CN115644321A - Feed additive for preventing and treating pig diarrhea and preparation method thereof - Google Patents

Feed additive for preventing and treating pig diarrhea and preparation method thereof Download PDF

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CN115644321A
CN115644321A CN202211420272.8A CN202211420272A CN115644321A CN 115644321 A CN115644321 A CN 115644321A CN 202211420272 A CN202211420272 A CN 202211420272A CN 115644321 A CN115644321 A CN 115644321A
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feed additive
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chinese herbal
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CN115644321B (en
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李玉礼
袁涛
常铁生
王从健
史效华
陈继伟
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Weifang Universal Sunshine Feed Technology Co ltd
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Abstract

The invention discloses a feed additive for preventing and treating pig diarrhea and a preparation method thereof, belonging to the technical field of feed additives, wherein the preparation method of the feed additive comprises the following steps: preparing Chinese herbal medicine extract, preparing synergist, and mixing; the mixing comprises the steps of uniformly mixing the Chinese herbal medicine extract, the synergist, the ascorbyl palmitate, the hydroxymethionine and the glycine, and then grinding to 200-300 mu m to obtain the feed additive for preventing and treating the pig diarrhea; the invention can improve the storage stability of the feed additive, enhance the treatment effect of the feed additive on pig diarrhea, shorten the action time of the feed additive, improve the daily gain and daily feed intake, reduce the feed conversion ratio and simplify the preparation method of the feed additive.

Description

Feed additive for preventing and treating pig diarrhea and preparation method thereof
Technical Field
The invention relates to the technical field of feed additives, in particular to a feed additive for preventing and treating pig diarrhea and a preparation method thereof.
Background
The feed additive is a small amount or trace substance added in the production, processing and using processes of feed, the dosage of the feed additive is small but the effect is obvious, the feed additive is a raw material inevitably used in modern feed industry, and the feed additive has obvious effects on enhancing the nutritive value of basic feed, improving the production performance of animals, ensuring the health of animals, saving the cost of feed, improving the quality of animal products and the like.
The diarrhea disease of the pig is a common disease and frequently encountered disease of the pig, not only brings death of the pig to a pig farm, causes direct loss and large medical expense, but also influences the growth and development of the survived pig, and in recent years, the disease becomes more and more serious in some areas and pig farms, and becomes an important factor for restricting the economic benefit of the pig industry.
The method for treating the pig diarrhea comprises a food stopping method, an insect expelling method, an antibiotic therapy and an oral salt supplementing method, the currently most common methods are the antibiotic therapy and the oral salt supplementing method, but the antibiotic therapy is easy to cause the generation of bacterial drug resistance in a pig body and the antibiotic residue in pork, and the oral salt supplementing method can only temporarily relieve the diarrhea symptom and cannot radically treat the diarrhea.
The feed additive can be used for treating diarrhea and simultaneously overcoming the defects of an antibiotic therapy and an oral salt supplementing method, the most commonly used feed additive for treating the porcine diarrhea at present is a Chinese herbal medicine feed additive, and the Chinese herbal medicine feed additive is a feed additive prepared by taking Chinese herbal medicines as raw materials and is mainly used for preventing diseases, protecting health, improving the production performance of animals, improving the quality of animal products, improving the quality of feeds and the like. However, the existing Chinese herbal medicine feed additive is prepared by directly crushing Chinese herbal medicines and then adding the crushed Chinese herbal medicines, the crushed Chinese herbal medicines are easy to absorb moisture and do not resist high temperature, so that the prepared feed additive is poor in storage stability, the Chinese herbal medicines are long in action time and need to be matched with western medicines for use, the Chinese herbal medicines and the western medicines can be mutually influenced, the drug effect can be weakened, the feed intake of pork pigs and the absorption of the feed can be influenced, the daily gain and the daily feed intake are reduced, and the feed conversion ratio is increased. Although the effective components can be extracted and microencapsulated, thereby improving the storage stability, different Chinese herbal medicine components have different sensitivities to temperature and different extraction modes of the effective components, so that the extraction time is long, the extraction difficulty is high, and if the effective components are uniformly heated and extracted, the effective components can be damaged, so that the treatment effect is reduced. Therefore, the storage stability of the feed additive is improved, the treatment effect of the feed additive on pig diarrhea is enhanced, the action time of the feed additive is shortened, the daily gain and the daily feed intake are improved, the feed conversion ratio is reduced, and the preparation method of the feed additive is simplified, which is a technical problem to be solved urgently at present.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides the feed additive for preventing and treating the pig diarrhea and the preparation method thereof, which can improve the storage stability of the feed additive, enhance the treatment effect of the feed additive on the pig diarrhea, shorten the action time of the feed additive, improve the daily gain and the daily feed intake, reduce the feed-meat ratio and simplify the preparation method of the feed additive.
In order to solve the technical problems, the technical scheme adopted by the invention is as follows:
a preparation method of a feed additive for preventing and treating pig diarrhea comprises the following steps: preparing Chinese herbal medicine extract, preparing synergist, and mixing.
The preparation method comprises the following steps of preparing a Chinese herbal medicine extract, cleaning pericarpium citri reticulatae, poria cocos, mangnolia officinalis, radix paeoniae rubra, pomegranate rind, radix puerariae, rhizoma atractylodis macrocephalae, radix codonopsis and oregano respectively, placing the cleaned pericarpium citri reticulatae, poria cocos, mangnolia officinalis, radix paeoniae rubra, pomegranate rind, radix puerariae, rhizoma atractylodis macrocephalae, radix codonopsis and oregano into a dryer, drying the dried pericarpium citri reticulatae, poria cocos, mangnolia officinalis, radix paeoniae rubra, mangnolia officinalis, radix puerariae, rhizoma atractylodis, radix codonopsis and oregano at 38-42 ℃, uniformly mixing the pericarpium citri reticulatae, poria cocos, mangnolia officinalis, radix paeoniae, radix puerariae, rhizoma atractylodis macrocephalae, radix codonopsis and oregano according to a weight ratio of 4-5;
in the preparation of the Chinese herbal medicine extract, the ball-material ratio during ball milling is 20-22, the rotating speed is 350-380rpm, and the time is 40-45min;
in the preparation of the Chinese herbal medicine extract, the ultraviolet wavelength in the ultraviolet treatment is 280-320nm, the temperature is 40-45 ℃, and the time is 35-40min;
in the preparation of the Chinese herbal medicine extract, the air inlet temperature during spray drying is 140-145 ℃, the air outlet temperature is 70-75 ℃, and the feeding speed is 9-10mL/min;
in the preparation of the Chinese herbal medicine extract, the weight ratio of the mixed traditional Chinese medicine powder, the maltodextrin, the vitamin E and the soybean lecithin is (100-105);
in the preparation of the Chinese herbal medicine extract, the weight ratio of mixed powder, deionized water and ethanol is 50-53;
in the preparation of the Chinese herbal medicine extract, the concentration of the high-concentration oxygen is 95-97%.
Adding Dunaliella salina polysaccharide, astragalus polysaccharides, sodium chloride and bentonite into deionized water, performing ultrasonic oscillation with the frequency of 30-40kHz for 40-45min, adding calcium carbonate and gluconolactone, continuing the ultrasonic oscillation for 45-50min, stopping the ultrasonic oscillation, performing vacuum freeze drying at-30 ℃ to-25 ℃ under the vacuum degree of 0.09-0.092MPa for 16-18h, and crushing to 300-400 meshes to obtain the synergist after the vacuum freeze drying;
in the preparation of the synergist, the weight ratio of dunaliella salina polysaccharide, astragalus polysaccharide, sodium chloride, bentonite, calcium carbonate and gluconolactone is 10-12.
The mixing comprises the steps of uniformly mixing the Chinese herbal medicine extract, the synergist, the ascorbyl palmitate, the hydroxymethionine and the glycine, and then grinding to 200-300 mu m to obtain the feed additive for preventing and treating the pig diarrhea;
in the mixing, the weight ratio of the Chinese herbal medicine extract to the synergist to the ascorbyl palmitate to the hydroxymethionine to the glycine is (100-103) - (32-35).
A feed additive for preventing and treating pig diarrhea is prepared by the above preparation method.
Compared with the prior art, the invention has the beneficial effects that:
(1) According to the preparation method of the feed additive for preventing and treating the pig diarrhea, the mixed traditional Chinese medicine powder is treated, so that the storage stability of the feed additive can be improved, the caking rate is reduced, and the caking rate of the prepared feed additive is reduced to 2.14-2.23%;
(2) According to the preparation method of the feed additive for preventing and treating the pig diarrhea, the mixed traditional Chinese medicine powder is treated, the synergist is added, the action time of the feed additive can be shortened, the prepared feed additive is added into the feed additive according to the mass fraction of 1.5%, then 28-day weaned piglets are fed for 3 days, the diarrhea rate after 3 days is 2-6%, and the death rate is 0-2%;
(3) According to the preparation method of the feed additive for preventing and treating the pig diarrhea, the mixed traditional Chinese medicine powder is treated and the synergist is added, so that the treatment effect of the feed additive on the pig diarrhea is enhanced, the action time of the feed additive is shortened, the daily gain and the daily feed intake are improved, the feed additive prepared by the method is added into the feed additive according to the mass fraction of 1.5%, then the healthy pigs with the weight of 35-37kg are fed for 30 days, the average daily gain is 796-827 g/d.head, the average daily feed intake is 1361-1390 g/d.head, the feed-meat ratio is 1.69-1.71, and the total diarrhea number of the heads is 0-3;
(4) The preparation method of the feed additive for preventing and treating the pig diarrhea can simplify the preparation method of the feed additive, does not cause great damage to traditional Chinese medicine components in preparation, does not need to extract the traditional Chinese medicine components respectively, and reduces the extraction difficulty.
Detailed Description
In order to more clearly understand the technical features, objects, and effects of the present invention, specific embodiments of the present invention will now be described.
Example 1
A preparation method of a feed additive for preventing and treating pig diarrhea specifically comprises the following steps:
1. preparing Chinese herbal medicine extracts: the preparation method comprises the following steps of cleaning dried orange peel, poria cocos, mangnolia officinalis, red paeony root, pomegranate rind, kudzuvine root, bighead atractylodes rhizome, codonopsis pilosula and oregano respectively, drying at 38 ℃, and then crushing to 200 meshes respectively to obtain tangerine peel powder, poria cocos powder, mangnolia officinalis powder, red paeony root powder, pomegranate rind powder, kudzuvine root powder, bighead atractylodes rhizome powder, large-headed atractylodes rhizome powder and oregano powder, uniformly mixing the tangerine peel powder, the poria cocos powder, the mangnolia officinalis powder, the red paeony root powder, the pomegranate rind powder, the kudzuvine root powder, the large-headed atractylodes rhizome powder, the codonopsis pilosula powder and the oregano powder according to the weight ratio of (1): controlling the wavelength of ultraviolet rays in ultraviolet treatment to be 280nm, controlling the temperature to be 40 ℃ and the time to be 35min, obtaining mixed powder after the ultraviolet treatment is finished, adding the mixed powder, deionized water and ethanol into a reactor, controlling the temperature of the reactor to be 0.5 ℃, then using high-concentration oxygen to replace air in the reactor, continuously introducing the high-concentration oxygen until the pressure of the reactor is 0.06MPa, starting stirring, controlling the stirring speed to be 120rpm, stopping stirring after stirring for 50min to obtain mixed liquid, filtering the mixed liquid, taking filtrate for spray drying, controlling the air inlet temperature during spray drying to be 140 ℃, the air outlet temperature to be 70 ℃, the feeding speed to be 9mL/min, and obtaining Chinese herbal medicine extract after the spray drying is finished;
wherein the weight ratio of the mixed traditional Chinese medicine powder, the maltodextrin, the vitamin E and the soybean lecithin is (100);
wherein the weight ratio of the mixed powder to the deionized water to the ethanol is 50;
the concentration of the high-concentration oxygen gas is 95%.
2. Preparing a synergist: adding Dunaliella salina polysaccharide, astragalus polysaccharides, sodium chloride and bentonite into deionized water, performing ultrasonic oscillation with frequency of 30kHz for 40min, adding calcium carbonate and gluconolactone, continuing ultrasonic oscillation, stopping ultrasonic oscillation after 45min, performing vacuum freeze drying at-30 deg.C under vacuum degree of 0.09MPa for 16h, and pulverizing to 300 mesh to obtain synergist;
wherein, the weight ratio of the dunaliella salina polysaccharide to the astragalus polysaccharide to the sodium chloride to the bentonite to the calcium carbonate to the gluconolactone is 10.
3. Mixing: uniformly mixing the Chinese herbal medicine extract, the synergist, ascorbyl palmitate, hydroxymethionine and glycine, and grinding to 200 mu m to obtain the feed additive for preventing and treating pig diarrhea;
wherein, the weight ratio of the Chinese herbal medicine extract to the synergist to the ascorbyl palmitate, the hydroxy methionine and the glycine is 100.
Example 2
A preparation method of a feed additive for preventing and treating pig diarrhea comprises the following steps:
1. preparing Chinese herbal medicine extracts: cleaning pericarpium citri reticulatae, poria cocos, mangnolia officinalis, radix paeoniae rubra, pomegranate rind, radix puerariae, rhizoma atractylodis macrocephalae, radix codonopsis and origanum vulgaris, drying at 40 ℃, then crushing to 250 meshes respectively to obtain tangerine peel powder, poria cocos powder, mangnolia officinalis powder, radix paeoniae rubra powder, pomegranate rind powder, radix puerariae powder, rhizoma atractylodis macrocephalae powder, radix codonopsis pilosulae powder and origanum vulgaris powder, uniformly mixing tangerine peel powder, poria cocos powder, mangnolia officinalis powder, radix paeoniae rubra powder, pomegranate rind powder, radix puerariae powder, rhizoma atractylodis macrocephalae powder, radix codonopsis powder and origanum vulgaris powder according to a weight ratio of 5: controlling the wavelength of ultraviolet rays in ultraviolet treatment to be 300nm, controlling the temperature to be 42 ℃ and the time to be 37min, obtaining mixed powder after the ultraviolet treatment is finished, adding the mixed powder, deionized water and ethanol into a reactor, controlling the temperature of the reactor to be 1 ℃, then using high-concentration oxygen to replace air in the reactor, continuously introducing high-concentration oxygen until the pressure of the reactor is 0.065MPa, starting stirring, controlling the stirring speed to be 130rpm, stopping stirring after stirring for 52min to obtain mixed liquid, filtering the mixed liquid, taking filtrate for spray drying, controlling the air inlet temperature during spray drying to be 142 ℃, the air outlet temperature to be 72 ℃, the feeding speed to be 9.5mL/min, and obtaining the Chinese herbal medicine extract after the spray drying is finished;
wherein the weight ratio of the mixed traditional Chinese medicine powder, the maltodextrin, the vitamin E and the soybean lecithin is 102;
wherein the weight ratio of the mixed powder to the deionized water to the ethanol is 52;
the concentration of the high-concentration oxygen is 96%.
2. Preparing a synergist: adding dunaliella salina polysaccharide, astragalus polysaccharide, sodium chloride and bentonite into deionized water, performing ultrasonic oscillation, controlling the frequency of the ultrasonic oscillation to be 35kHz and the time to be 42min, then adding calcium carbonate and gluconolactone, continuing the ultrasonic oscillation, after 47min, stopping the ultrasonic oscillation, performing vacuum freeze drying, controlling the temperature of the vacuum freeze drying to be-28 ℃, the vacuum degree to be 0.091MPa and the time to be 17h, finishing the vacuum freeze drying, and crushing to 350 meshes to obtain a synergist;
wherein, the weight ratio of the dunaliella salina polysaccharide to the astragalus polysaccharide to the sodium chloride to the bentonite to the calcium carbonate to the gluconolactone is 11.
3. Mixing: uniformly mixing the Chinese herbal medicine extract, the synergist, ascorbyl palmitate, hydroxymethionine and glycine, and grinding to 250 mu m to obtain the feed additive for preventing and treating pig diarrhea;
wherein, the weight ratio of the Chinese herbal medicine extract to the synergist to the ascorbyl palmitate, the hydroxymethionine and the glycine is 101.
Example 3
A preparation method of a feed additive for preventing and treating pig diarrhea comprises the following steps:
1. preparing Chinese herbal medicine extracts: cleaning pericarpium citri reticulatae, poria cocos, mangnolia officinalis, radix paeoniae rubra, pomegranate rind, radix puerariae, bighead atractylodes rhizome, radix codonopsis and origanum vulgaris, drying at 42 ℃, then crushing to 300 meshes respectively to obtain tangerine peel powder, poria cocos powder, mangnolia officinalis powder, radix paeoniae rubra powder, pomegranate rind powder, radix puerariae powder, bighead atractylodes rhizome powder, radix atractylodis macrocephalae powder, radix codonopsis pilosulae powder and origanum vulgaris powder, uniformly mixing according to a weight ratio of 7;
wherein, the weight ratio of the mixed traditional Chinese medicine powder, the maltodextrin, the vitamin E and the soybean lecithin is 105;
wherein the weight ratio of the mixed powder to the deionized water to the ethanol is 53;
the concentration of the high concentration oxygen gas is 97%.
2. Preparing a synergist: adding Dunaliella salina polysaccharide, astragalus polysaccharides, sodium chloride and bentonite into deionized water, performing ultrasonic oscillation with the frequency of 40kHz for 45min, adding calcium carbonate and gluconolactone, continuing ultrasonic oscillation, stopping ultrasonic oscillation after 50min, performing vacuum freeze drying at-25 deg.C under the vacuum degree of 0.092MPa for 18h, and pulverizing to 400 mesh to obtain synergist;
wherein, the weight ratio of the dunaliella salina polysaccharide to the astragalus polysaccharide to the sodium chloride to the bentonite to the calcium carbonate to the gluconolactone is 12.
3. Mixing: uniformly mixing the Chinese herbal medicine extract, the synergist, ascorbyl palmitate, hydroxymethionine and glycine, and grinding to 300 mu m to obtain the feed additive for preventing and treating pig diarrhea;
wherein, the weight ratio of the Chinese herbal medicine extract to the synergist to the ascorbyl palmitate, the hydroxymethionine and the glycine is 103.
Comparative example 1
The preparation method of the feed additive for preventing and treating porcine diarrhea described in embodiment 3 is characterized in that: the steps of mixing the mixed traditional Chinese medicine powder, maltodextrin, vitamin E and soybean lecithin, performing ball milling and ultraviolet treatment, and subsequently mixing the mixed powder, deionized water and ethanol, introducing high-concentration oxygen and performing spray drying in the step 1 for preparing the Chinese herbal medicine extract are omitted, namely the step 1 for preparing the Chinese herbal medicine extract is modified into the following steps: the preparation method comprises the following steps of (1) cleaning pericarpium citri reticulatae, poria cocos, mangnolia officinalis, radix paeoniae rubra, pomegranate rind, radix puerariae, rhizoma atractylodis macrocephalae, radix codonopsitis and origanum vulgaris respectively, then drying at 42 ℃, and then crushing to 300 meshes respectively to obtain tangerine peel powder, poria cocos powder, mangnolia officinalis powder, radix paeoniae rubra powder, pomegranate rind powder, radix puerariae powder, rhizoma atractylodis macrocephalae powder, radix atractylodis macrocephalae powder, and origanum powder, wherein the following components in parts by weight are;
and the same amount of the mixed traditional Chinese medicine powder is used for replacing the traditional Chinese medicine extract in the step 3.
Comparative example 2
The preparation method of the feed additive for preventing and treating porcine diarrhea described in example 3 is adopted, and the difference is that: the step of preparing the synergist in step 2 is omitted and the addition of the synergist in the mixing step 3 is omitted.
Test example 1
The feed additives for preventing and treating porcine diarrhea prepared in examples 1-3 and comparative examples 1-2 were subjected to accelerated caking test as follows:
respectively taking 500g of the feed additive for preventing and treating the pig diarrhea prepared in the embodiment 1-3 and the comparative example 1-2, filling the feed additive into a plastic package bag, pressing the feed additive by using a heavy object, standing the feed additive for 10d in an environment with the temperature of 30 ℃ and the humidity of 85%, respectively taking the feed additive out, sieving the feed additive by using a sieve of 500 mu m, weighing the mass of the feed additive intercepted on the sieve, and calculating the caking rate, wherein the calculation formula of the caking rate is as follows:
caking rate = mass of feed additive retained on sieve/500 x 100%
The result of the block ratio calculation is as follows:
Figure 319271DEST_PATH_IMAGE001
the results show that the caking rate of the comparative example 1 is the highest, and the caking rate of the comparative example 2 is the lowest, which indicates that the traditional Chinese medicine powder can be effectively prevented from caking and the storage stability of the feed additive can be improved by adding maltodextrin, vitamin E and soybean lecithin into the mixed traditional Chinese medicine powder and then carrying out ball milling and ultraviolet treatment; the addition of a synergist leads to an increased caking rate.
Test example 2
Selecting 300 piglets aged for 28 days from a farm for testing, randomly dividing into 6 groups, wherein 50 piglets in each group are numbered 1-6 groups, weaning all the piglets on the 1 st day of the test, and adding the feed additives for preventing and treating pig diarrhea prepared in the examples 1-3 and the comparative examples 1-2 into the pig feed of each group according to the mass fraction of 1.5%, wherein the corresponding relations are as follows:
Figure 461540DEST_PATH_IMAGE002
the feed fed by 6 groups is not added with any feed additive and is used as a blank control, and the types of the feed fed by each group are ensured to be the same in the test process;
in the test, free food intake and drinking are adopted for each group of pigs, immunization and parasite expelling are carried out according to the conventional method, the test is carried out for 3 days, the diarrhea number and the death number of each group of pigs are counted after 3 days, the diarrhea rate and the death rate are calculated, and the calculation result is as follows:
Figure 815161DEST_PATH_IMAGE003
the results show that the weaned pigs are easy to cause stress reaction to cause diarrhea or death, and the feed additive with short action time is needed to be adopted, so that the weaned pigs are treated in time; the treatment of the mixed traditional Chinese medicine powder and the addition of the synergist can shorten the action time of the feed additive, thereby reducing the diarrhea rate and the death rate.
Test example 3
300 healthy pigs with the weight of 35-37kg are selected from a farm, randomly divided into 6 groups, 50 pigs in each group are numbered from 1-6 groups, and then the feed additives for preventing and treating pig diarrhea prepared in the examples 1-3 and the comparative examples 1-2 are added into the feed for the pigs according to the mass fraction of 1.5 percent, wherein the corresponding relation is as follows:
Figure 613352DEST_PATH_IMAGE004
the feed fed by 6 groups is not added with any feed additive and is used as a blank control, and the types of the feed fed by each group are ensured to be the same in the test process;
in the test, pigs in each group are fed and drunk freely, immunization and parasite expelling are carried out according to the conventional method, the weight, daily feed intake and diarrhea condition of each pig in each group are recorded every day, the test is carried out for 30 days totally, the average daily gain, average daily feed intake and feed-meat ratio of the pigs in each group are calculated after the test is finished, and the total diarrhea head number of each group is counted, wherein the calculation result is as follows:
Figure 77832DEST_PATH_IMAGE005
from the above results, it can be seen that although the treatment of the mixed traditional Chinese medicine powder and the addition of the synergist have a certain influence on the taste of the feed, thereby affecting the daily feed intake, the daily gain can be increased, and the feed conversion ratio and the total diarrhea number can be reduced.
All percentages used in the present invention are mass percentages unless otherwise indicated.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (6)

1. The preparation method of the feed additive for preventing and treating the porcine diarrhea is characterized by comprising the following steps: preparing Chinese herbal medicine extract, preparing synergist, and mixing;
the preparation method comprises the steps of preparing a Chinese herbal medicine extract, cleaning pericarpium citri reticulatae, poria cocos, mangnolia officinalis, radix paeoniae rubra, pomegranate rind, radix puerariae, bighead atractylodes rhizome, codonopsis pilosula and oregano respectively, drying at 38-42 ℃, then crushing to 200-300 meshes respectively to obtain tangerine peel powder, poria cocos powder, mangnolia officinalis powder, radix paeoniae rubra powder, pomegranate rind powder, kudzuvine root powder, radix puerariae powder, bighead atractylodes rhizome powder, codonopsis pilosula powder and oregano powder, mixing uniformly according to a weight ratio of (4-5);
in the preparation of the Chinese herbal medicine extract, the weight ratio of the mixed traditional Chinese medicine powder, the maltodextrin, the vitamin E and the soybean lecithin is (100-105);
in the preparation of the Chinese herbal medicine extract, the weight ratio of mixed powder, deionized water and ethanol is 50-53;
adding Dunaliella salina polysaccharide, astragalus polysaccharide, sodium chloride and bentonite into deionized water, performing ultrasonic oscillation, controlling the frequency of the ultrasonic oscillation to be 30-40kHz and the time to be 40-45min, then adding calcium carbonate and gluconolactone, continuing the ultrasonic oscillation, stopping the ultrasonic oscillation after 45-50min, performing vacuum freeze drying, controlling the temperature of the vacuum freeze drying to be-30 ℃ to-25 ℃, controlling the vacuum degree to be 0.09-0.092MPa and the time to be 16-18h, finishing the vacuum freeze drying, and crushing to 300-400 meshes to obtain the synergist;
in the preparation of the synergist, the weight ratio of dunaliella salina polysaccharide, astragalus polysaccharide, sodium chloride, bentonite, calcium carbonate and gluconolactone is 10-12;
the mixing comprises the steps of uniformly mixing the Chinese herbal medicine extract, the synergist, the ascorbyl palmitate, the hydroxymethionine and the glycine, and then grinding to 200-300 mu m to obtain the feed additive for preventing and treating the pig diarrhea;
in the mixing, the weight ratio of the Chinese herbal medicine extract to the synergist to the ascorbyl palmitate, the hydroxymethionine and the glycine is (100-103).
2. The preparation method of the feed additive for preventing and treating pig diarrhea according to claim 1, wherein in the prepared Chinese herbal medicine extract, the ball-to-feed ratio during ball milling is 20-22, the rotation speed is 350-380rpm, and the time is 40-45min.
3. The method for preparing a feed additive for preventing and treating porcine diarrhea according to claim 1, wherein in the preparation of the Chinese herbal medicine extract, the ultraviolet wavelength in the ultraviolet treatment is 280-320nm, the temperature is 40-45 ℃, and the time is 35-40min.
4. The method for preparing a feed additive for preventing and treating porcine diarrhea according to claim 1, wherein in the preparation of the herbal extract, the air inlet temperature is 140-145 ℃, the air outlet temperature is 70-75 ℃, and the feed rate is 9-10mL/min during spray drying.
5. The method for preparing a feed additive for preventing and treating porcine diarrhea of claim 1, wherein the concentration of the high concentration oxygen in the prepared herbal extract is 95-97%.
6. A feed additive for preventing and treating porcine diarrhea, which is prepared by the preparation method of the feed additive for preventing and treating porcine diarrhea of any one of claims 1 to 5.
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Cited By (2)

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CN115777840A (en) * 2023-02-06 2023-03-14 潍坊天普阳光饲料科技有限公司 Feed additive for improving pork quality and preparation method thereof
CN117158518A (en) * 2023-10-28 2023-12-05 潍坊天普阳光饲料科技有限公司 Functional pre-mixed feed for laying ducks and preparation method thereof

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