CN106492200A - A kind of Chinese and western medicinal composition for treating anal fissure and preparation method - Google Patents

A kind of Chinese and western medicinal composition for treating anal fissure and preparation method Download PDF

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CN106492200A
CN106492200A CN201610924068.8A CN201610924068A CN106492200A CN 106492200 A CN106492200 A CN 106492200A CN 201610924068 A CN201610924068 A CN 201610924068A CN 106492200 A CN106492200 A CN 106492200A
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folium
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赵爱艳
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Abstract

The present invention relates to a kind of Chinese and western medicinal composition for treating anal fissure and preparation method, the raw material for making the Chinese and western medicinal composition effective ingredient is consisted of：Chondrus ocellatus Holmes, Folium Rumicis Japonici, Auricled Hedyotis Herb, Herba Ludwigiae Prostratae, Radix Rehmanniae, Folium rhois chinensiss, Citrus chachiensis Hort. (C. Suavissima Tanaka), Fructus Mori, Herba Beronicastri brunoniani, Radix Litseae, Folium Allii fistulosi, mountain Herba vallisneriae Spiralis, Coagulum Opuntiae sucus, Radix seu Folium Cassiae laevigatae, vitamin B1, lysozyme；The traditional Chinese medical science and western medicine therapy are combined by the present invention, using the co-action for treating anal fissure of each taste medicine, the effects such as there is heat-clearing and toxic substances removing, stomach function regulating relieving constipation, removing toxic substances and promoting subsidence of swelling, astringing to arrest bleeding, wind-dispelling eliminating carbuncle, intestine moistening of promoting the production of body fluid, regulating QI to relieve pain, sphincterismuss can be released, interrupt vicious cycle, promote wound healing, evident in efficacy, treating both the principal and secondary aspects of a disease will not be recurred once curing, and raw material easily takes, taking convenience, treatment cycle are short, low cost, resultant effect is good, while also having preferable preventive and therapeutic action to the complication of anal fissure.

Description

A kind of Chinese and western medicinal composition for treating anal fissure and preparation method
Technical field
The present invention relates to pharmaceutical technology field, more particularly to a kind of Chinese and western medicinal composition for treating anal fissure and preparation method.
Background technology
Anal fissure is the aphtha of the following anal canal skin holostrome of pectinate line.Its direction is parallel with the anal canal longitudinal axis, is about 0.5- 1.0cm, in fusiformis or ellipse, healing is difficult, is the common cause that young people produces severe pain at anal canal.And anal canal superficial is split Wound can not be considered as anal fissure, because its can spontaneous recovery quickly, and often asymptomatic.Anal fissure is apt to occur in middle place after anal canal, if there is anus anal canal side Split, or there are multiple breaches, it is envisioned that the Early manifestation of possibly inflammatory bowel disease.
External anal sphincter superficial part forms anococcygeal ligament at anus rear, and harder, retractility is poor；Levator ani m. major part is attached In anal canal both sides, therefore anal canal front and rear not as both sides strong, easily damage；Anal canal and rectum form anorectal region Angle, it is all to cause the factor of anal fissure to make anal canal rear portion bear the big grade of feces pressure.Patients with chronic constipation, row stiff due to defecating Overexert during excrement, easy damaged anal canal skin, damaging repeatedly makes laceration depth and full thickness skin, forms chronic infective ulcer.Have People reports that constipation causes anal fissure to account for 14%-24%, but constipation is also likely to be the consequence of anal fissure, is to fear defecation due to patient. Additionally, maternal infuries also can cause anal fissure, 3%-9% is accounted for.Frequent defecation during diarrhoea, anal canal is sensitive to tighten also easy damaged, damages repeatedly shape Into chronic infective ulcer.Anal sinusitis at chronic inflammatory disease near pectinate line, such as rear center, spread downwards and cause subcutaneous pus Swollen, ulceration and become chronic ulcer；The reason for also hardly possible heals after anal canal damage is failed to understand so far, it is believed that mainly damaging merging Caused by infection, during infection, inflammatory cell can discharge colloidal sol protoenzyme, prevent epithelial tissue regeneration and extend.In the recent period it has been proposed that anus Pipe posterior midline ischemia is the reason for anal fissure is apt to occur at this, because anal canal distal end is supplied by inferior rectal artery, the blood vessel is worn More ischiorectal fossa, separates ramuscule through anal sphincter to mucosa, but lacks inferior rectal artery branch after majority at joint（Account for 85%）.Also point out the blood capillary at posterior midline inside internal sphincter sparse from blood capillary Senile Mouse.Someone should Measured with laser Doppler flowmetry and join after anal canal
Blood flow at conjunction is compared with being few at other quadrants.
The typical clinical manifestations of anal fissure patient have pain, constipation and have blood in stool.If treatment is not in time, breach inflammation repeatedly, Development subcutaneous to anus edge is infected, subcutaneous abscess and fistula can be also formed.
Clinical doctor trained in Western medicine primary treatment principle is to soften stool, keeps free movement of the bowels, prevents pain, but cures the symptoms, not the disease, gives Patient brings greatly pain and financial burden；Then effect is slow for Chinese traditional treatment, and the course for the treatment of is longer, it is impossible to meet the demand of people.
Content of the invention
The invention provides a kind of Chinese and western medicinal composition for treating anal fissure and preparation method；The traditional Chinese medical science and doctor trained in Western medicine are treated by the present invention Method combines, and using the co-action for treating anal fissure of each taste medicine, stops with heat-clearing and toxic substances removing, stomach function regulating relieving constipation, removing toxic substances and promoting subsidence of swelling, convergence The effects such as blood, wind-dispelling eliminating carbuncle, intestine moistening of promoting the production of body fluid, regulating QI to relieve pain, sphincterismuss can be released, interrupt vicious cycle, promote wound surface to heal Close, evident in efficacy, treating both the principal and secondary aspects of a disease, will not recur once curing, and raw material easily takes, taking convenience, treatment cycle are short, cost Low, resultant effect is good, while also having preferable preventive and therapeutic action to the complication of anal fissure.
For achieving the above object, technical scheme is implemented as follows：
A kind of Chinese and western medicinal composition for treating anal fissure, making the Chinese and western medicinal composition effective ingredient includes Chinese medicinal components and Western medicine Component, the Chinese medicinal components are formed by the preparation of raw material of following weight number：Chondrus ocellatus Holmes 38-50g, Folium Rumicis Japonici 34-46g, Auricled Hedyotis Herb 34- 46g, Herba Ludwigiae Prostratae 32-44g, Radix Rehmanniae 28-40g, Folium rhois chinensiss 24-36g, Citrus chachiensis Hort. (C. Suavissima Tanaka) 24-36g, Fructus Mori 19-31g, Herba Beronicastri brunoniani 16- 24g, Radix Litseae 9-14g, Folium Allii fistulosi 9-14g, mountain Herba vallisneriae Spiralis 6-12g, Coagulum Opuntiae sucus 6-12g, Radix seu Folium Cassiae laevigatae 4-9g；The western medicine component by with The preparation of raw material of lower weight number is formed：Vitamin B10.1-0.2g, lysozyme 0.1-0.2g.
Making the Chinese and western medicinal composition effective ingredient includes Chinese medicinal components and western medicine component, and the Chinese medicinal components are by following The preparation of raw material of weight number is formed：Chondrus ocellatus Holmes 47g, Folium Rumicis Japonici 43g, Auricled Hedyotis Herb 43g, Herba Ludwigiae Prostratae 41g, Radix Rehmanniae 37g, Folium rhois chinensiss 33g, Citrus chachiensis Hort. (C. Suavissima Tanaka) 33g, Fructus Mori 28g, Herba Beronicastri brunoniani 22g, Radix Litseae 12g, Folium Allii fistulosi 12g, mountain Herba vallisneriae Spiralis 10g, Coagulum Opuntiae sucus 10g, Radix seu Folium Cassiae laevigatae 7g；The western medicine component is formed by the preparation of raw material of following weight number：Vitamin B10.17g, lysozyme 0.17g.
Making the Chinese and western medicinal composition effective ingredient includes Chinese medicinal components and western medicine component, and the Chinese medicinal components are by following The preparation of raw material of weight number is formed：Chondrus ocellatus Holmes 44g, Folium Rumicis Japonici 40g, Auricled Hedyotis Herb 40g, Herba Ludwigiae Prostratae 38g, Radix Rehmanniae 34g, Folium rhois chinensiss 30g, Citrus chachiensis Hort. (C. Suavissima Tanaka) 30g, Fructus Mori 25g, Herba Beronicastri brunoniani 20g, Radix Litseae 11g, Folium Allii fistulosi 11g, mountain Herba vallisneriae Spiralis 8g, Coagulum Opuntiae sucus 8g, Radix seu Folium Cassiae laevigatae 6g； The western medicine component is formed by the preparation of raw material of following weight number：Vitamin B10.15g, lysozyme 0.15g.
Making the Chinese and western medicinal composition effective ingredient includes Chinese medicinal components and western medicine component, and the Chinese medicinal components are by following The preparation of raw material of weight number is formed：Chondrus ocellatus Holmes 41g, Folium Rumicis Japonici 37g, Auricled Hedyotis Herb 37g, Herba Ludwigiae Prostratae 35g, Radix Rehmanniae 31g, Folium rhois chinensiss 27g, Citrus chachiensis Hort. (C. Suavissima Tanaka) 27g, Fructus Mori 22g, Herba Beronicastri brunoniani 18g, Radix Litseae 10g, Folium Allii fistulosi 10g, mountain Herba vallisneriae Spiralis 7g, Coagulum Opuntiae sucus 7g, Radix seu Folium Cassiae laevigatae 5g； The western medicine component is formed by the preparation of raw material of following weight number：Vitamin B10.13g, lysozyme 0.13g.
A kind of preparation method of the Chinese and western medicinal composition for treating anal fissure, comprises the following steps that：
(1) chondrus ocellatus Holmes, Folium Rumicis Japonici, Auricled Hedyotis Herb, Folium rhois chinensiss, Herba Beronicastri brunoniani, Radix Litseae, Folium Allii fistulosi, mountain Herba vallisneriae Spiralis, Coagulum Opuntiae sucus and Radix seu Folium Cassiae laevigatae are put Enter in container, be firstly added 10-15 times measure distilled water immersion 4-5 hours after, heated and boiled 3-4 hour, extract；Second plus 8- 10 times of amount distilled water heated and boiled 2-3 hours, extract；Third time adds 6-8 times and measures distilled water heated and boiled 1-2 hour, extracts；Close And extracting solution, filtration, filtrate is obtained, dry extract is condensed into standby；It is 90% alcoholic solution that dry extract is added volumetric concentration, stands, Supernatant is extracted, the extractum for precipitating is standby；
(2) by Herba Ludwigiae Prostratae and Fructus Mori immersion yellow wine 3-4 hours, after taking-up, sun dehydration is poured in pot, and slow fire parch is cooled Afterwards, smash to pieces and grind, obtained the fine powder of 120 mesh, standby；
(3) Radix Rehmanniae and Citrus chachiensis Hort. (C. Suavissima Tanaka) are smashed to pieces, twists juice, filtered, stay juice standby；
(4) by vitamin B1It is dissolved in 5 times of amount pure water with lysozyme, stirs, obtain solution, standby；
(5) extractum of above-mentioned gained, fine powder, juice and solution are mixed, adds dextrin to stir, gamma-rays radiation sterilization, Make the tablet of 0.4g/ pieces according to a conventional method, pack, the Chinese and western medicinal composition of as described treatment anal fissure.
Used by of the invention, the property of medicine of Chinese medicine is as follows：
Chondrus ocellatus Holmes：Sweet in the mouth, salty, cold in nature；Return large intestine, stomach.Heat-clearing and toxic substances removing, stomach function regulating relieving constipation.Main laryngopharynx swelling and pain, traumatic injury, sense Emit cold and heat, mumps, gastralgia, dry constipation of intestines.《Xinhua's book on Chinese herbal medicine outline》Carry：
" full algae：Sweet in the mouth, salty, cold in nature.There are heat-clearing and toxic substances removing, stomach function regulating bowel relaxing functions.For the gastric ulcer that hyperchlorhydria causes, also may be used Make aperient, often to eat among the people is used.Carrageenin is used for orthopaedics, can promote the growth of connective tissue and ossein, increases bone in children Absorption of the arm to calcium.”
Folium Rumicis Japonici：Sweet in the mouth, cold in nature.Cooling blood for hemostasis, relieving constipation, removing toxic substances and promoting subsidence of swelling, killing parasites for relieving itching.Main discharging fresh blood stool, constipation, infantile malnutrition Ulcerative carbuncle pyogenic infections, scabies.《This sketch of the southern regions of the Yunnan Province is said》Carry：" discharging fresh blood stool is controlled, constipation is obstructed.Temple are pasted in picking leaves, control cruelly red fire Eye pain.”
Auricled Hedyotis Herb：Bitter in the mouth, cool in nature.Heat-clearing and toxic substances removing, cool blood detumescence.Main cold, fever, cough due to lung-heat, laryngopharynx swelling and pain, enteritis, dysentery, Bleeding hemorrhoidss, metrorrhagia, venom, mastitis, carbuncle furuncle poison, eczema, traumatic injury.
Herba Ludwigiae Prostratae：Bitter in the mouth, cold in nature.Heat-clearing and toxic substances removing, inducing diuresis for treating stranguria syndrome, removing stasis to stop bleeding.Main cough due to lung-heat, laryngopharynx swelling and pain, conjunctival congestion Swell and ache, damp-heat dysentery, jaundice drench pain, and edema, leukorrhagia are spitted blood, and hematuria, discharging fresh blood stool, furuncle swell, scabies, and traumatic injury wound is swollen, wound Bleeding, snakeworm, lyssodexiss.
Radix Rehmanniae：Sweet in the mouth, hardship, cold in nature；GUIXIN, liver and kidney channel.Clearing away heat and cooling blood, fluid dryness.Main acute calenture, hyperpyrexia god Dusk, macule, Tianjin hinder excessive thirst, and the haematemesis of bleeding due to blood-heat, epistaxis, metrorrhagia are had blood in stool, aphtha of the mouth and tongue, laryngopharynx swelling and pain, and consumptive fever is coughed, and falls Injure bitterly, carbuncle.《Haigoushen》Carry：" Xie Zhure, removing blood stasis, the tonneau moon water blockage absolutely, also dredging water passages, smash thin trusted subordinate, can repercussive blood. Patient is empty and frequent fever, plus and uses it.”
Folium rhois chinensiss：Sour in the mouth, slight bitter, cool in nature.Cough-relieving, hemostasis, convergence, removing toxic substances.Main phlegmatic cough, has blood in stool, dysentery, night sweat, carbuncle, skin ulcer Infectionss, eczema, snake bite and insect sting.《Book on Chinese herbal medicine asks former》Carry：" except cough due to fluid-retention, promoting the production of body fluid to quench thirst, relieving heat toxin, alcoholism, sore throat, hematochezia, blood Dysentery, work(is with five times.”
Citrus chachiensis Hort. (C. Suavissima Tanaka)：Acrid in the mouth, hardship, mild-natured；Returns spleen, stomach, Liver Channel.Circulation of qi promoting the chest stuffiness relieving, dispersing the stagnated liver-QI for regulating the stomach, removing toxicity for eliminating carbuncles.Full vexed, the side of body rib of main septum pectorale Distending pain, blockage of menstruation, diaphragm carbuncle, acute mastitis, breast carcinoma.《Book on Chinese herbal medicine asks former》Carry：" septum pectorale is controlled against gas, row liver stomach stagnant gas, Sweeling-eliminating medicine powder poison.Disappear Acute mastitis, acute mastitis, breast carcinoma, hypochondriac pain, pass through.”
Fructus Mori：Sweet in the mouth, acid, cold in nature；Return liver and kidney channel.Nourishing YIN and benefiting blood, promotes the production of body fluid, intestine moistening.Main deficiency of the liver and kindey and the head of blood deficiency damage of essence Dizzy dizzy, soreness of waist tinnitus, early whitening of beard and hair, insomnia and dreamful sleep, injury thirst are quenched one's thirst, dry constipation of intestines.
Herba Beronicastri brunoniani：Bitter in the mouth, cold in nature.Heat-clearing and toxic substances removing, preventing phlegm from forming and stopping coughing.Main cough expectorant is yellow, laryngopharynx swelling and pain, dysentery, urine Drench drip, carbuncle sore tumefacting virus.《Xinhua's book on Chinese herbal medicine outline》Carry：" root stock.Bitter in the mouth, cold in nature.There are anti-inflammation and sterilization, removing toxic substances, dissipate swollen function. For tonsillitiss, stomach burning pain, cystitis, mastitis, carbuncle sore tumefacting virus, dysentery.”
Radix Litseae：Acrid in the mouth, hardship, warm in nature；Return liver, spleen, stomach.Expelling wind and removing dampness, regulating QI to relieve pain.Main flu, heart stomach cold type of pain, stomachache are told Rush down, tinea pedis, anemia of pregnant woman's edema, rheumatic arthralgia, traumatic injury, cerebral thrombosiss.《Guangdong Chinese medicine》Carry：" expelling wind and cold, ceases liver-wind, Detumescence.Dispelling the wind and dampness pathogens arthralgia pain, muscles and bones are powerless, and puerperal, foot was soft, phlegm-damp tinea pedis.”
Folium Allii fistulosi：Acrid in the mouth, warm in nature.Wind-dispelling diaphoresis, removing toxic substances and promoting subsidence of swelling.Cure cold wind and cold, headache nasal obstruction, and fever without sweat, apoplexy, appearance are floated Swollen, sore, carbuncle and painful swelling, traumatic injuries.《Japan hanako materia medica》Carry：" stem and leaf salt grinds net for catching birds or fish snakeworm wound incised wound.Water enters chap and swells, and stewing is ground Apply.”
Mountain Herba vallisneriae Spiralis：Bitter in the mouth, cold in nature.Heat-clearing and toxic substances removing, cool blood detumescence.Main chronic hepatitiss, urine leaching pain, aphtha, sore swollen toxin, traumatic injury Swell and ache.
Coagulum Opuntiae sucus：Sweet in the mouth, cold in nature.Clearing away heat and cooling blood, tranquilizing by nourishing the heart.Main hemorrhoidal bleeding, has blood in stool, and furuncle swells, and scalds, palpitation with a distress feeling, children's urgency Infantile convulsion.《Traditional Chinese Medicine in Sichuan will》Carry：" antipyretic calmness.Soothe sore throat, furuncle swells, scald, have blood in stool, proctoptosis, the ear heart are burst pus and acute infantile convulsion Wind.”
Radix seu Folium Cassiae laevigatae：Bitter in the mouth, puckery, cool in nature；Return lung, Liver Channel.Liver heat removing and eyesight improving, relieving constipation.Main cold, fever, the hot hot eyes of liver, nebula hinder mesh, Constipation.《Xinhua's book on Chinese herbal medicine outline》Carry：" root, leaf：Leaf is bitter, puckery, cool in nature.There is the function of heat clearing away, improving eyesight, relieving constipation.Root is used for tooth Bitterly, stomachache, laryngalgia, constipation.Under leaf is for catching a cold, rushing down.Seed be used for rush down under, corneal nebula, chronic conjunctivitiss, ascarifuge.”
The present invention compared with prior art, has the advantages that：
The traditional Chinese medical science and western medicine therapy are combined by the present invention, using the co-action for treating anal fissure of each taste medicine, with heat-clearing and toxic substances removing and The effects such as stomach relieving constipation, removing toxic substances and promoting subsidence of swelling, astringing to arrest bleeding, wind-dispelling eliminating carbuncle, intestine moistening of promoting the production of body fluid, regulating QI to relieve pain, sphincterismuss can be released, in Disconnected vicious cycle, promotes wound healing, evident in efficacy, treating both the principal and secondary aspects of a disease, will not recur once curing, and raw material easily takes, and takes Convenient, treatment cycle is short, and low cost, resultant effect are good, while also having preferable preventive and therapeutic action to the complication of anal fissure.
Specific embodiment
The present invention is further elaborated with reference to specific embodiment.
Embodiment 1
The raw material composition of Chinese and western medicinal composition effective ingredient of the present invention and weight are：Chondrus ocellatus Holmes 48g, Folium Rumicis Japonici 44g, Auricled Hedyotis Herb 44g, Herba Ludwigiae Prostratae 43g, Radix Rehmanniae 39g, Folium rhois chinensiss 34g, Citrus chachiensis Hort. (C. Suavissima Tanaka) 34g, Fructus Mori 29g, Herba Beronicastri brunoniani 23g, Radix Litseae 13g, Folium Allii fistulosi 13g, Mountain Herba vallisneriae Spiralis 11g, Coagulum Opuntiae sucus 11g, Radix seu Folium Cassiae laevigatae 8g, vitamin B10.19g, lysozyme 0.19g.
The preparation method of Chinese and western medicinal composition of the present invention, comprises the following steps that：
(1) chondrus ocellatus Holmes, Folium Rumicis Japonici, Auricled Hedyotis Herb, Folium rhois chinensiss, Herba Beronicastri brunoniani, Radix Litseae, Folium Allii fistulosi, mountain Herba vallisneriae Spiralis, Coagulum Opuntiae sucus and Radix seu Folium Cassiae laevigatae are put Enter in container, be firstly added 10-15 times measure distilled water immersion 4-5 hours after, heated and boiled 3-4 hour, extract；Second plus 8- 10 times of amount distilled water heated and boiled 2-3 hours, extract；Third time adds 6-8 times and measures distilled water heated and boiled 1-2 hour, extracts；Close And extracting solution, filtration, filtrate is obtained, dry extract is condensed into standby；It is 90% alcoholic solution that dry extract is added volumetric concentration, stands, Supernatant is extracted, the extractum for precipitating is standby；
(2) by Herba Ludwigiae Prostratae and Fructus Mori immersion yellow wine 3-4 hours, after taking-up, sun dehydration is poured in pot, and slow fire parch is cooled Afterwards, smash to pieces and grind, obtained the fine powder of 120 mesh, standby；
(3) Radix Rehmanniae and Citrus chachiensis Hort. (C. Suavissima Tanaka) are smashed to pieces, twists juice, filtered, stay juice standby；
(4) by vitamin B1It is dissolved in 5 times of amount pure water with lysozyme, stirs, obtain solution, standby；
(5) extractum of above-mentioned gained, fine powder, juice and solution are mixed, adds dextrin to stir, gamma-rays radiation sterilization, Make the tablet of 0.4g/ pieces according to a conventional method, pack, the Chinese and western medicinal composition of as described treatment anal fissure.
Usage and dosage：Orally, 2 times a day, and 2 tablets once（Every 0.4g）, warm water delivery service after meal 3 days is a course for the treatment of, 2 To 4 courses for the treatment of can recovery from illness, the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Embodiment 2
The raw material composition of Chinese and western medicinal composition effective ingredient of the present invention and weight are：Chondrus ocellatus Holmes 47g, Folium Rumicis Japonici 43g, Auricled Hedyotis Herb 43g, Herba Ludwigiae Prostratae 41g, Radix Rehmanniae 37g, Folium rhois chinensiss 33g, Citrus chachiensis Hort. (C. Suavissima Tanaka) 33g, Fructus Mori 28g, Herba Beronicastri brunoniani 22g, Radix Litseae 12g, Folium Allii fistulosi 12g, Mountain Herba vallisneriae Spiralis 10g, Coagulum Opuntiae sucus 10g, Radix seu Folium Cassiae laevigatae 7g, dimension life
Plain B10.17g, lysozyme 0.17g.
The present embodiment Chinese and western medicinal composition preparation method processing step and usage and dosage are same as Example 1.
Embodiment 3
The raw material composition of Chinese and western medicinal composition effective ingredient of the present invention and weight are：Chondrus ocellatus Holmes 44g, Folium Rumicis Japonici 40g, Auricled Hedyotis Herb 40g, Herba Ludwigiae Prostratae 38g, Radix Rehmanniae 34g, Folium rhois chinensiss 30g, Citrus chachiensis Hort. (C. Suavissima Tanaka) 30g, Fructus Mori 25g, Herba Beronicastri brunoniani 20g, Radix Litseae 11g, Folium Allii fistulosi 11g, Mountain Herba vallisneriae Spiralis 8g, Coagulum Opuntiae sucus 8g, Radix seu Folium Cassiae laevigatae 6g, vitamin B10.15g, lysozyme 0.15g.
The present embodiment Chinese and western medicinal composition preparation method processing step and usage and dosage are same as Example 1.
Embodiment 4
The raw material composition of Chinese and western medicinal composition effective ingredient of the present invention and weight are：Chondrus ocellatus Holmes 41g, Folium Rumicis Japonici 37g, Auricled Hedyotis Herb 37g, Herba Ludwigiae Prostratae 35g, Radix Rehmanniae 31g, Folium rhois chinensiss 27g, Citrus chachiensis Hort. (C. Suavissima Tanaka) 27g, Fructus Mori 22g, Herba Beronicastri brunoniani 18g, Radix Litseae 10g, Folium Allii fistulosi 10g, Mountain Herba vallisneriae Spiralis 7g, Coagulum Opuntiae sucus 7g, Radix seu Folium Cassiae laevigatae 5g, vitamin B10.13g, lysozyme 0.13g.
The present embodiment Chinese and western medicinal composition preparation method processing step and usage and dosage are same as Example 1.
Clinical data：
1st, case selection：
220 clinical observations of patient of anal fissure, patient are selected to be randomly divided into treatment group and matched group, wherein treatment group 110, man Property 55, women 55, age 18-72 year, 50.1 years old mean age, course of disease 1-5；Matched group 110, wherein male 55 Example, women 55, age 18-71 year, 49.7 years old mean age, course of disease 1-5；The course of disease of two groups of cases, degrees of symptoms Basically identical, without significant difference, with comparability.
2nd, medicament selection：
Treatment group patient takes Chinese and western medicinal composition of the present invention, and orally, 2 times a day, and 2 tablets once（Every 0.4g）, after meal temperature open Water delivery service, 3 days is a course for the treatment of, 2 to 4 courses for the treatment of can recovery from illness, the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Matched group external erythromycin ointment is smeared, and by specification is used, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
3rd, efficacy determination：
（1）Cure：Crissum pain, constipation, the symptom such as have blood in stool disappear, and physical recovery is normal.
（2）Effectively：Above-mentioned symptom has been alleviated.
（3）Invalid：Disease is unchanged.
4th, result：
Result above shows that treatment group's cure rate and total effective rate are apparently higher than matched group.
Model case is illustrated：
1st, Wang, man, 69 years old, peasant.Patient constipation occurred without obvious inducement before 5 years, and podex falling inflation is ached freely, after an action of the bowels Bitterly, even with a small amount of blood just, without mucopurulent bloody stool, do not take an evident turn for the better after local hospital treatment, to our hospital afterwards, through inspection Look into and be diagnosed as anal fissure.Give and take 1 course for the treatment of of Chinese and western medicinal composition of the present invention, above-mentioned symptom takes a turn for the better；Continue to take in the present invention 1 course for the treatment of of Western medicine compound, above-mentioned symptom disappear, and follow-up is not recurred, and thoroughly cure.
2nd, Lee, female, 66 years old, retired professor., there is proctalgia during stool in patient's pungent thing of eating usually before 4 years Unbearably, to our hospital, it is diagnosed as anal fissure on inspection.Give and take 1 course for the treatment of of Chinese and western medicinal composition of the present invention, above-mentioned symptom is good Turn；Continue to take 1 course for the treatment of of Chinese and western medicinal composition of the present invention, above-mentioned symptom disappears, and physical recovery is normal, and follow-up is not recurred, thorough Bottom cures.
3rd, Zhang, man, 55 years old, profession.Patient constipation occurred, has blood in stool symptom before 2 years, postemphasis, in local doctor Institute checks anal fissure, and on oral drugs, disease alleviates not substantially always, for asking thoroughly treatment, to our hospital.Give and take this 1 course for the treatment of of bright Chinese and western medicinal composition, above-mentioned symptom take a turn for the better；Continue to take 2 courses for the treatment of of Chinese and western medicinal composition of the present invention, above-mentioned symptom Disappear, follow-up is not recurred, thoroughly cure.
4th, Song, female, 41 years old, civil servant.Patient suffers from hemorrhoid, anal fissure more than 2 years, and internal hemorrhoid deviates from incarceration swelling, and defecation aches Bitterly, there is greatly blood after an action of the bowels, the treatment in local clinic does not take an evident turn for the better, then to our hospital.
Give and take 2 courses for the treatment of of Chinese and western medicinal composition of the present invention, above-mentioned symptom takes a turn for the better；Continue to take Chinese medicine and western medicine group of the present invention 1 course for the treatment of of compound, above-mentioned symptom all disappear, and body is fully recovered, and follow-up is not recurred, and thoroughly cure.
5th, beam, man, 32 years old, business personnel.There is dyschizia discomfort without obvious inducement in patient, and difficult defecation, to other Hospital admission, is diagnosed as anal fissure, using effect on driving birds is not good after Drug therapy, introduces by friend to our hospital.Give and take this 1 course for the treatment of of invention Chinese and western medicinal composition, above-mentioned symptom take a turn for the better；Continue to take 2 courses for the treatment of of Chinese and western medicinal composition of the present invention, above-mentioned disease Shape all disappears, and body is fully recovered, and follow-up is not recurred, and thoroughly cures.
6th, Zhao, female, 22 years old, student.Patient likes eating pungent irritable food and meat, occurred before 1 year fecal blood, Difficult defecation, is anal fissure through local clinic diagnosis, does not have bright after the therapeutic modalities such as demibain smoked soak medicine, oral drugs Aobvious improvement, to our hospital.Give and take 3 courses for the treatment of of Chinese and western medicinal composition of the present invention, above-mentioned symptom all disappears, physical recovery Normally, follow-up is not recurred, and thoroughly cures.

Claims (5)

1. a kind of Chinese and western medicinal composition for treating anal fissure, it is characterised in that：Making the Chinese and western medicinal composition effective ingredient includes Chinese medicinal components and western medicine component, the Chinese medicinal components are formed by the preparation of raw material of following weight number：Chondrus ocellatus Holmes 38-50g, Folium Rumicis Japonici 34-46g, Auricled Hedyotis Herb 34-46g, Herba Ludwigiae Prostratae 32-44g, Radix Rehmanniae 28-40g, Folium rhois chinensiss 24-36g, Citrus chachiensis Hort. (C. Suavissima Tanaka) 24-36g, Fructus Mori 19- 31g, Herba Beronicastri brunoniani 16-24g, Radix Litseae 9-14g, Folium Allii fistulosi 9-14g, mountain Herba vallisneriae Spiralis 6-12g, Coagulum Opuntiae sucus 6-12g, Radix seu Folium Cassiae laevigatae 4-9g；Institute State western medicine component to be formed by the preparation of raw material of following weight number：Vitamin B10.1-0.2g, lysozyme 0.1-0.2g.
2. a kind of Chinese and western medicinal composition for treating anal fissure according to claim 1, it is characterised in that：Make the Chinese medicine and western medicine Compositionss effective ingredient includes that Chinese medicinal components and western medicine component, the Chinese medicinal components are formed by the preparation of raw material of following weight number： Chondrus ocellatus Holmes 47g, Folium Rumicis Japonici 43g, Auricled Hedyotis Herb 43g, Herba Ludwigiae Prostratae 41g, Radix Rehmanniae 37g, Folium rhois chinensiss 33g, Citrus chachiensis Hort. (C. Suavissima Tanaka) 33g, Fructus Mori 28g, Herba Beronicastri brunoniani 22g, Radix Litseae 12g, Folium Allii fistulosi 12g, mountain Herba vallisneriae Spiralis 10g, Coagulum Opuntiae sucus 10g, Radix seu Folium Cassiae laevigatae 7g；The western medicine component is by following heavy The preparation of raw material of amount number is formed：Vitamin B10.17g, lysozyme 0.17g.
3. a kind of Chinese and western medicinal composition for treating anal fissure according to claim 1, it is characterised in that：Make the Chinese medicine and western medicine Compositionss effective ingredient includes that Chinese medicinal components and western medicine component, the Chinese medicinal components are formed by the preparation of raw material of following weight number： Chondrus ocellatus Holmes 44g, Folium Rumicis Japonici 40g, Auricled Hedyotis Herb 40g, Herba Ludwigiae Prostratae 38g, Radix Rehmanniae 34g, Folium rhois chinensiss 30g, Citrus chachiensis Hort. (C. Suavissima Tanaka) 30g, Fructus Mori 25g, Herba Beronicastri brunoniani 20g, Radix Litseae 11g, Folium Allii fistulosi 11g, mountain Herba vallisneriae Spiralis 8g, Coagulum Opuntiae sucus 8g, Radix seu Folium Cassiae laevigatae 6g；The western medicine component is by following weight Several preparation of raw material are formed：Vitamin B10.15g, lysozyme 0.15g.
4. a kind of Chinese and western medicinal composition for treating anal fissure according to claim 1, it is characterised in that：Make the Chinese medicine and western medicine Compositionss effective ingredient includes that Chinese medicinal components and western medicine component, the Chinese medicinal components are formed by the preparation of raw material of following weight number： Chondrus ocellatus Holmes 41g, Folium Rumicis Japonici 37g, Auricled Hedyotis Herb 37g, Herba Ludwigiae Prostratae 35g, Radix Rehmanniae 31g, Folium rhois chinensiss 27g, Citrus chachiensis Hort. (C. Suavissima Tanaka) 27g, Fructus Mori 22g, Herba Beronicastri brunoniani 18g, Radix Litseae 10g, Folium Allii fistulosi 10g, mountain Herba vallisneriae Spiralis 7g, Coagulum Opuntiae sucus 7g, Radix seu Folium Cassiae laevigatae 5g；The western medicine component is by following weight Several preparation of raw material are formed：Vitamin B10.13g, lysozyme 0.13g.
5. a kind of preparation method of the Chinese and western medicinal composition of the treatment anal fissure as described in any one of claim 1-4, its feature exist In：Comprise the following steps：
(1) chondrus ocellatus Holmes, Folium Rumicis Japonici, Auricled Hedyotis Herb, Folium rhois chinensiss, Herba Beronicastri brunoniani, Radix Litseae, Folium Allii fistulosi, mountain Herba vallisneriae Spiralis, Coagulum Opuntiae sucus and Radix seu Folium Cassiae laevigatae are put Enter in container, be firstly added 10-15 times measure distilled water immersion 4-5 hours after, heated and boiled 3-4 hour, extract；Second plus 8- 10 times of amount distilled water heated and boiled 2-3 hours, extract；Third time adds 6-8 times and measures distilled water heated and boiled 1-2 hour, extracts；Close And extracting solution, filtration, filtrate is obtained, dry extract is condensed into standby；It is 90% alcoholic solution that dry extract is added volumetric concentration, stands, Supernatant is extracted, the extractum for precipitating is standby；
(2) by Herba Ludwigiae Prostratae and Fructus Mori immersion yellow wine 3-4 hours, after taking-up, sun dehydration is poured in pot, and slow fire parch is cooled Afterwards, smash to pieces and grind, obtained the fine powder of 120 mesh, standby；
(3) Radix Rehmanniae and Citrus chachiensis Hort. (C. Suavissima Tanaka) are smashed to pieces, twists juice, filtered, stay juice standby；
(4) by vitamin B1It is dissolved in 5 times of amount pure water with lysozyme, stirs, obtain solution, standby；
(5) extractum of above-mentioned gained, fine powder, juice and solution are mixed, adds dextrin to stir, gamma-rays radiation sterilization, Make the tablet of 0.4g/ pieces according to a conventional method, pack, the Chinese and western medicinal composition of as described treatment anal fissure.
CN201610924068.8A 2016-10-24 2016-10-24 A kind of Chinese and western medicinal composition for treating anal fissure and preparation method Pending CN106492200A (en)

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CN103651867A (en) * 2013-11-22 2014-03-26 安徽金菜地食品有限公司 Multiple-adjusted soybean milk and preparation method thereof
CN105343309A (en) * 2015-12-09 2016-02-24 广东聚智诚科技有限公司 Pharmaceutical composition for treating haemorrhoids containing moringa oleifera leaves and preparing method thereof
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Application publication date: 20170315