehouse, it is freeze-dried after obtain 580 grams of lyophilized powders of yellow greenish powder, lyophilized powder Jing inflated with nitrogen is packed into
The powder finished product of 0.5g/ bags.
The volatile oil component of powder finished product is analyzed with GC-MS, method and condition and result are as follows：
Extract is taken and is placed in flask, plus distilled water, ether makees extractant, and Simultaneous distillation-extraction 4 hours is extract obtained to have
Anhydrous Na2SO4Eliminating water, rotary evaporation remove ether, obtain volatile aroma oil component.
Gas chromatography-mass spectrography analysis condition
Mass Spectrometry Conditions ion source：EI；Makings interface temperature：280℃；Ion source temperature：230℃；Level Four bar temperature:150℃；
Electron multiplier voltage：1894v；Electron energy：70ev.
Testing result is shown in accompanying drawing 1, sample volatile oil content >=0.4 ‰.
Embodiment 2
The freeze preservation Radix Notoginseng 60kg after cleaning is taken, defibrination after 1.5 times of purified water is added after defrosting 70%, then serosity is inserted
In cold reflux extraction element, add the purified water of 8 times of the serosity amount cold reflux in the case where 30 DEG C of ＜ to extract 180 minutes, be then peeled off carrying
Liquid and material residue being taken, then extracting solution being obtained Jing after 1.0um levels are filtered, extracting solution carries out frequency electromagnetic waves Jing after 35 DEG C of cryoconcentration of ＜
Sterilization, then quick-freezing is to less than -25 DEG C cold preservations.By the ice cube of extracting solution ice cube trash ice to 2 cms when being dried, then as
Precooling drying is carried out in lyophilization storehouse, after being dried, 3.4kg yellow greenish powders, the pure powder compressing machine tablettings of lyophilized powder Jing is obtained
After make tablet.
With analysis condition similarly to Example 1 and method, it is 0.14 ‰ that analysis obtains the volatile oil content of finished product sample.
Embodiment 3 (reference examples)
Fresh Radix Notoginseng 12kg is taken, the net fresh Radix Notoginseng of 10kg is obtained after cleaning, is then inserted after defibrination and is carried in cryogenic vacuum circumfluence distillation tank
Take, concentrate during vacuum and low temperature concentrating under reduced pressure tank is put into after extracting solution is clarified, concentrated solution or condensed cream insert low-temperature microwave drying
It is dried in device, obtains 550g and be dried Radix Notoginseng powder.
The volatile oil content that sample is obtained with analysis condition same as Example 1 and analysis method is 0.04 ‰.
Embodiment 4
Fresh Radix Notoginseng 12kg is taken, the net fresh Radix Notoginseng of 10kg is obtained after cleaning, 3 times of purified water defibrinations is added, is tried one's best for guarantee during defibrination
Low temperature, monitors defibrination temperature, and such as temperature is too high（Such as it is higher than 35 DEG C）, then appropriate frozen water cooling is added, then grinding slurry is inserted
In cold reflux extraction element, cold reflux is carried out at 25 DEG C and is extracted 180 minutes, after the completion of extraction, be separated by filtration material residue, Ran Houzai
Separated with high speed centrifuge and enter after impurity cryoconcentration, in 30 DEG C of ＜, concentrated solution quick-freezing is to less than -40 DEG C for thickening temperature control
Cold preservation, then yellow green lyophilized powder 610g is obtained Jing after -40 DEG C ~ 35 DEG C of lyophilization.
The volatile oil content that sample is obtained with analysis condition same as Example 1 and analysis method is 0.46 ‰.
Claims (9)
1. a kind of fresh pseudo-ginseng activity extract, it is characterised in that described fresh pseudo-ginseng activity extract is with fresh Radix Notoginseng or fresh-keeping three
Seven is raw material, and premenstrual process, extracting and developing, aftertreatment technology step are prepared, and described fresh pseudo-ginseng activity extract is Huang
Green, wherein volatile oil content ＞ 0.1 ‰.
2. the preparation method of the fresh pseudo-ginseng activity extract described in a kind of claim 1, it is characterised in that including pre-treatment, carry
Take, separate and post-processing step, specifically include：
A, pre-treatment：The water mill slurry of 1 ~ 3 times of fresh three seven weight of raw material is added after raw material fresh Radix Notoginseng is cleaned, is controlled during defibrination
35 DEG C of defibrination temperature ＜, obtains serosity；
B, extraction：Serosity is inserted in cold reflux extraction pot, the water of slurry weight 3-15 times is added, cold time below 35 DEG C of the temperature
Stream extracts 60 ~ 180 min；
C, separation：Extracting solution is separated into material residue, retains water soluble ingredient and lipid, volatile oil component；
D, post processing：Extracting solution is concentrated, sterilized, the fresh pseudo-ginseng activity extract of object is dried to obtain.
3. preparation method according to claim 2, it is characterised in that described water is redistilled water or purified water.
4. preparation method according to claim 2, it is characterised in that the temperature in preparation process is controlled below 35 DEG C.
5. preparation method according to claim 2, it is characterised in that it is the side with water on the rocks that defibrination temperature is controlled in step A
Temperature during method control defibrination is raised.
6. preparation method according to claim 2, it is characterised in that the temperature control that step B is extracted is carried out below 35 DEG C
Cold reflux is extracted, and it is a kind of new technology for being different from circumfluence distillation that cold reflux is extracted, and it is characterized in that extracting solution separates recirculation water
Be not the method condensed with heating evaporation, but recirculation water is separated with the method for room temperature Membrane Materials, membrance separation.
7. preparation method according to claim 2, it is characterised in that the concentration described in D steps be temperature be 35 DEG C with
Lower cold concentration, the temperature control of described sterilizing carry out cold sterilization below 35 DEG C；Described drying is lyophilization.
8. the preparation of the fresh pseudo-ginseng activity extract described in a kind of claim 1, it is characterised in that described fresh pseudo-ginseng activity is carried
Take the pure powder of thing or add pharmaceutically acceptable adjuvant to be prepared into powder, tablet, granule, capsule and pill.
9. the application of the fresh pseudo-ginseng activity extract described in a kind of claim 1, it is characterised in that described fresh pseudo-ginseng activity is carried
Take application of the thing in medicine, food and the health food for improving cardiovascular and Coronary microcirculation is prepared.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111096990A (en) * | 2020-02-19 | 2020-05-05 | 昆明邦宇制药有限公司 | Method for extracting panax notoginseng saponins from fresh panax notoginseng |
| CN112229148A (en) * | 2020-10-21 | 2021-01-15 | 湖北金贵中药饮片有限公司 | Vacuum freeze-drying method for pseudo-ginseng and application thereof |
| CN113350388A (en) * | 2020-03-04 | 2021-09-07 | 湖南鲜者尤良中药有限公司 | Preservative-free traditional Chinese medicine fresh minced fillet and preparation process and application thereof |
| CN113455604A (en) * | 2021-07-29 | 2021-10-01 | 文山学院 | Pseudo-ginseng extract and application thereof in functional beverage |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1704111A (en) * | 2004-05-27 | 2005-12-07 | 厦门今润医药科学开发有限公司 | Heating-free process for extracting fresh pseudo-ginseng |
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| CN105455129A (en) * | 2015-12-05 | 2016-04-06 | 戴群 | Cold chain based natural bionic technology, novel product produced with cold chain based natural bionic technology as well as application |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111096990A (en) * | 2020-02-19 | 2020-05-05 | 昆明邦宇制药有限公司 | Method for extracting panax notoginseng saponins from fresh panax notoginseng |
| CN113350388A (en) * | 2020-03-04 | 2021-09-07 | 湖南鲜者尤良中药有限公司 | Preservative-free traditional Chinese medicine fresh minced fillet and preparation process and application thereof |
| CN112229148A (en) * | 2020-10-21 | 2021-01-15 | 湖北金贵中药饮片有限公司 | Vacuum freeze-drying method for pseudo-ginseng and application thereof |
| CN113455604A (en) * | 2021-07-29 | 2021-10-01 | 文山学院 | Pseudo-ginseng extract and application thereof in functional beverage |
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