CN106509434A - Chinese herbal medicine feed additive capable of preventing and treating diarrhea of piggies - Google Patents

Chinese herbal medicine feed additive capable of preventing and treating diarrhea of piggies Download PDF

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Publication number
CN106509434A
CN106509434A CN201610966776.8A CN201610966776A CN106509434A CN 106509434 A CN106509434 A CN 106509434A CN 201610966776 A CN201610966776 A CN 201610966776A CN 106509434 A CN106509434 A CN 106509434A
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parts
chinese herbal
radix
feed additive
fructus
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CN106509434B (en
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林忠宁
应朝阳
李振武
陆烝
詹杰
邓素芳
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Institute of Agricultural Ecology of Fujian Academy of Agricultural Sciences
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Institute of Agricultural Ecology of Fujian Academy of Agricultural Sciences
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
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    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8998—Hordeum (barley)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9064—Amomum, e.g. round cardamom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
    • Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
    • Y02P60/87—Re-use of by-products of food processing for fodder production

Abstract

The invention belongs to the technical field of piggy feeds, and particularly relates to a Chinese herbal medicine feed additive capable of preventing and treating diarrhea of piggies and a preparation method of the Chinese herbal medicine feed additive. The preparation method comprises the following steps of performing reflux extraction on smoked plums, villous amomum fruits and dried orange peel using 60-90% ethanol to obtain extract a, and performing reflux extraction on the smoked plums, the villous amomum fruits and the dried orange peel with drinking water to obtain extract b, and merging the extract a with the extract b so as to obtain a mixed extract; mixing the mixed extract with aqueous extract of copperleaf herbs, barberry roots, medicated leaven, Chinese yams, radix codonopsis,bighead atractylodes rhizomes, heterophylly falsestarwort roots, radix astragali, haws and licorice roots to obtain mixed liquor, concentrating the mixed liquor, and performing drying and processing so as to obtain dried powder; and finally uniformly mixing the dried powder with crushed fried malt powder and poria cocos powder, and performing packaging. According to the Chinese herbal medicine feed additive disclosed by the invention, raw materials are scientific and reasonable, a preparation process is high in operability, the prepared additive is good in palatability, the occurrence of the diarrhea of the piggies can be effectively avoided, the digestive absorption capacity of the piggies can be improved, the immunity and the anti-stress capacity can be enhanced, the survival rate of the piggies can be increased, and the growth of the piggies can be promoted.

Description

A kind of Chinese herbal feed additive of prevention and treatment piglet diarrhea
Technical field
The invention belongs to pig starter feed technical field, is more particularly to a kind of Chinese herbal medicine of prevention and treatment piglet diarrhea and raises Feed additives and preparation method thereof.
Background technology
Chinese herbal medicine is natural green plantss, has nutrition and two medicinal attribute concurrently, with promotion animal growth, The function such as efficiency of feed utilization is improved, has had application in meat swine rearing, but the main pin of Chinese herbal feed additive at present On in terms of production performance, immunity to pig, and it is directed to less in terms of preventing and treating piglet diarrhea, and effect is not obvious enough；Abdomen It is one of piglet diseases disease for frequently occurring in recent years to rush down, and the growth for having a strong impact on piglet is even dead, to breeding enterprise or agriculture Great economic loss is caused at family, at present, is mainly adopted antibiotic therapy for piglet diarrhea, is brought more residual than more serious medicine Problem is stayed, and receipts is treated with Chinese herbal medicine and can be solved medicament residue problem very well；Meanwhile, many Chinese herbal feed additive groups Side's not enough scientific and precise, palatability are poor, and the powder that Chinese herbal feed additive mostly is drying, crushes, mixes makes work Skill falls behind, and addition is excessive, constrains the popularization and application of Chinese herbal feed additive.
The content of the invention
It is an object of the invention to provide a kind of Chinese herbal feed additive of preventing and treating piglet diarrhea and preparation method thereof, raw material Scientific and reasonable, preparation process is workable, and the additive palatability of preparation is good, can effective prevention of diarrhea in piglets generation, The abilities of digestive and absorption of piglet, enhancing immunity and anti-stress ability are improved, the survival rate of piglet is improved, promotes piglet growth.
A kind of piglet Chinese herbal feed additive of the present invention, the raw material components of the additive are according to parts by weight bag Include：Herba Acalyphae 5-15 parts, Radix Berberidis 5-15 parts, Fructus Mume 5-15 parts, Massa Medicata Fermentata 5-15 parts, Rhizoma Dioscoreae 4-10 parts, Radix Codonopsis 4-10 parts, Poria 4-10 parts, Rhizoma Atractylodis Macrocephalae 4-10 parts, Radix Pseudostellariae 3-9 parts, Radix Astragali 3-9 parts, Pericarpium Citri Reticulatae 3-9 parts, Fructus Hordei Germinatus (parched) 2-8 parts, Fructus Crataegi 2-8 parts, sand Core 1-5 part, Radix Glycyrrhizae 1-5 parts.
The preparation method of Chinese herbal feed additive of the present invention, including：Fructus Mume, Fructus Amomi and Pericarpium Citri Reticulatae are used into 60%-90% successively Ethanol, drinking water reflux, extract, united extraction liquid, then with Herba Acalyphae, Radix Berberidis, Massa Medicata Fermentata, Rhizoma Dioscoreae, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Radix Pseudostellariae, The Aqueous extracts mixing of the Radix Astragali, Fructus Crataegi and Radix Glycyrrhizae, mixed liquor concentration, is dried processing and forms dry powder, finally with the Fructus Hordei Germinatus (parched) powder crushed With Poria powder mix homogeneously and pack.
Comprise the following steps that：
（1）, crush：Fructus Hordei Germinatus (parched) and Poria are crushed, the screen cloth of 80-160 mesh is crossed, it is standby；
（2）, extraction：The mass concentration of Fructus Mume, Fructus Amomi and Pericarpium Citri Reticulatae 4-8 times of bulking value of medicine is that 60%-90% alcohol refluxs are carried 0.5-1.5 hours are taken, ethanol extract a is collected, are then extracted 2-3 time with the drinking water backflow of 4-8 times of bulking value of medicine again, Temperature 85-95 DEG C, each 0.5-1.5 hours collect extracting solution b；Herba Acalyphae, Radix Berberidis, Massa Medicata Fermentata, Rhizoma Dioscoreae, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, too Sub- ginseng, the Radix Astragali, Fructus Crataegi and Radix Glycyrrhizae add the drinking water of 4-8 times of bulking value of medicine to decoct 2-3 time, each 0.5-1.5 hours, temperature 85-95 DEG C of degree, collects extracting solution c；
（3）, concentration：By step extracting solution a, b and c mixing (2), when being concentrated into 40-60 DEG C, relative density is 1.05-1.10's Concentrated solution；
（4）, be spray-dried：Addition accounts for the dextrin that concentrated solution weight ratio is 1%-3%, stirs and is spray-dried；
（5）, prepare：Weight ratio is added to be that 0.02-0.05%CMC and weight ratio are 0.03- in dry powder toward after being spray-dried 0.05% phospholipid, mix homogeneously；
（6）, sieve：Cross 80-160 eye mesh screens；
（7）, mixing：By step（6）Dry powder and step after sieving（1）The Fructus Hordei Germinatus (parched) powder for obtaining and Poria powder mix homogeneously, bag Dress.
The present invention Chinese herbal feed additive application be：By the additive by the weight ratio of pig starter feed feed amount it is The ratio of 0.3-1.0% is added to the daily feedstuff of piglet（Powder）In, feed is carried out after mixing thoroughly, it is also possible to which premix material form adds Pellet is a granulated in being added to piglet basal diet formula carries out feed, and the Chinese herbal feed additive is from the beginning of weaned piglet Uninterruptedly it is added to piglet length to 40kg or so end.
The present invention remarkable advantage be：
（1）, the present invention preparation method take extraction, concentration with spray method, the " micro of feed additive can have been accomplished Change, it is efficient ", convenient production, transport and feed adapt to the demand of modern barren sow large-scale cultivation, at the same to Fructus Mume, Fructus Amomi and Leach extraction method of the medical materials such as Pericarpium Citri Reticulatae using first alcohol extraction water extraction again, it is ensured that the liposoluble constituent of these medical materials is together with water soluble ingredient It is leached out, ensures effect of Chinese herbal feed additive to greatest extent.
（2）, the present invention Chinese herbal feed additive scientific formula, it is reasonable to coordinate, the Chinese herbal feed additive prescription The effects such as middle Herba Acalyphae and Radix Berberidis have different degrees of heat-clearing and toxic substances removing, removing food stagnancy dysentery relieving respectively, synergistic application have pre- well Anti- treatment piglet diarrhea, while acting on fine antiinflammatory inhibitory anti-virus；Fructus Mume, Massa Medicata Fermentata, the Rhizoma Atractylodis Macrocephalae, Fructus Amomi, Radix Codonopsis, Fructus Hordei Germinatus (parched) There is the effects such as different degrees of spleen benefiting and stimulating the appetite, eliminate dampness and have diuretic effect, the de-swelling that helps digestion, stagnant change respectively with Fructus Crataegi, synergistic application has very well Prevention and treatment gi system disease such as suffer from diarrhoea the various symptoms for causing；The Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Dioscoreae, Radix Pseudostellariae, stir-fry Fructus Hordei Germinatus, Pericarpium Citri Reticulatae, Fructus Crataegi and Radix Glycyrrhizae have functions that different degrees of invigorating the spleen and replenishing QI, calming heart and tranquilizing mind respectively, and synergistic application has very well Growth promotion, anti-stress, the effect of enhance immunity.
（3）, the present invention have obvious preventive effect to the diarrhoea of piglet, Incidence of Diarrhea compares matched group（It is conventional without Medicine）Reduce 54.2%-75.3%；Meanwhile, the present invention is significantly improved to the growth performance and immunity of piglet effect, with Matched group is compared, and feedstuff-meat ratio reduces 10.2%-23.5%, and the content of piglet Immunoglobulin in Serum IgA improves 12.0%- 20.8%, the content of Immunoglobulin IgM improves 13.5%-24.3%, and the content of immunoglobulin IgG improves 9.8%-13.2%.
（4）, the present invention have obvious therapeutical effect to the diarrhoea of piglet, treatment total effective rate reaches 72.5%-88.4%, with west Medicine group（Even zinc+the colistine sulfate of addition bacitracin）It is close to, while treatment, the growth performance of piglet can also be improved, With Western medicine group ratio, feedstuff-meat ratio reduction 8.5%-14.0%.
Specific embodiment
It is below several instantiations of the present invention, further describes the present invention, but the present invention is not limited only to this.
Example 1
A kind of Chinese herbal feed additive of prevention and treatment piglet diarrhea, the raw material components of the additive are according to parts by weight Including：15 parts of Herba Acalyphae, 15 parts of Radix Berberidis, 5 parts of Fructus Mume, 5 parts of Massa Medicata Fermentata, 10 parts of Rhizoma Dioscoreae, 10 parts of Radix Codonopsis, 4 parts of Poria, 4 parts of the Rhizoma Atractylodis Macrocephalae, 9 parts of Radix Pseudostellariae, 6 parts of the Radix Astragali, 3 parts of Pericarpium Citri Reticulatae, 8 parts of Fructus Hordei Germinatus (parched), 2 parts of Fructus Crataegi, 5 parts of Fructus Amomi, 1 part of Radix Glycyrrhizae.（It is total 100 parts）
The preparation method of described Chinese herbal feed additive, comprises the following steps that：
（1）Crush：Fructus Hordei Germinatus (parched) and Poria are crushed, the screen cloth of 80 mesh is crossed, it is standby；
（2）Extraction：The mass concentration of 8 times of Fructus Mume, Fructus Amomi and Pericarpium Citri Reticulatae medicine bulking value is that 60% alcohol reflux 1.5 is little When, ethanol extract a is collected, is then extracted 2 times with the drinking water backflow of 8 times of medicine bulking value again, 85 DEG C of temperature, every time 1.5 hours, collect extracting solution b；Herba Acalyphae, Radix Berberidis, Massa Medicata Fermentata, Rhizoma Dioscoreae, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Radix Pseudostellariae, the Radix Astragali, Fructus Crataegi and Radix Glycyrrhizae The drinking water of 8 times of drug weight volume is added to decoct 2 times, 1.5 hours every time, 85 DEG C of temperature collected extracting solution c；
（3）Concentration：By step（2）Extracting solution a, b and c mixing, when being concentrated into 40 DEG C, relative density is 1.05 concentrated solution；
（4）It is spray-dried：Add in concentrated solution and account for the dextrin that concentrated solution weight ratio is 1%, stir and be spray-dried；
（5）Prepare：Weight ratio is added to be that 0.02%CMC and weight ratio are 0.05% phospholipid, mixing in dry powder toward after being spray-dried Uniformly；
（6）Sieve：Cross 80 eye mesh screens；
（7）Mixing：By step（6）Dry powder and step after sieving（1）The Fructus Hordei Germinatus (parched) powder for obtaining and Poria powder mix homogeneously, bag Dress.
The application of Chinese herbal feed additive, including：Chinese herbal feed additive is pressed into the weight of pig starter feed feed amount Ratio than 0.3% is added in the daily feedstuff of piglet, and feed is carried out after mixing thoroughly, and the Chinese herbal feed additive is disconnected from piglet Milk starts uninterruptedly to be added to piglet length and terminates to 40kg.
Example 2
A kind of Chinese herbal feed additive of prevention and treatment piglet diarrhea, the raw material components of the additive are according to parts by weight Including：10 parts of Herba Acalyphae, 10 parts of Radix Berberidis, 10 parts of Fructus Mume, 10 parts of Massa Medicata Fermentata, 7 parts of Rhizoma Dioscoreae, 7 parts of Radix Codonopsis, 7 parts of Poria, 7 parts of the Rhizoma Atractylodis Macrocephalae, 6 parts of Radix Pseudostellariae, 9 parts of the Radix Astragali, 3 parts of Pericarpium Citri Reticulatae, 4 parts of Fructus Hordei Germinatus (parched), 4 parts of Fructus Crataegi, 3 parts of Fructus Amomi, 3 parts of Radix Glycyrrhizae.（It is total 100 parts）
The preparation method of described Chinese herbal feed additive, comprises the following steps that：
（1）Crush：Fructus Hordei Germinatus (parched) and Poria are crushed, the screen cloth of 120 mesh is crossed, it is standby；
（2）Extraction：The mass concentration of 6 times of Fructus Mume, Fructus Amomi and Pericarpium Citri Reticulatae medicine bulking value is that 80% alcohol reflux 1.0 is little When, ethanol extract a is collected, is then extracted 2 times with the drinking water backflow of 6 times of medicine bulking value again, 90 DEG C of temperature, every time 1.0 hours, collect extracting solution b；Herba Acalyphae, Radix Berberidis, Massa Medicata Fermentata, Rhizoma Dioscoreae, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Radix Pseudostellariae, the Radix Astragali, Fructus Crataegi and Radix Glycyrrhizae The drinking water of 6 times of drug weight volume is added to decoct 2 times, 1.0 hours every time, 90 DEG C of temperature collected extracting solution c；
（3）Concentration：By step（2）Extracting solution a, b and c mixing, when being concentrated into 50 DEG C, relative density is 1.08 concentrated solution；
（4）It is spray-dried：Add in concentrated solution and account for the dextrin that concentrated solution weight ratio is 2%, stir and be spray-dried；
（5）Prepare：Weight ratio is added to be that 0.03%CMC and weight ratio are 0.04% phospholipid, mixing in dry powder toward after being spray-dried Uniformly；
（6）Sieve：Cross 120 eye mesh screens；
（7）Mixing：By step（6）Dry powder and step after sieving（1）The Fructus Hordei Germinatus (parched) powder for obtaining and Poria powder mix homogeneously, bag Dress.
The application of Chinese herbal feed additive, including：Chinese herbal feed additive is added to piglet base with premix material form Pellet is a granulated in plinth Diet Formula carries out feed, and the addition of Chinese herbal feed additive accounts for weight and compares 1.0%, in this Medical herbs feed additive starts uninterruptedly to be added to piglet length from weaned piglet and terminates to 40kg.
Example 3
A kind of Chinese herbal feed additive of prevention and treatment piglet diarrhea, the raw material components of the additive are according to parts by weight Including：5 parts of Herba Acalyphae, 5 parts of Radix Berberidis, 15 parts of Fructus Mume, 15 parts of Massa Medicata Fermentata, 4 parts of Rhizoma Dioscoreae, 4 parts of Radix Codonopsis, 10 parts of Poria, 10 parts of the Rhizoma Atractylodis Macrocephalae, 3 parts of Radix Pseudostellariae, 6 parts of the Radix Astragali, 9 parts of Pericarpium Citri Reticulatae, 1 part of Fructus Hordei Germinatus (parched), 5 parts of Fructus Crataegi, 1 part of Fructus Amomi, 5 parts of Radix Glycyrrhizae.
The preparation method of described Chinese herbal feed additive, comprises the following steps that：
（1）Crush：Fructus Hordei Germinatus (parched) and Poria are crushed, the screen cloth of 160 mesh is crossed, it is standby；
（2）Extraction：The mass concentration of 4 times of Fructus Mume, Fructus Amomi and Pericarpium Citri Reticulatae medicine bulking value is that 90% alcohol reflux 0.5 is little When, ethanol extract a is collected, is then extracted 3 times with the drinking water backflow of 4 times of medicine bulking value again, 95 DEG C of temperature, every time 0.5 hour, collect extracting solution b；Herba Acalyphae, Radix Berberidis, Massa Medicata Fermentata, Rhizoma Dioscoreae, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Radix Pseudostellariae, the Radix Astragali, Fructus Crataegi and Radix Glycyrrhizae The drinking water of 4 times of drug weight volume is added to decoct 3 times, 0.5 hour every time, 95 DEG C of temperature collected extracting solution c；
（3）Concentration：By step（2）Extracting solution a, b and c mixing, when being concentrated into 60 DEG C, relative density is 1.10 concentrated solution；
（4）It is spray-dried：Add in concentrated solution and account for the dextrin that concentrated solution weight ratio is 3%, stir and be spray-dried；
（5）Prepare：Weight ratio is added to be that 0.05%CMC and weight ratio are 0.03% phospholipid, mixing in dry powder toward after being spray-dried Uniformly；
（6）Sieve：Cross 200 eye mesh screens；
（7）Mixing：By step（6）Dry powder and step after sieving（1）The Fructus Hordei Germinatus (parched) powder for obtaining and Poria powder mix homogeneously, bag Dress.
The application of Chinese herbal feed additive, including：Chinese herbal feed additive is pressed into the weight of pig starter feed feed amount Ratio than 1.0% is added in the daily feedstuff of piglet, and feed is carried out after mixing thoroughly, and the Chinese herbal feed additive is disconnected from piglet Milk starts uninterruptedly to be added to piglet length and terminates to 40kg.
The present invention's is embodied as effect
The present invention has obvious preventive effect to the diarrhoea of piglet, and Incidence of Diarrhea compares matched group（Routine is without medicine）Reduce 54.2%-75.3%；Meanwhile, the present invention is significantly improved to the growth performance and immunity of piglet effect, with matched group phase Than feedstuff-meat ratio reduces 10.2%-23.5%, and the content of piglet Immunoglobulin in Serum IgA improves 12.0%-20.8%, immune ball The content of protein I gM improves 13.5%-24.3%, and the content of immunoglobulin IgG improves 9.8%-13.2%.
The present invention has obvious therapeutical effect to the diarrhoea of piglet, and treatment total effective rate reaches 72.5%-88.4%, with Western medicine group （Even zinc+the colistine sulfate of addition bacitracin）It is close to, while treatment, the growth performance of piglet can also be improved, with west Medicine group ratio, feedstuff-meat ratio reduce 8.5%-14.0%.
The foregoing is only presently preferred embodiments of the present invention, all impartial changes done according to scope of the present invention patent with Modification, should all belong to the covering scope of the present invention.

Claims (4)

1. it is a kind of prevention and treatment piglet diarrhea Chinese herbal feed additive, it is characterised in that the raw material group of the additive Dividing includes according to parts by weight：Herba Acalyphae 5-15 parts, Radix Berberidis 5-15 parts, Fructus Mume 5-15 parts, Massa Medicata Fermentata 5-15 parts, Rhizoma Dioscoreae 4-10 Part, Radix Codonopsis 4-10 parts, Poria 4-10 parts, Rhizoma Atractylodis Macrocephalae 4-10 parts, Radix Pseudostellariae 3-9 parts, Radix Astragali 3-9 parts, Pericarpium Citri Reticulatae 3-9 parts, Fructus Hordei Germinatus (parched) 2-8 parts, Fructus Crataegi 2-8 parts, Fructus Amomi 1-5 parts, Radix Glycyrrhizae 1-5 parts.
2. a kind of preparation method of Chinese herbal feed additive as claimed in claim 1, it is characterised in that：The preparation method Including：By Fructus Mume, Fructus Amomi and Pericarpium Citri Reticulatae successively use 60%-90% ethanol, drinking water reflux, extract, united extraction liquid, then with Herba Acalyphae, The Aqueous extracts mixing of Radix Berberidis, Massa Medicata Fermentata, Rhizoma Dioscoreae, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Radix Pseudostellariae, the Radix Astragali, Fructus Crataegi and Radix Glycyrrhizae, mixed liquor are concentrated, are dried Processing forms dry powder, finally mixs homogeneously and packs with the Fructus Hordei Germinatus (parched) powder and Poria powder crushed.
3. the preparation method of Chinese herbal feed additive according to claim 2, it is characterised in that：Comprise the following steps that：
（1）Crush：Fructus Hordei Germinatus (parched) and Poria are crushed, the screen cloth of 80-160 mesh is crossed, it is standby；
（2）Extraction：The mass concentration of Fructus Mume, Fructus Amomi and Pericarpium Citri Reticulatae medicine bulking value 4-8 times is 60%-90% alcohol reflux 0.5-1.5 hours, collect ethanol extract a, are then extracted 2-3 time with the drinking water backflow of medicine bulking value 4-8 times again, temperature 85-95 DEG C of degree, each 0.5-1.5 hours collect extracting solution b；Herba Acalyphae, Radix Berberidis, Massa Medicata Fermentata, Rhizoma Dioscoreae, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, crown prince Ginseng, the Radix Astragali, Fructus Crataegi and Radix Glycyrrhizae add the drinking water of drug weight volume 4-8 times to decoct 2-3 time, each 0.5-1.5 hours, temperature 85-95 DEG C, collect extracting solution c；
（3）Concentration：By step（2）Extracting solution a, b and c mixing, when being concentrated into 40-60 DEG C, relative density is for 1.05-1.10 Concentrated solution；
（4）It is spray-dried：The dextrin for accounting for that concentrated solution weight ratio is 1%-3% is added in concentrated solution, stirring carries out spray dried It is dry；
（5）Prepare：Weight ratio is added to be that 0.02-0.05%CMC and weight ratio are 0.03-0.05% in dry powder toward after being spray-dried Phospholipid, mix homogeneously；
（6）Sieve：Cross 80-160 eye mesh screens；
（7）Mixing：By step（6）Dry powder and step after sieving（1）The Fructus Hordei Germinatus (parched) powder for obtaining and Poria powder mix homogeneously, bag Dress.
4. a kind of application of Chinese herbal feed additive as claimed in claim 1, it is characterised in that：The application includes：Will Chinese herbal feed additive is added in the daily feedstuff of piglet than the ratio of 0.3-1.0% in the weight of pig starter feed feed amount, Feed is carried out after mixing thoroughly；Or be added in piglet basal diet formula with premix material form be a granulated into pellet carry out feed Raise, the Chinese herbal feed additive starts uninterruptedly to be added to piglet length from weaned piglet and terminates to 40kg.
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CN107048032A (en) * 2017-04-28 2017-08-18 铜仁市万山区绿涛牧业有限公司 A kind of pig starter feed
CN107594179A (en) * 2017-11-07 2018-01-19 广州美豆生物技术有限公司 A kind of modified form of combination expanded soybean and emulsifying agent easily absorbs feed and preparation method thereof
CN107712327A (en) * 2017-11-17 2018-02-23 广西博白县春福林家庭农场 A kind of health care sheep feed additive
CN108785368A (en) * 2018-08-29 2018-11-13 江苏食品药品职业技术学院 Treat " four wormwood artemisias " feed addictive and the preparation method and application thereof of grice diarrhoea
CN109497286A (en) * 2018-12-24 2019-03-22 福建省农业科学院农业生态研究所 A kind of somatotrophic Chinese herbal feed additive of piglet and preparation method thereof
CN114246268A (en) * 2021-12-27 2022-03-29 清远一生自然生物研究院有限公司 Production method of mixed feed additive for preventing piglet diarrhea
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CN115644321B (en) * 2022-11-15 2023-03-03 潍坊天普阳光饲料科技有限公司 Feed additive for preventing and treating pig diarrhea and preparation method thereof

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