CN106511405A - Ginkgo biloba extract soft capsule and preparation method thereof - Google Patents
Ginkgo biloba extract soft capsule and preparation method thereof Download PDFInfo
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- CN106511405A CN106511405A CN201611231829.8A CN201611231829A CN106511405A CN 106511405 A CN106511405 A CN 106511405A CN 201611231829 A CN201611231829 A CN 201611231829A CN 106511405 A CN106511405 A CN 106511405A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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Abstract
The invention discloses a ginkgo biloba extract soft capsule, which consists of the following components in parts by weight: 20-30 parts of a ginkgo biloba extract, 10-15 parts of propanediol, 1-5 parts of vitamin E, 10-20 parts of honey, 40-80 parts of soybean oil and 1-3 parts of dextrin. The ginkgo biloba extract soft capsule provided by the invention, with the scientific addition of the ginkgo biloba extract and the vitamin E as major components for improving human blood lipid and blood pressure, is of great significance to the improvement of patient's health status. With the adoption of the prescription of the soft capsule, a water-soluble medicinal component of ginkgo biloba can be effectively and rapidly distributed in an entire gastrointestinal tract, so that the purpose of efficient and rapid absorption and utilization is achieved, and the bioavailability of the medicine (the soft capsule) is rapidly improved.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, more particularly to a kind of Ginkgo Biloba Extract soft capsule and its
Preparation method, belongs to the traditional Chinese medicine novel formulation of preventing and treating cardiovascular and cerebrovascular disease.
Background technology
Semen Ginkgo is one of most ancient gymnosperm for carrying over after quaternary glacier motion, has the laudatory title of living fossil.
Semen Ginkgo accounts for more than the 70% of whole world total amount in China's yield very abundant, is one of Chinese distinctive Chinese crude drug raw material.
Folium Ginkgo, also known as moth leaf, duck bottom sediment, are Ginkgoaceae plant Ginkgo bilobaGinkgo biloba L.Dried leaves.Silver
Folium Pruni, harvests when autumn leaf is still green, is dried in time.The many fold of Folium Ginkgo are broken, and, in sector, long 3～12cm is wide by 5 for complete person
～15cm.Yellow green or sundown, in irregular wavy bending, some centres are recessed, and deep person up to leaf length 4/ for upper limb
5。
Folium Ginkgo body is light, feeble QI, mildly bitter flavor.GUIXIN, lung meridian.Indication：Astringe the lung, relieving asthma, blood circulation promoting and blood stasis dispelling, pain relieving.With
In cough and asthma due to lung deficiency；Coronary heart disease, angina pectoriss, hyperlipidemia.
Existing Ginkgo Biloba Extract research is mainly prepared into oral liquid formulations, but the drug effect in Folium Ginkgo into
Dissolubility point in water is not good, causes the bioavailability in the preparation actual application of Folium Ginkgo not high.
The content of the invention
It is an object of the invention to overcome the oral liquid formulations practical application effect that in prior art prepared by Folium Ginkgo not good
Defect, there is provided a kind of Ginkgo Biloba Extract soft capsule and preparation method thereof.The present invention soft capsule during application, energy
Enough show good dissolubility, with bioavailability it is high the characteristics of, it is possible to increase the therapeutic effect of medicine.For preventing the heart
The major diseases such as cerebrovascular disease, tumor, cancer have good effect.
In order to realize foregoing invention purpose, the invention provides technical scheme below：
A kind of Ginkgo Biloba Extract soft capsule, constitutes including the following component of weight portion：Ginkgo Biloba Extract 20-30 part, the third two
Alcohol 10-15 parts, Vitamin E 1-5 part, Mel 10-20 parts, soybean oil 40-80 parts, dextrin 1-3 parts.
Further, the Ginkgo Biloba Extract soft capsule, constitutes including the following component of weight portion：Ginkgo Biloba Extract
25-30 parts, Propylene Glycol 10-14 part, Vitamin E 1-4 part, Mel 12-20 parts, soybean oil 50-80 parts, dextrin 1-2 parts.
Further, the Ginkgo Biloba Extract soft capsule, constitutes including the following component of weight portion：Ginkgo Biloba Extract
25-28 parts, Propylene Glycol 11-14 part, Vitamin E 1-3 part, Mel 15-20 parts, soybean oil 60-75 parts, dextrin 1-2 parts.
The Ginkgo Biloba Extract soft capsule science of the present invention with the addition of Ginkgo Biloba Extract and Vitamin E as improving human body
The main component of blood fat, blood pressure, for the health status for improving patient have significant meaning.The formula of soft capsule causes Semen Ginkgo
The water solublity active ingredient of leaf effectively quickly can be distributed in whole gastrointestinal tract, reach the mesh for efficiently quickly absorbing
So that the bioavailability of medicine is quickly improved.
Further, the Ginkgo Biloba Extract soft capsule, is made up of the following component of weight portion：Ginkgo Biloba Extract 30
Part, 12 parts of Propylene Glycol, 2 parts of Vitamin E, 20 parts of Mel, 80 parts of soybean oil, 2 parts of dextrin.
Further, the Ginkgo Biloba Extract soft capsule, is made up of the following component of weight portion：Ginkgo Biloba Extract 25
Part, 10 parts of Propylene Glycol, 2 parts of Vitamin E, 20 parts of Mel, 75 parts of soybean oil, 1 part of dextrin.
Further, the Ginkgo Biloba Extract soft capsule, can also include one or more in following component：Cortex cocois radiciss
Oil, Oleic acid sorbitol ester, glyceryl linoleate, lecithin, Polyethylene Glycol, Tween 80 etc..
Further, described Ginkgo Biloba Extract is prepared by the following method：
（1）Pretreatment：Fresh Folium Ginkgo is taken, is cleaned, is dried or dry, smashed to blade area and be not more than 20 square millimeters.
（2）Extract：Semen Ginkgo leaf raw material prepared by step 1, adds the 40-90v% ethanol solution of 1-5 times of weight, is heated to
50-80 DEG C of holding 1-4 hour, filters, and filtering residue is washed with the 10-99v% ethanol solution of 0.5-1 times of weight, merges wash solution,
As the first ethanol extract.
（3）By the first ethanol extract, with 200 eye mesh screen fine straining, sucking filtration, ethanol is reclaimed, is concentrated to dryness, is obtained Folium Ginkgo
Extract.
Further, step 1, in drying course, temperature is less than 85 DEG C.
Further, step 1, smashes to Ginkgo Biloba Leaves Extract Tablets area and is not more than 18 square millimeters.
Further, step 2, adds 2-4 times of ethanol solution to be extracted.
Note：The preparation method of the Ginkgo Biloba Extract in the application separately patent protection.
Compared with prior art, beneficial effects of the present invention：
1. the Ginkgo Biloba Extract soft capsule science of the present invention with the addition of Ginkgo Biloba Extract and Vitamin E as improving human body
The main component of blood fat, blood pressure, for the health status for improving patient have significant meaning.
2. the formula of soft capsule of the present invention enables the water solublity active ingredient of Folium Ginkgo to be effectively quickly distributed in
In whole gastrointestinal tract, the purpose for efficiently quickly absorbing is reached so that the bioavailability of medicine is quickly improved.
3. the Ginkgo Biloba Extract used in the composition of soft capsule of the present invention can be obtained through sufficient extraction process
Folium Ginkgo in active ingredient it is more abundant, with high extracting efficiency, so cause soft capsule medicine quality it is more outstanding.
Specific embodiment
With reference to test example and specific embodiment, the present invention is described in further detail.But this should not be understood
Scope for above-mentioned theme of the invention is only limitted to below example, and all technologies realized based on present invention belong to this
The scope of invention.In the present invention, not specified percentage ratio is weight percentage.
Embodiment 1
Prepare Ginkgo Biloba Extract
（1）Pretreatment：Fresh Folium Ginkgo is taken, is cleaned, is dried, smashed to blade area and be not more than 20 square millimeters.
（2）Extract：Semen Ginkgo leaf raw material prepared by step 1, adds the 60v% ethanol solution of 4 times of weight, is heated to 65-70
DEG C kept for 3 hours, filtered, filtering residue washed with the 30v% ethanol solution of 1 times of weight, and merging wash solution, as the first ethanol are carried
Take liquid.
（3）By the first ethanol extract, with 200 eye mesh screen fine straining, sucking filtration, ethanol is reclaimed, is concentrated to dryness, is obtained Folium Ginkgo
Extract.
Prepare Ginkgo Biloba Extract soft capsule
The following component for taking weight portion is prepared into soft capsule：25 parts of Ginkgo Biloba Extract, 15 parts of Propylene Glycol, 2 parts of Vitamin E,
18 parts of Mel, 80 parts of soybean oil, 1 part of dextrin.
Embodiment 2
Ginkgo Biloba Extract soft capsule, constitutes including the following component of weight portion：20 parts of Ginkgo Biloba Extract, 10 parts of Propylene Glycol,
1 part of Vitamin E, 12 parts of Mel, 72 parts of soybean oil, 2 parts of dextrin.Ginkgo Biloba Extract is carried using Folium Ginkgo prepared by embodiment 1
Take thing.
Embodiment 3
Ginkgo Biloba Extract soft capsule, constitutes including the following component of weight portion：28 parts of Ginkgo Biloba Extract, 14 parts of Propylene Glycol,
3 parts of Vitamin E, 20 parts of Mel, 75 parts of soybean oil, 1 part of dextrin.Ginkgo Biloba Extract is carried using Folium Ginkgo prepared by embodiment 1
Take thing.
Embodiment 4
Ginkgo Biloba Extract soft capsule, is made up of the following component of weight portion：30 parts of Ginkgo Biloba Extract, 12 parts of Propylene Glycol, dimension
2 parts of raw element E, 20 parts of Mel, 80 parts of soybean oil, 2 parts of dextrin.Ginkgo Biloba Extract is extracted using Folium Ginkgo prepared by embodiment 1
Thing.
Embodiment 5
Prepare Ginkgo Biloba Extract
（1）Pretreatment：Fresh Folium Ginkgo is taken, is cleaned, 60-80 DEG C of drying is smashed to blade area and be not more than 20 square millimeters.
（2）Extract：Semen Ginkgo leaf raw material prepared by step 1, adds the 75v% ethanol solution of 3 times of weight, is heated to 70-75
DEG C kept for 4 hours, filtered, filtering residue washed with the 20v% ethanol solution of 1 times of weight, and merging wash solution, as the first ethanol are carried
Take liquid.
（3）By the first ethanol extract, with 200 eye mesh screen fine straining, sucking filtration, ethanol is reclaimed, is concentrated to dryness, is obtained Folium Ginkgo
Extract.
Prepare Ginkgo Biloba Extract soft capsule
Ginkgo Biloba Extract soft capsule, is made up of the following component of weight portion：25 parts of Ginkgo Biloba Extract, 10 parts of Propylene Glycol, dimension
2 parts of raw element E, 20 parts of Mel, 75 parts of soybean oil, 1 part of dextrin.
Embodiment 6
Ginkgo Biloba Extract soft capsule, is made up of the following component of weight portion：30 parts of Ginkgo Biloba Extract, 12 parts of Propylene Glycol, dimension
2 parts of raw element E, 20 parts of Mel, 80 parts of soybean oil, 2 parts of dextrin.Ginkgo Biloba Extract is extracted using Folium Ginkgo prepared by embodiment 5
Thing.
Embodiment 7
Ginkgo Biloba Extract soft capsule, is made up of the following component of weight portion：25 parts of Ginkgo Biloba Extract, 10 parts of Propylene Glycol, dimension
2 parts of raw element E, 20 parts of Mel, 75 parts of soybean oil, 1 part of dextrin.Ginkgo Biloba Extract is extracted using Folium Ginkgo prepared by embodiment 5
Thing.
Claims (9)
1. a kind of Ginkgo Biloba Extract soft capsule, constitutes including the following component of weight portion：Ginkgo Biloba Extract 20-30 part, third
Glycol 10-15 parts, Vitamin E 1-5 part, Mel 10-20 parts, soybean oil 40-80 parts, dextrin 1-3 parts.
2. Ginkgo Biloba Extract soft capsule as claimed in claim 1, it is characterised in that the Ginkgo Biloba Extract soft capsule, bag
Include the following component composition of weight portion：Ginkgo Biloba Extract 25-30 part, Propylene Glycol 10-14 part, Vitamin E 1-4 part, Mel
12-20 parts, soybean oil 50-80 parts, dextrin 1-2 parts.
3. Ginkgo Biloba Extract soft capsule as claimed in claim 1, it is characterised in that the Ginkgo Biloba Extract soft capsule, bag
Include the following component composition of weight portion：Ginkgo Biloba Extract 25-28 part, Propylene Glycol 11-14 part, Vitamin E 1-3 part, Mel
15-20 parts, soybean oil 60-75 parts, dextrin 1-2 parts.
4. Ginkgo Biloba Extract soft capsule as claimed in claim 1, it is characterised in that the Ginkgo Biloba Extract soft capsule, by
The following component composition of weight portion：30 parts of Ginkgo Biloba Extract, 12 parts of Propylene Glycol, 2 parts of Vitamin E, 20 parts of Mel, soybean oil
80 parts, 2 parts of dextrin.
5. Ginkgo Biloba Extract soft capsule as claimed in claim 1, it is characterised in that the Ginkgo Biloba Extract soft capsule, by
The following component composition of weight portion：25 parts of Ginkgo Biloba Extract, 10 parts of Propylene Glycol, 2 parts of Vitamin E, 20 parts of Mel, soybean oil
75 parts, 1 part of dextrin.
6. Ginkgo Biloba Extract soft capsule as claimed in claim 1, it is characterised in that the Ginkgo Biloba Extract soft capsule, also
One or more in following component can be included：Oleum Cocois, Oleic acid sorbitol ester, glyceryl linoleate, lecithin, poly- second
Glycol, Tween 80 etc..
7. Ginkgo Biloba Extract soft capsule as claimed in claim 1, it is characterised in that described Ginkgo Biloba Extract be by with
It is prepared by lower section method：
（1）Pretreatment：Fresh Folium Ginkgo is taken, is cleaned, is dried or dry, smashed to blade area and be not more than 20 square millimeters；
（2）Extract：Semen Ginkgo leaf raw material prepared by step 1, adds the 40-90v% ethanol solution of 1-5 times of weight, is heated to 50-
80 DEG C of holding 1-4 hours, filter, and filtering residue is washed with the 10-99v% ethanol solution of 0.5-1 times of weight, merges wash solution, as
First ethanol extract；
（3）By the first ethanol extract, with 200 eye mesh screen fine straining, sucking filtration, ethanol is reclaimed, is concentrated to dryness, obtain Folium Ginkgo extraction
Thing.
8. Ginkgo Biloba Extract soft capsule as claimed in claim 7, it is characterised in that step 1, temperature is less than in drying course
85℃。
9. Ginkgo Biloba Extract soft capsule as claimed in claim 7, it is characterised in that step 1, smashes to Ginkgo Biloba Leaves Extract Tablets area not
More than 18 square millimeters.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611231829.8A CN106511405A (en) | 2016-12-28 | 2016-12-28 | Ginkgo biloba extract soft capsule and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611231829.8A CN106511405A (en) | 2016-12-28 | 2016-12-28 | Ginkgo biloba extract soft capsule and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106511405A true CN106511405A (en) | 2017-03-22 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611231829.8A Withdrawn CN106511405A (en) | 2016-12-28 | 2016-12-28 | Ginkgo biloba extract soft capsule and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110192588A (en) * | 2019-06-13 | 2019-09-03 | 四川顺翔银杏生物科技开发有限公司 | A kind of ginkgo leaf granular tea and preparation method thereof |
-
2016
- 2016-12-28 CN CN201611231829.8A patent/CN106511405A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110192588A (en) * | 2019-06-13 | 2019-09-03 | 四川顺翔银杏生物科技开发有限公司 | A kind of ginkgo leaf granular tea and preparation method thereof |
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| PB01 | Publication | ||
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| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20170322 |
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