CN106491567A - A kind of marine organisms spray film for light moderate burn and scald and preparation method thereof - Google Patents
A kind of marine organisms spray film for light moderate burn and scald and preparation method thereof Download PDFInfo
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- CN106491567A CN106491567A CN201610985061.7A CN201610985061A CN106491567A CN 106491567 A CN106491567 A CN 106491567A CN 201610985061 A CN201610985061 A CN 201610985061A CN 106491567 A CN106491567 A CN 106491567A
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- scald
- radix
- burn
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Abstract
The present invention discloses a kind of marine organisms spray film for light moderate burn and scald and preparation method thereof, belongs to marine organisms medical material tech field.The spray film is processed by certain technique by sodium alginate, chitin, Olibanum, Myrrha, Borneolum Syntheticum, Mel, Rhizoma Polygoni Cuspidati, Cortex Phellodendri, Radix Sanguisorbae, Radix Et Rhizoma Rhei, Radix Scutellariae, Fructus Schisandrae Chinensis, Galla Chinensiss, each raw material of Rhizoma Atractylodis.Compared with prior art, present invention spray film treats light moderate burn and scald, with film forming fast, pain relieving is rapid, good effect, more after the significant treatment advantage such as cicatrix is little；Also, the present invention also has, simplify burn and scald handling process, be convenient for carrying use, technology difficulty is little, cost of material is low, the significantly technical advantage such as easy to spread.
Description
Technical field
The present invention discloses a kind of marine organisms spray film for light moderate burn and scald, belongs to marine organisms medical material technology
Field.
Background technology
Burn and scald is common unexpected injury in life, and boiling water, rolling medicated porridge, deep fat, the burn and scald of heat steam can often occur
Thing.Judged according to the weight at the position, size and burn and scald of the main root root burn and scald of the order of severity of burn and scald.Burn
Scald in Head And Face, though or not in Head And Face, burn and scald area is big, depth is deep, belongs to severe patient.Burn and scald is by deep
Degree, is generally divided into three degree：
（1）Once burn and scald：Only injure epidermal area, smartly pain is felt in injured skin rubefaction, swelling, but anhydrous bubble out
Existing；
（2）Two degree of burn and scald：Skin corium is injured, local is red and swollen, heating, hurt like hell has obvious blister；
（3）Degree burn and scald：Full thickness skin includes that fat below skin, bone and muscle all come to harm, and skin is burned black, downright bad,
At this moment pain is not violent on the contrary, because many nerves are also all damaged together.Light moderate burn of the present invention is referred to
Once with two degree of burn.
Epidemic febrile disease of Chinese medicine theory analysis burns are broadly divided into three classes because of the pyretic toxicity trend for being formed：One class is burning hot
Damage, intenseness of heat impairment of YIN, fire-toxin main story；Two is vehement in pathogenic heat, and burn is ruined, fire-toxin adverse transference；Three is fire-toxin direct attack internal organs.Here institute
" main story " that says refers to that the state of an illness is taken advantage of a situation development, conventional therapy favourable prognosis." adverse transference " generally refers to the state of an illness and deteriorates in advance." direct attack "
Refer to that burn is serious, disease just sees visceral complications." adverse transference " is all critically ill syndrome with " direct attack ", it is necessary to rescue in time.No
Then, trend is not surveyed, and prognosis is dangerous.Three of the above pathology machine is turned analysis now to be discussed below.
（1）" burning hot damage, intenseness of heat impairment of YIN " fire-toxin main story
Chinese medicine thinks " soup sprinkle burn ", burning hot property, and its gas is fierce, and momentariness makes skin Jiao's roulade, heat very fire, " intenseness of heat then meat
Rotten ", then skin rots into skin ulcer, and name says " burn ".Fire is YANG pathogen, and yin-damaging and Qi consuming burns bright internal organs, and disappear bright body fluid, is its feature.Again
Say：" hyperactive fire wasting QI ", therefore after burning, inevitable impairment of YIN damage liquid, consume healthy energy, gram cut down internal organs.Therefore fire victim is often presented with：Hyperpyrexia
Continue, the greedy drink of extreme thirst, irritated coma, delirium are twitched, if terrified mad, seek clothing and touch the diseases such as bed, constipation, bleeding, collapse.Which goes out
The mechanism of these syndromes existing, can go to explain according to Basic Theories of Chinese Medicine.
（2）" and feel exopathogen, and fire-toxin is ruined " fire-toxin adverse transference
Infection is the common severe complication of burn patient.Human body skin is the anti-evil the first line of defence of diseases prevention, is to prevent antibacterial
The natural cover for defense of intrusion, after burn, this defensive enginery is destroyed, and therefore, the area of burn is bigger deeper, then concurrently feel
The chance of dye the more, more seriously.In addition skin Jiao roulade after burning, failure of defensive QI to protect the body against pathogen lose normal resistances against diseases, and exopathogen is easily
Take advantage of a weak point, " healthy energy deposit in, heresy can not be done ", " heresy is gathered, its gas must void ", during extensive burn, each viscera tissue of whole body
Impaired organ, dysfunction weaken Abwehrkraft des Koepers, and antibacterial is taken advantage of a weak point in opponent's defence, particularly in recovery and crust dissolving
When more easy infection.Again because fire is YANG pathogen, characteristic of fire being flaring up, most easy impairment of YIN consume liquid, burn bright internal organs, so after burning, it is seen that high fever
Tired drink, deficiency of vital energy body fluid exhausting, pathological changes wait rapidly the danger of one febrile disease to wait.Burn patients, lower for the resistance, extensive wound surface exposes, pole
Easily positive exogenous pathogen falls into and main story occurs, the pyemia of adverse transference, septicemia and " receiving on pathogenic warmth, attacking the lung first, the pathogen attacking the pericardium adversely " sudden and violent
Hair style septicemia, the low temperature septicemia and internal organs complication of " deficiency of YIN affecting YANG ".
（3）" fire-toxin " or " fire-toxin is ruined ", internal organs direct attack
Human body is a unified organic whole, internal organs and each histoorgan, complements each other, and is mutually use, inseparable
The substantial connection that cuts.After burning, particularly extensive burn, though wound makes the life of body in skin, venation, muscle, muscles and bones
Reason changes, and heat must cause the physiological change of internal organs and damage internal organs, and a variety of internal organs complication occur.
Scorchingly hot flourishing clearing away heat from YING and blood systems of answering is detoxified.Detoxification and promoting urination is answered to intenseness of heat impairment of YIN, resistance heat clearing away is supported.To deficiency in both Qi and blood
Answer benefiting QI and nourishing blood, invigorating the spleen and regulating the stomach.
Marine organisms medical material is the important component part of bio-medical material and marine biotechnology, because its resource rich
Richness, structure, property, function are unique, and with good biological safety, so the extensive concern by biomaterial circle.Sea
Foreign bio-medical material research and development have unique advantage：
（1）Aboundresources：Living marine resources are enriched, and belong to natural biological regenerated resources；
（2）Function is unique：Marine organisms medical material is natural polymer, and various structures, function are unique, with certain biology
Learn activity；
（3）Bio-safety：Big point of the biology extracted in the biodegradable absorption of marine organisms medical material, with land mammals
Sub- material is compared, and marine organisms medical material avoids the disease virus such as terraria such as bovine spongiform encephalopathy, foot and mouth disease, reproductive and respiratory syndrome biography
The risk that broadcasts；
（4）With low cost：Raw material mostly is the leftover bits and pieces of marine products processing industry, and production and processing relative inexpensiveness, product are added
Value is high, and provides a practical approuch for inquiring into low-carbon (LC), green management pattern；
（5）Formability thereof good：Marine organisms medical material can be made into multiple material dosage form such as sponge, powder, thin film, spraying, gel
Deng for application.
Content of the invention
The technical problem to be solved in the present invention is a kind of marine organisms spray for having good therapeutic effect to light moderate burn and scald of exploitation
Film.For solving the technical problem, inventor draws the heart that ancients treat burn and scald according to itself tcm clinical practice experience for many years
, using the characteristic of marine organisms medical material, through scientific research repeatedly and clinical practice, finally invent a kind of spray
Film, its have good therapeutic effect to light moderate burn and scald, and the formula of the spray film is（In parts by weight）：
Sodium alginate 8-26 parts, chitin 15-50 parts, Chinese medicine extract 5-20 parts.
The formula of the Chinese medicine extract is（In parts by weight）：Olibanum 5-19 parts, Myrrha 7-29 parts, Borneolum Syntheticum 7-20 parts,
Mel 4-14 parts, Rhizoma Polygoni Cuspidati 4-12 parts, Cortex Phellodendri 8-24 parts, Radix Sanguisorbae 8-22 parts, Radix Et Rhizoma Rhei 5-17 parts, Radix Scutellariae 5-15 parts, Fructus Schisandrae Chinensis 4-14
Part, Galla Chinensiss 4-16 parts, Rhizoma Atractylodis 6-20 parts.
Have excellent curative effect empirical formula be（In parts by weight）：
14 parts of sodium alginate, 26 parts of chitin, 11 parts of Chinese medicine extract.
The formula of the Chinese medicine extract is（In parts by weight）：11 parts of Olibanum, 17 parts of Myrrha, 13 parts of Borneolum Syntheticum, Mel 8
Part, 7 parts of Rhizoma Polygoni Cuspidati, 15 parts of Cortex Phellodendri, 15 parts of Radix Sanguisorbae, 11 parts of Radix Et Rhizoma Rhei, 9 parts of Radix Scutellariae, 8 parts of Fructus Schisandrae Chinensis, 8 parts of Galla Chinensiss, 12 parts of Rhizoma Atractylodis.
The preparation method of present invention spray film is following steps：
（1）Each raw material is accurately weighed by inventive formulation；
（2）By Olibanum, Myrrha parch, crush respectively, levigate, 70-120 mesh sieves are crossed, mixing fine powders are obtained, standby；
（3）Rhizoma Polygoni Cuspidati, Cortex Phellodendri, Radix Sanguisorbae are crushed respectively, plus the ethanol of 3-14 times of 80-95%, soak 4-24 hours, distillation extraction
Twice, each 1-6 hours, filter, and filtrate will mix twice, ethanol is distilled off, and be concentrated into 55 DEG C of relative densities for 1.16-
1.20 concentrated solution, standby；
（4）Borneolum Syntheticum, Radix Et Rhizoma Rhei, Radix Scutellariae, Fructus Schisandrae Chinensis, Galla Chinensiss, Rhizoma Atractylodis are crushed respectively, the purification of 5-14 times of weight after mixing, is added
Water, soaks 4-24 hours, and backflow is decocted twice, and each 1-5 hours are filtered, merging filtrate, and being concentrated into 55 DEG C of relative densities is
1.16-1.20 concentrated solution, standby；
（5）By step（3）With（4）In obtained concentrated solution merge, add Mel and step（2）Made mixing fine powders, mixing
Uniformly, continue to be concentrated into the thick paste that 55 DEG C of relative densities are 1.37-1.41, as Chinese medicine extract；
（6）It is the alkali liquor of 40-70% by the concentration that chitin adds 3-12 times, under conditions of 85-95 DEG C, reacts 8-19 hours,
During the course of the reaction per stirring every other hour once, reaction is finished, and is centrifuged off alkali liquor, is washed 3-8 time with purification, except roguing
Matter, dries pulverizing is levigate, crosses 70-120 mesh sieves, obtains fine powder, plus the lactic acid of 2-10 times of 3-20%, stirring and dissolving, filter clear
Clear solution, standby；
（7）Sodium alginate is levigate, 70-120 mesh sieves are crossed, fine powder is obtained, is added to step（6）Settled solution in, stirring is until solid
Body all dissolves, standby；
（8）Step is weighed in proportion（5）Gained Chinese medicine extract, is added to step（7）In resulting solution, mix, equal with homogenizer
Matter, that is, obtain spray film raw material suspension；
（9）Spray film raw material suspension is added appropriate adjuvant, bottled spray film is made using modern general preparation technique, as
Finished product.Additionally, the present invention spray film raw material suspension can also be made into ointment, gel, patch, plaster, liniment, medicated wine,
The medicine of the dosage forms such as tincture.
The property feature of raw materials of the present invention：
Sodium alginate：Sodium alginate, a kind of natural polysaccharide, with the stability needed for pharmaceutical preparation adjuvant, dissolubility, viscosity and
Safety.Can be used to increase blood volume and maintain blood pressure, exclude the histamine toxoid produced by burn and wound is lost blood, performed the operation
The whole body such as the stable of blood circulation, bleeding profusely property shock, burn shock, hyperpyrexia and acute dysentery is dehydrated in front and back, controls curative effect
Fruit is good.Suspending agent, emulsifying agent, sticky dose, the capsule material of microcapsule etc. is mainly used as on medicament.With alginic acid sulfuric ester dispersant
The PS type gastrointestinal double radiography barium sulfate preparations that makes, fine size low with viscosity, attached wall are good, the features such as stable performance.
PSS is a kind of fucoidin diesteras that is developed as raw material with alginic acid, with anticoagulation, blood fat reducing and reduction blood viscosity
Effect.Replace with alginate jelly rubber, Gypsum Fibrosum to make dental impression silica material, not only low price, easy to operate, and the profile of tooth that prints off is more
Accurately.Alginate jelly can also make the hemorrhage of various dosage forms, and including styptic sponge used, hemostatic gauze, stop blooding thin film, scalds gauze,
Spraying hemorrhage etc..
Chitin：Chitin (C8H13O5N) n, also known as chitin, chitin, English name Chitin.Pure chitin is one
Nonpoisonous and tasteless white or the translucent solid of canescence is planted, is difficult in water, diluted acid, diluted alkaline and general organic solvent molten
Solution, thus limit its application and development.People were had found in research and probe later, and chitin is sloughed wherein through concentrated base process
Acetyl group reform into soluble chitin, also known as chitosan or shitosan, its chemical name is（Isosorbide-5-Nitrae）- 2- amino -2- takes off
Oxygen-β-D-Glucose, or abbreviation Chitin.Chitin is a kind of natural resourcess that storage is extremely enriched on the earth,
It is the unique positively charged tunicin being found in nature so far.Due to carrying not in its molecular structure
The cation group of saturation, thus there is powerful adsorption to negatively charged all kinds of harmful substances.Glucosamine and
2-Acetamido-2-deoxy-D-glucose is one of main composition in skin.And glucosamine and 2-Acetamido-2-deoxy-D-glucose are shitosans
Ultimate unit, when the shitosan in spray-filming agent is with Wound contact, as wound healing early stage can secret out of lysozyme and albumen
Enzyme, both enzymes shitosan of degrading generate glucosamine and 2-Acetamido-2-deoxy-D-glucose, supplement in skin both into
Point, while also having stimulation to macrophage, Immunosuppressant therapy effect is improve, is strengthened anti-infection ability, can be accelerated to hinder
The healing of mouth.
Olibanum：Burseraceae Boswellia carterii platymiscium Boswellia carterii, medicine glue XIANGSHU and wild Boswellia carterii etc., are oozed with its trunk skin zone wound
The oleo-gum-resin for going out is used as medicine.Acrid in the mouth is bitter, warm in nature；Enter the heart, liver, spleen channel；Regulating qi and activating blood, analgesic therapy are chased after poison.
Myrrha：Burseraceae Myrrha platymiscium myrrh and belong to him together and plant the oleo-gum-resin that the trunk skin zone of plant oozes out.Taste
Hardship, mild-natured；Enter Liver Channel；Eliminating stasis to stop pain, externally used detumescence granulation promoting.
Borneolum Syntheticum：It is divided to BORNEOLUM SYNTHETICUM and two class of Blumeae preparatum Tabellae.BORNEOLUM SYNTHETICUM is raw material through being chemically synthesized with Oleum Terebinthinae, Camphora etc.
Borneolum Syntheticum；Blumeae preparatum Tabellae for Compositae Herba Blumeae Balsamiferae platymiscium Balsamiferou Blumea Herb fresh leaf through steam distillation, cooling gained crystallization, also known as " Chinese mugwort powder "
Or " sheeting ".Acrid in the mouth, hardship, cold nature；GUIXIN, spleen, lung meridian；Inducing resuscitation of having one's ideas straightened out, clearing away heat to alleviate pain.
Mel：The honey that the nectar that Mel is Apiss to be adopted from the spending of flowering plant is brewed in Nidus Vespae.Sweet in the mouth, mild-natured；
Enter spleen, stomach, lung, large intestine channel；Harmonizing the spleen and stomach, relieving spasm to stop pain, nourishing the lung to arrest cough, loosening bowel to relieve constipation, skin moistening granulation promoting, removing toxic substances.
Rhizoma Polygoni Cuspidati：Dry rhizome and root of this product for polygonaceae plant Rhizoma Polygoni Cuspidati.Spring, the excavation of two season of autumn, remove fibrous root, clean, take advantage of
Fresh-cut short section or sheet, dry.Mildly bitter flavor, cold nature；Return liver, gallbladder, lung meridian；Expelling wind and removing dampness, scattered stasis pain, relieving cough and resolving phlegm.With
In arthralgia, jaundice due to damp-heat, amenorrhea, lump in the abdomen, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus, cough with copious phlegm.
Cortex Phellodendri：This product is the dry bark of rutaceae wampee or Cortex Phellodendri.Bitter in the mouth, cold in nature；Return kidney, bladder warp；Clearly
Hot dampness, purging intense heat, except steaming, detoxification sore treatment.
Radix Sanguisorbae：This product is the dry root of rosaceous plant Radix Sanguisorbae or the Radix Sanguisorbae that comes into leaves.The latter practises and claims " continuous Radix Sanguisorbae ".Spring will be sent out
Excavate during bud or after autumn plant is withered, remove fibrous root, cleaning, drying, or take advantage of fresh slices, dry.Bitter in the mouth, acid, puckery, property is micro-
Cold；Cooling blood for hemostasis, removing toxic substances sore.For having blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, burn due to hot liquid or fire, carbuncle sore tumefacting virus.
Radix Et Rhizoma Rhei：This product dries root and rhizome for polygonum rheum palmatum, Rheum tanguticum or Rheum officinale.Bitter in the mouth,
Cold in nature；Returns spleen, stomach, large intestine, liver, pericardium channel；Purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.
Radix Scutellariae：Dry root of this product for labiate Radix Scutellariae.Bitter in the mouth, cold in nature；Return lung, gallbladder, spleen, large intestine, small intestine meridian；Clearly
Hot dampness, eliminating fire and detoxication, hemostasis are antiabortive.
Fructus Schisandrae Chinensis：This product is the dry mature fruit of magnoliaceae schisandra or schisandra chinensis.Sour in the mouth, sweet, warm in nature；
Return lung, the heart, kidney channel；Restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.
Galla Chinensiss：This product is the insect gall on Anacardiaceae plant Fructus rhois chinensiss, potanin sumac or Radix Rhois Sinicae leaf, mainly by melaphis chinensis Baker
Parasitic and formed.Sour in the mouth, puckery, cold in nature；Return lung, large intestine, kidney channel；Astringe the lung pathogenic fire reducing, relieving diarrhea with astringents, arresting sweating stop blooding, removing dampness sore.
Rhizoma Atractylodis：This product is the dry rhizome of feverfew Atractylodes lancea (Thunb.) DC. or Atractylis chinensiss.Acrid in the mouth, hardship, warm in nature；Returns spleen, stomach, liver
Through；Drying damp and strengthening spleen, expelling wind and cold, improving eyesight.
Formula effect parsing of present invention spray film：
The formula of present invention spray film is dimeric, and a part is a Chinese prescription, and another part is marine organisms
Material.For resolving to for above-mentioned Chinese prescription：With Myrrha, Cortex Phellodendri, Radix Sanguisorbae, Borneolum Syntheticum as monarch drug, detumescence and promoting granulation, purging intense heat, except steaming,
Removing toxic substances sore, clearing away heat to alleviate pain；With Rhizoma Atractylodis, Olibanum, Radix Et Rhizoma Rhei as ministerial drug, drying damp and strengthening spleen, regulating qi and activating blood, eliminating blood stasis and inducing menstruation；With Galla Chinensiss,
Rhizoma Polygoni Cuspidati, Mel be adjuvant drug, removing dampness sore, scattered stasis pain, skin moistening granulation promoting；With Radix Scutellariae, Fructus Schisandrae Chinensis as making medicine, eliminating fire and detoxication, convergence
Astringent or styptic treatment for spontaneous sweating；The all medicine of monarch coordinates, and aids in each other, synergism, so as to reach detumescence and promoting granulation, purging intense heat, except steaming, removing toxic substances sore, clear
The effects such as hot pain relieving, regulating qi and activating blood, eliminating blood stasis and inducing menstruation, skin moistening granulation promoting, astringent or styptic treatment for spontaneous sweating convergence.And sodium alginate and chitin are except with good
Outside good film forming characteristicss, also there is the histamine toxoid excluded produced by burn, improve Immunosuppressant therapy effect, strengthen anti-sense
The effects such as dye ability, healing of acceleration wound.Two kinds of marine organism materials reach treating both the principal and secondary aspects of a disease with Chinese prescription cooperation, simplify and burn
The significant effect such as treatment of scald flow process.
Compared with prior art, present invention spray film have that film forming is fast, pain relieving rapid, good effect, more after cicatrix little etc. significantly
Treatment advantage；Also, the present invention also has, simplify the handling process of burn and scald, to be convenient for carrying use, technology difficulty little, former
Material low cost, the significantly technical advantage such as easy to spread.
Specific embodiment
Embodiment 1
The practice production of present invention spray film, it is A, B, C, D that several groups of representational formulation ratios are numbered respectively, each group formulation ratio
Value is as shown in table 1.
1 each group of formula catalog of table
（1）Proportion speed as shown in table 1 weighs each raw material；
（2）By Olibanum, Myrrha parch, crush respectively, levigate, 90 mesh sieves are crossed, mixing fine powders are obtained, standby；
（3）Rhizoma Polygoni Cuspidati, Cortex Phellodendri, Radix Sanguisorbae are crushed respectively, plus 10 times 90% ethanol, soak 18 hours, distillation extraction twice, per
Secondary 4 hours, filter, filtrate will mix twice, ethanol is distilled off, and be concentrated into the concentration that 55 DEG C of relative densities are 1.16-1.20
Liquid, standby；
（4）Borneolum Syntheticum, Radix Et Rhizoma Rhei, Radix Scutellariae, Fructus Schisandrae Chinensis, Galla Chinensiss, Rhizoma Atractylodis are crushed respectively, the purified water of 9 times of weight after mixing, is added,
Immersion 10 hours, backflow are decocted twice, 3 hours every time, are filtered, merging filtrate, are concentrated into 55 DEG C of relative densities for 1.16-1.20
Concentrated solution, standby；
（5）By step（3）With（4）In obtained concentrated solution merge, add Mel and step（2）Made mixing fine powders, mixing
Uniformly, continue to be concentrated into the thick paste that 55 DEG C of relative densities are 1.37-1.41, as Chinese medicine extract；
（6）By the alkali liquor that 7 times of concentration of chitin addition is 55%, under conditions of 90 DEG C, react 15 hours, in course of reaction
In per stirring every other hour once, reaction is finished, and is centrifuged off alkali liquor, is washed 6 times with purification, removes impurity, dries pulverizing, mill
Carefully, 100 mesh sieves are crossed, obtain fine powder, plus 6 times 13% lactic acid, stirring and dissolving filters to obtain settled solution, standby；
（7）Sodium alginate is levigate, 100 mesh sieves are crossed, fine powder is obtained, is added to step（6）Settled solution in, stirring until solid complete
Portion dissolves, standby；
（8）Step is weighed in proportion（5）Gained Chinese medicine extract, is added to step（7）In resulting solution, mix, equal with homogenizer
Matter, that is, obtain spray film raw material suspension；
（9）Spray film raw material suspension is added appropriate adjuvant, bottled spray film, specification is made using modern general preparation technique
For：100g/ bottles, Chinese medicine content：64.6g crude drugs/bottle.
Embodiment 2
Toxicity test
The irritation test of 1 present invention spray film
（1）Trial drug：The numbering produced by the embodiment of the present invention 1 is the spray film of A-D, and specification is：64.6g crude drugs/bottle.
（2）Experimental technique：
Healthy guinea pig 15 is taken, 5 groups are randomly divided into, 3 per group, depilatory is uniformly coated with by guinea pig back spinal column both sides, is made
About 20 square centimeters of unhairing scope.Clean depilatory returns cage to observe 24 hours, and 4 groups of Cavia porcelluss spray the present invention spray film 4g, 8g respectively
And 12g, 0.52g containing crude drug, 1.04g and 1.56g respectively, matched group apply solvent 0.8ml twice daily, and continuous one week, experiment was tied
Shu Hou, Cavia porcelluss are put to death, and the heart, liver, kidney and depilation skin do pathological examination.
（3）As a result
Above-mentioned 5 groups of Cavia porcelluss trunk hair removal section, has no that local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group globefish
Mus chroma of hair, ingest, the matched group no significant difference such as extremity activity, histopathologic examination, the administration group heart, liver, kidney and de-
Fur compares also no significant difference with word is compareed.As a result point out, present invention spray film also has no general toxicity without local irritant effect
And the performance of Transdermal absorption toxicity.Show present invention spray film Clinical practice safety.
2 acute toxicity tests
20 mices are taken, is divided into 4 groups, 5 per group, per group of difference oral administration gavage maximum（The saturation capacity of maximum administered volume）
Numbering obtained by the embodiment of the present invention 1 of 46.1g/kg is the raw material suspension of A-D, Continuous Observation 7 days, itemized record animal
Response situation, calculates total dosage.As a result show：20 Mouse orals（Gavage）After maximum, activity and appetite are as good as
Often, none is dead.Said preparation its maximum tolerated dose ＞ 46.1g/kg is measured, equivalent to 269 times of clinical adult's consumption, shows which
Without acute toxicity, Clinical practice safety.
3 long term toxicity tests：
Using Wistar rat continuous orals（Gavage）Administration observes its long term toxicity in 2 weeks.Test sets four test groups and one
Blank control group.Experimental animal outward appearance behavioral activity is normal；Body weight each group is in rising trend；Pathological examination, each group
Animal viscera does not find that substantial cellular is damaged；Hematological indices, hemoglobin（Hb）And numeration of leukocyte value, blood biochemical
The third Cyklokapren of index paddy（SGDT, reitman-frankel method）And urea nitrogen（Urease methods）Deng each test group is with blank control group without obvious
Difference（P ＞ 0.05）.
In addition, record according to successive dynasties ancient TCM books showing with modern pharmacology toxicological study document, the spray film institute of the present invention
It is nontoxic under common dose containing various Chinese medicines.
Above experiment absolutely proves that present invention spray film external has very high safety.
Embodiment 3
Clinical trial
1 physical data
The patient of this time clinical trial is provided by certain First People's Hospital of city.Burn and scald is generally divided into three degree by depth：
（1）Once burn and scald：Only injure epidermal area, smartly pain is felt in injured skin rubefaction, swelling, but anhydrous bubble out
Existing；
（2）Two degree of burn and scald：Skin corium is injured, local is red and swollen, heating, hurt like hell has obvious blister；
（3）Three degree of burn and scald：Full thickness skin includes that fat below skin, bone and muscle all come to harm, and skin is burned black, bad
Extremely, at this moment pain is not violent on the contrary, because many nerves are also all damaged together.
Light moderate burn and scald of the present invention refers to one, two degree of burn and scald, from the institute in June, 2014 in July, 2016
In the burned patient that accepts for medical treatment, filter out 224 one, two degree of burned patients and voluntarily take part in this clinical trial, wherein one
Degree burned patient 84, two degree of burned patients 140, men and women half and half, age 18-62 year.By one or two degree of burned patients
It is divided into two groups respectively, respectively matched group and test group, is the two groups at aspects such as age, sex, the orders of severity
Possesses the comparability on statistical significance.
2 test specimens
Comparison medicine：JINGWANHONG RUANGAO, specification：20g/, authentication code：Chinese medicines quasi-word Z12020440, Tianjin Da Rentang JINGWANHONG
Pharmaceutcal corporation, Ltd.
Test specimen：The numbering produced by the embodiment of the present invention 1 is the spray film of D, and specification is：100g/ bottles, Chinese medicine content：
64.6g crude drugs/bottle.
3 test methods
Matched group patient smears comparison medicine in affected part, covers affected part bigger scope, is wrapped up with gauze；Test group spray test sample
Product, cover affected part bigger scope, process without any wrapping；The daily dressing of all patients once, one week is a course for the treatment of,
Continuously 2 courses for the treatment of of treatment, after treatment end, count therapeutic outcome.
4 evaluation criterions
Cure：Patient affected part skin recovers normal completely, or leaves the cicatrix of healing, presses not pain；
Effective：Patient wound is reduced significantly, scabs, but does not heal completely, has pressed pain；
Effectively：Patient pain mitigates, wound makes moderate progress, it is still necessary to further treat；
Invalid：Patient wound does not improve significantly, even more seriously.
5 result of the test statistical analysiss
After test all terminates, will be as shown in table 2 for result of the test statistical analysiss.
2 result of the test statistical analysis table of table
6 conclusions
From the result of the test of table 2 statistics as can be seen that for once burned patient, the cure rate of test group is higher than matched group
14.3 percentage points；For the treatment of two degree of burned patients, the cure rate of test group is higher than matched group 44.3 percentage points,
Total effective rate improves 8.6 percentage points.These result explanation present invention spray films show very aobvious relative to prior art
The technical advantage of work, especially when two degree of burn and scald are treated, this advantage is mirable, and therefore, the present invention sprays film
Unexpected technological achievement is achieved in terms of light moderate burn and scald is treated, its creativeness should be taken seriously.
Claims (4)
1. a kind of marine organisms for light moderate burn and scald spray film, it is characterised in that the formula of the spray film is with weight portion table
It is shown as：Sodium alginate 8-26 parts, chitin 15-50 parts, Chinese medicine extract 5-20 parts；
The formula of the Chinese medicine extract is：Olibanum 5-19 parts, Myrrha 7-29 parts, Borneolum Syntheticum 7-20 parts, Mel 4-14 parts, Rhizoma Polygoni Cuspidati 4-
12 parts, Cortex Phellodendri 8-24 parts, Radix Sanguisorbae 8-22 parts, Radix Et Rhizoma Rhei 5-17 parts, Radix Scutellariae 5-15 parts, Fructus Schisandrae Chinensis 4-14 parts, Galla Chinensiss 4-16 parts, grey
Art 6-20 part.
2. a kind of marine organisms for light moderate burn and scald according to claim 1 spray film, it is characterised in that the spray
The formula of film is expressed as with weight portion：14 parts of sodium alginate, 26 parts of chitin, 11 parts of Chinese medicine extract；
The formula of the Chinese medicine extract is：11 parts of Olibanum, 17 parts of Myrrha, 13 parts of Borneolum Syntheticum, 8 parts of Mel, 7 parts of Rhizoma Polygoni Cuspidati, Cortex Phellodendri 15
Part, 15 parts of Radix Sanguisorbae, 11 parts of Radix Et Rhizoma Rhei, 9 parts of Radix Scutellariae, 8 parts of Fructus Schisandrae Chinensis, 8 parts of Galla Chinensiss, 12 parts of Rhizoma Atractylodis.
3. a kind of marine organisms for light moderate burn and scald according to claim 1 and 2 spray film, it is characterised in that institute
The preparation method for stating spray film is following steps：
（1）Each raw material is accurately weighed by formula；
（2）By Olibanum, Myrrha parch, crush respectively, levigate, 70-120 mesh sieves are crossed, mixing fine powders are obtained, standby；
（3）Rhizoma Polygoni Cuspidati, Cortex Phellodendri, Radix Sanguisorbae are crushed respectively, plus the ethanol of 3-14 times of 80-95%, soak 4-24 hours, distillation extraction
Twice, each 1-6 hours, filter, and filtrate will mix twice, ethanol is distilled off, and be concentrated into 55 DEG C of relative densities for 1.16-
1.20 concentrated solution, standby；
（4）Borneolum Syntheticum, Radix Et Rhizoma Rhei, Radix Scutellariae, Fructus Schisandrae Chinensis, Galla Chinensiss, Rhizoma Atractylodis are crushed respectively, the purification of 5-14 times of weight after mixing, is added
Water, soaks 4-24 hours, and backflow is decocted twice, and each 1-5 hours are filtered, merging filtrate, and being concentrated into 55 DEG C of relative densities is
1.16-1.20 concentrated solution, standby；
（5）By step（3）With（4）In obtained concentrated solution merge, add Mel and step（2）Made mixing fine powders, mixing
Uniformly, continue to be concentrated into the thick paste that 55 DEG C of relative densities are 1.37-1.41, as Chinese medicine extract；
（6）It is the alkali liquor of 40-70% by the concentration that chitin adds 3-12 times, under conditions of 85-95 DEG C, reacts 8-19 hours,
During the course of the reaction per stirring every other hour once, reaction is finished, and is centrifuged off alkali liquor, is washed 3-8 time with purification, except roguing
Matter, dries pulverizing is levigate, crosses 70-120 mesh sieves, obtains fine powder, plus the lactic acid of 2-10 times of 3-20%, stirring and dissolving, filter clear
Clear solution, standby；
（7）Sodium alginate is levigate, 70-120 mesh sieves are crossed, fine powder is obtained, is added to step（6）Settled solution in, stirring is until solid
Body all dissolves, standby；
（8）Step is weighed in proportion（5）Gained Chinese medicine extract, is added to step（7）In resulting solution, mix, equal with homogenizer
Matter, that is, obtain spray film raw material suspension；
（9）Spray film raw material suspension is added appropriate adjuvant, bottled spray film is made using modern general preparation technique, as
Finished product.
4. a kind of marine organisms for light moderate burn and scald according to claim 3 spray film, it is characterised in that：Will be described
Step（8）Obtained spray film raw material suspension makes ointment, gel, patch, plaster, liniment, medicated wine or tincture.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201610985061.7A CN106491567A (en) | 2016-11-09 | 2016-11-09 | A kind of marine organisms spray film for light moderate burn and scald and preparation method thereof |
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| CN201610985061.7A CN106491567A (en) | 2016-11-09 | 2016-11-09 | A kind of marine organisms spray film for light moderate burn and scald and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103272040A (en) * | 2013-05-31 | 2013-09-04 | 刘建飞 | Burn and scald treatment medicine |
| CN104173369A (en) * | 2013-05-22 | 2014-12-03 | 何佩峰 | Drug for burns |
-
2016
- 2016-11-09 CN CN201610985061.7A patent/CN106491567A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104173369A (en) * | 2013-05-22 | 2014-12-03 | 何佩峰 | Drug for burns |
| CN103272040A (en) * | 2013-05-31 | 2013-09-04 | 刘建飞 | Burn and scald treatment medicine |
Non-Patent Citations (1)
| Title |
|---|
| 段久芳: "《天然高分子材料》", 30 September 2016, 华中科技大学出版社 * |
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Application publication date: 20170315 |