CN106491966A - 茯苓灵芝玉竹口服液 - Google Patents
茯苓灵芝玉竹口服液 Download PDFInfo
- Publication number
- CN106491966A CN106491966A CN201611178849.3A CN201611178849A CN106491966A CN 106491966 A CN106491966 A CN 106491966A CN 201611178849 A CN201611178849 A CN 201611178849A CN 106491966 A CN106491966 A CN 106491966A
- Authority
- CN
- China
- Prior art keywords
- parts
- poria
- ganoderma
- rhizoma polygonati
- polygonati odorati
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 42
- 241001619461 Poria <basidiomycete fungus> Species 0.000 title claims abstract description 30
- 241000222336 Ganoderma Species 0.000 title claims abstract description 27
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 15
- 238000000926 separation method Methods 0.000 claims abstract description 11
- 229960000935 dehydrated alcohol Drugs 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 239000000084 colloidal system Substances 0.000 claims abstract description 5
- 239000002893 slag Substances 0.000 claims abstract description 5
- 239000000284 extract Substances 0.000 claims abstract description 3
- 238000002360 preparation method Methods 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 238000000605 extraction Methods 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 5
- 238000005267 amalgamation Methods 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims description 3
- 239000003755 preservative agent Substances 0.000 claims description 3
- 230000002335 preservative effect Effects 0.000 claims description 3
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 3
- 235000010234 sodium benzoate Nutrition 0.000 claims description 3
- 239000004299 sodium benzoate Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 6
- 230000036039 immunity Effects 0.000 abstract description 4
- 230000008558 metabolic pathway by substance Effects 0.000 abstract description 2
- 238000007873 sieving Methods 0.000 abstract 1
- 239000012535 impurity Substances 0.000 description 4
- 239000008280 blood Substances 0.000 description 3
- 150000004676 glycans Chemical class 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 238000001256 steam distillation Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 241000756042 Polygonatum Species 0.000 description 2
- 235000008737 Polygonatum biflorum Nutrition 0.000 description 2
- 229930013930 alkaloid Natural products 0.000 description 2
- 150000003797 alkaloid derivatives Chemical class 0.000 description 2
- 230000000259 anti-tumor effect Effects 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229960004756 ethanol Drugs 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- 241000903946 Clematidis Species 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 235000002917 Fraxinus ornus Nutrition 0.000 description 1
- 244000182067 Fraxinus ornus Species 0.000 description 1
- 206010061192 Haemorrhagic fever Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000019926 Keshan disease Diseases 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000222341 Polyporaceae Species 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000003035 anti-peroxidant effect Effects 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 229940097217 cardiac glycoside Drugs 0.000 description 1
- 239000002368 cardiac glycoside Substances 0.000 description 1
- 229930182483 coumarin glycoside Natural products 0.000 description 1
- 150000008140 coumarin glycosides Chemical class 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 201000005577 familial hyperlipidemia Diseases 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 239000010977 jade Substances 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- LPMXVESGRSUGHW-HBYQJFLCSA-N ouabain Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C[C@@]2(O)CC[C@H]3[C@@]4(O)CC[C@H](C=5COC(=O)C=5)[C@@]4(C)C[C@@H](O)[C@@H]3[C@@]2(CO)[C@H](O)C1 LPMXVESGRSUGHW-HBYQJFLCSA-N 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229930002534 steroid glycoside Natural products 0.000 description 1
- 229930002600 steroidal saponin Natural products 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- -1 triterpeness Chemical class 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
茯苓灵芝玉竹口服液，包括以下质量份的原料：茯苓：200~400份、玉竹：200~400份、大枣：100~200份、灵芝：15~30份、薄荷50~75份，其制备时，先将薄荷进行薄荷油提取，并融入无水乙醇中，同时，将提取过薄荷油的薄荷渣与茯苓、大枣、玉竹合并并进行两次煎煮，分别进行固液分离后合并两次的煎液，然后将灵芝用胶体磨超微粉碎后过筛并加入到无水乙醇中静置，再将两种液体合并并减压浓缩后得到成品。本发明可有效提高人体免疫力、促进物质代谢，并具有抗疲劳及抗衰老等功效。
Description
技术领域
本发明涉及口服中药制剂领域，具体涉及一种健脾、润燥的茯苓灵芝玉竹口服液。
背景技术
茯苓，别名云苓、茯灵、松茯苓、松薯等，是寄生在松树根部的多孔菌科植物，是一种珍贵的药食两用菌，自古以来就是药食同源的保健食品，一直受到人们的关注，富含茯苓多糖等多种功效成分，具有健脾胃、利水消肿、降血脂、调节机体免疫、抗衰老、抗肿瘤、抗突变等功能；古人称茯苓为“四时神药”，因为它功效非常广泛，不分四季，将它与各种药物配伍，不管寒、温、风、湿诸疾，都能发挥其独特功效。
灵芝又称林中灵、琼珍，是多孔菌科真菌灵芝的子实体，自古以来都被认为一种珍贵的药食两用菌。其主含氨基酸、多肽、蛋白质、真菌溶菌酶，以及糖类（还原糖和多糖）、麦角甾醇、三萜类、香豆精甙、挥发油、硬脂酸、苯甲酸、生物碱、维生素B2及C等；孢子还含甘露醇、海藻糖，具有补气安神、止咳平喘、延年益寿的功效。经过大量临床研究，灵芝对神经衰弱、高脂血症、冠心病心绞痛、心律失常、克山病、高原不适症、肝炎、出血热、消化不良、气管炎等各有不同程度的疗效。
玉竹又名藏羹、女萎，为百合科植物玉竹的干燥根茎。玉竹性微寒，味甘平，归肺、胃经，具有养阴润燥，生津止渴之功。玉竹中含有多糖、甾体皂苷、黄酮、生物碱、强心苷等多种成分，其中含量最高的玉竹多糖，作为玉竹的有效药用成分之一，玉竹多糖具有免疫调节、降血糖、抗衰老、调血脂和抗脂质过氧化、增强小鼠耐缺氧能力、抗肿瘤作用等药理活性。
目前，对于上述组分的药物的应用主要是以简单的散剂为主，需要经过人体机体的消化后方能被吸收，使得其这些制剂生物利用率相对较低，使用不方便，起效慢，而若采用传统水提法制备口服液制剂，其提取率仅为25%~32%，根本达不到工业生产的需要，造成了物料的严重浪费。
发明内容
本发明所解决的技术问题在于提供一种茯苓灵芝玉竹口服液，以解决上述技术背景中的缺陷。
本发明所解决的技术问题采用以下技术方案来实现：
茯苓灵芝玉竹口服液，包括以下质量份的原料：
茯苓：200~400份、玉竹：200~400份、大枣：100~200份、灵芝：15~30份、薄荷：50~75份。
其优选质量份为：茯苓：300份、玉竹：300份、大枣：160份、灵芝：24份、薄荷：60份。
其具体制备方法如下：
1）按上述质量份取薄荷提取薄荷油，将提取的薄荷油按每100g薄荷5~8ml的比例溶于无水乙醇中。
2）将提取过薄荷油的薄荷渣与茯苓、大枣、玉竹合并，按每500g药物总质量加入5000~6000ml的比例加水，然后大火煮沸后转小火煎煮2~3h，进行固液分离，然后再加入2000~3000ml水，大火煮沸后转小火煎煮1~2h，进行固液分离后合并两次的煎液，过滤。
3）将灵芝用胶体磨进行超微粉碎，过300~500目筛，然后将磨细粉体一并加入步骤1）中的无水乙醇中，在70~85℃条件下静置1.5~2h。
4）将步骤2）与步骤3）中的液体合并，减压浓缩使药液在20℃下的相对密度为1.05~1.12，即得成品。
作为上述步骤的进一步改进：
所述薄荷油采用水蒸气蒸馏法提取。
所述步骤4)中合并液在进行减压浓缩之前，可添加苯甲酸钠作为防腐剂进行使用。
对步骤4)所得的成品须在高压灭菌后才能进行灌装。
有益效果：本发明茯苓灵芝玉竹口服液，通过在茯苓中添加玉竹进行调和补充，配合灵芝中的多种有效物质可有效提高人体免疫力、促进物质代谢，具有抗疲劳、抗衰老等作用，同时还具有抗疲劳及抗衰老等功效。
具体实施方式
为了使本发明实现的技术手段、创作特征、达成目的与功效易于明白了解，下面结合具体实施例，进一步阐述本发明。
实施例一：
在该实施例中包括以下组分的原料：
茯苓：240g、玉竹：220g、大枣：130g、灵芝：15g、薄荷：50g。
制备时先将薄荷用水蒸气蒸馏法提取薄荷油，然后将提取的薄荷油加入到4ml的无水乙醇中；然后将提取过薄荷油的薄荷渣与茯苓、大枣、玉竹合并与5800ml的水一并加入容器中，对容器进行大火加热，煮沸后转小火煎煮130min，然后进行第一次固液分离，将固液分离后的残渣加2400ml水，大火煮沸后转小火煎煮2h，然后进行第二次固液分离，合并两次固液分离的液体，过滤掉液体中的杂质。
将灵芝用胶体磨进行超微粉碎，过300目筛，然后将磨细粉体一并加入溶有薄荷油的无水乙醇中，在82℃条件下静置1.5h，然后将此无水乙醇溶液加入到过滤掉杂质的上述合并液中，搅拌均匀后减压浓缩使药液在20℃下的相对密度为1.08，然后高压灭菌后灌装即可。
实施例二：
在该实施例中包括以下组分的原料：
茯苓：300份、玉竹：300g、大枣：160g、灵芝：24g、薄荷60g。
制备时先将薄荷用水蒸气蒸馏法提取薄荷油，然后将提取的薄荷油加入到6ml的无水乙醇中；然后将提取过薄荷油的薄荷渣与茯苓、大枣、玉竹合并与6500ml的水一并加入容器中，对容器进行大火加热，煮沸后转小火煎煮150min，然后进行第一次固液分离，将固液分离后的残渣加2400ml水，大火煮沸后转小火煎煮2h，然后进行第二次固液分离，合并两次固液分离的液体，过滤掉液体中的杂质。
将灵芝用胶体磨进行超微粉碎，过500目筛，然后将磨细粉体一并加入溶有薄荷油的无水乙醇中，在85℃条件下静置2h，然后将此无水乙醇溶液加入到过滤掉杂质的上述合并液中，搅拌均匀后加入5g苯甲酸钠作为防腐剂，然后减压浓缩使药液在20℃下的相对密度为1.10，然后高压灭菌后灌装即可。
以上显示和描述了本发明的基本原理、主要特征和本发明的优点。本行业的技术人员应该了解，本发明不受上述实施例的限制，上述实施例和说明书中描述的只是说明本发明的原理，在不脱离本发明精神和范围的前提下，本发明还会有各种变化和改进，这些变化和改进都落入要求保护的本发明范围内。本发明要求保护范围由所附的权利要求书及其等效物界定。
Claims (5)
1.茯苓灵芝玉竹口服液，其特征在于，包括以下质量份的原料：茯苓：200~400份、玉竹：200~400份、大枣：100~200份、灵芝：15~30份、薄荷：50~75份。
2.根据权利要求1所述的茯苓灵芝玉竹口服液，其特征在于，包括以下质量份的原料：茯苓：300份、玉竹：300份、大枣：160份、灵芝：24份、薄荷：60份。
3.一种茯苓灵芝玉竹口服液的制备方法，其特征在于，采用权利要求1或2中所述的各组分的原料制备茯苓灵芝玉竹口服液，其具体制备方法如下：
1）按上述质量份取薄荷提取薄荷油，将提取的薄荷油按每100g薄荷5~8ml的比例溶于无水乙醇中；
2）将提取过薄荷油的薄荷渣与茯苓、大枣、玉竹合并，按每500g药物总质量加入5000~6000ml的比例加水，然后大火煮沸后转小火煎煮2~3h，进行固液分离，然后再加入2000~3000ml水，大火煮沸后转小火煎煮1~2h，进行固液分离后合并两次的煎液，过滤；
3）将灵芝用胶体磨进行超微粉碎，过300~500目筛，然后将磨细粉体一并加入步骤1）中的无水乙醇中，在70~85℃条件下静置1.5~2h；
4）将步骤2）与步骤3）中的液体合并，减压浓缩使药液在20℃下的相对密度为1.05~1.12，即得成品。
4.根据权利要求3所述的制备方法，其特征在于，所述步骤1）中的薄荷油采用水蒸气蒸馏法提取。
5.根据权利要求3所述的制备方法，其特征在于，所述步骤4)中合并液在进行减压浓缩之前添加苯甲酸钠作为防腐剂。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611178849.3A CN106491966A (zh) | 2016-12-19 | 2016-12-19 | 茯苓灵芝玉竹口服液 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611178849.3A CN106491966A (zh) | 2016-12-19 | 2016-12-19 | 茯苓灵芝玉竹口服液 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106491966A true CN106491966A (zh) | 2017-03-15 |
Family
ID=58334943
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611178849.3A Withdrawn CN106491966A (zh) | 2016-12-19 | 2016-12-19 | 茯苓灵芝玉竹口服液 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106491966A (zh) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1145234A (zh) * | 1995-09-15 | 1997-03-19 | 曾淑纯 | 养身美容口服液 |
| CN101243883A (zh) * | 2008-03-27 | 2008-08-20 | 北京惠中铭捷生物科技有限公司 | 一种具有降血糖功能的保健食品及其制备方法 |
| CN101543594A (zh) * | 2009-05-15 | 2009-09-30 | 河南牧翔动物药业有限公司 | 桑菊口服液 |
| CN102228234A (zh) * | 2011-04-23 | 2011-11-02 | 张行伟 | 一种具有改善人体循环系统功能的功能食品配方及配制方法 |
-
2016
- 2016-12-19 CN CN201611178849.3A patent/CN106491966A/zh not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1145234A (zh) * | 1995-09-15 | 1997-03-19 | 曾淑纯 | 养身美容口服液 |
| CN101243883A (zh) * | 2008-03-27 | 2008-08-20 | 北京惠中铭捷生物科技有限公司 | 一种具有降血糖功能的保健食品及其制备方法 |
| CN101543594A (zh) * | 2009-05-15 | 2009-09-30 | 河南牧翔动物药业有限公司 | 桑菊口服液 |
| CN102228234A (zh) * | 2011-04-23 | 2011-11-02 | 张行伟 | 一种具有改善人体循环系统功能的功能食品配方及配制方法 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103990081B (zh) | 一种中药组合物及其在制备治疗婴幼儿黄疸药物中的用途 | |
| CN104083727A (zh) | 一种养肝护肝中药组合物 | |
| CN101502588B (zh) | 一种美容祛痘组合物及其制备方法 | |
| CN107950929A (zh) | 一种具有改善睡眠功能的组合物及其制备方法和用途 | |
| CN105012707A (zh) | 一种铁皮石斛胶囊及其制备方法 | |
| CN103637179B (zh) | 一种降血糖、降血脂和改善脂肪肝的食物组合物 | |
| CN101507800A (zh) | 金线莲和南瓜复合降血糖保健品及其制备方法 | |
| CN102302673B (zh) | 一种预防和治疗糖尿病肾病的中药复方制剂 | |
| CN105770462A (zh) | 一种具有降血脂功能的保健茶 | |
| CN107836620A (zh) | 一种养生固体饮料及其制备方法 | |
| CN106581166A (zh) | 一种具有抗疲劳功效的食品、保健品或药物组合物 | |
| CN106511782A (zh) | 茯苓天麻含片 | |
| CN106215118A (zh) | 抗肿瘤的保健制剂及其制备方法 | |
| CN103705860B (zh) | 一种治疗婴幼儿黄疸的中药组合物及其制备方法 | |
| CN106072656A (zh) | 一种无添加剂预防及缓解痛经的健康食品及其生产方法 | |
| CN106728373A (zh) | 茯苓灵芝蜂蜜口服液 | |
| JP2007131605A (ja) | 不定愁訴改善組成物及び食品 | |
| CN107648330A (zh) | 一种基于黑种草的降血糖组合物以及降血糖蒙药 | |
| CN106215094A (zh) | 一种解酒护肝保健品及其制备方法 | |
| CN106491966A (zh) | 茯苓灵芝玉竹口服液 | |
| CN106581236A (zh) | 一种促进胃动力的药物组合物及其制备方法和应用 | |
| CN113826882A (zh) | 防治糖尿病的膳食营养补充剂及其制备工艺 | |
| CN105056170A (zh) | 一种中药组合物在制备治疗急性胃炎药物中的用途 | |
| CN106620017A (zh) | 茯苓竹荪口服液 | |
| CN106581420A (zh) | 茯苓灵芝玉竹含片 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20170315 |
|
| WW01 | Invention patent application withdrawn after publication |