CN106491426A - A kind of toothpaste and preparation method thereof - Google Patents

A kind of toothpaste and preparation method thereof Download PDF

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Publication number
CN106491426A
CN106491426A CN201610984514.4A CN201610984514A CN106491426A CN 106491426 A CN106491426 A CN 106491426A CN 201610984514 A CN201610984514 A CN 201610984514A CN 106491426 A CN106491426 A CN 106491426A
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CN
China
Prior art keywords
toothpaste
agent
sodium
mitigation
present
Prior art date
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Application number
CN201610984514.4A
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Chinese (zh)
Inventor
许海燕
何威
肖小红
夏美莲
李超
骆朋
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JIANGXI CHENGZHI DAILY CHEMICAL CO Ltd
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JIANGXI CHENGZHI DAILY CHEMICAL CO Ltd
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Priority to CN201610984514.4A priority Critical patent/CN106491426A/en
Publication of CN106491426A publication Critical patent/CN106491426A/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

The invention provides a kind of toothpaste, including the component of following weight/mass percentage composition：Fructus Vitis viniferae Fructus Citri grandis extract 1.0～10.0%；Pyridoxine hydrochloride (0%, 1.0%]；Abrasivuss 12 55%；Wetting agent 10～70%；Binding agent 0.5～2.5%；Foaming agent 1～3%；Sweeting agent 0.1～0.5%；Preservative 0.1～0.5%；Essence 0.6～3%；Auxiliary agent 0～0.5%；Balance of water.The toothpaste that the present invention is provided can effectively mitigate or slow down various symptoms of the anemia of pregnant woman in the pregnancy period, mitigation that anemia of pregnant woman is vomited during pregnancy slows down effective percentage for more than 91%, to the mitigation of anemia of pregnant woman's dental caries or slow down effective percentage for more than 85%, to the mitigation of gingivitis or slow down effective percentage for more than 79%, to the mitigation of periodontitis or slow down effective percentage more than 83%, to the mitigation of oral ulcer or slow down effective percentage more than 80%.

Description

A kind of toothpaste and preparation method thereof
Technical field
The invention belongs to oral cavity health technical field, more particularly to a kind of toothpaste and preparation method thereof.
Background technology
Anemia of pregnant woman selects the reaction such as tired of food, inappetence, mild nausea, vomiting, dizziness and body, referred to as early pregnancy in gestation Reaction.Anemia of pregnant woman is vomitted because sensitive, easily stimulates nauseant nerve when brushing teeth in period of gestation, easily nausea, and vomiting is led Cause a lot of anemia of pregnant woman to remove the process of brushing teeth because of gestation reaction from, can only increase the risk of periodontal like that, have a strong impact on pregnant The health of woman's tooth and mouth care, are all unfavorable to anemia of pregnant woman and fetus.And anemia of pregnant woman usually has oral cavity different in gestation Taste, gingival hemorrhage, swelling, or even form the diseases such as epuliss, gingivitiss, dental caries, periodontitis and oral ulcer.
As the continuous development of science and technology, technological equipment are updated and perfect, various types of toothpaste are asked in succession Generation, the quality of product and class are improved constantly, and current toothpaste variety develops into kind neat by single clean type toothpaste The Mobyneb toothpaste of entirely, vdiverse in function, up to a hundred brand, meets the needs of different levels level of consumption.But current market On specialize in the conventional anemia of pregnant woman's toothpaste of toothpaste that anemia of pregnant woman uses and only consider no added safety factorss, but have ignored anemia of pregnant woman in the pregnancy period The symptom problem such as morning sickness, gingivitiss, dental caries, periodontitis and oral ulcer.
Content of the invention
In view of this, present invention aims to the deficiencies in the prior art, and a kind of toothpaste is provided, enables toothpaste Effectively mitigate or slow down anemia of pregnant woman in symptoms such as the morning sickness in pregnancy period, gingivitiss, dental caries, periodontitis and oral ulcer.
In order to realize that foregoing invention purpose, the present invention provide technical scheme below：
A kind of toothpaste, including the component of following weight/mass percentage composition：
Preferably, the weight/mass percentage composition of the Fructus Vitis viniferae Fructus Citri grandis extract is 2.0～6.0%.
Preferably, the weight/mass percentage composition of the pyridoxine hydrochloride is 0.05～0.7%.
Preferably, the abrasivuss are one or more in stone powder, silicon dioxide, calcium hydrogen phosphate and aluminium hydroxide.
Preferably, the wetting agent is one or more in glycerol, Sorbitol, Propylene Glycol and Polyethylene Glycol.
Preferably, the binding agent is sodium carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl guar gum, xanthan gum, card Draw one or more in glue, carbomer, Magnesiumaluminumsilicate and poloxamer.
Preferably, the foaming agent is sodium lauryl sulphate, sodium lauroyl sarcosine and cocamido propyl betaine In one or more.
Preferably, the water is deionized water.
Present invention also offers the preparation method of toothpaste described in above-mentioned technical proposal, comprises the following steps：
1) wetting agent, sweeting agent, Fructus Vitis viniferae Fructus Citri grandis extract, pyridoxine hydrochloride, auxiliary agent, preservative and water are mixed, is obtained Water mixes solution；
2) by the step 1) water that obtains is mixed solution and is mixed with binding agent, foaming agent and abrasivuss, then located Reason material；
3) by the step 2) the reprocessing material that obtains mixed with essence, obtains toothpaste.
The invention provides a kind of toothpaste, including the component of following weight/mass percentage composition：Fructus Vitis viniferae Fructus Citri grandis extract 1.0～ 10.0%；Pyridoxine hydrochloride (0%, 1.0%]；Wetting agent 10～70%；Abrasivuss 12～55%；Binding agent 0.5～2.5%； Foaming agent 1～3%；Sweeting agent 0.1～0.5%；Preservative 0.1～0.5%；Essence 0.6～3%；Auxiliary agent 0～0.5%；Surplus For water.In the present invention, the Fructus Vitis viniferae Fructus Citri grandis extract can suppress funguses, antibacterial, yeast and virus, such as to large intestine bar Bacterium, bacillus pyocyaneus, staphylococcus aureuses, Candida albicans and influenza virus etc. have good inhibiting effect, the salt Sour pyridoxol can prevent and treat vomiting during pregnancy；Enable that the toothpaste of present invention offer effectively mitigates or to slow down anemia of pregnant woman pregnant in the pregnancy period Tell, the symptom such as dental caries, gingivitiss, periodontitis and oral ulcer.Result of the test shows that the toothpaste that the present invention is provided is vomited during pregnancy to anemia of pregnant woman Mitigation or slow down effective percentage for more than 91%, to the mitigation of anemia of pregnant woman's dental caries or slow down effective percentage for more than 85%, to gingivitiss The mitigation of disease slows down effective percentage for more than 79%, to the mitigation of periodontitis or slows down effective percentage more than 83%, and oral cavity is burst The mitigation of infectionss slows down effective percentage more than 80%.
Specific embodiment
The invention provides a kind of toothpaste, including the component of following weight/mass percentage composition：Fructus Vitis viniferae Fructus Citri grandis extract 1.0～ 10.0%；Pyridoxine hydrochloride (0%, 1%]；Abrasivuss 12～55%；Wetting agent 10～70%；Binding agent 0.5～2.5%；Send out Infusion 1～3%；Sweeting agent 0.1～0.5%；Preservative 0.1～0.5%；Essence 0.6～3%；Auxiliary agent 0～0.5%；Balance of Water.
The toothpaste that the present invention is provided includes the Fructus Vitis viniferae Fructus Citri grandis extract that weight/mass percentage composition is 1.0～10.0%, preferably 2.0～6.0%, more preferably 3.0～5.0%.The present invention is not particularly limited to the source of the Fructus Vitis viniferae Fructus Citri grandis extract, is adopted With commercial goods, provided by Ke Naiou trades (Shanghai) Co., Ltd., trade name Protectence 5% Solution.
In the present invention, the Fructus Vitis viniferae Fructus Citri grandis extract can suppress funguses, antibacterial, yeast and virus, such as to large intestine Bacillus, bacillus pyocyaneus, staphylococcus aureuses, Candida albicans and influenza virus etc. have good inhibiting effect.
The present invention provide toothpaste include weight/mass percentage composition for (0%, 1.0%] pyridoxine hydrochloride, preferably 0.05 ～0.7%, more preferably 0.2～0.5%.The present invention is not particularly limited to the source of the pyridoxine hydrochloride, using commercially available Commodity.In the present invention, the pyridoxine hydrochloride can prevent and treat vomiting during pregnancy.
The toothpaste that the present invention is provided includes abrasivuss that weight/mass percentage composition is 12～55%, preferably 15～45%, more Preferably 20～35%, most preferably 25～30%.In the present invention, the abrasivuss are preferably stone powder, silicon dioxide, phosphoric acid One or more in hydrogen calcium and aluminium hydroxide, specially a kind, 2 kinds, 3 kinds or 4 kinds.In the present invention, when the abrasivuss are When 2～3 kinds of mentioned reagent, can arbitrary proportion mixing；When 4 kinds that the abrasivuss are mentioned reagent, the stone powder and two Silicon oxide, calcium bicarbonate, the mass ratio of aluminium hydroxide are preferably (2～35):(2～30):(2～25):(2～20), more preferably For (4～30):(4～25):(4～20):(4～15), most preferably (6～20):(6～15):(6～15):(6～12).This Invention is not particularly limited to the source of mentioned reagent, the commercial goods that is routinely selected using those skilled in the art.
The toothpaste that the present invention is provided includes wetting agent that weight/mass percentage composition is 10～70%, preferably 20～60%, more Preferably 30～50%, most preferably 35～45%.In the present invention, the wetting agent is preferably glycerol, Sorbitol, Propylene Glycol With one or more in Polyethylene Glycol, specially a kind, 2 kinds, 3 kinds or 4 kinds.In the present invention, when the wetting agent is above-mentioned When 2～3 kinds of reagent, can arbitrary proportion mixing；When the wetting agent for 4 kinds of mentioned reagent when, the glycerol and Sorbitol, Propylene Glycol, the mass ratio of Polyethylene Glycol are preferably (1～45):(1～65):(1～40):(1～20), more preferably (2～40): (2～60):(2～35):(2～18), most preferably (5～35):(5～40):(5～30):(5～16).The present invention is to above-mentioned The source of reagent is not particularly limited, the commercial goods that is routinely selected using those skilled in the art.
The toothpaste that the present invention is provided includes binding agent that weight/mass percentage composition is 0.5～2.5%, preferably 0.8～2.0, More preferably 1.2～1.5%.In the present invention, the binding agent is preferably sodium carboxymethyl cellulose, hydroxyethyl cellulose, hydroxyl One or more in propyl group guar gum, xanthan gum, carrageenan, carbomer, Magnesiumaluminumsilicate and poloxamer.When the bonding When agent is two kinds in said components, preferably sodium carboxymethyl cellulose and xanthan gum；When the binding agent is in said components Three kinds when, preferably sodium carboxymethyl cellulose, Magnesiumaluminumsilicate and carrageenan.When the binding agent be sodium carboxymethyl cellulose and During xanthan gum, the sodium carboxymethyl cellulose is preferably (0.1～2.5) with the mass ratio of xanthan gum:(0.1～2.5), more preferably For (0.2～2.0):(0.2～2.0), most preferably (0.3～1.5):(0.3～1.5).When the binding agent is that carboxymethyl is fine When the plain sodium of dimension, Magnesiumaluminumsilicate and carrageenan, the sodium carboxymethyl cellulose is preferably with the mass ratio of Magnesiumaluminumsilicate and carrageenan (0.1～2.5):(0.1～2.0):(0.1～1.5), is most more preferably (0.3～2.0):(0.3～1.5):(0.3～1.2), Most preferably (0.5～1.5):(0.5～1.2):(0.5～1.0).The present invention is not particularly limited to the source of mentioned reagent, The commercial goods that is routinely selected using those skilled in the art.
The toothpaste that the present invention is provided includes foaming agent that weight/mass percentage composition is 1～3%, preferably 1.5～2.5%, more Preferably 2%.In the present invention, the foaming agent is preferably sodium lauryl sulphate, sodium lauroyl sarcosine and coconut oleoyl amine One or more in CAB, specially a kind, 2 kinds or 3 kinds.In the present invention, when the foaming agent is mentioned reagent In two kinds when, preferably sodium lauryl sulphate and sodium lauroyl sarcosine；The sodium lauryl sulphate and lauroyl flesh The mass ratio of propylhomoserin sodium is preferably (0.5～2.2):(0.5～2.2), more preferably (0.8～2.0):(0.8～2.0), optimum Elect 1.1 as:1.1.When the foaming agent is 3 kinds of mentioned reagent, specially sodium lauryl sulphate, sodium lauroyl sarcosine and Cocamido propyl betaine, the sodium lauryl sulphate and sodium lauroyl sarcosine, the matter of cocamido propyl betaine Amount is than being preferably (0.3～2.0):(0.3～2.0):(0.3～2.0), more preferably (0.5～1.2):(0.5～1.2):(0.5 ～1.2), most preferably 0.7:0.8:0.6.The present invention is not particularly limited to the source of mentioned reagent, using art technology The commercial goods that personnel routinely select.
The toothpaste that the present invention is provided includes sweeting agent that weight/mass percentage composition is 0.1～0.5%, preferably 0.2～ 0.4%, more elect 0.3% as.In the present invention, the sweeting agent is preferably saccharin sodium, aspartame, stevioside, trichlorine sugarcane One or more in sugar, erythritol and xylitol, specially a kind, 2 kinds, 3 kinds, 4 kinds, 5 kinds or 6 kinds.In the present invention, When the sweeting agent is two kinds in mentioned reagent, preferably saccharin sodium and stevioside；The saccharin sodium and the matter of stevioside Amount is than being preferably (0.05～0.45):(0.05～0.45), more preferably (0.1～0.4):(0.1～0.4).When the sweet taste When agent is three kinds in mentioned reagent, preferably saccharin sodium, sucralose and erythritol；The saccharin sodium and sucralose, The mass ratio of erythritol is preferably (0.05～0.35):(0.05～0.35):(0.05～0.35), more preferably (0.1～ 0.2):(0.1～0.2):(0.1～0.2).The present invention is not particularly limited to the source of mentioned reagent, using art technology The commercial goods that personnel routinely select.
The toothpaste that the present invention is provided includes preservative that weight/mass percentage composition is 0.1～0.5%, preferably 0.2～ 0.4%, more preferably 0.3%.In the present invention, the preservative is preferably sodium benzoate or/and parabenses.At this In bright, when the preservative is sodium benzoate and parabenses, the sodium benzoate is excellent with the mass ratio of parabenses Elect (0.1～0.4) as:(0.1～0.4), more preferably (0.1～0.3):(0.1～0.3), most elects 0.2 as:0.2.At this In invention, the Metagin esters preservative preferably includes soluble metyl hydroxybenzoate, ethylparaben, para hydroxybenzene first Propyl propionate and butyl p-hydroxybenzoate.The present invention is not particularly limited to the source of mentioned reagent, using people in the art The conventional commercial goods that selects of member.
The toothpaste that the present invention is provided includes essence that weight/mass percentage composition is 0.6～3%, preferably 1～2.5%, more excellent Elect 1.5～2% as.The present invention is not particularly limited to the source of the essence, is routinely selected using those skilled in the art Commercial goods, such as Herba Menthae Rotundifoliae essence, Ilicis Purpureae essence, fruit essence etc..
The toothpaste that the present invention is provided includes auxiliary agent that weight/mass percentage composition is 0～0.5%, preferably 0.2～0.4%, more Preferably 0.3%.In the present invention, the auxiliary agent be preferably tetrasodium pyrophosphate, sodium dihydrogen phosphate, sodium carbonate, sodium bicarbonate and One or more in sodium silicate, specially a kind, 2 kinds, 3 kinds, 4 kinds or 5 kinds.When the auxiliary agent is two kinds in mentioned reagent When, preferably tetrasodium pyrophosphate and sodium carbonate；The tetrasodium pyrophosphate is preferably (0～0.5) with the mass ratio of sodium carbonate:(0～ 0.5), more preferably (0～0.4):(0～0.4), most preferably 0.3:0.1.The present invention is not special to the source of mentioned reagent Limit, the commercial goods that is routinely selected using those skilled in the art.
In the present invention, including the water of surplus, more preferably deionized water.
The invention provides the preparation method of toothpaste described in above-mentioned technical proposal, comprises the following steps：
1) wetting agent, sweeting agent, Fructus Vitis viniferae Fructus Citri grandis extract, pyridoxine hydrochloride, preservative, auxiliary agent and water are mixed, is obtained Water mixes solution；
2) by the step 1) water that obtains mixes the mixing of solution, binding agent, foaming agent and abrasivuss, reprocessed Material；
3) by the step 2) the reprocessing material that obtains mixed with essence, obtains toothpaste.
In the present invention, the preparation method is preferably carried out under vacuum conditions, and the vacuum under the vacuum state is excellent Elect -0.02～-0.095MPa, most preferably more preferably -0.05～-0.094MPa, -0.093MPa as.
In the present invention, the step 1) in the incorporation time of mixing be preferably 10-30min, more preferably 15- 25min, most preferably 20min；The step 2) the middle incorporation time for mixing preferably 40～60min, more preferably 45～ 55min, most preferably 50min；The step 3) the middle incorporation time for mixing preferably 15～30min, more preferably 20～ 28min, most preferably 25min.
The present invention is not particularly limited to the equipment of the preparation of the toothpaste, is routinely selected using those skilled in the art Equipment, specific is preferably vacuum Manufacturing medicine extract machine.
When being prepared using vacuum Manufacturing medicine extract machine, specific flow process is：
1. wetting agent is sucked in vacuum Manufacturing medicine extract machine under vacuum conditions；
2. sweeting agent, Fructus Vitis viniferae Fructus Citri grandis extract, pyridoxine hydrochloride, auxiliary agent, preservative water dissolution are stirred in small powder pot After mixing uniformly, stir with wetting agent in suction vacuum Manufacturing medicine extract machine under vacuum conditions, obtain water and mix solution；
3. binding agent, foaming agent and abrasive is poured into after stirring in powder pot, sucks vacuum under vacuum conditions Manufacturing medicine extract machine neutralization procedure 2. in water to mix solution stirring uniform, obtain reprocessing material；
4. under vacuum conditions suction essence and step 3. in reprocessing material be stirred, obtain final product toothpaste.
In the present invention, the using method and consumption of the toothpaste are not particularly limited, using those skilled in the art The conventional using method that selects and consumption.
Toothpaste and preparation method thereof that the present invention is provided is described in detail with reference to embodiment, but can not be They are interpreted as limiting the scope of the present invention.
Embodiment 1
In terms of weight/mass percentage composition, by pyridoxine hydrochloride 0.15%, Fructus Vitis viniferae Fructus Citri grandis extract 1.8%, silica 1 5%, Sorbitol 60%, sodium carboxymethyl cellulose 0.8%, sodium lauroyl sarcosine 2%, saccharin sodium 0.2%, soluble metyl hydroxybenzoate 0.05%, essence 0.8%, tetrasodium pyrophosphate 0.3%, deionized water supplies 100%.
The source of Fructus Vitis viniferae Fructus Citri grandis extract is commercially available prod, is provided by Ke Naiou trades (Shanghai) Co., Ltd., trade name For Protectence 5%Solution.
Preparation method：The vacuum of vacuum Manufacturing medicine extract machine is set to as -0.06MPa, first by wetting agent, sweeting agent, Fructus Vitis viniferae Fructus Citri grandis extract, pyridoxine hydrochloride and water mix 20min in vacuum Manufacturing medicine extract machine, obtain water and mix solution, then by binding agent, Foaming agent, abrasivuss solution mixed with water mixes 50min in vacuum Manufacturing medicine extract machine, obtain reprocessing material, finally by essence with Reprocessing material mixes 25min in vacuum Manufacturing medicine extract machine, obtains toothpaste.
Embodiment 2
In terms of weight/mass percentage composition, by pyridoxine hydrochloride 0.05%, Fructus Vitis viniferae Fructus Citri grandis extract 6%, stone powder 12%, Sorbitol 20%, sodium carboxymethyl cellulose 1%, sodium lauryl sulphate 2%, saccharin sodium 0.2%, sodium benzoate 0.1%, essence 0.6%, Tetrasodium pyrophosphate 0.3%, deionized water supplies 100%.
The source phase of the Fructus Vitis viniferae Fructus Citri grandis extract in the source of the Fructus Vitis viniferae Fructus Citri grandis extract in the present embodiment and embodiment 1 With.
According to technical scheme same as Example 1, toothpaste is prepared with said components as raw material.
Embodiment 3
In terms of weight/mass percentage composition, by pyridoxine hydrochloride 0.55%, Fructus Vitis viniferae Fructus Citri grandis extract 5%, stone powder 12%, titanium dioxide Silicon 15%, Sorbitol 10%, Propylene Glycol 10%, sodium carboxymethyl cellulose 1%, silicic acid Latin America 1%, sodium lauryl sulphate 2%, Sodium lauroyl sarcosine 1%, saccharin sodium 0.2%, stevioside 0.2%, sodium benzoate 0.1%, soluble metyl hydroxybenzoate 0.3% are fragrant Essence 3%, sodium carbonate 0.3%, tetrasodium pyrophosphate 0.2%, deionized water supplies 100%.
Fructus Vitis viniferae Fructus Citri grandis extract in the present embodiment is identical with the Fructus Vitis viniferae Fructus Citri grandis extract source in embodiment 1.
According to technical scheme same as Example 1, toothpaste is prepared with said components as raw material.
Embodiment 4
In terms of weight/mass percentage composition, by pyridoxine hydrochloride 0.5%, Fructus Vitis viniferae Fructus Citri grandis extract 5.5%, stone powder 6%, titanium dioxide Silicon 8%, calcium hydrogen phosphate 10%, Sorbitol 10%, Propylene Glycol 10%, glycerol 8%, Polyethylene Glycol 10%, sodium carboxymethyl cellulose 1%, silicic acid Latin America 1%, sodium lauryl sulphate 2%, sodium lauroyl sarcosine 1%, saccharin sodium 0.2%, sucralose 0.2%, erythritol 0.1%, sodium benzoate 0.1%, propyl p-hydroxybenzoate 0.3%, essence 3%, sodium carbonate 0.3%, Tetrasodium pyrophosphate 0.2%, deionized water supplies 100%.
Fructus Vitis viniferae Fructus Citri grandis extract in the present embodiment is identical with the Fructus Vitis viniferae Fructus Citri grandis extract source in embodiment 1.
According to technical scheme same as Example 1, toothpaste is prepared with said components as raw material.
Embodiment 5
In terms of weight/mass percentage composition, by pyridoxine hydrochloride 0.2%, Fructus Vitis viniferae Fructus Citri grandis extract 9.5%, stone powder 10%, dioxy SiClx 10%, calcium hydrogen phosphate 12%, Sorbitol 12%, Propylene Glycol 8%, glycerol 12%, Polyethylene Glycol 10%, carboxymethyl cellulose Sodium 0.8%, silicic acid Latin America 1.2%, sodium lauryl sulphate 2%, sodium lauroyl sarcosine 1%, saccharin sodium 0.3%, trichlorine sugarcane Sugar 0.1%, erythritol 0.1%, sodium benzoate 0.1%, ethylparaben 0.3%, essence 1.5%, sodium carbonate 0.3%, sodium silicate 0.2%, deionized water supplies 100%.
Fructus Vitis viniferae Fructus Citri grandis extract in the present embodiment is identical with the Fructus Vitis viniferae Fructus Citri grandis extract source in embodiment 1.
According to technical scheme same as Example 1, toothpaste is prepared with said components as raw material.
Choose patient age 20～40 years old, wherein primipara 142, multipara 58, all patients brush teeth occasional nausea Symptom is told, after the toothpaste prepared using the embodiment of the present invention 1～5, various symptoms have all mitigated or slowed down, and the results are shown in Table 1：
Toothpaste prepared by 1 embodiment of table 1～5 to the mitigation of various symptoms or slows down effective percentage
As can be drawn from Table 1, the toothpaste mitigation that anemia of pregnant woman is vomited during pregnancy that prepared by the present invention slows down effective percentage more than 91%, To the mitigation of dental caries or slow down effective percentage more than 85%, to the mitigation of gingivitiss or slow down effective percentage more than 79%, to tooth The mitigation of Zhou Yan slows down effective percentage more than 83%, to the mitigation of oral ulcer or slows down effective percentage more than 80%.
As seen from the above embodiment, the morning sickness, tooth during the toothpaste of present invention preparation can effectively mitigate or slow down anemia of pregnant woman The symptoms such as gingivitis, dental caries, periodontitis and oral ulcer.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should It is considered as protection scope of the present invention.

Claims (9)

1. a kind of toothpaste, including the component of following weight/mass percentage composition：
2. toothpaste according to claim 1, it is characterised in that carry including the Fructus Vitis viniferae Fructus Citri grandis that weight/mass percentage composition is 2～6% Take thing.
3. toothpaste according to claim 1, it is characterised in that including the hydrochloric acid that weight/mass percentage composition is 0.05～0.7% Pyridoxol.
4. the toothpaste according to claim 1～2 any one, it is characterised in that the abrasivuss are stone powder, titanium dioxide One or more in silicon, calcium hydrogen phosphate and aluminium hydroxide.
5. the toothpaste according to claim 1～2 any one, it is characterised in that the wetting agent be glycerol, Sorbitol, One or more in Propylene Glycol and Polyethylene Glycol.
6. the toothpaste according to claim 1～2 any one, it is characterised in that the binding agent is carboxymethyl cellulose In sodium, hydroxyethyl cellulose, hydroxypropyl guar gum, xanthan gum, carrageenan, carbomer, Magnesiumaluminumsilicate and poloxamer one Plant or several.
7. the toothpaste according to claim 1～2 any one, it is characterised in that the foaming agent is lauryl sulphate acid One or more in sodium, sodium lauroyl sarcosine and cocamido propyl betaine.
8. the toothpaste according to claim 1～2 any one, it is characterised in that the water is deionized water.
9. the preparation method of the toothpaste described in claim 1～8 any one, comprises the following steps：
1) wetting agent, sweeting agent, Fructus Vitis viniferae Fructus Citri grandis extract, pyridoxine hydrochloride, preservative, auxiliary agent and water are mixed, obtains water phase Mixed solution；
2) by the step 1) water that obtains mixed solution and mixed with binding agent, foaming agent and abrasivuss, obtains reprocessing material；
3) by the step 2) the reprocessing material that obtains mixed with essence, obtains toothpaste.
CN201610984514.4A 2016-11-09 2016-11-09 A kind of toothpaste and preparation method thereof Pending CN106491426A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107648062A (en) * 2017-09-18 2018-02-02 广州星业科技股份有限公司 A kind of amino acid toothpaste of no added laruyl alcohol sodium sulfovinate and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101947198A (en) * 2010-09-10 2011-01-19 甘肃奇正藏药有限公司 Toothpaste special for pregnant women and preparation process thereof
CN102397193A (en) * 2011-11-18 2012-04-04 大连得达科技发展有限公司 Essential oil toothpaste composition

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101947198A (en) * 2010-09-10 2011-01-19 甘肃奇正藏药有限公司 Toothpaste special for pregnant women and preparation process thereof
CN102397193A (en) * 2011-11-18 2012-04-04 大连得达科技发展有限公司 Essential oil toothpaste composition

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107648062A (en) * 2017-09-18 2018-02-02 广州星业科技股份有限公司 A kind of amino acid toothpaste of no added laruyl alcohol sodium sulfovinate and preparation method thereof

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